Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 125 | 318 | 2.54 | 65 | 52.00% | 30 | 24.00% | 30 | 24.00% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 10 | 7 | 2 | 1 | 17 | 11 | +6 | 23 | WWWW | 5 | 5 | 0 | 0 | 10 | 4 | 5 | 2 | 2 | 1 | 7 | 7 | ||
| 2 | Orlando City | 9 | 5 | 3 | 1 | 16 | 6 | +10 | 18 | WWLW | 5 | 3 | 2 | 0 | 10 | 1 | 4 | 2 | 1 | 1 | 6 | 5 | ||
| 3 | Philadelphia Union | 10 | 5 | 3 | 2 | 12 | 7 | +5 | 18 | WXWW | 6 | 3 | 1 | 2 | 7 | 5 | 4 | 2 | 2 | 0 | 5 | 2 | ||
| 4 | 3 | New York City | 9 | 4 | 2 | 3 | 16 | 10 | +6 | 14 | WLWL | 5 | 2 | 1 | 2 | 10 | 6 | 4 | 2 | 1 | 1 | 6 | 4 | |
| 5 | 1 | Columbus Crew | 9 | 4 | 2 | 3 | 9 | 7 | +2 | 14 | LWWW | 4 | 3 | 1 | 0 | 7 | 2 | 5 | 1 | 1 | 3 | 2 | 5 | |
| 6 | 3 | Nashville | 9 | 3 | 5 | 1 | 12 | 10 | +2 | 14 | WLXW | 6 | 3 | 3 | 0 | 10 | 6 | 3 | 0 | 2 | 1 | 2 | 4 | |
| 7 | 1 | D.C. United | 10 | 4 | 1 | 5 | 9 | 11 | -2 | 13 | OWWL | 5 | 3 | 0 | 2 | 4 | 3 | 5 | 1 | 1 | 3 | 5 | 8 | |
| 8 | 3 | New York Red Bulls | 9 | 4 | 0 | 5 | 14 | 13 | +1 | 12 | LWWL | 5 | 4 | 0 | 1 | 9 | 3 | 4 | 0 | 0 | 4 | 5 | 10 | |
| 9 | 1 | CF Montréal | 9 | 3 | 3 | 3 | 10 | 9 | +1 | 12 | OWLL | 4 | 1 | 2 | 1 | 5 | 4 | 5 | 2 | 1 | 2 | 5 | 5 | |
| 10 | Atlanta United | 9 | 2 | 5 | 2 | 11 | 10 | +1 | 11 | LXXX | 4 | 2 | 2 | 0 | 8 | 5 | 5 | 0 | 3 | 2 | 3 | 5 | ||
| 11 | Inter Miami | 9 | 2 | 2 | 5 | 8 | 14 | -6 | 8 | LLLW | 4 | 0 | 1 | 3 | 3 | 9 | 5 | 2 | 1 | 2 | 5 | 5 | ||
| 12 | 2 | FC Cincinnati | 8 | 2 | 1 | 5 | 7 | 17 | -10 | 7 | WLLW | 3 | 0 | 0 | 3 | 2 | 6 | 5 | 2 | 1 | 2 | 5 | 11 | |
| 13 | 1 | Toronto FC | 9 | 1 | 2 | 6 | 12 | 18 | -6 | 5 | LLLL | 3 | 1 | 1 | 1 | 6 | 5 | 6 | 0 | 1 | 5 | 6 | 13 | |
| 14 | 1 | Chicago Fire | 9 | 1 | 1 | 7 | 4 | 14 | -10 | 4 | LLLW | 5 | 1 | 1 | 3 | 3 | 6 | 4 | 0 | 0 | 4 | 1 | 8 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 10 | 7 | 3 | 0 | 18 | 5 | +13 | 24 | WWOX | 6 | 4 | 2 | 0 | 12 | 2 | 4 | 3 | 1 | 0 | 6 | 3 | ||
| 2 | Sporting Kansas City | 11 | 6 | 2 | 3 | 20 | 14 | +6 | 20 | WLXW | 6 | 4 | 2 | 0 | 13 | 6 | 5 | 2 | 0 | 3 | 7 | 8 | ||
| 3 | 1 | LA Galaxy | 9 | 6 | 0 | 3 | 14 | 14 | +0 | 18 | WLWL | 5 | 4 | 0 | 1 | 9 | 5 | 4 | 2 | 0 | 2 | 5 | 9 | |
| 4 | 1 | Colorado Rapids | 9 | 5 | 1 | 3 | 15 | 11 | +4 | 16 | LWWL | 4 | 3 | 0 | 1 | 10 | 6 | 5 | 2 | 1 | 2 | 5 | 5 | |
| 5 | Portland Timbers | 9 | 4 | 1 | 4 | 13 | 14 | -1 | 13 | XWLW | 4 | 3 | 0 | 1 | 8 | 4 | 5 | 1 | 1 | 3 | 5 | 10 | ||
| 6 | 1 | Houston Dynamo | 10 | 3 | 4 | 3 | 14 | 15 | -1 | 13 | XXLW | 5 | 3 | 2 | 0 | 8 | 5 | 5 | 0 | 2 | 3 | 6 | 10 | |
| 7 | 1 | Real Salt Lake | 8 | 3 | 3 | 2 | 13 | 10 | +3 | 12 | LWXX | 5 | 2 | 2 | 1 | 8 | 5 | 3 | 1 | 1 | 1 | 5 | 5 | |
| 8 | 1 | Los Angeles | 9 | 3 | 3 | 3 | 11 | 10 | +1 | 12 | WXLW | 6 | 3 | 2 | 1 | 9 | 5 | 3 | 0 | 1 | 2 | 2 | 5 | |
| 9 | 2 | Minnesota United | 9 | 3 | 2 | 4 | 9 | 12 | -3 | 11 | WXXW | 5 | 3 | 0 | 2 | 5 | 3 | 4 | 0 | 2 | 2 | 4 | 9 | |
| 10 | 2 | San Jose Earthquakes | 10 | 3 | 1 | 6 | 11 | 17 | -6 | 10 | LOLL | 5 | 2 | 0 | 3 | 8 | 8 | 5 | 1 | 1 | 3 | 3 | 9 | |
| 11 | 1 | Austin FC | 10 | 2 | 3 | 5 | 6 | 11 | -5 | 9 | LOXO | 1 | 0 | 1 | 0 | 0 | 0 | 9 | 2 | 2 | 5 | 6 | 11 | |
| 12 | Vancouver Whitecaps | 9 | 2 | 1 | 6 | 8 | 14 | -6 | 7 | LLLL | 4 | 2 | 0 | 2 | 4 | 3 | 5 | 0 | 1 | 4 | 4 | 11 | ||
| 13 | FC Dallas | 9 | 1 | 4 | 4 | 9 | 14 | -5 | 7 | LXLX | 5 | 1 | 4 | 0 | 8 | 5 | 4 | 0 | 0 | 4 | 1 | 9 | ||
| 8 | +1 | Javier HERNÁNDEZ (LA Galaxy) |
| +1 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 6 | +2 | Dániel SALLÓI (Sporting Kansas City) |
| 5 | +1 | NANI (Orlando City) |
| Jesús MEDINA (New York City) | ||
| Damir KREILACH (Real Salt Lake) | ||
| Alan PULIDO (Sporting Kansas City) | ||
| Maximiliano URRUTI (Houston Dynamo) | ||
| 4 | Gonzalo HIGUAÍN (Inter Miami) | |
| Caden CLARK (New York Red Bulls) | ||
| Ola KAMARA (D.C. United) | ||
| Adam BUKSA (New England Revolution) | ||
| Rubio RUBIN (Real Salt Lake) | ||
| Valentín CASTELLANOS (New York City) | ||
| +1 | Ismaël TAJOURI-SHRADI (New York City) | |
| +1 | Gustavo BOU (New England Revolution) |
| Sunday, 20 June 2021 | |||||
| Atlanta United | 2-2 | Philadelphia Union | |||
| 58(og) | Przybyłko | 84 | Burke | ||
| 83 | Walkes | 90 | Glesnes | ||
| Tuesday, 22 June 2021 | |||||
| Orlando City | 5-0 | San Jose Earthquakes | |||
| 7(p) | Nani | ||||
| 16 | Michel | ||||
| 31 | Dike | ||||
| 49 | Dike | ||||
| 90 | Michel | ||||
| Wednesday, 23 June 2021 | |||||
| Houston Dynamo | 2-2 | Portland Timbers | |||
| 15 | Picault | 50 | Asprilla | ||
| 33 | Pasher | 90 | Ebobisse | ||
| New England Revolution | 3-2 | New York Red Bulls | |||
| 26 | Buchanan | 53 | Klimala | ||
| 32 | Jones | 75 | Reyes | ||
| 51 | Bou | ||||
| Sporting Kansas City | 3-1 | Colorado Rapids | |||
| 14 | Sallói | 84 | Rosenberry | ||
| 38 | Sallói | ||||
| 64 | Hernández | ||||
| Chicago Fire | 0-1 | FC Cincinnati | |||
| 50 | Barreal | ||||
| Vancouver Whitecaps | 1-2 | LA Galaxy | |||
| 90 | Bikel | 47 | Hernández | ||
| 90 | Álvarez | ||||
| CF Montréal | 0-0 | D.C. United | |||
| Seattle Sounders | 2-1 | Real Salt Lake | |||
| 58 | Roldan | 79(p) | Rusnák | ||
| 88(p) | Ruidíaz | ||||
| Philadelphia Union | 1-0 | Columbus Crew | |||
| 24 | Monteiro | ||||
| Minnesota United | 2-0 | Austin FC | |||
| 10 | Fragapane | ||||
| 18 | Hunou | ||||
| Los Angeles | 2-0 | FC Dallas | |||
| 4 | Vela | ||||
| 69 | Blessing | ||||
| Nashville | 3-2 | Toronto FC | |||
| 62 | Maher | 26 | Osorio | ||
| 83 | Haakenson | 81 | Mullins | ||
| 90 | Haakenson | ||||
| New York City | 1-0 | Atlanta United | |||
| 69 | Tajouri-Shradi | ||||
