Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 285 | 761 | 2.67 | 134 | 47.02% | 84 | 29.47% | 67 | 23.51% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 23 | 15 | 4 | 4 | 44 | 28 | +16 | 49 | LWWW | 11 | 9 | 1 | 1 | 23 | 12 | 12 | 6 | 3 | 3 | 21 | 16 | ||
| 2 | Orlando City | 21 | 9 | 8 | 4 | 30 | 24 | +6 | 35 | OWXX | 11 | 6 | 4 | 1 | 18 | 7 | 10 | 3 | 4 | 3 | 12 | 17 | ||
| 3 | 1 | Nashville | 21 | 8 | 11 | 2 | 34 | 20 | +14 | 35 | WXWL | 13 | 7 | 6 | 0 | 28 | 13 | 8 | 1 | 5 | 2 | 6 | 7 | |
| 4 | 1 | New York City | 20 | 10 | 4 | 6 | 36 | 19 | +17 | 34 | WLWX | 11 | 8 | 1 | 2 | 26 | 8 | 9 | 2 | 3 | 4 | 10 | 11 | |
| 5 | 2 | Philadelphia Union | 22 | 8 | 8 | 6 | 28 | 23 | +5 | 32 | LXWL | 11 | 6 | 3 | 2 | 15 | 8 | 11 | 2 | 5 | 4 | 13 | 15 | |
| 6 | CF Montréal | 22 | 8 | 7 | 7 | 30 | 27 | +3 | 31 | WXOW | 10 | 6 | 3 | 1 | 20 | 13 | 12 | 2 | 4 | 6 | 10 | 14 | ||
| 7 | D.C. United | 22 | 9 | 3 | 10 | 35 | 32 | +3 | 30 | WLLL | 10 | 7 | 0 | 3 | 18 | 8 | 12 | 2 | 3 | 7 | 17 | 24 | ||
| 8 | 1 | Columbus Crew | 22 | 7 | 6 | 9 | 25 | 29 | -4 | 27 | WLLL | 11 | 5 | 3 | 3 | 19 | 16 | 11 | 2 | 3 | 6 | 6 | 13 | |
| 9 | 1 | Atlanta United | 22 | 6 | 9 | 7 | 25 | 28 | -3 | 27 | LWWW | 10 | 4 | 3 | 3 | 10 | 9 | 12 | 2 | 6 | 4 | 15 | 19 | |
| 10 | 2 | Chicago Fire | 22 | 6 | 5 | 11 | 24 | 33 | -9 | 23 | WLLW | 13 | 5 | 4 | 4 | 18 | 15 | 9 | 1 | 1 | 7 | 6 | 18 | |
| 11 | Inter Miami | 20 | 6 | 5 | 9 | 21 | 31 | -10 | 23 | OWWL | 11 | 4 | 2 | 5 | 15 | 22 | 9 | 2 | 3 | 4 | 6 | 9 | ||
| 12 | 2 | New York Red Bulls | 20 | 6 | 4 | 10 | 23 | 25 | -2 | 22 | LWLL | 10 | 5 | 2 | 3 | 13 | 8 | 10 | 1 | 2 | 7 | 10 | 17 | |
| 13 | FC Cincinnati | 20 | 3 | 8 | 9 | 21 | 37 | -16 | 17 | LLOX | 8 | 0 | 5 | 3 | 6 | 10 | 12 | 3 | 3 | 6 | 15 | 27 | ||
| 14 | Toronto FC | 22 | 3 | 6 | 13 | 26 | 47 | -21 | 15 | LLLL | 9 | 1 | 5 | 3 | 12 | 14 | 13 | 2 | 1 | 10 | 14 | 33 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 21 | 12 | 6 | 3 | 35 | 17 | +18 | 42 | WWWX | 11 | 5 | 4 | 2 | 18 | 9 | 10 | 7 | 2 | 1 | 17 | 8 | ||
| 2 | Sporting Kansas City | 22 | 11 | 7 | 4 | 37 | 22 | +15 | 40 | XOXW | 11 | 5 | 5 | 1 | 19 | 12 | 11 | 6 | 2 | 3 | 18 | 10 | ||
| 3 | Colorado Rapids | 20 | 11 | 5 | 4 | 30 | 20 | +10 | 38 | XWWW | 10 | 6 | 3 | 1 | 18 | 9 | 10 | 5 | 2 | 3 | 12 | 11 | ||
| 4 | LA Galaxy | 22 | 11 | 3 | 8 | 35 | 35 | +0 | 36 | XLLW | 12 | 7 | 1 | 4 | 20 | 14 | 10 | 4 | 2 | 4 | 15 | 21 | ||
| 5 | Minnesota United | 21 | 8 | 7 | 6 | 24 | 24 | +0 | 31 | WOXL | 11 | 6 | 2 | 3 | 12 | 7 | 10 | 2 | 5 | 3 | 12 | 17 | ||
| 6 | Real Salt Lake | 20 | 7 | 6 | 7 | 30 | 23 | +7 | 27 | LWWL | 11 | 5 | 4 | 2 | 17 | 10 | 9 | 2 | 2 | 5 | 13 | 13 | ||
| 7 | San Jose Earthquakes | 21 | 6 | 8 | 7 | 24 | 29 | -5 | 26 | WXOW | 10 | 3 | 3 | 4 | 13 | 14 | 11 | 3 | 5 | 3 | 11 | 15 | ||
| 8 | Portland Timbers | 20 | 7 | 3 | 10 | 27 | 39 | -12 | 24 | LXLW | 10 | 6 | 1 | 3 | 17 | 15 | 10 | 1 | 2 | 7 | 10 | 24 | ||
| 9 | Los Angeles | 21 | 6 | 6 | 9 | 28 | 31 | -3 | 24 | XLLL | 11 | 4 | 5 | 2 | 19 | 17 | 10 | 2 | 1 | 7 | 9 | 14 | ||
| 10 | Vancouver Whitecaps | 20 | 5 | 8 | 7 | 23 | 30 | -7 | 23 | WWOX | 9 | 4 | 2 | 3 | 10 | 11 | 11 | 1 | 6 | 4 | 13 | 19 | ||
| 11 | FC Dallas | 21 | 5 | 7 | 9 | 25 | 30 | -5 | 22 | XLLW | 11 | 4 | 5 | 2 | 18 | 11 | 10 | 1 | 2 | 7 | 7 | 19 | ||
| 12 | Austin FC | 20 | 5 | 4 | 11 | 17 | 24 | -7 | 19 | WLLL | 9 | 3 | 2 | 4 | 11 | 10 | 11 | 2 | 2 | 7 | 6 | 14 | ||
| 13 | Houston Dynamo | 22 | 3 | 10 | 9 | 24 | 34 | -10 | 19 | LXLL | 10 | 3 | 5 | 2 | 13 | 13 | 12 | 0 | 5 | 7 | 11 | 21 | ||
| 14 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 12 | Gustavo BOU (New England Revolution) | |
| Dániel SALLÓI (Sporting Kansas City) | ||
| +1 | Ola KAMARA (D.C. United) | |
| 10 | Adam BUKSA (New England Revolution) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| +2 | Valentín CASTELLANOS (New York City) | |
| 9 | C.J. SAPONG (Nashville) | |
| Ricardo PEPI (FC Dallas) | ||
| NANI (Orlando City) | ||
| 8 | Gonzalo HIGUAÍN (Inter Miami) | |
| Damir KREILACH (Real Salt Lake) | ||
| Alan PULIDO (Sporting Kansas City) | ||
| Hany MUKHTAR (Nashville) | ||
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| 7 | Jesús MEDINA (New York City) | |
| Felipe MORA (Portland Timbers) | ||
| Luka STOJANOVIĆ (Chicago Fire) | ||
| Marcelino MORENO (Atlanta United) | ||
| +1 | Lucas ZELARAYÁN (Columbus Crew) | |
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Mason TOYE (CF Montréal) | ||
| 6 | Josef MARTÍNEZ (Atlanta United) | |
| Robin LOD (Minnesota United) | ||
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| Fredy MONTERO (Seattle Sounders) | ||
| Diego ROSSI (Los Angeles) | ||
| Tajon BUCHANAN (New England Revolution) | ||
| Fabrice PICAULT (Houston Dynamo) | ||
| Maximiliano URRUTI (Houston Dynamo) |
| Friday, 27 August 2021 | |||||
| Columbus Crew | 3-2 | FC Cincinnati | |||
| 45 | Zelarayán | 45 | Matarrita | ||
| 81 | Berry | 74 | Atanga | ||
| 82 | Berry | ||||
| CF Montréal | 3-1 | Toronto FC | |||
| 23 | Piette | 58 | Achara | ||
| 68 | Torres | ||||
| 75 | Quioto | ||||
| Orlando City | 0-0 | Inter Miami | |||
| Saturday, 28 August 2021 | |||||
| D.C. United | 3-1 | Philadelphia Union | |||
| 36(p) | Kamara | 22(og) | Birnbaum | ||
| 49 | Reyna | ||||
| 90 | Ábila | ||||
| Houston Dynamo | 1-2 | Minnesota United | |||
| 1 | Carrasquilla | 16 | Hunou | ||
| 73 | Hunou | ||||
| New York Red Bulls | 0-1 | Chicago Fire | |||
| 32 | Berić | ||||
| Sporting Kansas City | 1-1 | Colorado Rapids | |||
| 41 | Russell | 17 | Lewis | ||
| Los Angeles | 3-3 | LA Galaxy | |||
| 44(p) | Arango | 20 | Joveljić | ||
| 58 | Rodríguez | 64 | Joveljić | ||
| 66 | Rodríguez | 86 | Cabral | ||
| New York City | 2-0 | New England Revolution | |||
| 31 | Castellanos | ||||
| 55 | Castellanos | ||||
| Atlanta United | 0-2 | Nashville | |||
| 45 | Rios | ||||
| 90 | Leal | ||||
