Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 363 | 1,001 | 2.75 | 175 | 48.21% | 98 | 27.00% | 90 | 24.79% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 29 | 20 | 5 | 4 | 57 | 34 | +23 | 65 | WWWX | 14 | 11 | 2 | 1 | 28 | 15 | 15 | 9 | 3 | 3 | 29 | 19 | ||
| 2 | Nashville | 27 | 11 | 13 | 3 | 46 | 26 | +20 | 46 | XOWL | 15 | 8 | 7 | 0 | 33 | 16 | 12 | 3 | 6 | 3 | 13 | 10 | ||
| 3 | 3 | D.C. United | 27 | 12 | 4 | 11 | 48 | 39 | +9 | 40 | WWLW | 13 | 10 | 0 | 3 | 28 | 11 | 14 | 2 | 4 | 8 | 20 | 28 | |
| 4 | 1 | New York City | 27 | 11 | 6 | 10 | 44 | 32 | +12 | 39 | LLXW | 13 | 8 | 2 | 3 | 29 | 12 | 14 | 3 | 4 | 7 | 15 | 20 | |
| 5 | 1 | Philadelphia Union | 26 | 10 | 9 | 7 | 33 | 26 | +7 | 39 | XWWL | 14 | 8 | 3 | 3 | 19 | 10 | 12 | 2 | 6 | 4 | 14 | 16 | |
| 6 | 2 | Atlanta United | 27 | 10 | 9 | 8 | 36 | 31 | +5 | 39 | WLWW | 14 | 8 | 3 | 3 | 21 | 11 | 13 | 2 | 6 | 5 | 15 | 20 | |
| 7 | 2 | Orlando City | 27 | 10 | 9 | 8 | 39 | 40 | -1 | 39 | XLLL | 13 | 7 | 4 | 2 | 23 | 13 | 14 | 3 | 5 | 6 | 16 | 27 | |
| 8 | 1 | CF Montréal | 27 | 10 | 7 | 10 | 38 | 36 | +2 | 37 | LLWW | 13 | 7 | 3 | 3 | 23 | 18 | 14 | 3 | 4 | 7 | 15 | 18 | |
| 9 | Columbus Crew | 27 | 9 | 7 | 11 | 32 | 36 | -4 | 34 | WXWL | 13 | 7 | 3 | 3 | 23 | 18 | 14 | 2 | 4 | 8 | 9 | 18 | ||
| 10 | Inter Miami | 26 | 9 | 5 | 12 | 25 | 41 | -16 | 32 | LLLW | 14 | 5 | 2 | 7 | 17 | 31 | 12 | 4 | 3 | 5 | 8 | 10 | ||
| 11 | New York Red Bulls | 26 | 8 | 7 | 11 | 32 | 30 | +2 | 31 | XWXW | 13 | 5 | 5 | 3 | 16 | 11 | 13 | 3 | 2 | 8 | 16 | 19 | ||
| 12 | Chicago Fire | 28 | 7 | 6 | 15 | 28 | 43 | -15 | 27 | WOLL | 16 | 6 | 5 | 5 | 22 | 18 | 12 | 1 | 1 | 10 | 6 | 25 | ||
| 13 | 1 | Toronto FC | 27 | 5 | 7 | 15 | 31 | 53 | -22 | 22 | WOWL | 12 | 3 | 5 | 4 | 17 | 18 | 15 | 2 | 2 | 11 | 14 | 35 | |
| 14 | 1 | FC Cincinnati | 26 | 4 | 8 | 14 | 28 | 51 | -23 | 20 | LLLL | 11 | 1 | 5 | 5 | 9 | 13 | 15 | 3 | 3 | 9 | 19 | 38 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 26 | 15 | 6 | 5 | 41 | 22 | +19 | 51 | WWLW | 13 | 6 | 4 | 3 | 19 | 11 | 13 | 9 | 2 | 2 | 22 | 11 | ||
| 2 | Sporting Kansas City | 27 | 14 | 7 | 6 | 47 | 29 | +18 | 49 | WLWW | 14 | 7 | 5 | 2 | 26 | 14 | 13 | 7 | 2 | 4 | 21 | 15 | ||
| 3 | Colorado Rapids | 26 | 13 | 9 | 4 | 38 | 24 | +14 | 48 | WOXX | 14 | 7 | 6 | 1 | 23 | 11 | 12 | 6 | 3 | 3 | 15 | 13 | ||
| 4 | Portland Timbers | 27 | 13 | 4 | 10 | 44 | 44 | +0 | 43 | WWWX | 13 | 8 | 2 | 3 | 27 | 19 | 14 | 5 | 2 | 7 | 17 | 25 | ||
| 5 | 2 | Real Salt Lake | 27 | 11 | 6 | 10 | 44 | 42 | +2 | 39 | WLWW | 14 | 8 | 4 | 2 | 23 | 13 | 13 | 3 | 2 | 8 | 21 | 29 | |
| 6 | 1 | LA Galaxy | 27 | 11 | 5 | 11 | 38 | 44 | -6 | 38 | LLLX | 13 | 7 | 2 | 4 | 21 | 15 | 14 | 4 | 3 | 7 | 17 | 29 | |
| 7 | 1 | Minnesota United | 26 | 10 | 7 | 9 | 30 | 32 | -2 | 37 | LWWL | 13 | 8 | 2 | 3 | 17 | 7 | 13 | 2 | 5 | 6 | 13 | 25 | |
| 8 | 1 | Vancouver Whitecaps | 26 | 8 | 10 | 8 | 31 | 34 | -3 | 34 | OWXL | 13 | 7 | 2 | 4 | 17 | 14 | 13 | 1 | 8 | 4 | 14 | 20 | |
| 9 | 1 | Los Angeles | 27 | 9 | 6 | 12 | 39 | 40 | -1 | 33 | LLLW | 14 | 6 | 5 | 3 | 27 | 21 | 13 | 3 | 1 | 9 | 12 | 19 | |
| 10 | San Jose Earthquakes | 27 | 8 | 9 | 10 | 35 | 41 | -6 | 33 | LWWL | 14 | 4 | 3 | 7 | 19 | 22 | 13 | 4 | 6 | 3 | 16 | 19 | ||
| 11 | FC Dallas | 28 | 6 | 9 | 13 | 39 | 47 | -8 | 27 | LLLX | 13 | 4 | 6 | 3 | 20 | 15 | 15 | 2 | 3 | 10 | 19 | 32 | ||
| 12 | Houston Dynamo | 28 | 5 | 12 | 11 | 31 | 41 | -10 | 27 | OLWX | 14 | 5 | 6 | 3 | 19 | 17 | 14 | 0 | 6 | 8 | 12 | 24 | ||
| 13 | Austin FC | 27 | 6 | 4 | 17 | 27 | 43 | -16 | 22 | LWLL | 13 | 4 | 2 | 7 | 20 | 21 | 14 | 2 | 2 | 10 | 7 | 22 | ||
| 17 | +1 | Ola KAMARA (D.C. United) |
| 16 | +2 | Raúl RUIDÍAZ (Seattle Sounders) |
| 15 | +2 | Dániel SALLÓI (Sporting Kansas City) |
| 13 | +1 | Ricardo PEPI (FC Dallas) |
| +1 | Gustavo BOU (New England Revolution) | |
| +1 | Adam BUKSA (New England Revolution) | |
| +1 | Hany MUKHTAR (Nashville) | |
| Valentín CASTELLANOS (New York City) | ||
| 12 | +1 | Damir KREILACH (Real Salt Lake) |
| +1 | Javier HERNÁNDEZ (LA Galaxy) | |
| 11 | Felipe MORA (Portland Timbers) | |
| Javier LÓPEZ (San Jose Earthquakes) | ||
| 10 | Gonzalo HIGUAÍN (Inter Miami) | |
| +1 | Josef MARTÍNEZ (Atlanta United) | |
| C.J. SAPONG (Nashville) | ||
| Fabrice PICAULT (Houston Dynamo) | ||
| 9 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| NANI (Orlando City) | ||
| 8 | +1 | Dairon ASPRILLA (Portland Timbers) |
| Jesús MEDINA (New York City) | ||
| Alan PULIDO (Sporting Kansas City) | ||
| Jáder OBRIAN (FC Dallas) | ||
| +1 | Johnny RUSSELL (Sporting Kansas City) | |
| Cristian DÁJOME (Vancouver Whitecaps) |
| Wednesday, 29 September 2021 | |||||
| D.C. United | 3-1 | Minnesota United | |||
| 23(p) | Kamara | 40 | Dibassy | ||
| 45 | Gressel | ||||
| 85 | Moreno | ||||
| FC Dallas | 1-3 | Sporting Kansas City | |||
| 68 | Pepi | 13 | Sallói | ||
| 55(p) | Russell | ||||
| 61 | Sallói | ||||
| Houston Dynamo | 0-0 | Vancouver Whitecaps | |||
| Colorado Rapids | 3-0 | Austin FC | |||
| 45 | Lewis | ||||
| 46 | Mezquida | ||||
| 59 | Trusty | ||||
| New York Red Bulls | 1-1 | Philadelphia Union | |||
| 37 | Fernandez | 17 | Santos | ||
| Chicago Fire | 2-0 | New York City | |||
| 48 | Berić | ||||
| 66 | Navarro | ||||
| CF Montréal | 1-4 | New England Revolution | |||
| 32 | Torres | 10 | Jones | ||
| 17 | Buksa | ||||
| 30(og) | Camacho | ||||
| 86 | Bou | ||||
| Real Salt Lake | 2-1 | LA Galaxy | |||
| 45 | Kreilach | 76 | Hernández | ||
| 90 | Julio | ||||
| Toronto FC | 3-2 | FC Cincinnati | |||
| 48 | Shaffelburg | 38 | Matarrita | ||
| 55 | Delgado | 72 | Acosta | ||
| 65 | Achara | ||||
| San Jose Earthquakes | 1-3 | Seattle Sounders | |||
| 51(og) | O'Neill | 25 | Ruidíaz | ||
| 42(p) | Ruidíaz | ||||
| 49 | Roldan | ||||
| Los Angeles | 1-2 | Portland Timbers | |||
| 55 | Musovski | 45 | Chará | ||
| 59 | Asprilla | ||||
| Nashville | 2-2 | Orlando City | |||
| 11 | Mukhtar | 76(p) | Dike | ||
| 59 | Leal | 90(og) | Anunga | ||
| Atlanta United | 1-0 | Inter Miami | |||
| 78(p) | Martínez | ||||
