| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 430 | 1,201 | 2.79 | 211 | 49.07% | 114 | 26.51% | 105 | 24.42% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 33 | 22 | 7 | 4 | 65 | 40 | +25 | 73 | WXWX | 16 | 12 | 3 | 1 | 31 | 17 | 17 | 10 | 4 | 3 | 34 | 23 | ||
| 2 | 1 | Nashville | 32 | 12 | 16 | 4 | 53 | 31 | +22 | 52 | WLXO | 16 | 8 | 8 | 0 | 34 | 17 | 16 | 4 | 8 | 4 | 19 | 14 | |
| 3 | 1 | Philadelphia Union | 32 | 13 | 11 | 8 | 45 | 34 | +11 | 50 | XWLX | 16 | 10 | 3 | 3 | 23 | 10 | 16 | 3 | 8 | 5 | 22 | 24 | |
| 4 | 1 | New York City | 32 | 13 | 8 | 11 | 52 | 34 | +18 | 47 | WWXL | 16 | 10 | 3 | 3 | 36 | 12 | 16 | 3 | 5 | 8 | 16 | 22 | |
| 5 | 1 | Orlando City | 32 | 12 | 11 | 9 | 47 | 47 | +0 | 47 | LXXW | 16 | 8 | 6 | 2 | 28 | 17 | 16 | 4 | 5 | 7 | 19 | 30 | |
| 6 | 1 | Atlanta United | 31 | 12 | 10 | 9 | 42 | 35 | +7 | 46 | WXWL | 16 | 9 | 4 | 3 | 24 | 13 | 15 | 3 | 6 | 6 | 18 | 22 | |
| 7 | 2 | D.C. United | 32 | 13 | 5 | 14 | 52 | 50 | +2 | 44 | WLLO | 16 | 11 | 1 | 4 | 31 | 14 | 16 | 2 | 4 | 10 | 21 | 36 | |
| 8 | 2 | New York Red Bulls | 31 | 12 | 7 | 12 | 37 | 32 | +5 | 43 | LWWW | 15 | 7 | 5 | 3 | 18 | 11 | 16 | 5 | 2 | 9 | 19 | 21 | |
| 9 | 1 | CF Montréal | 31 | 11 | 10 | 10 | 44 | 41 | +3 | 43 | XXXW | 15 | 8 | 4 | 3 | 27 | 21 | 16 | 3 | 6 | 7 | 17 | 20 | |
| 10 | 1 | Columbus Crew | 32 | 11 | 8 | 13 | 41 | 44 | -3 | 41 | WLXW | 16 | 9 | 3 | 4 | 31 | 22 | 16 | 2 | 5 | 9 | 10 | 22 | |
| 11 | 1 | Inter Miami | 32 | 11 | 5 | 16 | 34 | 50 | -16 | 38 | LWWL | 16 | 7 | 2 | 7 | 25 | 32 | 16 | 4 | 3 | 9 | 9 | 18 | |
| 12 | Chicago Fire | 33 | 9 | 7 | 17 | 36 | 52 | -16 | 34 | LWWX | 17 | 7 | 5 | 5 | 23 | 18 | 16 | 2 | 2 | 12 | 13 | 34 | ||
| 13 | Toronto FC | 32 | 6 | 9 | 17 | 37 | 62 | -25 | 27 | XXLL | 16 | 4 | 7 | 5 | 23 | 24 | 16 | 2 | 2 | 12 | 14 | 38 | ||
| 14 | FC Cincinnati | 32 | 4 | 8 | 20 | 36 | 70 | -34 | 20 | LLLL | 16 | 1 | 5 | 10 | 16 | 27 | 16 | 3 | 3 | 10 | 20 | 43 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Sporting Kansas City | 31 | 17 | 7 | 7 | 56 | 34 | +22 | 58 | WWLW | 16 | 9 | 5 | 2 | 32 | 16 | 15 | 8 | 2 | 5 | 24 | 18 | |
| 2 | 1 | Seattle Sounders | 32 | 17 | 7 | 8 | 51 | 31 | +20 | 58 | LLXL | 16 | 8 | 4 | 4 | 27 | 14 | 16 | 9 | 3 | 4 | 24 | 17 | |
| 3 | Colorado Rapids | 32 | 15 | 10 | 7 | 45 | 33 | +12 | 55 | LWXL | 16 | 8 | 7 | 1 | 26 | 12 | 16 | 7 | 3 | 6 | 19 | 21 | ||
| 4 | Portland Timbers | 32 | 15 | 4 | 13 | 50 | 51 | -1 | 49 | WLLL | 16 | 10 | 2 | 4 | 32 | 22 | 16 | 5 | 2 | 9 | 18 | 29 | ||
| 5 | 2 | Vancouver Whitecaps | 32 | 12 | 11 | 9 | 43 | 43 | +0 | 47 | WXWW | 16 | 10 | 2 | 4 | 24 | 16 | 16 | 2 | 9 | 5 | 19 | 27 | |
| 6 | 1 | LA Galaxy | 32 | 13 | 7 | 12 | 46 | 50 | -4 | 46 | LXWW | 16 | 8 | 4 | 4 | 26 | 19 | 16 | 5 | 3 | 8 | 20 | 31 | |
| 7 | 1 | Real Salt Lake | 31 | 13 | 6 | 12 | 50 | 47 | +3 | 45 | WLWL | 15 | 9 | 4 | 2 | 26 | 14 | 16 | 4 | 2 | 10 | 24 | 33 | |
| 8 | 2 | Minnesota United | 32 | 12 | 9 | 11 | 37 | 40 | -3 | 45 | LXWW | 16 | 9 | 3 | 4 | 22 | 13 | 16 | 3 | 6 | 7 | 15 | 27 | |
| 9 | Los Angeles | 32 | 12 | 8 | 12 | 50 | 45 | +5 | 44 | WXWW | 16 | 8 | 5 | 3 | 33 | 22 | 16 | 4 | 3 | 9 | 17 | 23 | ||
| 10 | San Jose Earthquakes | 32 | 9 | 10 | 13 | 41 | 50 | -9 | 37 | LXWL | 16 | 5 | 4 | 7 | 24 | 23 | 16 | 4 | 6 | 6 | 17 | 27 | ||
| 11 | Houston Dynamo | 32 | 6 | 12 | 14 | 36 | 51 | -15 | 30 | LLWL | 16 | 6 | 6 | 4 | 21 | 21 | 16 | 0 | 6 | 10 | 15 | 30 | ||
| 12 | FC Dallas | 32 | 6 | 11 | 15 | 44 | 54 | -10 | 29 | LXLO | 16 | 4 | 7 | 5 | 23 | 20 | 16 | 2 | 4 | 10 | 21 | 34 | ||
| 13 | Austin FC | 31 | 8 | 4 | 19 | 31 | 50 | -19 | 28 | WLLW | 16 | 6 | 2 | 8 | 24 | 24 | 15 | 2 | 2 | 11 | 7 | 26 | ||
| 17 | Ola KAMARA (D.C. United) | |
| 16 | Dániel SALLÓI (Sporting Kansas City) | |
| Adam BUKSA (New England Revolution) | ||
| Raúl RUIDÍAZ (Seattle Sounders) | ||
| +1 | Valentín CASTELLANOS (New York City) | |
| 15 | +1 | Damir KREILACH (Real Salt Lake) |
| Gustavo BOU (New England Revolution) | ||
| 14 | +2 | Johnny RUSSELL (Sporting Kansas City) |
| Hany MUKHTAR (Nashville) | ||
| Javier HERNÁNDEZ (LA Galaxy) | ||
| 13 | Ricardo PEPI (FC Dallas) | |
| +1 | Cristian ARANGO (Los Angeles) | |
| 12 | +1 | Gonzalo HIGUAÍN (Inter Miami) |
| +2 | C.J. SAPONG (Nashville) | |
| Javier LÓPEZ (San Jose Earthquakes) | ||
| +1 | Brian WHITE (Vancouver Whitecaps) | |
| 11 | +1 | Josef MARTÍNEZ (Atlanta United) |
| Felipe MORA (Portland Timbers) | ||
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| Fabrice PICAULT (Houston Dynamo) | ||
| 10 | +1 | Dairon ASPRILLA (Portland Timbers) |
| NANI (Orlando City) | ||
| 9 | Jesús MEDINA (New York City) | |
| Gyasi ZARDES (Columbus Crew) | ||
| Marcelino MORENO (Atlanta United) | ||
| +1 | Lucas ZELARAYÁN (Columbus Crew) | |
| Cristian DÁJOME (Vancouver Whitecaps) |
| Tuesday, 26 October 2021 | |||||
| Los Angeles | 3-0 | Seattle Sounders | |||
| 21 | Rodríguez | ||||
| 45 | Blessing | ||||
| 51 | Arango | ||||
| Wednesday, 27 October 2021 | |||||
| D.C. United | 1-0 | New York Red Bulls | |||
| 9 | Paredes | ||||
| FC Dallas | 1-2 | Real Salt Lake | |||
| 20 | Hedges | 80 | Kreilach | ||
| 90 | Rusnák | ||||
| Columbus Crew | 3-2 | Orlando City | |||
| 20 | Berry | 52(p) | Dike | ||
| 31 | Etienne | 90 | Jansson | ||
| 61 | Zelarayán | ||||
| New England Revolution | 1-0 | Colorado Rapids | |||
| 74 | Buchanan | ||||
| Sporting Kansas City | 2-0 | LA Galaxy | |||
| 40 | Russell | ||||
| 82 | Russell | ||||
| Vancouver Whitecaps | 2-1 | Minnesota United | |||
| 45(og) | Boxall | 90 | Adi | ||
| 63 | White | ||||
| Portland Timbers | 2-0 | San Jose Earthquakes | |||
| 34 | Chará | ||||
| 55 | Asprilla | ||||
| Toronto FC | 2-2 | Philadelphia Union | |||
| 66 | Altidore | 1 | Bedoya | ||
| 70(og) | Elliott | 77 | Santos | ||
| New York City | 1-0 | Chicago Fire | |||
| 51(p) | Castellanos | ||||
| Atlanta United | 2-1 | Inter Miami | |||
| 59 | Luiz Araújo | 32(p) | Higuaín | ||
| 73 | Martínez | ||||
| FC Cincinnati | 3-6 | Nashville | |||
| 6(og) | Romney | 28 | Zimmerman | ||
| 17(p) | Brenner | 45 | Leal | ||
| 32 | Vázquez | 71 | Sapong | ||
| 76 | Leal | ||||
| 80 | Loba | ||||
| 90 | Sapong | ||||