Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 159 | 417 | 2.62 | 78 | 49.06% | 41 | 25.79% | 40 | 25.16% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 13 | 7 | 3 | 3 | 22 | 18 | +4 | 24 | LXLW | 6 | 5 | 0 | 1 | 12 | 7 | 7 | 2 | 3 | 2 | 10 | 11 | ||
| 2 | Orlando City | 12 | 6 | 3 | 3 | 20 | 12 | +8 | 21 | LLWW | 6 | 3 | 2 | 1 | 11 | 3 | 6 | 3 | 1 | 2 | 9 | 9 | ||
| 3 | Philadelphia Union | 12 | 5 | 4 | 3 | 15 | 11 | +4 | 19 | LXWX | 6 | 3 | 1 | 2 | 7 | 5 | 6 | 2 | 3 | 1 | 8 | 6 | ||
| 4 | 4 | CF Montréal | 12 | 5 | 4 | 3 | 14 | 11 | +3 | 19 | WWXO | 6 | 3 | 2 | 1 | 8 | 5 | 6 | 2 | 2 | 2 | 6 | 6 | |
| 5 | 1 | Nashville | 11 | 4 | 6 | 1 | 14 | 11 | +3 | 18 | WXWL | 8 | 4 | 4 | 0 | 12 | 7 | 3 | 0 | 2 | 1 | 2 | 4 | |
| 6 | 1 | New York City | 11 | 5 | 2 | 4 | 19 | 13 | +6 | 17 | LWWL | 6 | 3 | 1 | 2 | 12 | 7 | 5 | 2 | 1 | 2 | 7 | 6 | |
| 7 | 1 | D.C. United | 12 | 5 | 1 | 6 | 17 | 14 | +3 | 16 | WLOW | 6 | 4 | 0 | 2 | 11 | 4 | 6 | 1 | 1 | 4 | 6 | 10 | |
| 8 | 1 | New York Red Bulls | 11 | 5 | 1 | 5 | 16 | 14 | +2 | 16 | WOLW | 5 | 4 | 0 | 1 | 9 | 3 | 6 | 1 | 1 | 4 | 7 | 11 | |
| 9 | Columbus Crew | 11 | 4 | 4 | 3 | 11 | 9 | +2 | 16 | XOLW | 5 | 3 | 2 | 0 | 9 | 4 | 6 | 1 | 2 | 3 | 2 | 5 | ||
| 10 | Atlanta United | 11 | 2 | 6 | 3 | 11 | 13 | -2 | 12 | LOLX | 5 | 2 | 3 | 0 | 8 | 5 | 6 | 0 | 3 | 3 | 3 | 8 | ||
| 11 | 1 | Chicago Fire | 12 | 3 | 2 | 7 | 13 | 18 | -5 | 11 | WWXL | 8 | 3 | 2 | 3 | 12 | 10 | 4 | 0 | 0 | 4 | 1 | 8 | |
| 12 | 1 | FC Cincinnati | 10 | 3 | 2 | 5 | 10 | 18 | -8 | 11 | XWWL | 3 | 0 | 0 | 3 | 2 | 6 | 7 | 3 | 2 | 2 | 8 | 12 | |
| 13 | Inter Miami | 11 | 2 | 2 | 7 | 9 | 17 | -8 | 8 | LLLL | 5 | 0 | 1 | 4 | 4 | 11 | 6 | 2 | 1 | 3 | 5 | 6 | ||
| 14 | Toronto FC | 12 | 2 | 2 | 8 | 16 | 29 | -13 | 8 | WLLL | 4 | 1 | 1 | 2 | 6 | 7 | 8 | 1 | 1 | 6 | 10 | 22 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 13 | 8 | 5 | 0 | 23 | 8 | +15 | 29 | WXXW | 8 | 5 | 3 | 0 | 16 | 4 | 5 | 3 | 2 | 0 | 7 | 4 | ||
| 2 | Sporting Kansas City | 13 | 8 | 2 | 3 | 24 | 15 | +9 | 26 | WWWL | 7 | 5 | 2 | 0 | 15 | 7 | 6 | 3 | 0 | 3 | 9 | 8 | ||
| 3 | LA Galaxy | 12 | 8 | 0 | 4 | 20 | 18 | +2 | 24 | WLWW | 7 | 5 | 0 | 2 | 12 | 8 | 5 | 3 | 0 | 2 | 8 | 10 | ||
| 4 | Colorado Rapids | 11 | 6 | 2 | 3 | 18 | 12 | +6 | 20 | WXLW | 6 | 4 | 1 | 1 | 13 | 7 | 5 | 2 | 1 | 2 | 5 | 5 | ||
| 5 | Los Angeles | 12 | 5 | 3 | 4 | 15 | 12 | +3 | 18 | WWLW | 6 | 3 | 2 | 1 | 9 | 5 | 6 | 2 | 1 | 3 | 6 | 7 | ||
| 6 | 3 | Real Salt Lake | 11 | 4 | 4 | 3 | 18 | 12 | +6 | 16 | WLXL | 7 | 2 | 3 | 2 | 9 | 7 | 4 | 2 | 1 | 1 | 9 | 5 | |
| 7 | 1 | Minnesota United | 12 | 4 | 3 | 5 | 12 | 16 | -4 | 15 | LXWW | 6 | 3 | 1 | 2 | 7 | 5 | 6 | 1 | 2 | 3 | 5 | 11 | |
| 8 | 1 | Houston Dynamo | 13 | 3 | 6 | 4 | 16 | 19 | -3 | 15 | LXXX | 6 | 3 | 3 | 0 | 9 | 6 | 7 | 0 | 3 | 4 | 7 | 13 | |
| 9 | 1 | Portland Timbers | 11 | 4 | 1 | 6 | 14 | 19 | -5 | 13 | LLXW | 5 | 3 | 0 | 2 | 8 | 5 | 6 | 1 | 1 | 4 | 6 | 14 | |
| 10 | Austin FC | 13 | 3 | 4 | 6 | 10 | 14 | -4 | 13 | LWOL | 4 | 1 | 2 | 1 | 4 | 3 | 9 | 2 | 2 | 5 | 6 | 11 | ||
| 11 | San Jose Earthquakes | 12 | 3 | 2 | 7 | 14 | 22 | -8 | 11 | XLLO | 6 | 2 | 0 | 4 | 9 | 11 | 6 | 1 | 2 | 3 | 5 | 11 | ||
| 12 | FC Dallas | 12 | 2 | 5 | 5 | 14 | 20 | -6 | 11 | LXWL | 7 | 2 | 5 | 0 | 12 | 8 | 5 | 0 | 0 | 5 | 2 | 12 | ||
| 13 | Vancouver Whitecaps | 12 | 2 | 3 | 7 | 12 | 22 | -10 | 9 | LXXL | 5 | 2 | 0 | 3 | 4 | 7 | 7 | 0 | 3 | 4 | 8 | 15 | ||
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| +1 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 7 | Dániel SALLÓI (Sporting Kansas City) | |
| +2 | Damir KREILACH (Real Salt Lake) | |
| 6 | NANI (Orlando City) | |
| Alan PULIDO (Sporting Kansas City) | ||
| Maximiliano URRUTI (Houston Dynamo) | ||
| Gustavo BOU (New England Revolution) | ||
| 5 | Gonzalo HIGUAÍN (Inter Miami) | |
| Jesús MEDINA (New York City) | ||
| Ola KAMARA (D.C. United) | ||
| +1 | Adam BUKSA (New England Revolution) | |
| +1 | Ricardo PEPI (FC Dallas) | |
| 4 | Caden CLARK (New York Red Bulls) | |
| +1 | José CIFUENTES (Los Angeles) | |
| Cory BURKE (Philadelphia Union) | ||
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| Rubio RUBIN (Real Salt Lake) | ||
| Cade COWELL (San Jose Earthquakes) | ||
| Valentín CASTELLANOS (New York City) | ||
| Gyasi ZARDES (Columbus Crew) | ||
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Cristian CÁSSERES (New York Red Bulls) | ||
| +1 | Mason TOYE (CF Montréal) | |
| +1 | Diego ROSSI (Los Angeles) |
| Sunday, 4 July 2021 | |||||
| FC Dallas | 2-2 | Vancouver Whitecaps | |||
| 22 | Pepi | 30 | Cavallini | ||
| 90(og) | Veselinović | 45 | Rose | ||
| Colorado Rapids | 1-1 | Seattle Sounders | |||
| 58 | Barrios | 41 | Roldán | ||
| LA Galaxy | 0-2 | Sporting Kansas City | |||
| 81 | Russell | ||||
| 90 | Shelton | ||||
| Wednesday, 7 July 2021 | |||||
| Colorado Rapids | 2-0 | Minnesota United | |||
| 45 | Galván | ||||
| 81 | André Bava | ||||
| New England Revolution | 2-3 | Toronto FC | |||
| 56 | Carles Gil | 9 | Soteldo | ||
| 78 | Buksa | 15 | Lawrence | ||
| 24 | Endoh | ||||
| LA Galaxy | 3-1 | FC Dallas | |||
| 17 | Raveloson | 71 | Jara | ||
| 27 | Cabral | ||||
| 51 | Zubak | ||||
| Chicago Fire | 3-1 | Orlando City | |||
| 45 | Sekulić | 34 | Perea | ||
| 72 | Berić | ||||
| 90 | Offor | ||||
| Vancouver Whitecaps | 0-4 | Real Salt Lake | |||
| 1 | Kreilach | ||||
| 57 | Kreilach | ||||
| 74(p) | Rusnák | ||||
| 90 | Julio | ||||
| CF Montréal | 2-1 | New York City | |||
| 43(p) | Toye | 29 | Parks | ||
| 73 | Quioto | ||||
| Seattle Sounders | 2-0 | Houston Dynamo | |||
| 62 | Rowe | ||||
| 90 | Ruidíaz | ||||
| Austin FC | 0-2 | Los Angeles | |||
| 39 | Cifuentes | ||||
| 89 | Rossi | ||||
