Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 172 | 460 | 2.67 | 85 | 49.42% | 46 | 26.74% | 41 | 23.84% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 14 | 8 | 3 | 3 | 23 | 18 | +5 | 27 | WLXL | 6 | 5 | 0 | 1 | 12 | 7 | 8 | 3 | 3 | 2 | 11 | 11 | ||
| 2 | 1 | Philadelphia Union | 14 | 6 | 5 | 3 | 18 | 13 | +5 | 23 | WXLX | 7 | 4 | 1 | 2 | 9 | 6 | 7 | 2 | 4 | 1 | 9 | 7 | |
| 3 | 1 | Orlando City | 13 | 6 | 4 | 3 | 21 | 13 | +8 | 22 | XLLW | 6 | 3 | 2 | 1 | 11 | 3 | 7 | 3 | 2 | 2 | 10 | 10 | |
| 4 | CF Montréal | 13 | 6 | 4 | 3 | 19 | 15 | +4 | 22 | WWWX | 7 | 4 | 2 | 1 | 13 | 9 | 6 | 2 | 2 | 2 | 6 | 6 | ||
| 5 | Nashville | 13 | 5 | 7 | 1 | 21 | 14 | +7 | 22 | WXWX | 10 | 5 | 5 | 0 | 19 | 10 | 3 | 0 | 2 | 1 | 2 | 4 | ||
| 6 | 3 | Columbus Crew | 13 | 5 | 5 | 3 | 15 | 12 | +3 | 20 | WXXO | 6 | 4 | 2 | 0 | 11 | 5 | 7 | 1 | 3 | 3 | 4 | 7 | |
| 7 | 1 | New York City | 12 | 5 | 2 | 5 | 20 | 15 | +5 | 17 | LLWW | 6 | 3 | 1 | 2 | 12 | 7 | 6 | 2 | 1 | 3 | 8 | 8 | |
| 8 | New York Red Bulls | 12 | 5 | 2 | 5 | 17 | 15 | +2 | 17 | XWOL | 6 | 4 | 1 | 1 | 10 | 4 | 6 | 1 | 1 | 4 | 7 | 11 | ||
| 9 | 2 | D.C. United | 13 | 5 | 1 | 7 | 18 | 16 | +2 | 16 | LWLO | 6 | 4 | 0 | 2 | 11 | 4 | 7 | 1 | 1 | 5 | 7 | 12 | |
| 10 | Atlanta United | 13 | 2 | 7 | 4 | 13 | 16 | -3 | 13 | LXLO | 6 | 2 | 3 | 1 | 8 | 6 | 7 | 0 | 4 | 3 | 5 | 10 | ||
| 11 | 1 | FC Cincinnati | 12 | 3 | 3 | 6 | 16 | 25 | -9 | 12 | LXXW | 4 | 0 | 1 | 3 | 4 | 8 | 8 | 3 | 2 | 3 | 12 | 17 | |
| 12 | 1 | Chicago Fire | 13 | 3 | 2 | 8 | 14 | 23 | -9 | 11 | LWWX | 8 | 3 | 2 | 3 | 12 | 10 | 5 | 0 | 0 | 5 | 2 | 13 | |
| 13 | 1 | Toronto FC | 13 | 2 | 3 | 8 | 17 | 30 | -13 | 9 | XWLL | 5 | 1 | 2 | 2 | 7 | 8 | 8 | 1 | 1 | 6 | 10 | 22 | |
| 14 | 1 | Inter Miami | 11 | 2 | 2 | 7 | 9 | 17 | -8 | 8 | LLLL | 5 | 0 | 1 | 4 | 4 | 11 | 6 | 2 | 1 | 3 | 5 | 6 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 13 | 8 | 5 | 0 | 23 | 8 | +15 | 29 | WXXW | 8 | 5 | 3 | 0 | 16 | 4 | 5 | 3 | 2 | 0 | 7 | 4 | ||
| 2 | Sporting Kansas City | 13 | 8 | 2 | 3 | 24 | 15 | +9 | 26 | WWWL | 7 | 5 | 2 | 0 | 15 | 7 | 6 | 3 | 0 | 3 | 9 | 8 | ||
| 3 | LA Galaxy | 13 | 8 | 0 | 5 | 21 | 20 | +1 | 24 | LWLW | 7 | 5 | 0 | 2 | 12 | 8 | 6 | 3 | 0 | 3 | 9 | 12 | ||
| 4 | Colorado Rapids | 12 | 6 | 3 | 3 | 19 | 13 | +6 | 21 | XWXL | 7 | 4 | 2 | 1 | 14 | 8 | 5 | 2 | 1 | 2 | 5 | 5 | ||
| 5 | Los Angeles | 13 | 6 | 3 | 4 | 17 | 13 | +4 | 21 | WWWL | 7 | 4 | 2 | 1 | 11 | 6 | 6 | 2 | 1 | 3 | 6 | 7 | ||
| 6 | 3 | Portland Timbers | 12 | 5 | 1 | 6 | 15 | 19 | -4 | 16 | WLLX | 6 | 4 | 0 | 2 | 9 | 5 | 6 | 1 | 1 | 4 | 6 | 14 | |
| 7 | 1 | Real Salt Lake | 12 | 4 | 4 | 4 | 19 | 14 | +5 | 16 | LWLX | 7 | 2 | 3 | 2 | 9 | 7 | 5 | 2 | 1 | 2 | 10 | 7 | |
| 8 | 1 | Minnesota United | 12 | 4 | 3 | 5 | 12 | 16 | -4 | 15 | LXWW | 6 | 3 | 1 | 2 | 7 | 5 | 6 | 1 | 2 | 3 | 5 | 11 | |
| 9 | 1 | Houston Dynamo | 13 | 3 | 6 | 4 | 16 | 19 | -3 | 15 | LXXX | 6 | 3 | 3 | 0 | 9 | 6 | 7 | 0 | 3 | 4 | 7 | 13 | |
| 10 | Austin FC | 13 | 3 | 4 | 6 | 10 | 14 | -4 | 13 | LWOL | 4 | 1 | 2 | 1 | 4 | 3 | 9 | 2 | 2 | 5 | 6 | 11 | ||
| 11 | San Jose Earthquakes | 13 | 3 | 3 | 7 | 15 | 23 | -8 | 12 | XXLL | 6 | 2 | 0 | 4 | 9 | 11 | 7 | 1 | 3 | 3 | 6 | 12 | ||
| 12 | 1 | Vancouver Whitecaps | 13 | 3 | 3 | 7 | 14 | 23 | -9 | 12 | WLXX | 6 | 3 | 0 | 3 | 6 | 8 | 7 | 0 | 3 | 4 | 8 | 15 | |
| 13 | 1 | FC Dallas | 13 | 2 | 5 | 6 | 14 | 21 | -7 | 11 | LLXW | 7 | 2 | 5 | 0 | 12 | 8 | 6 | 0 | 0 | 6 | 2 | 13 | |
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| Raúl RUIDÍAZ (Seattle Sounders) | ||
| 7 | Dániel SALLÓI (Sporting Kansas City) | |
| +1 | NANI (Orlando City) | |
| Damir KREILACH (Real Salt Lake) | ||
| +4 | Hany MUKHTAR (Nashville) | |
| +1 | Gustavo BOU (New England Revolution) | |
| 6 | +1 | Jesús MEDINA (New York City) |
| Alan PULIDO (Sporting Kansas City) | ||
| +2 | Mason TOYE (CF Montréal) | |
| Maximiliano URRUTI (Houston Dynamo) | ||
| 5 | Gonzalo HIGUAÍN (Inter Miami) | |
| Ola KAMARA (D.C. United) | ||
| Adam BUKSA (New England Revolution) | ||
| +2 | Lucas ZELARAYÁN (Columbus Crew) | |
| +1 | Cristian DÁJOME (Vancouver Whitecaps) | |
| Ricardo PEPI (FC Dallas) | ||
| +1 | Diego ROSSI (Los Angeles) | |
| 4 | Caden CLARK (New York Red Bulls) | |
| José CIFUENTES (Los Angeles) | ||
| Cory BURKE (Philadelphia Union) | ||
| Rubio RUBIN (Real Salt Lake) | ||
| Cade COWELL (San Jose Earthquakes) | ||
| Valentín CASTELLANOS (New York City) | ||
| +1 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| Gyasi ZARDES (Columbus Crew) | ||
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Cristian CÁSSERES (New York Red Bulls) |
| Thursday, 8 July 2021 | |||||
| New York Red Bulls | 1-1 | Philadelphia Union | |||
| 60(p) | Klimala | 85 | Santos | ||
| Nashville | 2-2 | Atlanta United | |||
| 14 | Anibaba | 5 | Walkes | ||
| 49(p) | Mukhtar | 59 | Conway | ||
| Friday, 9 July 2021 | |||||
| FC Cincinnati | 2-2 | Columbus Crew | |||
| 1 | Castillo | 45 | Zelarayán | ||
| 24 | Acosta | 77 | Berry | ||
| Saturday, 17 July 2021 | |||||
| Colorado Rapids | 1-1 | San Jose Earthquakes | |||
| 53 | Bassett | 11 | López | ||
| Columbus Crew | 2-1 | New York City | |||
| 45 | Nagbe | 47 | Medina | ||
| 62 | Zelarayán | ||||
| Vancouver Whitecaps | 2-1 | LA Galaxy | |||
| 48 | Caicedo | 5 | Raveloson | ||
| 77 | Dájome | ||||
| CF Montréal | 5-4 | FC Cincinnati | |||
| 21 | Toye | 6 | Medunjanin | ||
| 34 | Torres | 14 | Brenner | ||
| 72(p) | Toye | 42 | Vallecilla | ||
| 74 | Hamdy | 46 | Brenner | ||
| 87 | Hamdy | ||||
| Portland Timbers | 1-0 | FC Dallas | |||
| 84 | Ebobisse | ||||
| Toronto FC | 1-1 | Orlando City | |||
| 72 | Altidore | 77(p) | Nani | ||
| Philadelphia Union | 2-1 | D.C. United | |||
| 11 | Santos | 51(p) | Asad | ||
| 83 | Przybyłko | ||||
| Los Angeles | 2-1 | Real Salt Lake | |||
| 10 | Rossi | 18 | Herrera | ||
| 79 | Vela | ||||
| Nashville | 5-1 | Chicago Fire | |||
| 10 | Mukhtar | 47 | Aliseda | ||
| 13 | Mukhtar | ||||
| 16 | Mukhtar | ||||
| 39 | Sapong | ||||
| 62 | Anunga | ||||
| Atlanta United | 0-1 | New England Revolution | |||
| 18 | Bou | ||||
