Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 275 | 732 | 2.66 | 130 | 47.27% | 81 | 29.45% | 64 | 23.27% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 22 | 15 | 4 | 3 | 44 | 26 | +18 | 49 | WWWW | 11 | 9 | 1 | 1 | 23 | 12 | 11 | 6 | 3 | 2 | 21 | 14 | ||
| 2 | 3 | Orlando City | 20 | 9 | 7 | 4 | 30 | 24 | +6 | 34 | WXXX | 10 | 6 | 3 | 1 | 18 | 7 | 10 | 3 | 4 | 3 | 12 | 17 | |
| 3 | 1 | Philadelphia Union | 21 | 8 | 8 | 5 | 27 | 20 | +7 | 32 | XWLW | 11 | 6 | 3 | 2 | 15 | 8 | 10 | 2 | 5 | 3 | 12 | 12 | |
| 4 | 2 | Nashville | 20 | 7 | 11 | 2 | 32 | 20 | +12 | 32 | XWLO | 13 | 7 | 6 | 0 | 28 | 13 | 7 | 0 | 5 | 2 | 4 | 7 | |
| 5 | 2 | New York City | 19 | 9 | 4 | 6 | 34 | 19 | +15 | 31 | LWXO | 10 | 7 | 1 | 2 | 24 | 8 | 9 | 2 | 3 | 4 | 10 | 11 | |
| 6 | 1 | CF Montréal | 21 | 7 | 7 | 7 | 27 | 26 | +1 | 28 | XOWL | 9 | 5 | 3 | 1 | 17 | 12 | 12 | 2 | 4 | 6 | 10 | 14 | |
| 7 | 1 | D.C. United | 21 | 8 | 3 | 10 | 32 | 31 | +1 | 27 | LLLW | 9 | 6 | 0 | 3 | 15 | 7 | 12 | 2 | 3 | 7 | 17 | 24 | |
| 8 | 1 | Atlanta United | 21 | 6 | 9 | 6 | 25 | 26 | -1 | 27 | WWWW | 9 | 4 | 3 | 2 | 10 | 7 | 12 | 2 | 6 | 4 | 15 | 19 | |
| 9 | 1 | Columbus Crew | 21 | 6 | 6 | 9 | 22 | 27 | -5 | 24 | LLLL | 10 | 4 | 3 | 3 | 16 | 14 | 11 | 2 | 3 | 6 | 6 | 13 | |
| 10 | New York Red Bulls | 19 | 6 | 4 | 9 | 23 | 24 | -1 | 22 | WLLO | 9 | 5 | 2 | 2 | 13 | 7 | 10 | 1 | 2 | 7 | 10 | 17 | ||
| 11 | 1 | Inter Miami | 19 | 6 | 4 | 9 | 21 | 31 | -10 | 22 | WWLW | 11 | 4 | 2 | 5 | 15 | 22 | 8 | 2 | 2 | 4 | 6 | 9 | |
| 12 | 1 | Chicago Fire | 21 | 5 | 5 | 11 | 23 | 33 | -10 | 20 | LLWW | 13 | 5 | 4 | 4 | 18 | 15 | 8 | 0 | 1 | 7 | 5 | 18 | |
| 13 | FC Cincinnati | 19 | 3 | 8 | 8 | 19 | 34 | -15 | 17 | LOXO | 8 | 0 | 5 | 3 | 6 | 10 | 11 | 3 | 3 | 5 | 13 | 24 | ||
| 14 | Toronto FC | 21 | 3 | 6 | 12 | 25 | 44 | -19 | 15 | LLLX | 9 | 1 | 5 | 3 | 12 | 14 | 12 | 2 | 1 | 9 | 13 | 30 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 21 | 12 | 6 | 3 | 35 | 17 | +18 | 42 | WWWX | 11 | 5 | 4 | 2 | 18 | 9 | 10 | 7 | 2 | 1 | 17 | 8 | ||
| 2 | Sporting Kansas City | 21 | 11 | 6 | 4 | 36 | 21 | +15 | 39 | OXWO | 10 | 5 | 4 | 1 | 18 | 11 | 11 | 6 | 2 | 3 | 18 | 10 | ||
| 3 | 1 | Colorado Rapids | 19 | 11 | 4 | 4 | 29 | 19 | +10 | 37 | WWWO | 10 | 6 | 3 | 1 | 18 | 9 | 9 | 5 | 1 | 3 | 11 | 10 | |
| 4 | 1 | LA Galaxy | 21 | 11 | 2 | 8 | 32 | 32 | +0 | 35 | LLWX | 12 | 7 | 1 | 4 | 20 | 14 | 9 | 4 | 1 | 4 | 12 | 18 | |
| 5 | 1 | Minnesota United | 20 | 7 | 7 | 6 | 22 | 23 | -1 | 28 | OXLW | 11 | 6 | 2 | 3 | 12 | 7 | 9 | 1 | 5 | 3 | 10 | 16 | |
| 6 | 1 | Real Salt Lake | 20 | 7 | 6 | 7 | 30 | 23 | +7 | 27 | LWWL | 11 | 5 | 4 | 2 | 17 | 10 | 9 | 2 | 2 | 5 | 13 | 13 | |
| 7 | 2 | San Jose Earthquakes | 21 | 6 | 8 | 7 | 24 | 29 | -5 | 26 | WXOW | 10 | 3 | 3 | 4 | 13 | 14 | 11 | 3 | 5 | 3 | 11 | 15 | |
| 8 | 1 | Portland Timbers | 20 | 7 | 3 | 10 | 27 | 39 | -12 | 24 | LXLW | 10 | 6 | 1 | 3 | 17 | 15 | 10 | 1 | 2 | 7 | 10 | 24 | |
| 9 | 1 | Los Angeles | 20 | 6 | 5 | 9 | 25 | 28 | -3 | 23 | LLLL | 10 | 4 | 4 | 2 | 16 | 14 | 10 | 2 | 1 | 7 | 9 | 14 | |
| 10 | 1 | Vancouver Whitecaps | 20 | 5 | 8 | 7 | 23 | 30 | -7 | 23 | WWOX | 9 | 4 | 2 | 3 | 10 | 11 | 11 | 1 | 6 | 4 | 13 | 19 | |
| 11 | 1 | FC Dallas | 21 | 5 | 7 | 9 | 25 | 30 | -5 | 22 | XLLW | 11 | 4 | 5 | 2 | 18 | 11 | 10 | 1 | 2 | 7 | 7 | 19 | |
| 12 | 1 | Austin FC | 20 | 5 | 4 | 11 | 17 | 24 | -7 | 19 | WLLL | 9 | 3 | 2 | 4 | 11 | 10 | 11 | 2 | 2 | 7 | 6 | 14 | |
| 13 | 1 | Houston Dynamo | 21 | 3 | 10 | 8 | 23 | 32 | -9 | 19 | XLLL | 9 | 3 | 5 | 1 | 12 | 11 | 12 | 0 | 5 | 7 | 11 | 21 | |
| 14 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 12 | Gustavo BOU (New England Revolution) | |
| Dániel SALLÓI (Sporting Kansas City) | ||
| 11 | Ola KAMARA (D.C. United) | |
| 10 | +2 | Adam BUKSA (New England Revolution) |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| 9 | C.J. SAPONG (Nashville) | |
| +1 | Ricardo PEPI (FC Dallas) | |
| NANI (Orlando City) | ||
| 8 | Gonzalo HIGUAÍN (Inter Miami) | |
| Damir KREILACH (Real Salt Lake) | ||
| Alan PULIDO (Sporting Kansas City) | ||
| Hany MUKHTAR (Nashville) | ||
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| Valentín CASTELLANOS (New York City) | ||
| 7 | Jesús MEDINA (New York City) | |
| Felipe MORA (Portland Timbers) | ||
| Luka STOJANOVIĆ (Chicago Fire) | ||
| +1 | Marcelino MORENO (Atlanta United) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Mason TOYE (CF Montréal) | ||
| 6 | +1 | Josef MARTÍNEZ (Atlanta United) |
| Robin LOD (Minnesota United) | ||
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| Fredy MONTERO (Seattle Sounders) | ||
| +1 | Diego ROSSI (Los Angeles) | |
| +1 | Tajon BUCHANAN (New England Revolution) | |
| +1 | Fabrice PICAULT (Houston Dynamo) | |
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Maximiliano URRUTI (Houston Dynamo) |
| Friday, 20 August 2021 | |||||
| LA Galaxy | 1-2 | San Jose Earthquakes | |||
| 65 | Víctor Vázquez | 52 | Ebobisse | ||
| 71(og) | Hämäläinen | ||||
| Saturday, 21 August 2021 | |||||
| D.C. United | 1-2 | Atlanta United | |||
| 54 | Reyna | 25 | Martínez | ||
| 82 | Moreno | ||||
| Houston Dynamo | 2-2 | FC Dallas | |||
| 25(p) | Picault | 54 | Tafari | ||
| 72 | Vera | 58 | Pepi | ||
| Colorado Rapids | 2-1 | Real Salt Lake | |||
| 64 | Rubio | 51 | Rusnák | ||
| 71 | Kaye | ||||
| Columbus Crew | 1-2 | Seattle Sounders | |||
| 77 | Wright-Phillips | 88 | Arreaga | ||
| 89 | Bruin | ||||
| New England Revolution | 4-1 | FC Cincinnati | |||
| 7 | Buchanan | 54 | Brenner | ||
| 21 | Boateng | ||||
| 33 | Buksa | ||||
| 61 | Buksa | ||||
| Vancouver Whitecaps | 2-1 | Los Angeles | |||
| 60 | White | 45(p) | Rossi | ||
| 89 | Gauld | ||||
| Orlando City | 1-0 | Chicago Fire | |||
| 51 | Michel | ||||
| Philadelphia Union | 1-1 | CF Montréal | |||
| 87 | Sullivan | 45 | Mihailovic | ||
| Minnesota United | 0-0 | Sporting Kansas City | |||
| Austin FC | 3-1 | Portland Timbers | |||
| 11(p) | Domínguez | 55 | Asprilla | ||
| 14 | Fagúndez | ||||
| 29 | Driussi | ||||
| Inter Miami | 3-1 | Toronto FC | |||
| 15 | Pizarro | 62(og) | Gibbs | ||
| 35 | Robinson | ||||
| 48 | Pizarro | ||||
