Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 391 | 1,076 | 2.75 | 191 | 48.85% | 104 | 26.60% | 96 | 24.55% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 30 | 20 | 6 | 4 | 59 | 36 | +23 | 66 | XWWW | 15 | 11 | 3 | 1 | 30 | 17 | 15 | 9 | 3 | 3 | 29 | 19 | ||
| 2 | Nashville | 29 | 11 | 15 | 3 | 46 | 26 | +20 | 48 | OOXO | 15 | 8 | 7 | 0 | 33 | 16 | 14 | 3 | 8 | 3 | 13 | 10 | ||
| 3 | Philadelphia Union | 29 | 12 | 10 | 7 | 40 | 29 | +11 | 46 | XWWX | 15 | 9 | 3 | 3 | 22 | 10 | 14 | 3 | 7 | 4 | 18 | 19 | ||
| 4 | Orlando City | 29 | 12 | 9 | 8 | 42 | 41 | +1 | 45 | WWXL | 14 | 8 | 4 | 2 | 25 | 14 | 15 | 4 | 5 | 6 | 17 | 27 | ||
| 5 | 3 | Atlanta United | 29 | 11 | 9 | 9 | 39 | 33 | +6 | 42 | WLWL | 14 | 8 | 3 | 3 | 21 | 11 | 15 | 3 | 6 | 6 | 18 | 22 | |
| 6 | 1 | D.C. United | 29 | 12 | 5 | 12 | 49 | 41 | +8 | 41 | OLWW | 14 | 10 | 1 | 3 | 28 | 11 | 15 | 2 | 4 | 9 | 21 | 30 | |
| 7 | CF Montréal | 29 | 11 | 8 | 10 | 42 | 39 | +3 | 41 | XWLL | 15 | 8 | 4 | 3 | 27 | 21 | 14 | 3 | 4 | 7 | 15 | 18 | ||
| 8 | 2 | New York City | 28 | 11 | 7 | 10 | 44 | 32 | +12 | 40 | OLLX | 14 | 8 | 3 | 3 | 29 | 12 | 14 | 3 | 4 | 7 | 15 | 20 | |
| 9 | New York Red Bulls | 28 | 10 | 7 | 11 | 34 | 30 | +4 | 37 | WWXW | 14 | 6 | 5 | 3 | 17 | 11 | 14 | 4 | 2 | 8 | 17 | 19 | ||
| 10 | Columbus Crew | 29 | 10 | 7 | 12 | 36 | 39 | -3 | 37 | WLWX | 14 | 8 | 3 | 3 | 27 | 18 | 15 | 2 | 4 | 9 | 9 | 21 | ||
| 11 | Inter Miami | 29 | 9 | 5 | 15 | 25 | 47 | -22 | 32 | LLLL | 14 | 5 | 2 | 7 | 17 | 31 | 15 | 4 | 3 | 8 | 8 | 16 | ||
| 12 | Chicago Fire | 30 | 7 | 7 | 16 | 31 | 48 | -17 | 28 | XLWO | 16 | 6 | 5 | 5 | 22 | 18 | 14 | 1 | 2 | 11 | 9 | 30 | ||
| 13 | Toronto FC | 29 | 6 | 7 | 16 | 34 | 56 | -22 | 25 | LWWO | 14 | 4 | 5 | 5 | 20 | 21 | 15 | 2 | 2 | 11 | 14 | 35 | ||
| 14 | FC Cincinnati | 29 | 4 | 8 | 17 | 29 | 55 | -26 | 20 | LLLL | 14 | 1 | 5 | 8 | 10 | 17 | 15 | 3 | 3 | 9 | 19 | 38 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 29 | 17 | 6 | 6 | 49 | 25 | +24 | 57 | LWWW | 15 | 8 | 4 | 3 | 26 | 12 | 14 | 9 | 2 | 3 | 23 | 13 | ||
| 2 | Sporting Kansas City | 28 | 15 | 7 | 6 | 51 | 31 | +20 | 52 | WWLW | 15 | 8 | 5 | 2 | 30 | 16 | 13 | 7 | 2 | 4 | 21 | 15 | ||
| 3 | Colorado Rapids | 29 | 14 | 9 | 6 | 42 | 31 | +11 | 51 | LWLW | 14 | 7 | 6 | 1 | 23 | 11 | 15 | 7 | 3 | 5 | 19 | 20 | ||
| 4 | Portland Timbers | 29 | 14 | 4 | 11 | 46 | 46 | +0 | 46 | LWWW | 14 | 9 | 2 | 3 | 28 | 19 | 15 | 5 | 2 | 8 | 18 | 27 | ||
| 5 | Real Salt Lake | 29 | 12 | 6 | 11 | 48 | 45 | +3 | 42 | WLWL | 15 | 9 | 4 | 2 | 26 | 14 | 14 | 3 | 2 | 9 | 22 | 31 | ||
| 6 | LA Galaxy | 29 | 12 | 6 | 11 | 41 | 46 | -5 | 42 | WXLL | 15 | 8 | 3 | 4 | 24 | 17 | 14 | 4 | 3 | 7 | 17 | 29 | ||
| 7 | Minnesota United | 29 | 11 | 8 | 10 | 32 | 35 | -3 | 41 | WLOL | 14 | 8 | 2 | 4 | 18 | 10 | 15 | 3 | 6 | 6 | 14 | 25 | ||
| 8 | 1 | Los Angeles | 29 | 10 | 7 | 12 | 43 | 42 | +1 | 37 | WXLL | 15 | 7 | 5 | 3 | 30 | 22 | 14 | 3 | 2 | 9 | 13 | 20 | |
| 9 | 1 | Vancouver Whitecaps | 28 | 9 | 10 | 9 | 35 | 38 | -3 | 37 | LWOW | 14 | 8 | 2 | 4 | 20 | 14 | 14 | 1 | 8 | 5 | 15 | 24 | |
| 10 | San Jose Earthquakes | 29 | 8 | 9 | 12 | 36 | 47 | -11 | 33 | LLLW | 14 | 4 | 3 | 7 | 19 | 22 | 15 | 4 | 6 | 5 | 17 | 25 | ||
| 11 | 1 | Houston Dynamo | 30 | 6 | 12 | 12 | 35 | 46 | -11 | 30 | WLOL | 15 | 6 | 6 | 3 | 21 | 18 | 15 | 0 | 6 | 9 | 14 | 28 | |
| 12 | 1 | FC Dallas | 29 | 6 | 10 | 13 | 39 | 47 | -8 | 28 | OLLL | 14 | 4 | 7 | 3 | 20 | 15 | 15 | 2 | 3 | 10 | 19 | 32 | |
| 13 | Austin FC | 29 | 7 | 4 | 18 | 29 | 45 | -16 | 25 | LWLW | 15 | 5 | 2 | 8 | 22 | 23 | 14 | 2 | 2 | 10 | 7 | 22 | ||
| 17 | Ola KAMARA (D.C. United) | |
| 16 | Dániel SALLÓI (Sporting Kansas City) | |
| Raúl RUIDÍAZ (Seattle Sounders) | ||
| 14 | +1 | Damir KREILACH (Real Salt Lake) |
| +1 | Gustavo BOU (New England Revolution) | |
| 13 | Ricardo PEPI (FC Dallas) | |
| Adam BUKSA (New England Revolution) | ||
| Hany MUKHTAR (Nashville) | ||
| +1 | Javier HERNÁNDEZ (LA Galaxy) | |
| Valentín CASTELLANOS (New York City) | ||
| 11 | Felipe MORA (Portland Timbers) | |
| Javier LÓPEZ (San Jose Earthquakes) | ||
| Fabrice PICAULT (Houston Dynamo) | ||
| 10 | Gonzalo HIGUAÍN (Inter Miami) | |
| Josef MARTÍNEZ (Atlanta United) | ||
| C.J. SAPONG (Nashville) | ||
| +1 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| Johnny RUSSELL (Sporting Kansas City) | ||
| +1 | Brian WHITE (Vancouver Whitecaps) | |
| 9 | +2 | Gyasi ZARDES (Columbus Crew) |
| NANI (Orlando City) |
| Saturday, 9 October 2021 | |||||
| New York Red Bulls | 1-0 | Inter Miami | |||
| 25 | Klimala | ||||
| Seattle Sounders | 4-1 | Vancouver Whitecaps | |||
| 5 | O'Neill | 45 | White | ||
| 14 | Benezet | ||||
| 55 | Bruin | ||||
| 90 | Léo Chú | ||||
| FC Cincinnati | 1-2 | Philadelphia Union | |||
| 82 | Medunjanin | 45 | Przybyłko | ||
| 56 | Aaronson | ||||
| Sunday, 10 October 2021 | |||||
| Minnesota United | 1-3 | Colorado Rapids | |||
| 8 | Hunou | 73(p) | Bassett | ||
| 84 | Barrios | ||||
| 90 | Lucas Esteves | ||||
| Saturday, 16 October 2021 | |||||
| D.C. United | 0-0 | Nashville | |||
| Houston Dynamo | 2-1 | Seattle Sounders | |||
| 14 | Urruti | 41 | Medranda | ||
| 20 | Quintero | ||||
| Columbus Crew | 4-0 | Inter Miami | |||
| 39 | Zardes | ||||
| 44 | Pedro Santos | ||||
| 64 | Zardes | ||||
| 83(og) | González Pirez | ||||
| New England Revolution | 2-2 | Chicago Fire | |||
| 47 | Kaptoum | 49 | Medrán | ||
| 76 | Bou | 88 | Aliseda | ||
| LA Galaxy | 2-1 | Portland Timbers | |||
| 62 | Hernández | 72 | Blanco | ||
| 90(p) | Kljestan | ||||
| CF Montréal | 2-2 | Philadelphia Union | |||
| 33 | Miljevic | 63(og) | Pantemis | ||
| 90 | Ibrahim | 77 | Wagner | ||
| Real Salt Lake | 3-1 | Colorado Rapids | |||
| 13 | Kreilach | 73 | Namli | ||
| 56 | Rubin | ||||
| 90 | Julio | ||||
| Toronto FC | 0-2 | Atlanta United | |||
| 45 | Luiz Araújo | ||||
| 90 | Moreno | ||||
| Los Angeles | 3-1 | San Jose Earthquakes | |||
| 3 | Musovski | 61 | Fierro | ||
| 28(p) | Arango | ||||
| 88 | Arango | ||||
| Austin FC | 0-1 | Minnesota United | |||
| 16 | Fragapane | ||||
| FC Cincinnati | 0-1 | Orlando City | |||
| 13 | Júnior Urso | ||||
