Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 263 | 697 | 2.65 | 124 | 47.15% | 78 | 29.66% | 61 | 23.19% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 21 | 14 | 4 | 3 | 40 | 25 | +15 | 46 | WWWO | 10 | 8 | 1 | 1 | 19 | 11 | 11 | 6 | 3 | 2 | 21 | 14 | ||
| 2 | 3 | Nashville | 20 | 7 | 11 | 2 | 32 | 20 | +12 | 32 | XWLO | 13 | 7 | 6 | 0 | 28 | 13 | 7 | 0 | 5 | 2 | 4 | 7 | |
| 3 | 1 | New York City | 19 | 9 | 4 | 6 | 34 | 19 | +15 | 31 | LWXO | 10 | 7 | 1 | 2 | 24 | 8 | 9 | 2 | 3 | 4 | 10 | 11 | |
| 4 | Philadelphia Union | 20 | 8 | 7 | 5 | 26 | 19 | +7 | 31 | WLWX | 10 | 6 | 2 | 2 | 14 | 7 | 10 | 2 | 5 | 3 | 12 | 12 | ||
| 5 | 2 | Orlando City | 19 | 8 | 7 | 4 | 29 | 24 | +5 | 31 | XXXW | 9 | 5 | 3 | 1 | 17 | 7 | 10 | 3 | 4 | 3 | 12 | 17 | |
| 6 | D.C. United | 20 | 8 | 3 | 9 | 31 | 29 | +2 | 27 | LLWW | 8 | 6 | 0 | 2 | 14 | 5 | 12 | 2 | 3 | 7 | 17 | 24 | ||
| 7 | CF Montréal | 20 | 7 | 6 | 7 | 26 | 25 | +1 | 27 | OWLX | 9 | 5 | 3 | 1 | 17 | 12 | 11 | 2 | 3 | 6 | 9 | 13 | ||
| 8 | Columbus Crew | 20 | 6 | 6 | 8 | 21 | 25 | -4 | 24 | LLLL | 9 | 4 | 3 | 2 | 15 | 12 | 11 | 2 | 3 | 6 | 6 | 13 | ||
| 9 | 1 | Atlanta United | 20 | 5 | 9 | 6 | 23 | 25 | -2 | 24 | WWWX | 9 | 4 | 3 | 2 | 10 | 7 | 11 | 1 | 6 | 4 | 13 | 18 | |
| 10 | 1 | New York Red Bulls | 19 | 6 | 4 | 9 | 23 | 24 | -1 | 22 | WLLO | 9 | 5 | 2 | 2 | 13 | 7 | 10 | 1 | 2 | 7 | 10 | 17 | |
| 11 | Chicago Fire | 20 | 5 | 5 | 10 | 23 | 32 | -9 | 20 | LWWO | 13 | 5 | 4 | 4 | 18 | 15 | 7 | 0 | 1 | 6 | 5 | 17 | ||
| 12 | Inter Miami | 18 | 5 | 4 | 9 | 18 | 30 | -12 | 19 | WLWX | 10 | 3 | 2 | 5 | 12 | 21 | 8 | 2 | 2 | 4 | 6 | 9 | ||
| 13 | FC Cincinnati | 18 | 3 | 8 | 7 | 18 | 30 | -12 | 17 | OXOO | 8 | 0 | 5 | 3 | 6 | 10 | 10 | 3 | 3 | 4 | 12 | 20 | ||
| 14 | Toronto FC | 20 | 3 | 6 | 11 | 24 | 41 | -17 | 15 | LLXL | 9 | 1 | 5 | 3 | 12 | 14 | 11 | 2 | 1 | 8 | 12 | 27 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | Seattle Sounders | 20 | 11 | 6 | 3 | 33 | 16 | +17 | 39 | WWXL | 11 | 5 | 4 | 2 | 18 | 9 | 9 | 6 | 2 | 1 | 15 | 7 | |
| 2 | 1 | Sporting Kansas City | 20 | 11 | 5 | 4 | 36 | 21 | +15 | 38 | XWOW | 10 | 5 | 4 | 1 | 18 | 11 | 10 | 6 | 1 | 3 | 18 | 10 | |
| 3 | 1 | LA Galaxy | 20 | 11 | 2 | 7 | 31 | 30 | +1 | 35 | LWXW | 11 | 7 | 1 | 3 | 19 | 12 | 9 | 4 | 1 | 4 | 12 | 18 | |
| 4 | Colorado Rapids | 18 | 10 | 4 | 4 | 27 | 18 | +9 | 34 | WWOW | 9 | 5 | 3 | 1 | 16 | 8 | 9 | 5 | 1 | 3 | 11 | 10 | ||
| 5 | 1 | Real Salt Lake | 19 | 7 | 6 | 6 | 29 | 21 | +8 | 27 | WWLL | 11 | 5 | 4 | 2 | 17 | 10 | 8 | 2 | 2 | 4 | 12 | 11 | |
| 6 | 1 | Minnesota United | 19 | 7 | 6 | 6 | 22 | 23 | -1 | 27 | XLWX | 10 | 6 | 1 | 3 | 12 | 7 | 9 | 1 | 5 | 3 | 10 | 16 | |
| 7 | Portland Timbers | 19 | 7 | 3 | 9 | 26 | 36 | -10 | 24 | XLWX | 10 | 6 | 1 | 3 | 17 | 15 | 9 | 1 | 2 | 6 | 9 | 21 | ||
| 8 | Los Angeles | 19 | 6 | 5 | 8 | 24 | 26 | -2 | 23 | LLLX | 10 | 4 | 4 | 2 | 16 | 14 | 9 | 2 | 1 | 6 | 8 | 12 | ||
| 9 | San Jose Earthquakes | 20 | 5 | 8 | 7 | 22 | 28 | -6 | 23 | XOWX | 10 | 3 | 3 | 4 | 13 | 14 | 10 | 2 | 5 | 3 | 9 | 14 | ||
| 10 | FC Dallas | 20 | 5 | 6 | 9 | 23 | 28 | -5 | 21 | LLWX | 11 | 4 | 5 | 2 | 18 | 11 | 9 | 1 | 1 | 7 | 5 | 17 | ||
| 11 | 1 | Vancouver Whitecaps | 19 | 4 | 8 | 7 | 21 | 29 | -8 | 20 | WOXX | 8 | 3 | 2 | 3 | 8 | 10 | 11 | 1 | 6 | 4 | 13 | 19 | |
| 12 | 1 | Houston Dynamo | 20 | 3 | 9 | 8 | 21 | 30 | -9 | 18 | LLLL | 8 | 3 | 4 | 1 | 10 | 9 | 12 | 0 | 5 | 7 | 11 | 21 | |
| 13 | Austin FC | 19 | 4 | 4 | 11 | 14 | 23 | -9 | 16 | LLLW | 8 | 2 | 2 | 4 | 8 | 9 | 11 | 2 | 2 | 7 | 6 | 14 | ||
| 14 | +3 | Raúl RUIDÍAZ (Seattle Sounders) |
| 12 | Gustavo BOU (New England Revolution) | |
| +1 | Dániel SALLÓI (Sporting Kansas City) | |
| 11 | +1 | Ola KAMARA (D.C. United) |
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| 9 | +3 | C.J. SAPONG (Nashville) |
| NANI (Orlando City) | ||
| 8 | Gonzalo HIGUAÍN (Inter Miami) | |
| Damir KREILACH (Real Salt Lake) | ||
| Ricardo PEPI (FC Dallas) | ||
| Alan PULIDO (Sporting Kansas City) | ||
| Adam BUKSA (New England Revolution) | ||
| +1 | Hany MUKHTAR (Nashville) | |
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| Valentín CASTELLANOS (New York City) | ||
| 7 | Jesús MEDINA (New York City) | |
| +1 | Felipe MORA (Portland Timbers) | |
| +2 | Luka STOJANOVIĆ (Chicago Fire) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Mason TOYE (CF Montréal) | ||
| 6 | Robin LOD (Minnesota United) | |
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| +2 | Fredy MONTERO (Seattle Sounders) | |
| Marcelino MORENO (Atlanta United) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Maximiliano URRUTI (Houston Dynamo) |
| Sunday, 15 August 2021 | |||||
| Chicago Fire | 1-0 | Columbus Crew | |||
| 77 | Stojanović | ||||
| Portland Timbers | 2-6 | Seattle Sounders | |||
| 32 | Blanco | 13 | Montero | ||
| 52 | Fochive | 29 | Montero | ||
| 55 | Ruidíaz | ||||
| 72 | Ruidíaz | ||||
| 77 | Medranda | ||||
| 90 | Benezet | ||||
| Nashville | 5-2 | D.C. United | |||
| 14 | Sapong | 3 | Brillant | ||
| 31 | Sapong | 41 | Kamara | ||
| 37 | Mukhtar | ||||
| 80 | Muyl | ||||
| 87(p) | Muyl | ||||
| Atlanta United | 1-0 | Los Angeles | |||
| 47 | Martínez | ||||
| Tuesday, 17 August 2021 | |||||
| LA Galaxy | 1-2 | Colorado Rapids | |||
| 34 | Raveloson | 13(p) | Lewis | ||
| 73 | André Bava | ||||
| San Jose Earthquakes | 1-1 | Minnesota United | |||
| 12(og) | Dibassy | 22 | Trapp | ||
| Wednesday, 18 August 2021 | |||||
| FC Dallas | 0-1 | Seattle Sounders | |||
| 63 | Ruidíaz | ||||
| New York Red Bulls | 1-0 | Columbus Crew | |||
| 33 | Tolkin | ||||
| New England Revolution | 3-2 | D.C. United | |||
| 49 | McNamara | 10 | Arriola | ||
| 53 | Buchanan | 90 | Ábila | ||
| 85 | Jones | ||||
| Sporting Kansas City | 1-1 | Portland Timbers | |||
| 90 | Sallói | 17 | Mora | ||
| Real Salt Lake | 2-1 | Houston Dynamo | |||
| 6 | Meram | 51 | Picault | ||
| 88 | Julio | ||||
| Philadelphia Union | 1-0 | New York City | |||
| 67 | Bedoya | ||||
| Austin FC | 1-2 | Vancouver Whitecaps | |||
| 37 | Ring | 52 | Nerwinski | ||
| 74 | White | ||||
| Nashville | 1-1 | Orlando City | |||
| 23 | Sapong | 58 | Antônio Carlos | ||
| Atlanta United | 1-0 | Toronto FC | |||
| 20 | Barco | ||||
| FC Cincinnati | 0-0 | CF Montréal | |||
| Inter Miami | 3-2 | Chicago Fire | |||
| 34 | Vassilev | 40 | Calvo | ||
| 62 | Robinson | 48 | Stojanović | ||
| 90 | Pizarro | ||||
