Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 203 | 547 | 2.69 | 100 | 49.26% | 57 | 28.08% | 46 | 22.66% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 16 | 10 | 3 | 3 | 30 | 19 | +11 | 33 | WWWL | 7 | 6 | 0 | 1 | 14 | 8 | 9 | 4 | 3 | 2 | 16 | 11 | ||
| 2 | 1 | Orlando City | 16 | 8 | 4 | 4 | 26 | 21 | +5 | 28 | WLWX | 8 | 5 | 2 | 1 | 16 | 6 | 8 | 3 | 2 | 3 | 10 | 15 | |
| 3 | 4 | New York City | 15 | 8 | 2 | 5 | 30 | 16 | +14 | 26 | WWWL | 9 | 6 | 1 | 2 | 22 | 8 | 6 | 2 | 1 | 3 | 8 | 8 | |
| 4 | 2 | Nashville | 15 | 6 | 8 | 1 | 24 | 14 | +10 | 26 | WOWX | 11 | 6 | 5 | 0 | 22 | 10 | 4 | 0 | 3 | 1 | 2 | 4 | |
| 5 | Philadelphia Union | 16 | 6 | 6 | 4 | 20 | 16 | +4 | 24 | XLWX | 7 | 4 | 1 | 2 | 9 | 6 | 9 | 2 | 5 | 2 | 11 | 10 | ||
| 6 | 2 | Columbus Crew | 16 | 6 | 6 | 4 | 17 | 16 | +1 | 24 | LWOW | 7 | 4 | 3 | 0 | 11 | 5 | 9 | 2 | 3 | 4 | 6 | 11 | |
| 7 | 1 | CF Montréal | 15 | 6 | 4 | 5 | 20 | 18 | +2 | 22 | LLWW | 7 | 4 | 2 | 1 | 13 | 9 | 8 | 2 | 2 | 4 | 7 | 9 | |
| 8 | 1 | D.C. United | 15 | 6 | 2 | 7 | 21 | 18 | +3 | 20 | WXLW | 7 | 5 | 0 | 2 | 12 | 4 | 8 | 1 | 2 | 5 | 9 | 14 | |
| 9 | 1 | New York Red Bulls | 14 | 5 | 3 | 6 | 18 | 17 | +1 | 18 | LXXW | 6 | 4 | 1 | 1 | 10 | 4 | 8 | 1 | 2 | 5 | 8 | 13 | |
| 10 | Atlanta United | 16 | 2 | 8 | 6 | 16 | 21 | -5 | 14 | LLXL | 7 | 2 | 3 | 2 | 8 | 7 | 9 | 0 | 5 | 4 | 8 | 14 | ||
| 11 | Toronto FC | 15 | 3 | 4 | 8 | 20 | 32 | -12 | 13 | WXXW | 6 | 1 | 3 | 2 | 8 | 9 | 9 | 2 | 1 | 6 | 12 | 23 | ||
| 12 | FC Cincinnati | 14 | 3 | 4 | 7 | 17 | 29 | -12 | 13 | LXLX | 5 | 0 | 2 | 3 | 5 | 9 | 9 | 3 | 2 | 4 | 12 | 20 | ||
| 13 | Chicago Fire | 15 | 3 | 3 | 9 | 17 | 27 | -10 | 12 | LXLW | 10 | 3 | 3 | 4 | 15 | 14 | 5 | 0 | 0 | 5 | 2 | 13 | ||
| 14 | Inter Miami | 13 | 2 | 3 | 8 | 10 | 23 | -13 | 9 | XLLL | 7 | 0 | 2 | 5 | 5 | 17 | 6 | 2 | 1 | 3 | 5 | 6 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 16 | 9 | 5 | 2 | 25 | 12 | +13 | 32 | LWLW | 9 | 5 | 3 | 1 | 17 | 7 | 7 | 4 | 2 | 1 | 8 | 5 | ||
| 2 | Sporting Kansas City | 15 | 9 | 3 | 3 | 28 | 17 | +11 | 30 | WXWW | 8 | 5 | 3 | 0 | 16 | 8 | 7 | 4 | 0 | 3 | 12 | 9 | ||
| 3 | LA Galaxy | 16 | 9 | 1 | 6 | 27 | 27 | +0 | 28 | WLXL | 8 | 6 | 0 | 2 | 16 | 9 | 8 | 3 | 1 | 4 | 11 | 18 | ||
| 4 | Colorado Rapids | 14 | 7 | 3 | 4 | 21 | 16 | +5 | 24 | LWXW | 8 | 5 | 2 | 1 | 16 | 8 | 6 | 2 | 1 | 3 | 5 | 8 | ||
| 5 | Los Angeles | 16 | 6 | 5 | 5 | 22 | 19 | +3 | 23 | XXLW | 9 | 4 | 4 | 1 | 15 | 10 | 7 | 2 | 1 | 4 | 7 | 9 | ||
| 6 | Minnesota United | 15 | 6 | 4 | 5 | 17 | 19 | -2 | 22 | XWWL | 8 | 5 | 1 | 2 | 10 | 6 | 7 | 1 | 3 | 3 | 7 | 13 | ||
| 7 | Real Salt Lake | 14 | 5 | 5 | 4 | 24 | 16 | +8 | 20 | WXLW | 9 | 3 | 4 | 2 | 14 | 9 | 5 | 2 | 1 | 2 | 10 | 7 | ||
| 8 | Portland Timbers | 15 | 6 | 1 | 8 | 19 | 26 | -7 | 19 | LLWW | 7 | 5 | 0 | 2 | 11 | 6 | 8 | 1 | 1 | 6 | 8 | 20 | ||
| 9 | Houston Dynamo | 15 | 3 | 8 | 4 | 17 | 20 | -3 | 17 | XOLX | 6 | 3 | 3 | 0 | 9 | 6 | 9 | 0 | 5 | 4 | 8 | 14 | ||
| 10 | FC Dallas | 15 | 3 | 5 | 7 | 18 | 23 | -5 | 14 | WLLL | 8 | 3 | 5 | 0 | 16 | 8 | 7 | 0 | 0 | 7 | 2 | 15 | ||
| 11 | San Jose Earthquakes | 15 | 3 | 5 | 7 | 17 | 25 | -8 | 14 | XXXX | 7 | 2 | 1 | 4 | 10 | 12 | 8 | 1 | 4 | 3 | 7 | 13 | ||
| 12 | Vancouver Whitecaps | 15 | 3 | 5 | 7 | 16 | 25 | -9 | 14 | XOWL | 7 | 3 | 1 | 3 | 6 | 8 | 8 | 0 | 4 | 4 | 10 | 17 | ||
| 13 | Austin FC | 14 | 3 | 4 | 7 | 10 | 15 | -5 | 13 | LLWO | 5 | 1 | 2 | 2 | 4 | 4 | 9 | 2 | 2 | 5 | 6 | 11 | ||
| 11 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| 9 | +1 | Dániel SALLÓI (Sporting Kansas City) |
| +2 | Gustavo BOU (New England Revolution) | |
| 8 | +1 | NANI (Orlando City) |
| Ricardo PEPI (FC Dallas) | ||
| 7 | +1 | Jesús MEDINA (New York City) |
| +1 | Ola KAMARA (D.C. United) | |
| Adam BUKSA (New England Revolution) | ||
| Damir KREILACH (Real Salt Lake) | ||
| Hany MUKHTAR (Nashville) | ||
| 6 | Cristian DÁJOME (Vancouver Whitecaps) | |
| +2 | Valentín CASTELLANOS (New York City) | |
| +1 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| +1 | Ismaël TAJOURI-SHRADI (New York City) | |
| Alan PULIDO (Sporting Kansas City) | ||
| Mason TOYE (CF Montréal) | ||
| Maximiliano URRUTI (Houston Dynamo) | ||
| 5 | Gonzalo HIGUAÍN (Inter Miami) | |
| José CIFUENTES (Los Angeles) | ||
| +1 | Carlos VELA (Los Angeles) | |
| C.J. SAPONG (Nashville) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Rubio RUBIN (Real Salt Lake) | ||
| Diego ROSSI (Los Angeles) |
| Sunday, 25 July 2021 | |||||
| D.C. United | 1-0 | New York Red Bulls | |||
| 27 | Kamara | ||||
| New England Revolution | 2-1 | CF Montréal | |||
| 29 | Bou | 79 | Mihailovic | ||
| 73 | Bou | ||||
| Seattle Sounders | 1-3 | Sporting Kansas City | |||
| 51 | Montero | 31 | Russell | ||
| 42 | Sallói | ||||
| 72 | Duke | ||||
| New York City | 5-0 | Orlando City | |||
| 40 | Medina | ||||
| 53 | Tajouri-Shradi | ||||
| 65 | Moralez | ||||
| 79 | Amundsen | ||||
| 82 | Castellanos | ||||
| Inter Miami | 1-1 | Philadelphia Union | |||
| 71 | Robinson | 85 | Przybyłko | ||
| Wednesday, 28 July 2021 | |||||
| Los Angeles | 2-2 | Minnesota United | |||
| 40 | Vela | 49 | Reynoso | ||
| 77 | Blackmon | 90 | Dotson | ||
| Friday, 30 July 2021 | |||||
| LA Galaxy | 4-1 | Portland Timbers | |||
| 27 | Raveloson | 29 | Ebobisse | ||
| 34 | Víctor Vázquez | ||||
| 53(p) | Kljestan | ||||
| 56 | Grandsir | ||||
| Orlando City | 3-2 | Atlanta United | |||
| 43 | Smith | 1 | Martínez | ||
| 79 | van Der Water | 66 | Moreno | ||
| 87 | Nani | ||||
| New York City | 4-1 | Columbus Crew | |||
| 14 | Castellanos | 90(p) | Pedro Santos | ||
| 35 | Thiago Andrade | ||||
| 51 | Parks | ||||
| 71 | Rodríguez | ||||
