Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 148 | 383 | 2.58 | 73 | 49.32% | 39 | 26.35% | 36 | 24.32% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 12 | 7 | 3 | 2 | 20 | 15 | +5 | 24 | XLWW | 5 | 5 | 0 | 0 | 10 | 4 | 7 | 2 | 3 | 2 | 10 | 11 | ||
| 2 | Orlando City | 11 | 6 | 3 | 2 | 19 | 9 | +10 | 21 | LWWW | 6 | 3 | 2 | 1 | 11 | 3 | 5 | 3 | 1 | 1 | 8 | 6 | ||
| 3 | Philadelphia Union | 12 | 5 | 4 | 3 | 15 | 11 | +4 | 19 | LXWX | 6 | 3 | 1 | 2 | 7 | 5 | 6 | 2 | 3 | 1 | 8 | 6 | ||
| 4 | Nashville | 11 | 4 | 6 | 1 | 14 | 11 | +3 | 18 | WXWL | 8 | 4 | 4 | 0 | 12 | 7 | 3 | 0 | 2 | 1 | 2 | 4 | ||
| 5 | New York City | 10 | 5 | 2 | 3 | 18 | 11 | +7 | 17 | WWLW | 6 | 3 | 1 | 2 | 12 | 7 | 4 | 2 | 1 | 1 | 6 | 4 | ||
| 6 | 1 | D.C. United | 12 | 5 | 1 | 6 | 17 | 14 | +3 | 16 | WLOW | 6 | 4 | 0 | 2 | 11 | 4 | 6 | 1 | 1 | 4 | 6 | 10 | |
| 7 | 2 | New York Red Bulls | 11 | 5 | 1 | 5 | 16 | 14 | +2 | 16 | WOLW | 5 | 4 | 0 | 1 | 9 | 3 | 6 | 1 | 1 | 4 | 7 | 11 | |
| 8 | CF Montréal | 11 | 4 | 4 | 3 | 12 | 10 | +2 | 16 | WXOW | 5 | 2 | 2 | 1 | 6 | 4 | 6 | 2 | 2 | 2 | 6 | 6 | ||
| 9 | 3 | Columbus Crew | 11 | 4 | 4 | 3 | 11 | 9 | +2 | 16 | XOLW | 5 | 3 | 2 | 0 | 9 | 4 | 6 | 1 | 2 | 3 | 2 | 5 | |
| 10 | Atlanta United | 11 | 2 | 6 | 3 | 11 | 13 | -2 | 12 | LOLX | 5 | 2 | 3 | 0 | 8 | 5 | 6 | 0 | 3 | 3 | 3 | 8 | ||
| 11 | FC Cincinnati | 10 | 3 | 2 | 5 | 10 | 18 | -8 | 11 | XWWL | 3 | 0 | 0 | 3 | 2 | 6 | 7 | 3 | 2 | 2 | 8 | 12 | ||
| 12 | 2 | Chicago Fire | 11 | 2 | 2 | 7 | 10 | 17 | -7 | 8 | WXLL | 7 | 2 | 2 | 3 | 9 | 9 | 4 | 0 | 0 | 4 | 1 | 8 | |
| 13 | 1 | Inter Miami | 11 | 2 | 2 | 7 | 9 | 17 | -8 | 8 | LLLL | 5 | 0 | 1 | 4 | 4 | 11 | 6 | 2 | 1 | 3 | 5 | 6 | |
| 14 | 1 | Toronto FC | 11 | 1 | 2 | 8 | 13 | 27 | -14 | 5 | LLLL | 4 | 1 | 1 | 2 | 6 | 7 | 7 | 0 | 1 | 6 | 7 | 20 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 11 | 7 | 4 | 0 | 20 | 7 | +13 | 25 | XWWO | 7 | 4 | 3 | 0 | 14 | 4 | 4 | 3 | 1 | 0 | 6 | 3 | ||
| 2 | Sporting Kansas City | 12 | 7 | 2 | 3 | 22 | 15 | +7 | 23 | WWLX | 7 | 5 | 2 | 0 | 15 | 7 | 5 | 2 | 0 | 3 | 7 | 8 | ||
| 3 | LA Galaxy | 10 | 7 | 0 | 3 | 17 | 15 | +2 | 21 | WWLW | 5 | 4 | 0 | 1 | 9 | 5 | 5 | 3 | 0 | 2 | 8 | 10 | ||
| 4 | Colorado Rapids | 9 | 5 | 1 | 3 | 15 | 11 | +4 | 16 | LWWL | 4 | 3 | 0 | 1 | 10 | 6 | 5 | 2 | 1 | 2 | 5 | 5 | ||
| 5 | 4 | Los Angeles | 11 | 4 | 3 | 4 | 13 | 12 | +1 | 15 | WLWX | 6 | 3 | 2 | 1 | 9 | 5 | 5 | 1 | 1 | 3 | 4 | 7 | |
| 6 | 1 | Minnesota United | 11 | 4 | 3 | 4 | 12 | 14 | -2 | 15 | XWWX | 6 | 3 | 1 | 2 | 7 | 5 | 5 | 1 | 2 | 2 | 5 | 9 | |
| 7 | 1 | Houston Dynamo | 12 | 3 | 6 | 3 | 16 | 17 | -1 | 15 | XXXX | 6 | 3 | 3 | 0 | 9 | 6 | 6 | 0 | 3 | 3 | 7 | 11 | |
| 8 | 1 | Portland Timbers | 11 | 4 | 1 | 6 | 14 | 19 | -5 | 13 | LLXW | 5 | 3 | 0 | 2 | 8 | 5 | 6 | 1 | 1 | 4 | 6 | 14 | |
| 9 | 1 | Real Salt Lake | 10 | 3 | 4 | 3 | 14 | 12 | +2 | 13 | LXLW | 7 | 2 | 3 | 2 | 9 | 7 | 3 | 1 | 1 | 1 | 5 | 5 | |
| 10 | 1 | Austin FC | 12 | 3 | 4 | 5 | 10 | 12 | -2 | 13 | WOLO | 3 | 1 | 2 | 0 | 4 | 1 | 9 | 2 | 2 | 5 | 6 | 11 | |
| 11 | 1 | San Jose Earthquakes | 12 | 3 | 2 | 7 | 14 | 22 | -8 | 11 | XLLO | 6 | 2 | 0 | 4 | 9 | 11 | 6 | 1 | 2 | 3 | 5 | 11 | |
| 12 | 1 | FC Dallas | 10 | 2 | 4 | 4 | 11 | 15 | -4 | 10 | WLXL | 6 | 2 | 4 | 0 | 10 | 6 | 4 | 0 | 0 | 4 | 1 | 9 | |
| 13 | 1 | Vancouver Whitecaps | 10 | 2 | 2 | 6 | 10 | 16 | -6 | 8 | XLLL | 4 | 2 | 0 | 2 | 4 | 3 | 6 | 0 | 2 | 4 | 6 | 13 | |
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| 9 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 7 | Dániel SALLÓI (Sporting Kansas City) | |
| 6 | NANI (Orlando City) | |
| Alan PULIDO (Sporting Kansas City) | ||
| Maximiliano URRUTI (Houston Dynamo) | ||
| +2 | Gustavo BOU (New England Revolution) | |
| 5 | Gonzalo HIGUAÍN (Inter Miami) | |
| Jesús MEDINA (New York City) | ||
| +1 | Ola KAMARA (D.C. United) | |
| Damir KREILACH (Real Salt Lake) | ||
| 4 | Caden CLARK (New York Red Bulls) | |
| Adam BUKSA (New England Revolution) | ||
| Cory BURKE (Philadelphia Union) | ||
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| Rubio RUBIN (Real Salt Lake) | ||
| +1 | Cade COWELL (San Jose Earthquakes) | |
| Valentín CASTELLANOS (New York City) | ||
| +2 | Ricardo PEPI (FC Dallas) | |
| +1 | Gyasi ZARDES (Columbus Crew) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| +1 | Cristian CÁSSERES (New York Red Bulls) |
| Sunday, 27 June 2021 | |||||
| FC Dallas | 2-1 | New England Revolution | |||
| 11 | Pepi | 33 | Bou | ||
| 54 | Pepi | ||||
| Austin FC | 0-0 | Columbus Crew | |||
| New York City | 2-1 | D.C. United | |||
| 84 | Parks | 9 | Robertha | ||
| 90 | Thiago Andrade | ||||
| Atlanta United | 0-0 | New York Red Bulls | |||
| Thursday, 1 July 2021 | |||||
| Austin FC | 4-1 | Portland Timbers | |||
| 28 | Gallagher | 45 | Ebobisse | ||
| 33 | Fagúndez | ||||
| 77 | Ring | ||||
| 81 | Jimenez | ||||
| Saturday, 3 July 2021 | |||||
| D.C. United | 7-1 | Toronto FC | |||
| 2 | Paredes | 39 | Akinola | ||
| 8 | Robertha | ||||
| 21(og) | Priso-Mbongue | ||||
| 71 | Arriola | ||||
| 81 | Kamara | ||||
| 85 | Asad | ||||
| 90 | Yow | ||||
| Houston Dynamo | 1-1 | FC Cincinnati | |||
| 3 | Pasher | 5 | Barreal | ||
| Columbus Crew | 2-2 | New England Revolution | |||
| 39 | Zardes | 13 | Buchanan | ||
| 69(og) | Farrell | 30 | Bou | ||
| Chicago Fire | 3-0 | Atlanta United | |||
| 34 | Aliseda | ||||
| 45 | Aliseda | ||||
| 58 | Frankowski | ||||
| CF Montréal | 1-0 | Inter Miami | |||
| 41 | Choinière | ||||
| Real Salt Lake | 0-1 | Los Angeles | |||
| 69 | Cifuentes | ||||
| Orlando City | 1-2 | New York Red Bulls | |||
| 59 | Mueller | 6 | Cásseres | ||
| 79 | Fábio | ||||
| Minnesota United | 2-2 | San Jose Earthquakes | |||
| 45 | Kallman | 15 | Cowell | ||
| 69 | Ábila | 82 | Kikanovic | ||
| Nashville | 1-0 | Philadelphia Union | |||
| 2 | Sapong | ||||
