Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 194 | 513 | 2.64 | 94 | 48.45% | 55 | 28.35% | 45 | 23.20% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 15 | 9 | 3 | 3 | 28 | 18 | +10 | 30 | WWLX | 6 | 5 | 0 | 1 | 12 | 7 | 9 | 4 | 3 | 2 | 16 | 11 | ||
| 2 | 1 | Nashville | 15 | 6 | 8 | 1 | 24 | 14 | +10 | 26 | WOWX | 11 | 6 | 5 | 0 | 22 | 10 | 4 | 0 | 3 | 1 | 2 | 4 | |
| 3 | 1 | Orlando City | 14 | 7 | 4 | 3 | 23 | 14 | +9 | 25 | WXLL | 7 | 4 | 2 | 1 | 13 | 4 | 7 | 3 | 2 | 2 | 10 | 10 | |
| 4 | 2 | Columbus Crew | 15 | 6 | 6 | 3 | 16 | 12 | +4 | 24 | WOWX | 7 | 4 | 3 | 0 | 11 | 5 | 8 | 2 | 3 | 3 | 5 | 7 | |
| 5 | 3 | Philadelphia Union | 15 | 6 | 5 | 4 | 19 | 15 | +4 | 23 | LWXL | 7 | 4 | 1 | 2 | 9 | 6 | 8 | 2 | 4 | 2 | 10 | 9 | |
| 6 | 1 | CF Montréal | 14 | 6 | 4 | 4 | 19 | 16 | +3 | 22 | LWWW | 7 | 4 | 2 | 1 | 13 | 9 | 7 | 2 | 2 | 3 | 6 | 7 | |
| 7 | New York City | 13 | 6 | 2 | 5 | 21 | 15 | +6 | 20 | WLLW | 7 | 4 | 1 | 2 | 13 | 7 | 6 | 2 | 1 | 3 | 8 | 8 | ||
| 8 | New York Red Bulls | 13 | 5 | 3 | 5 | 18 | 16 | +2 | 18 | XXWO | 6 | 4 | 1 | 1 | 10 | 4 | 7 | 1 | 2 | 4 | 8 | 12 | ||
| 9 | D.C. United | 14 | 5 | 2 | 7 | 20 | 18 | +2 | 17 | XLWL | 6 | 4 | 0 | 2 | 11 | 4 | 8 | 1 | 2 | 5 | 9 | 14 | ||
| 10 | Atlanta United | 15 | 2 | 8 | 5 | 14 | 18 | -4 | 14 | LXLX | 7 | 2 | 3 | 2 | 8 | 7 | 8 | 0 | 5 | 3 | 6 | 11 | ||
| 11 | 2 | Toronto FC | 15 | 3 | 4 | 8 | 20 | 32 | -12 | 13 | WXXW | 6 | 1 | 3 | 2 | 8 | 9 | 9 | 2 | 1 | 6 | 12 | 23 | |
| 12 | 1 | FC Cincinnati | 14 | 3 | 4 | 7 | 17 | 29 | -12 | 13 | LXLX | 5 | 0 | 2 | 3 | 5 | 9 | 9 | 3 | 2 | 4 | 12 | 20 | |
| 13 | 1 | Chicago Fire | 15 | 3 | 3 | 9 | 17 | 27 | -10 | 12 | LXLW | 10 | 3 | 3 | 4 | 15 | 14 | 5 | 0 | 0 | 5 | 2 | 13 | |
| 14 | Inter Miami | 12 | 2 | 2 | 8 | 9 | 22 | -13 | 8 | LLLL | 6 | 0 | 1 | 5 | 4 | 16 | 6 | 2 | 1 | 3 | 5 | 6 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 15 | 9 | 5 | 1 | 24 | 9 | +15 | 32 | WLWX | 8 | 5 | 3 | 0 | 16 | 4 | 7 | 4 | 2 | 1 | 8 | 5 | ||
| 2 | Sporting Kansas City | 14 | 8 | 3 | 3 | 25 | 16 | +9 | 27 | XWWW | 8 | 5 | 3 | 0 | 16 | 8 | 6 | 3 | 0 | 3 | 9 | 8 | ||
| 3 | LA Galaxy | 15 | 8 | 1 | 6 | 23 | 26 | -3 | 25 | LXLW | 7 | 5 | 0 | 2 | 12 | 8 | 8 | 3 | 1 | 4 | 11 | 18 | ||
| 4 | Colorado Rapids | 14 | 7 | 3 | 4 | 21 | 16 | +5 | 24 | LWXW | 8 | 5 | 2 | 1 | 16 | 8 | 6 | 2 | 1 | 3 | 5 | 8 | ||
| 5 | Los Angeles | 15 | 6 | 4 | 5 | 20 | 17 | +3 | 22 | XLWW | 8 | 4 | 3 | 1 | 13 | 8 | 7 | 2 | 1 | 4 | 7 | 9 | ||
| 6 | 1 | Minnesota United | 14 | 6 | 3 | 5 | 15 | 17 | -2 | 21 | WWLX | 8 | 5 | 1 | 2 | 10 | 6 | 6 | 1 | 2 | 3 | 5 | 11 | |
| 7 | 1 | Real Salt Lake | 14 | 5 | 5 | 4 | 24 | 16 | +8 | 20 | WXLW | 9 | 3 | 4 | 2 | 14 | 9 | 5 | 2 | 1 | 2 | 10 | 7 | |
| 8 | 2 | Portland Timbers | 14 | 6 | 1 | 7 | 18 | 22 | -4 | 19 | LWWL | 7 | 5 | 0 | 2 | 11 | 6 | 7 | 1 | 1 | 5 | 7 | 16 | |
| 9 | Houston Dynamo | 15 | 3 | 8 | 4 | 17 | 20 | -3 | 17 | XOLX | 6 | 3 | 3 | 0 | 9 | 6 | 9 | 0 | 5 | 4 | 8 | 14 | ||
| 10 | 3 | FC Dallas | 15 | 3 | 5 | 7 | 18 | 23 | -5 | 14 | WLLL | 8 | 3 | 5 | 0 | 16 | 8 | 7 | 0 | 0 | 7 | 2 | 15 | |
| 11 | San Jose Earthquakes | 15 | 3 | 5 | 7 | 17 | 25 | -8 | 14 | XXXX | 7 | 2 | 1 | 4 | 10 | 12 | 8 | 1 | 4 | 3 | 7 | 13 | ||
| 12 | Vancouver Whitecaps | 15 | 3 | 5 | 7 | 16 | 25 | -9 | 14 | XOWL | 7 | 3 | 1 | 3 | 6 | 8 | 8 | 0 | 4 | 4 | 10 | 17 | ||
| 13 | 3 | Austin FC | 14 | 3 | 4 | 7 | 10 | 15 | -5 | 13 | LLWO | 5 | 1 | 2 | 2 | 4 | 4 | 9 | 2 | 2 | 5 | 6 | 11 | |
| 11 | +1 | Raúl RUIDÍAZ (Seattle Sounders) |
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| 8 | Dániel SALLÓI (Sporting Kansas City) | |
| +3 | Ricardo PEPI (FC Dallas) | |
| 7 | NANI (Orlando City) | |
| Adam BUKSA (New England Revolution) | ||
| Damir KREILACH (Real Salt Lake) | ||
| Hany MUKHTAR (Nashville) | ||
| Gustavo BOU (New England Revolution) | ||
| 6 | Jesús MEDINA (New York City) | |
| Ola KAMARA (D.C. United) | ||
| +1 | Cristian DÁJOME (Vancouver Whitecaps) | |
| Alan PULIDO (Sporting Kansas City) | ||
| Mason TOYE (CF Montréal) | ||
| Maximiliano URRUTI (Houston Dynamo) | ||
| 5 | Gonzalo HIGUAÍN (Inter Miami) | |
| +1 | José CIFUENTES (Los Angeles) | |
| +2 | C.J. SAPONG (Nashville) | |
| Lucas ZELARAYÁN (Columbus Crew) | ||
| +1 | Rubio RUBIN (Real Salt Lake) | |
| +1 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Diego ROSSI (Los Angeles) |
| Thursday, 22 July 2021 | |||||
| Orlando City | 2-1 | Philadelphia Union | |||
| 10 | Michel | 68 | Przybyłko | ||
| 59 | Perea | ||||
| Austin FC | 0-1 | Seattle Sounders | |||
| 67 | Ruidíaz | ||||
| Saturday, 24 July 2021 | |||||
| FC Dallas | 4-0 | LA Galaxy | |||
| 27 | Pepi | ||||
| 44 | Pepi | ||||
| 50 | Pepi | ||||
| 88 | Obrian | ||||
| Chicago Fire | 1-2 | Toronto FC | |||
| 77 | Medrán | 2 | Soteldo | ||
| 76 | Deleon | ||||
| Real Salt Lake | 3-0 | Colorado Rapids | |||
| 14(og) | Yarbrough | ||||
| 30 | Wood | ||||
| 76 | Rubin | ||||
| San Jose Earthquakes | 1-1 | Houston Dynamo | |||
| 45(og) | Valentin | 40 | Vera | ||
| Minnesota United | 2-1 | Portland Timbers | |||
| 74 | Gasper | 10 | Mora | ||
| 85 | Lod | ||||
| Los Angeles | 2-2 | Vancouver Whitecaps | |||
| 40 | Vela | 25 | Caicedo | ||
| 75 | Cifuentes | 38 | Dájome | ||
| Nashville | 3-0 | FC Cincinnati | |||
| 13 | Sapong | ||||
| 35 | Leal | ||||
| 57 | Sapong | ||||
| Atlanta United | 0-1 | Columbus Crew | |||
| 65 | Mensah | ||||
