Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 321 | 873 | 2.71 | 152 | 47.35% | 90 | 28.04% | 79 | 24.61% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 25 | 17 | 4 | 4 | 47 | 29 | +18 | 55 | WWLW | 12 | 10 | 1 | 1 | 25 | 13 | 13 | 7 | 3 | 3 | 22 | 16 | ||
| 2 | Nashville | 23 | 10 | 11 | 2 | 38 | 21 | +17 | 41 | WWWX | 14 | 8 | 6 | 0 | 31 | 14 | 9 | 2 | 5 | 2 | 7 | 7 | ||
| 3 | Orlando City | 24 | 10 | 8 | 6 | 35 | 33 | +2 | 38 | LLWO | 13 | 7 | 4 | 2 | 23 | 13 | 11 | 3 | 4 | 4 | 12 | 20 | ||
| 4 | New York City | 23 | 10 | 5 | 8 | 41 | 27 | +14 | 35 | XLLW | 12 | 8 | 2 | 2 | 29 | 11 | 11 | 2 | 3 | 6 | 12 | 16 | ||
| 5 | 1 | D.C. United | 24 | 10 | 4 | 10 | 39 | 33 | +6 | 34 | WXWL | 11 | 8 | 0 | 3 | 21 | 8 | 13 | 2 | 4 | 7 | 18 | 25 | |
| 6 | 1 | CF Montréal | 24 | 9 | 7 | 8 | 34 | 30 | +4 | 34 | WLWX | 11 | 6 | 3 | 2 | 20 | 14 | 13 | 3 | 4 | 6 | 14 | 16 | |
| 7 | 1 | Atlanta United | 24 | 8 | 9 | 7 | 32 | 28 | +4 | 33 | WWLW | 12 | 6 | 3 | 3 | 17 | 9 | 12 | 2 | 6 | 4 | 15 | 19 | |
| 8 | 1 | Inter Miami | 23 | 9 | 5 | 9 | 24 | 31 | -7 | 32 | WWWO | 12 | 5 | 2 | 5 | 16 | 22 | 11 | 4 | 3 | 4 | 8 | 9 | |
| 9 | 4 | Philadelphia Union | 23 | 8 | 8 | 7 | 28 | 24 | +4 | 32 | LLXW | 12 | 6 | 3 | 3 | 15 | 9 | 11 | 2 | 5 | 4 | 13 | 15 | |
| 10 | Columbus Crew | 25 | 8 | 6 | 11 | 29 | 34 | -5 | 30 | WLLW | 12 | 6 | 3 | 3 | 21 | 17 | 13 | 2 | 3 | 8 | 8 | 17 | ||
| 11 | New York Red Bulls | 22 | 6 | 5 | 11 | 25 | 28 | -3 | 23 | LXLW | 11 | 5 | 3 | 3 | 14 | 9 | 11 | 1 | 2 | 8 | 11 | 19 | ||
| 12 | Chicago Fire | 24 | 6 | 5 | 13 | 24 | 38 | -14 | 23 | LLWL | 13 | 5 | 4 | 4 | 18 | 15 | 11 | 1 | 1 | 9 | 6 | 23 | ||
| 13 | FC Cincinnati | 23 | 4 | 8 | 11 | 23 | 42 | -19 | 20 | LWLL | 10 | 1 | 5 | 4 | 8 | 11 | 13 | 3 | 3 | 7 | 15 | 31 | ||
| 14 | Toronto FC | 24 | 3 | 6 | 15 | 26 | 50 | -24 | 15 | LLLL | 10 | 1 | 5 | 4 | 12 | 15 | 14 | 2 | 1 | 11 | 14 | 35 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Sporting Kansas City | 25 | 13 | 7 | 5 | 43 | 26 | +17 | 46 | WWLX | 13 | 7 | 5 | 1 | 25 | 12 | 12 | 6 | 2 | 4 | 18 | 14 | |
| 2 | 1 | Seattle Sounders | 23 | 13 | 6 | 4 | 36 | 19 | +17 | 45 | WLWW | 13 | 6 | 4 | 3 | 19 | 11 | 10 | 7 | 2 | 1 | 17 | 8 | |
| 3 | Colorado Rapids | 23 | 12 | 7 | 4 | 34 | 23 | +11 | 43 | XXWX | 11 | 6 | 4 | 1 | 19 | 10 | 12 | 6 | 3 | 3 | 15 | 13 | ||
| 4 | LA Galaxy | 24 | 11 | 5 | 8 | 37 | 37 | +0 | 38 | XXXL | 13 | 7 | 2 | 4 | 21 | 15 | 11 | 4 | 3 | 4 | 16 | 22 | ||
| 5 | Portland Timbers | 24 | 10 | 4 | 10 | 34 | 41 | -7 | 34 | XWWW | 11 | 6 | 2 | 3 | 19 | 17 | 13 | 4 | 2 | 7 | 15 | 24 | ||
| 6 | 1 | Real Salt Lake | 24 | 9 | 6 | 9 | 40 | 35 | +5 | 33 | WLWL | 12 | 6 | 4 | 2 | 20 | 12 | 12 | 3 | 2 | 7 | 20 | 23 | |
| 7 | 2 | Los Angeles | 24 | 9 | 6 | 9 | 37 | 34 | +3 | 33 | WWWX | 13 | 6 | 5 | 2 | 26 | 19 | 11 | 3 | 1 | 7 | 11 | 15 | |
| 8 | 2 | Minnesota United | 23 | 8 | 7 | 8 | 24 | 29 | -5 | 31 | LLWO | 11 | 6 | 2 | 3 | 12 | 7 | 12 | 2 | 5 | 5 | 12 | 22 | |
| 9 | 1 | Vancouver Whitecaps | 23 | 7 | 8 | 8 | 29 | 33 | -4 | 29 | LWWW | 12 | 6 | 2 | 4 | 16 | 14 | 11 | 1 | 6 | 4 | 13 | 19 | |
| 10 | 1 | FC Dallas | 25 | 6 | 9 | 10 | 36 | 40 | -4 | 27 | XXLW | 12 | 4 | 6 | 2 | 19 | 12 | 13 | 2 | 3 | 8 | 17 | 28 | |
| 11 | 1 | San Jose Earthquakes | 24 | 6 | 9 | 9 | 28 | 35 | -7 | 27 | LXLW | 12 | 3 | 3 | 6 | 16 | 19 | 12 | 3 | 6 | 3 | 12 | 16 | |
| 12 | Houston Dynamo | 25 | 4 | 11 | 10 | 28 | 37 | -9 | 23 | XWLL | 12 | 4 | 5 | 3 | 16 | 15 | 13 | 0 | 6 | 7 | 12 | 22 | ||
| 13 | Austin FC | 24 | 5 | 4 | 15 | 22 | 36 | -14 | 19 | LLLL | 11 | 3 | 2 | 6 | 15 | 17 | 13 | 2 | 2 | 9 | 7 | 19 | ||
| 16 | +3 | Ola KAMARA (D.C. United) |
| 14 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 13 | +1 | Dániel SALLÓI (Sporting Kansas City) |
| 12 | Ricardo PEPI (FC Dallas) | |
| Gustavo BOU (New England Revolution) | ||
| 11 | +1 | Javier HERNÁNDEZ (LA Galaxy) |
| Valentín CASTELLANOS (New York City) | ||
| 10 | +1 | Felipe MORA (Portland Timbers) |
| Adam BUKSA (New England Revolution) | ||
| Hany MUKHTAR (Nashville) | ||
| 9 | Gonzalo HIGUAÍN (Inter Miami) | |
| +1 | Damir KREILACH (Real Salt Lake) | |
| C.J. SAPONG (Nashville) | ||
| NANI (Orlando City) | ||
| +1 | Fabrice PICAULT (Houston Dynamo) | |
| 8 | +2 | Josef MARTÍNEZ (Atlanta United) |
| +1 | Jesús MEDINA (New York City) | |
| +3 | Javier LÓPEZ (San Jose Earthquakes) | |
| Alan PULIDO (Sporting Kansas City) | ||
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| 7 | +1 | Michael BARRIOS (Colorado Rapids) |
| +2 | Rubio RUBIN (Real Salt Lake) | |
| Luka STOJANOVIĆ (Chicago Fire) | ||
| Tajon BUCHANAN (New England Revolution) | ||
| +1 | Albert RUSNÁK (Real Salt Lake) | |
| Marcelino MORENO (Atlanta United) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Mason TOYE (CF Montréal) |
| Sunday, 12 September 2021 | |||||
| Los Angeles | 3-2 | Real Salt Lake | |||
| 1 | Arango | 28 | Kreilach | ||
| 30 | Arango | 48 | Julio | ||
| 59(og) | Datković | ||||
| Tuesday, 14 September 2021 | |||||
| Columbus Crew | 2-1 | New York Red Bulls | |||
| 74 | Nagbe | 25 | Klimala | ||
| 88 | Berry | ||||
| Toronto FC | 0-1 | Inter Miami | |||
| 90(p) | Makoun | ||||
| New York City | 3-3 | FC Dallas | |||
| 20 | Moralez | 4 | Obrian | ||
| 57 | Medina | 63 | Ferreira | ||
| 68 | Talles Magno | 73 | Obrian | ||
| Wednesday, 15 September 2021 | |||||
| D.C. United | 3-0 | Chicago Fire | |||
| 9(p) | Kamara | ||||
| 35(p) | Kamara | ||||
| 44 | Kamara | ||||
| Sporting Kansas City | 4-0 | Minnesota United | |||
| 14 | Shelton | ||||
| 36 | Sallói | ||||
| 45(p) | Russell | ||||
| 52 | Duke | ||||
| LA Galaxy | 1-1 | Houston Dynamo | |||
| 61 | Hernández | 13 | Picault | ||
| Portland Timbers | 2-2 | Colorado Rapids | |||
| 67 | Mora | 64 | Lewis | ||
| 90 | Blanco | 87 | Barrios | ||
| San Jose Earthquakes | 3-4 | Real Salt Lake | |||
| 26 | López | 45 | Rubin | ||
| 50 | López | 49 | Rusnák | ||
| 65 | López | 71 | Meram | ||
| 81 | Rubin | ||||
| Orlando City | 2-4 | CF Montréal | |||
| 40 | Jansson | 18 | Choinière | ||
| 63 | Ruan | 37 | Quioto | ||
| 73 | Lappalainen | ||||
| 80 | Ibrahim | ||||
| Austin FC | 1-2 | Los Angeles | |||
| 67 | Fagúndez | 59(p) | Arango | ||
| 81 | Musovski | ||||
| Atlanta United | 4-0 | FC Cincinnati | |||
| 5 | Luiz Araújo | ||||
| 40 | Martínez | ||||
| 55 | Martínez | ||||
| 86 | Barco | ||||
