| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 376 | 1,033 | 2.74 | 184 | 48.94% | 101 | 26.86% | 91 | 24.20% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 29 | 20 | 5 | 4 | 57 | 34 | +23 | 65 | WWWX | 14 | 11 | 2 | 1 | 28 | 15 | 15 | 9 | 3 | 3 | 29 | 19 | ||
| 2 | Nashville | 28 | 11 | 14 | 3 | 46 | 26 | +20 | 47 | OXOW | 15 | 8 | 7 | 0 | 33 | 16 | 13 | 3 | 7 | 3 | 13 | 10 | ||
| 3 | 2 | Philadelphia Union | 27 | 11 | 9 | 7 | 36 | 26 | +10 | 42 | WXWW | 15 | 9 | 3 | 3 | 22 | 10 | 12 | 2 | 6 | 4 | 14 | 16 | |
| 4 | 3 | Orlando City | 28 | 11 | 9 | 8 | 41 | 41 | +0 | 42 | WXLL | 14 | 8 | 4 | 2 | 25 | 14 | 14 | 3 | 5 | 6 | 16 | 27 | |
| 5 | 2 | D.C. United | 28 | 12 | 4 | 12 | 49 | 41 | +8 | 40 | LWWL | 13 | 10 | 0 | 3 | 28 | 11 | 15 | 2 | 4 | 9 | 21 | 30 | |
| 6 | 2 | New York City | 28 | 11 | 7 | 10 | 44 | 32 | +12 | 40 | OLLX | 14 | 8 | 3 | 3 | 29 | 12 | 14 | 3 | 4 | 7 | 15 | 20 | |
| 7 | 1 | CF Montréal | 28 | 11 | 7 | 10 | 40 | 37 | +3 | 40 | WLLW | 14 | 8 | 3 | 3 | 25 | 19 | 14 | 3 | 4 | 7 | 15 | 18 | |
| 8 | 2 | Atlanta United | 28 | 10 | 9 | 9 | 37 | 33 | +4 | 39 | LWLW | 14 | 8 | 3 | 3 | 21 | 11 | 14 | 2 | 6 | 6 | 16 | 22 | |
| 9 | 2 | New York Red Bulls | 27 | 9 | 7 | 11 | 33 | 30 | +3 | 34 | WXWX | 13 | 5 | 5 | 3 | 16 | 11 | 14 | 4 | 2 | 8 | 17 | 19 | |
| 10 | 1 | Columbus Crew | 28 | 9 | 7 | 12 | 32 | 39 | -7 | 34 | LWXW | 13 | 7 | 3 | 3 | 23 | 18 | 15 | 2 | 4 | 9 | 9 | 21 | |
| 11 | 1 | Inter Miami | 27 | 9 | 5 | 13 | 25 | 42 | -17 | 32 | LLLL | 14 | 5 | 2 | 7 | 17 | 31 | 13 | 4 | 3 | 6 | 8 | 11 | |
| 12 | Chicago Fire | 29 | 7 | 6 | 16 | 29 | 46 | -17 | 27 | LWOL | 16 | 6 | 5 | 5 | 22 | 18 | 13 | 1 | 1 | 11 | 7 | 28 | ||
| 13 | Toronto FC | 28 | 6 | 7 | 15 | 34 | 54 | -20 | 25 | WWOW | 13 | 4 | 5 | 4 | 20 | 19 | 15 | 2 | 2 | 11 | 14 | 35 | ||
| 14 | FC Cincinnati | 27 | 4 | 8 | 15 | 28 | 52 | -24 | 20 | LLLL | 12 | 1 | 5 | 6 | 9 | 14 | 15 | 3 | 3 | 9 | 19 | 38 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 27 | 16 | 6 | 5 | 44 | 22 | +22 | 54 | WWWL | 14 | 7 | 4 | 3 | 22 | 11 | 13 | 9 | 2 | 2 | 22 | 11 | ||
| 2 | Sporting Kansas City | 28 | 15 | 7 | 6 | 51 | 31 | +20 | 52 | WWLW | 15 | 8 | 5 | 2 | 30 | 16 | 13 | 7 | 2 | 4 | 21 | 15 | ||
| 3 | Colorado Rapids | 27 | 13 | 9 | 5 | 38 | 27 | +11 | 48 | LWOX | 14 | 7 | 6 | 1 | 23 | 11 | 13 | 6 | 3 | 4 | 15 | 16 | ||
| 4 | Portland Timbers | 28 | 14 | 4 | 10 | 45 | 44 | +1 | 46 | WWWW | 14 | 9 | 2 | 3 | 28 | 19 | 14 | 5 | 2 | 7 | 17 | 25 | ||
| 5 | Real Salt Lake | 28 | 11 | 6 | 11 | 45 | 44 | +1 | 39 | LWLW | 14 | 8 | 4 | 2 | 23 | 13 | 14 | 3 | 2 | 9 | 22 | 31 | ||
| 6 | LA Galaxy | 28 | 11 | 6 | 11 | 39 | 45 | -6 | 39 | XLLL | 14 | 7 | 3 | 4 | 22 | 16 | 14 | 4 | 3 | 7 | 17 | 29 | ||
| 7 | Minnesota United | 27 | 10 | 8 | 9 | 30 | 32 | -2 | 38 | OLWW | 13 | 8 | 2 | 3 | 17 | 7 | 14 | 2 | 6 | 6 | 13 | 25 | ||
| 8 | Vancouver Whitecaps | 27 | 9 | 10 | 8 | 34 | 34 | +0 | 37 | WOWX | 14 | 8 | 2 | 4 | 20 | 14 | 13 | 1 | 8 | 4 | 14 | 20 | ||
| 9 | Los Angeles | 28 | 9 | 7 | 12 | 40 | 41 | -1 | 34 | XLLL | 14 | 6 | 5 | 3 | 27 | 21 | 14 | 3 | 2 | 9 | 13 | 20 | ||
| 10 | San Jose Earthquakes | 28 | 8 | 9 | 11 | 35 | 44 | -9 | 33 | LLWW | 14 | 4 | 3 | 7 | 19 | 22 | 14 | 4 | 6 | 4 | 16 | 22 | ||
| 11 | FC Dallas | 29 | 6 | 10 | 13 | 39 | 47 | -8 | 28 | OLLL | 14 | 4 | 7 | 3 | 20 | 15 | 15 | 2 | 3 | 10 | 19 | 32 | ||
| 12 | Houston Dynamo | 29 | 5 | 12 | 12 | 33 | 45 | -12 | 27 | LOLW | 14 | 5 | 6 | 3 | 19 | 17 | 15 | 0 | 6 | 9 | 14 | 28 | ||
| 13 | Austin FC | 28 | 7 | 4 | 17 | 29 | 44 | -15 | 25 | WLWL | 14 | 5 | 2 | 7 | 22 | 22 | 14 | 2 | 2 | 10 | 7 | 22 | ||
| 17 | Ola KAMARA (D.C. United) | |
| 16 | +1 | Dániel SALLÓI (Sporting Kansas City) |
| Raúl RUIDÍAZ (Seattle Sounders) | ||
| 13 | +1 | Damir KREILACH (Real Salt Lake) |
| Ricardo PEPI (FC Dallas) | ||
| Gustavo BOU (New England Revolution) | ||
| Adam BUKSA (New England Revolution) | ||
| Hany MUKHTAR (Nashville) | ||
| Valentín CASTELLANOS (New York City) | ||
| 12 | Javier HERNÁNDEZ (LA Galaxy) | |
| 11 | Felipe MORA (Portland Timbers) | |
| Javier LÓPEZ (San Jose Earthquakes) | ||
| +1 | Fabrice PICAULT (Houston Dynamo) | |
| 10 | Gonzalo HIGUAÍN (Inter Miami) | |
| Josef MARTÍNEZ (Atlanta United) | ||
| C.J. SAPONG (Nashville) | ||
| +2 | Johnny RUSSELL (Sporting Kansas City) | |
| 9 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| NANI (Orlando City) | ||
| +3 | Brian WHITE (Vancouver Whitecaps) | |
| 8 | Dairon ASPRILLA (Portland Timbers) | |
| Jesús MEDINA (New York City) | ||
| Alan PULIDO (Sporting Kansas City) | ||
| Jáder OBRIAN (FC Dallas) | ||
| +2 | Rommel QUIOTO (CF Montréal) | |
| Cristian DÁJOME (Vancouver Whitecaps) |
| Saturday, 2 October 2021 | |||||
| FC Dallas | 0-0 | Minnesota United | |||
| Vancouver Whitecaps | 3-0 | San Jose Earthquakes | |||
| 26 | White | ||||
| 59 | White | ||||
| 73 | White | ||||
| CF Montréal | 2-1 | Atlanta United | |||
| 50 | Quioto | 48 | Mulraney | ||
| 55(p) | Quioto | ||||
| Orlando City | 2-1 | D.C. United | |||
| 16 | Jansson | 6 | Gressel | ||
| 90 | Dike | ||||
| Austin FC | 2-1 | Real Salt Lake | |||
| 17 | Domínguez | 64 | Kreilach | ||
| 55 | Domínguez | ||||
| FC Cincinnati | 0-1 | New York Red Bulls | |||
| 73 | Gutman | ||||
| Sunday, 3 October 2021 | |||||
| Sporting Kansas City | 4-2 | Houston Dynamo | |||
| 16(p) | Russell | 50 | Picault | ||
| 26 | Sallói | 76 | Quintero | ||
| 57 | Kinda | ||||
| 90 | Russell | ||||
| LA Galaxy | 1-1 | Los Angeles | |||
| 19 | Grandsir | 11 | Fall | ||
| Portland Timbers | 1-0 | Inter Miami | |||
| 83 | Niezgoda | ||||
| Seattle Sounders | 3-0 | Colorado Rapids | |||
| 2 | Roldan | ||||
| 22 | Medranda | ||||
| 45 | João Paulo | ||||
| Toronto FC | 3-1 | Chicago Fire | |||
| 44 | Delgado | 16 | Berić | ||
| 56 | González | ||||
| 70 | Soteldo | ||||
| Philadelphia Union | 3-0 | Columbus Crew | |||
| 25 | Elliott | ||||
| 46 | Bedoya | ||||
| 89 | Flach | ||||
| New York City | 0-0 | Nashville | |||