Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 418 | 1,164 | 2.78 | 202 | 48.33% | 113 | 27.03% | 103 | 24.64% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 32 | 21 | 7 | 4 | 64 | 40 | +24 | 70 | XWXW | 15 | 11 | 3 | 1 | 30 | 17 | 17 | 10 | 4 | 3 | 34 | 23 | ||
| 2 | 1 | Philadelphia Union | 31 | 13 | 10 | 8 | 43 | 32 | +11 | 49 | WLXW | 16 | 10 | 3 | 3 | 23 | 10 | 15 | 3 | 7 | 5 | 20 | 22 | |
| 3 | 1 | Nashville | 31 | 11 | 16 | 4 | 47 | 28 | +19 | 49 | LXOO | 16 | 8 | 8 | 0 | 34 | 17 | 15 | 3 | 8 | 4 | 13 | 11 | |
| 4 | Orlando City | 31 | 12 | 11 | 8 | 45 | 44 | +1 | 47 | XXWW | 16 | 8 | 6 | 2 | 28 | 17 | 15 | 4 | 5 | 6 | 17 | 27 | ||
| 5 | 3 | New York City | 31 | 12 | 8 | 11 | 51 | 34 | +17 | 44 | WXLO | 15 | 9 | 3 | 3 | 35 | 12 | 16 | 3 | 5 | 8 | 16 | 22 | |
| 6 | 3 | New York Red Bulls | 30 | 12 | 7 | 11 | 37 | 31 | +6 | 43 | WWWW | 15 | 7 | 5 | 3 | 18 | 11 | 15 | 5 | 2 | 8 | 19 | 20 | |
| 7 | 2 | Atlanta United | 30 | 11 | 10 | 9 | 40 | 34 | +6 | 43 | XWLW | 15 | 8 | 4 | 3 | 22 | 12 | 15 | 3 | 6 | 6 | 18 | 22 | |
| 8 | 2 | CF Montréal | 31 | 11 | 10 | 10 | 44 | 41 | +3 | 43 | XXXW | 15 | 8 | 4 | 3 | 27 | 21 | 16 | 3 | 6 | 7 | 17 | 20 | |
| 9 | 2 | D.C. United | 31 | 12 | 5 | 14 | 51 | 50 | +1 | 41 | LLOL | 15 | 10 | 1 | 4 | 30 | 14 | 16 | 2 | 4 | 10 | 21 | 36 | |
| 10 | 1 | Inter Miami | 31 | 11 | 5 | 15 | 33 | 48 | -15 | 38 | WWLL | 16 | 7 | 2 | 7 | 25 | 32 | 15 | 4 | 3 | 8 | 8 | 16 | |
| 11 | 1 | Columbus Crew | 31 | 10 | 8 | 13 | 38 | 42 | -4 | 38 | LXWL | 15 | 8 | 3 | 4 | 28 | 20 | 16 | 2 | 5 | 9 | 10 | 22 | |
| 12 | Chicago Fire | 32 | 9 | 7 | 16 | 36 | 51 | -15 | 34 | WWXL | 17 | 7 | 5 | 5 | 23 | 18 | 15 | 2 | 2 | 11 | 13 | 33 | ||
| 13 | Toronto FC | 31 | 6 | 8 | 17 | 35 | 60 | -25 | 26 | XLLW | 15 | 4 | 6 | 5 | 21 | 22 | 16 | 2 | 2 | 12 | 14 | 38 | ||
| 14 | FC Cincinnati | 31 | 4 | 8 | 19 | 33 | 64 | -31 | 20 | LLLL | 15 | 1 | 5 | 9 | 13 | 21 | 16 | 3 | 3 | 10 | 20 | 43 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 31 | 17 | 7 | 7 | 51 | 28 | +23 | 58 | LXLW | 16 | 8 | 4 | 4 | 27 | 14 | 15 | 9 | 3 | 3 | 24 | 14 | ||
| 2 | Sporting Kansas City | 30 | 16 | 7 | 7 | 54 | 34 | +20 | 55 | WLWW | 15 | 8 | 5 | 2 | 30 | 16 | 15 | 8 | 2 | 5 | 24 | 18 | ||
| 3 | Colorado Rapids | 31 | 15 | 10 | 6 | 45 | 32 | +13 | 55 | WXLW | 16 | 8 | 7 | 1 | 26 | 12 | 15 | 7 | 3 | 5 | 19 | 20 | ||
| 4 | Portland Timbers | 31 | 14 | 4 | 13 | 48 | 51 | -3 | 46 | LLLW | 15 | 9 | 2 | 4 | 30 | 22 | 16 | 5 | 2 | 9 | 18 | 29 | ||
| 5 | LA Galaxy | 31 | 13 | 7 | 11 | 46 | 48 | -2 | 46 | XWWX | 16 | 8 | 4 | 4 | 26 | 19 | 15 | 5 | 3 | 7 | 20 | 29 | ||
| 6 | Minnesota United | 31 | 12 | 9 | 10 | 36 | 38 | -2 | 45 | XWWL | 16 | 9 | 3 | 4 | 22 | 13 | 15 | 3 | 6 | 6 | 14 | 25 | ||
| 7 | Vancouver Whitecaps | 31 | 11 | 11 | 9 | 41 | 42 | -1 | 44 | XWWL | 15 | 9 | 2 | 4 | 22 | 15 | 16 | 2 | 9 | 5 | 19 | 27 | ||
| 8 | Real Salt Lake | 30 | 12 | 6 | 12 | 48 | 46 | +2 | 42 | LWLW | 15 | 9 | 4 | 2 | 26 | 14 | 15 | 3 | 2 | 10 | 22 | 32 | ||
| 9 | Los Angeles | 31 | 11 | 8 | 12 | 47 | 45 | +2 | 41 | XWWX | 15 | 7 | 5 | 3 | 30 | 22 | 16 | 4 | 3 | 9 | 17 | 23 | ||
| 10 | San Jose Earthquakes | 31 | 9 | 10 | 12 | 41 | 48 | -7 | 37 | XWLL | 16 | 5 | 4 | 7 | 24 | 23 | 15 | 4 | 6 | 5 | 17 | 25 | ||
| 11 | Houston Dynamo | 32 | 6 | 12 | 14 | 36 | 51 | -15 | 30 | LLWL | 16 | 6 | 6 | 4 | 21 | 21 | 16 | 0 | 6 | 10 | 15 | 30 | ||
| 12 | FC Dallas | 31 | 6 | 11 | 14 | 43 | 52 | -9 | 29 | XLOL | 15 | 4 | 7 | 4 | 22 | 18 | 16 | 2 | 4 | 10 | 21 | 34 | ||
| 13 | Austin FC | 31 | 8 | 4 | 19 | 31 | 50 | -19 | 28 | WLLW | 16 | 6 | 2 | 8 | 24 | 24 | 15 | 2 | 2 | 11 | 7 | 26 | ||
| 17 | Ola KAMARA (D.C. United) | |
| 16 | Dániel SALLÓI (Sporting Kansas City) | |
| +2 | Adam BUKSA (New England Revolution) | |
| Raúl RUIDÍAZ (Seattle Sounders) | ||
| 15 | Gustavo BOU (New England Revolution) | |
| +2 | Valentín CASTELLANOS (New York City) | |
| 14 | Damir KREILACH (Real Salt Lake) | |
| Hany MUKHTAR (Nashville) | ||
| +1 | Javier HERNÁNDEZ (LA Galaxy) | |
| 13 | Ricardo PEPI (FC Dallas) | |
| 12 | Javier LÓPEZ (San Jose Earthquakes) | |
| +1 | Johnny RUSSELL (Sporting Kansas City) | |
| +1 | Cristian ARANGO (Los Angeles) | |
| 11 | +1 | Gonzalo HIGUAÍN (Inter Miami) |
| Felipe MORA (Portland Timbers) | ||
| +1 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| Fabrice PICAULT (Houston Dynamo) | ||
| Brian WHITE (Vancouver Whitecaps) | ||
| 10 | Josef MARTÍNEZ (Atlanta United) | |
| C.J. SAPONG (Nashville) | ||
| +1 | NANI (Orlando City) | |
| 9 | Dairon ASPRILLA (Portland Timbers) | |
| +1 | Jesús MEDINA (New York City) | |
| Gyasi ZARDES (Columbus Crew) | ||
| Marcelino MORENO (Atlanta United) | ||
| Cristian DÁJOME (Vancouver Whitecaps) |
| Saturday, 23 October 2021 | |||||
| Colorado Rapids | 2-0 | Portland Timbers | |||
| 45 | Badji | ||||
| 63 | Rubio | ||||
| Columbus Crew | 1-2 | New York Red Bulls | |||
| 18 | Berry | 7 | Cásseres | ||
| 87 | Nealis | ||||
| LA Galaxy | 2-2 | FC Dallas | |||
| 65(p) | Hernández | 30 | Ferreira | ||
| 83 | Lletget | 41 | Jara | ||
| Chicago Fire | 1-0 | Real Salt Lake | |||
| 45 | Berić | ||||
| Seattle Sounders | 1-2 | Sporting Kansas City | |||
| 58 | Benezet | 4 | Walter | ||
| 79 | Russell | ||||
| Toronto FC | 1-1 | CF Montréal | |||
| 90 | Altidore | 55 | Ibrahim | ||
| San Jose Earthquakes | 1-1 | Vancouver Whitecaps | |||
| 60 | Kikanovic | 53 | Bruno Gaspar | ||
| Philadelphia Union | 1-0 | Nashville | |||
| 18(p) | Przybyłko | ||||
| Minnesota United | 1-1 | Los Angeles | |||
| 65 | Alonso | 32 | Arango | ||
| New York City | 6-0 | D.C. United | |||
| 1 | Thiago Andrade | ||||
| 7 | Castellanos | ||||
| 11 | Castellanos | ||||
| 44 | Moralez | ||||
| 52 | Callens | ||||
| 74 | Medina | ||||
| Inter Miami | 5-1 | FC Cincinnati | |||
| 6 | Higuaín | 21 | Vázquez | ||
| 53 | Higuaín | ||||
| 69 | Vassilev | ||||
| 74 | Morgan | ||||
| 85 | Carranza | ||||
| Sunday, 24 October 2021 | |||||
| Orlando City | 2-2 | New England Revolution | |||
| 39 | Nani | 81 | Buksa | ||
| 50(p) | Dike | 90 | Buksa | ||
| Austin FC | 2-1 | Houston Dynamo | |||
| 7(og) | Marić | 90(og) | Cascante | ||
| 45 | Driussi | ||||
