Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 442 | 1,234 | 2.79 | 215 | 48.64% | 118 | 26.70% | 109 | 24.66% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 33 | 22 | 7 | 4 | 65 | 40 | +25 | 73 | WXWX | 16 | 12 | 3 | 1 | 31 | 17 | 17 | 10 | 4 | 3 | 34 | 23 | ||
| 2 | 1 | Philadelphia Union | 33 | 14 | 11 | 8 | 47 | 34 | +13 | 53 | WXWL | 17 | 11 | 3 | 3 | 25 | 10 | 16 | 3 | 8 | 5 | 22 | 24 | |
| 3 | 1 | Nashville | 33 | 12 | 17 | 4 | 54 | 32 | +22 | 53 | XWLX | 16 | 8 | 8 | 0 | 34 | 17 | 17 | 4 | 9 | 4 | 20 | 15 | |
| 4 | New York City | 33 | 14 | 8 | 11 | 55 | 35 | +20 | 50 | WWWX | 16 | 10 | 3 | 3 | 36 | 12 | 17 | 4 | 5 | 8 | 19 | 23 | ||
| 5 | Orlando City | 33 | 12 | 12 | 9 | 48 | 48 | +0 | 48 | XLXX | 17 | 8 | 7 | 2 | 29 | 18 | 16 | 4 | 5 | 7 | 19 | 30 | ||
| 6 | Atlanta United | 32 | 12 | 11 | 9 | 43 | 36 | +7 | 47 | XWXW | 17 | 9 | 5 | 3 | 25 | 14 | 15 | 3 | 6 | 6 | 18 | 22 | ||
| 7 | 1 | New York Red Bulls | 32 | 13 | 7 | 12 | 38 | 32 | +6 | 46 | WLWW | 16 | 8 | 5 | 3 | 19 | 11 | 16 | 5 | 2 | 9 | 19 | 21 | |
| 8 | 1 | D.C. United | 33 | 13 | 5 | 15 | 53 | 53 | +0 | 44 | LWLL | 17 | 11 | 1 | 5 | 32 | 17 | 16 | 2 | 4 | 10 | 21 | 36 | |
| 9 | 1 | Columbus Crew | 33 | 12 | 8 | 13 | 44 | 45 | -1 | 44 | WWLX | 16 | 9 | 3 | 4 | 31 | 22 | 17 | 3 | 5 | 9 | 13 | 23 | |
| 10 | 1 | CF Montréal | 32 | 11 | 10 | 11 | 44 | 42 | +2 | 43 | LXXX | 15 | 8 | 4 | 3 | 27 | 21 | 17 | 3 | 6 | 8 | 17 | 21 | |
| 11 | Inter Miami | 33 | 11 | 5 | 17 | 35 | 53 | -18 | 38 | LLWW | 17 | 7 | 2 | 8 | 26 | 35 | 16 | 4 | 3 | 9 | 9 | 18 | ||
| 12 | Chicago Fire | 33 | 9 | 7 | 17 | 36 | 52 | -16 | 34 | LWWX | 17 | 7 | 5 | 5 | 23 | 18 | 16 | 2 | 2 | 12 | 13 | 34 | ||
| 13 | Toronto FC | 33 | 6 | 10 | 17 | 38 | 63 | -25 | 28 | XXXL | 16 | 4 | 7 | 5 | 23 | 24 | 17 | 2 | 3 | 12 | 15 | 39 | ||
| 14 | FC Cincinnati | 33 | 4 | 8 | 21 | 36 | 72 | -36 | 20 | LLLL | 16 | 1 | 5 | 10 | 16 | 27 | 17 | 3 | 3 | 11 | 20 | 45 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Seattle Sounders | 33 | 17 | 8 | 8 | 52 | 32 | +20 | 59 | XLLX | 17 | 8 | 5 | 4 | 28 | 15 | 16 | 9 | 3 | 4 | 24 | 17 | |
| 2 | 1 | Sporting Kansas City | 32 | 17 | 7 | 8 | 57 | 36 | +21 | 58 | LWWL | 16 | 9 | 5 | 2 | 32 | 16 | 16 | 8 | 2 | 6 | 25 | 20 | |
| 3 | Colorado Rapids | 33 | 16 | 10 | 7 | 46 | 33 | +13 | 58 | WLWX | 16 | 8 | 7 | 1 | 26 | 12 | 17 | 8 | 3 | 6 | 20 | 21 | ||
| 4 | Portland Timbers | 32 | 15 | 4 | 13 | 50 | 51 | -1 | 49 | WLLL | 16 | 10 | 2 | 4 | 32 | 22 | 16 | 5 | 2 | 9 | 18 | 29 | ||
| 5 | 3 | Minnesota United | 33 | 13 | 9 | 11 | 39 | 41 | -2 | 48 | WLXW | 17 | 10 | 3 | 4 | 24 | 14 | 16 | 3 | 6 | 7 | 15 | 27 | |
| 6 | 1 | Vancouver Whitecaps | 33 | 12 | 12 | 9 | 44 | 44 | +0 | 48 | XWXW | 16 | 10 | 2 | 4 | 24 | 16 | 17 | 2 | 10 | 5 | 20 | 28 | |
| 7 | 1 | LA Galaxy | 33 | 13 | 8 | 12 | 47 | 51 | -4 | 47 | XLXW | 16 | 8 | 4 | 4 | 26 | 19 | 17 | 5 | 4 | 8 | 21 | 32 | |
| 8 | 1 | Real Salt Lake | 32 | 13 | 6 | 13 | 53 | 51 | +2 | 45 | LWLW | 16 | 9 | 4 | 3 | 29 | 18 | 16 | 4 | 2 | 10 | 24 | 33 | |
| 9 | Los Angeles | 33 | 12 | 9 | 12 | 51 | 46 | +5 | 45 | XWXW | 17 | 8 | 6 | 3 | 34 | 23 | 16 | 4 | 3 | 9 | 17 | 23 | ||
| 10 | San Jose Earthquakes | 33 | 10 | 10 | 13 | 45 | 53 | -8 | 40 | WLXW | 16 | 5 | 4 | 7 | 24 | 23 | 17 | 5 | 6 | 6 | 21 | 30 | ||
| 11 | 1 | FC Dallas | 33 | 7 | 11 | 15 | 46 | 55 | -9 | 32 | WLXL | 17 | 5 | 7 | 5 | 25 | 21 | 16 | 2 | 4 | 10 | 21 | 34 | |
| 12 | 1 | Houston Dynamo | 33 | 6 | 12 | 15 | 36 | 52 | -16 | 30 | LLLW | 17 | 6 | 6 | 5 | 21 | 22 | 16 | 0 | 6 | 10 | 15 | 30 | |
| 13 | Austin FC | 32 | 8 | 4 | 20 | 32 | 52 | -20 | 28 | LWLL | 16 | 6 | 2 | 8 | 24 | 24 | 16 | 2 | 2 | 12 | 8 | 28 | ||
| 18 | +2 | Valentín CASTELLANOS (New York City) |
| 17 | Ola KAMARA (D.C. United) | |
| +1 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 16 | Dániel SALLÓI (Sporting Kansas City) | |
| Adam BUKSA (New England Revolution) | ||
| 15 | Damir KREILACH (Real Salt Lake) | |
| Gustavo BOU (New England Revolution) | ||
| +1 | Hany MUKHTAR (Nashville) | |
| +1 | Javier HERNÁNDEZ (LA Galaxy) | |
| 14 | Johnny RUSSELL (Sporting Kansas City) | |
| 13 | Ricardo PEPI (FC Dallas) | |
| Cristian ARANGO (Los Angeles) | ||
| 12 | Gonzalo HIGUAÍN (Inter Miami) | |
| C.J. SAPONG (Nashville) | ||
| Javier LÓPEZ (San Jose Earthquakes) | ||
| Brian WHITE (Vancouver Whitecaps) | ||
| 11 | Josef MARTÍNEZ (Atlanta United) | |
| Felipe MORA (Portland Timbers) | ||
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| Fabrice PICAULT (Houston Dynamo) | ||
| +2 | Lucas ZELARAYÁN (Columbus Crew) | |
| 10 | Dairon ASPRILLA (Portland Timbers) | |
| NANI (Orlando City) | ||
| +2 | Albert RUSNÁK (Real Salt Lake) | |
| +1 | Cristian DÁJOME (Vancouver Whitecaps) | |
| 9 | Jesús MEDINA (New York City) | |
| Gyasi ZARDES (Columbus Crew) | ||
| Marcelino MORENO (Atlanta United) | ||
| +1 | Daryl DIKE (Orlando City) |
| Saturday, 30 October 2021 | |||||
| D.C. United | 1-3 | Columbus Crew | |||
| 3 | Arriola | 45(p) | Zelarayán | ||
| 66 | Pedro Santos | ||||
| 76 | Zelarayán | ||||
| FC Dallas | 2-1 | Austin FC | |||
| 38 | Ferreira | 36 | Fagúndez | ||
| 80 | Jara | ||||
| New York Red Bulls | 1-0 | CF Montréal | |||
| 90 | Fábio | ||||
| Real Salt Lake | 3-4 | San Jose Earthquakes | |||
| 9 | Rusnák | 37 | Fierro | ||
| 85 | Chang | 45 | Wondolowski | ||
| 90 | Rusnák | 69 | Cowell | ||
| 79 | Yueill | ||||
| Atlanta United | 1-1 | Toronto FC | |||
| 15 | Luiz Araújo | 88 | Perruzza | ||
| Inter Miami | 1-3 | New York City | |||
| 56 | Figal | 33 | Castellanos | ||
| 60 | Castellanos | ||||
| 83 | Talles Magno | ||||
| Sunday, 31 October 2021 | |||||
| Houston Dynamo | 0-1 | Colorado Rapids | |||
| 58 | Badji | ||||
| Orlando City | 1-1 | Nashville | |||
| 18 | Dike | 53 | Mukhtar | ||
| Philadelphia Union | 2-0 | FC Cincinnati | |||
| 11 | Gazdag | ||||
| 53 | Aaronson | ||||
| Minnesota United | 2-1 | Sporting Kansas City | |||
| 20 | Fragapane | 8 | Shelton | ||
| 39(p) | Reynoso | ||||
| Monday, 1 November 2021 | |||||
| Seattle Sounders | 1-1 | LA Galaxy | |||
| 51(p) | Ruidíaz | 19 | Hernández | ||
| Tuesday, 2 November 2021 | |||||
| Los Angeles | 1-1 | Vancouver Whitecaps | |||
| 45 | Fall | 14 | Dájome | ||
