Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 246 | 651 | 2.64 | 115 | 46.75% | 74 | 30.08% | 57 | 23.17% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 20 | 13 | 4 | 3 | 37 | 23 | +14 | 43 | WWOW | 9 | 7 | 1 | 1 | 16 | 9 | 11 | 6 | 3 | 2 | 21 | 14 | ||
| 2 | 1 | New York City | 18 | 9 | 4 | 5 | 34 | 18 | +16 | 31 | WXOW | 10 | 7 | 1 | 2 | 24 | 8 | 8 | 2 | 3 | 3 | 10 | 10 | |
| 3 | 1 | Orlando City | 18 | 8 | 6 | 4 | 28 | 23 | +5 | 30 | XXWL | 9 | 5 | 3 | 1 | 17 | 7 | 9 | 3 | 3 | 3 | 11 | 16 | |
| 4 | Philadelphia Union | 19 | 7 | 7 | 5 | 25 | 19 | +6 | 28 | LWXX | 9 | 5 | 2 | 2 | 13 | 7 | 10 | 2 | 5 | 3 | 12 | 12 | ||
| 5 | Nashville | 18 | 6 | 10 | 2 | 26 | 17 | +9 | 28 | LOXW | 11 | 6 | 5 | 0 | 22 | 10 | 7 | 0 | 5 | 2 | 4 | 7 | ||
| 6 | D.C. United | 18 | 8 | 3 | 7 | 27 | 21 | +6 | 27 | WWOW | 8 | 6 | 0 | 2 | 14 | 5 | 10 | 2 | 3 | 5 | 13 | 16 | ||
| 7 | 1 | CF Montréal | 19 | 7 | 5 | 7 | 26 | 25 | +1 | 26 | WLXL | 9 | 5 | 3 | 1 | 17 | 12 | 10 | 2 | 2 | 6 | 9 | 13 | |
| 8 | 1 | Columbus Crew | 18 | 6 | 6 | 6 | 21 | 23 | -2 | 24 | LLLW | 9 | 4 | 3 | 2 | 15 | 12 | 9 | 2 | 3 | 4 | 6 | 11 | |
| 9 | New York Red Bulls | 18 | 5 | 4 | 9 | 22 | 24 | -2 | 19 | LLOL | 8 | 4 | 2 | 2 | 12 | 7 | 10 | 1 | 2 | 7 | 10 | 17 | ||
| 10 | Atlanta United | 18 | 3 | 9 | 6 | 21 | 25 | -4 | 18 | WXLL | 7 | 2 | 3 | 2 | 8 | 7 | 11 | 1 | 6 | 4 | 13 | 18 | ||
| 11 | 2 | Chicago Fire | 18 | 4 | 5 | 9 | 20 | 29 | -9 | 17 | WOXL | 12 | 4 | 4 | 4 | 17 | 15 | 6 | 0 | 1 | 5 | 3 | 14 | |
| 12 | 2 | Inter Miami | 17 | 4 | 4 | 9 | 15 | 28 | -13 | 16 | LWXW | 9 | 2 | 2 | 5 | 9 | 19 | 8 | 2 | 2 | 4 | 6 | 9 | |
| 13 | 2 | FC Cincinnati | 17 | 3 | 7 | 7 | 18 | 30 | -12 | 16 | XOOL | 7 | 0 | 4 | 3 | 6 | 10 | 10 | 3 | 3 | 4 | 12 | 20 | |
| 14 | 2 | Toronto FC | 19 | 3 | 6 | 10 | 24 | 40 | -16 | 15 | LXLX | 9 | 1 | 5 | 3 | 12 | 14 | 10 | 2 | 1 | 7 | 12 | 26 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sporting Kansas City | 19 | 11 | 4 | 4 | 35 | 20 | +15 | 37 | WOWL | 9 | 5 | 3 | 1 | 17 | 10 | 10 | 6 | 1 | 3 | 18 | 10 | ||
| 2 | 1 | LA Galaxy | 19 | 11 | 2 | 6 | 30 | 28 | +2 | 35 | WXWW | 10 | 7 | 1 | 2 | 18 | 10 | 9 | 4 | 1 | 4 | 12 | 18 | |
| 3 | 1 | Seattle Sounders | 18 | 9 | 6 | 3 | 26 | 14 | +12 | 33 | XLLW | 11 | 5 | 4 | 2 | 18 | 9 | 7 | 4 | 2 | 1 | 8 | 5 | |
| 4 | Colorado Rapids | 17 | 9 | 4 | 4 | 25 | 17 | +8 | 31 | WOWL | 9 | 5 | 3 | 1 | 16 | 8 | 8 | 4 | 1 | 3 | 9 | 9 | ||
| 5 | Minnesota United | 18 | 7 | 5 | 6 | 21 | 22 | -1 | 26 | LWXX | 10 | 6 | 1 | 3 | 12 | 7 | 8 | 1 | 4 | 3 | 9 | 15 | ||
| 6 | 2 | Real Salt Lake | 18 | 6 | 6 | 6 | 27 | 20 | +7 | 24 | WLLO | 10 | 4 | 4 | 2 | 15 | 9 | 8 | 2 | 2 | 4 | 12 | 11 | |
| 7 | 1 | Portland Timbers | 17 | 7 | 2 | 8 | 23 | 29 | -6 | 23 | WXLL | 9 | 6 | 1 | 2 | 15 | 9 | 8 | 1 | 1 | 6 | 8 | 20 | |
| 8 | 1 | Los Angeles | 18 | 6 | 5 | 7 | 24 | 25 | -1 | 23 | LLXX | 10 | 4 | 4 | 2 | 16 | 14 | 8 | 2 | 1 | 5 | 8 | 11 | |
| 9 | 1 | San Jose Earthquakes | 19 | 5 | 7 | 7 | 21 | 27 | -6 | 22 | OWXW | 9 | 3 | 2 | 4 | 12 | 13 | 10 | 2 | 5 | 3 | 9 | 14 | |
| 10 | 1 | FC Dallas | 19 | 5 | 6 | 8 | 23 | 27 | -4 | 21 | LWXW | 10 | 4 | 5 | 1 | 18 | 10 | 9 | 1 | 1 | 7 | 5 | 17 | |
| 11 | Houston Dynamo | 19 | 3 | 9 | 7 | 20 | 28 | -8 | 18 | LLLO | 8 | 3 | 4 | 1 | 10 | 9 | 11 | 0 | 5 | 6 | 10 | 19 | ||
| 12 | 1 | Vancouver Whitecaps | 18 | 3 | 8 | 7 | 19 | 28 | -9 | 17 | OXXX | 8 | 3 | 2 | 3 | 8 | 10 | 10 | 0 | 6 | 4 | 11 | 18 | |
| 13 | 1 | Austin FC | 18 | 4 | 4 | 10 | 13 | 21 | -8 | 16 | LLWL | 7 | 2 | 2 | 3 | 7 | 7 | 11 | 2 | 2 | 7 | 6 | 14 | |
| 12 | +2 | Gustavo BOU (New England Revolution) |
| 11 | +1 | Dániel SALLÓI (Sporting Kansas City) |
| Raúl RUIDÍAZ (Seattle Sounders) | ||
| 10 | +1 | Ola KAMARA (D.C. United) |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| 9 | NANI (Orlando City) | |
| 8 | +1 | Gonzalo HIGUAÍN (Inter Miami) |
| Damir KREILACH (Real Salt Lake) | ||
| Ricardo PEPI (FC Dallas) | ||
| +1 | Alan PULIDO (Sporting Kansas City) | |
| Adam BUKSA (New England Revolution) | ||
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| +2 | Valentín CASTELLANOS (New York City) | |
| 7 | Jesús MEDINA (New York City) | |
| Hany MUKHTAR (Nashville) | ||
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Mason TOYE (CF Montréal) | ||
| 6 | Robin LOD (Minnesota United) | |
| +1 | C.J. SAPONG (Nashville) | |
| Felipe MORA (Portland Timbers) | ||
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| Marcelino MORENO (Atlanta United) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Maximiliano URRUTI (Houston Dynamo) |
| Sunday, 8 August 2021 | |||||
| D.C. United | 2-1 | CF Montréal | |||
| 40 | Najar | 16 | Brault-Guillard | ||
| 54 | Kamara | ||||
| New England Revolution | 2-1 | Philadelphia Union | |||
| 10 | Polster | 31 | Aaronson | ||
| 39 | Bou | ||||
| LA Galaxy | 1-1 | Vancouver Whitecaps | |||
| 32 | Cabral | 50 | Veselinović | ||
| Chicago Fire | 2-1 | New York Red Bulls | |||
| 2 | Stojanović | 90 | Barlow | ||
| 8 | Stojanović | ||||
| San Jose Earthquakes | 2-1 | Los Angeles | |||
| 11 | Nathan | 39(og) | Yueill | ||
| 28 | López | ||||
| Inter Miami | 2-1 | Nashville | |||
| 60 | Higuaín | 48 | Sapong | ||
| 90 | Vassilev | ||||
| Friday, 13 August 2021 | |||||
| San Jose Earthquakes | 0-0 | Vancouver Whitecaps | |||
| Saturday, 14 August 2021 | |||||
| FC Dallas | 0-2 | Sporting Kansas City | |||
| 12 | Pulido | ||||
| 63 | Sallói | ||||
| Houston Dynamo | 1-3 | Colorado Rapids | |||
| 45(p) | Picault | 5 | Abubakar | ||
| 60 | Barrios | ||||
| 80 | Galván | ||||
| CF Montréal | 2-1 | New York Red Bulls | |||
| 71 | Ibrahim | 45(p) | Klimala | ||
| 90(p) | Wanyama | ||||
| Real Salt Lake | 1-0 | Austin FC | |||
| 32 | Wood | ||||
| Toronto FC | 1-2 | New England Revolution | |||
| 79 | Osorio | 20 | Buchanan | ||
| 83(p) | Bou | ||||
| Minnesota United | 0-1 | LA Galaxy | |||
| 43 | Cabral | ||||
| New York City | 2-0 | Inter Miami | |||
| 21 | Castellanos | ||||
| 45(p) | Castellanos | ||||
