Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 96 | 242 | 2.52 | 50 | 52.08% | 22 | 22.92% | 24 | 25.00% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 8 | 5 | 2 | 1 | 11 | 7 | +4 | 17 | WWWX | 4 | 4 | 0 | 0 | 7 | 2 | 4 | 1 | 2 | 1 | 4 | 5 | ||
| 2 | Orlando City | 7 | 3 | 3 | 1 | 8 | 4 | +4 | 12 | LWWX | 4 | 2 | 2 | 0 | 5 | 1 | 3 | 1 | 1 | 1 | 3 | 3 | ||
| 3 | New York City | 7 | 3 | 2 | 2 | 13 | 7 | +6 | 11 | WLXX | 3 | 1 | 1 | 1 | 7 | 3 | 4 | 2 | 1 | 1 | 6 | 4 | ||
| 4 | 1 | CF Montréal | 8 | 3 | 2 | 3 | 10 | 9 | +1 | 11 | WLLW | 3 | 1 | 1 | 1 | 5 | 4 | 5 | 2 | 1 | 2 | 5 | 5 | |
| 5 | 2 | Columbus Crew | 7 | 3 | 2 | 2 | 7 | 6 | +1 | 11 | WWLL | 3 | 2 | 1 | 0 | 5 | 2 | 4 | 1 | 1 | 2 | 2 | 4 | |
| 6 | Philadelphia Union | 7 | 3 | 2 | 2 | 6 | 5 | +1 | 11 | WWXW | 4 | 1 | 1 | 2 | 3 | 5 | 3 | 2 | 1 | 0 | 3 | 0 | ||
| 7 | 2 | Nashville | 7 | 2 | 5 | 0 | 9 | 6 | +3 | 11 | XWOW | 5 | 2 | 3 | 0 | 7 | 4 | 2 | 0 | 2 | 0 | 2 | 2 | |
| 8 | 4 | Atlanta United | 7 | 2 | 4 | 1 | 9 | 7 | +2 | 10 | XXWX | 3 | 2 | 1 | 0 | 6 | 3 | 4 | 0 | 3 | 1 | 3 | 4 | |
| 9 | 1 | New York Red Bulls | 7 | 3 | 0 | 4 | 10 | 10 | +0 | 9 | WLLW | 4 | 3 | 0 | 1 | 7 | 3 | 3 | 0 | 0 | 3 | 3 | 7 | |
| 10 | 1 | D.C. United | 8 | 3 | 0 | 5 | 8 | 11 | -3 | 9 | WLLW | 4 | 2 | 0 | 2 | 3 | 3 | 4 | 1 | 0 | 3 | 5 | 8 | |
| 11 | 3 | Inter Miami | 8 | 2 | 2 | 4 | 8 | 13 | -5 | 8 | LLWL | 4 | 0 | 1 | 3 | 3 | 9 | 4 | 2 | 1 | 1 | 5 | 4 | |
| 12 | Toronto FC | 7 | 1 | 2 | 4 | 8 | 12 | -4 | 5 | LLXW | 2 | 1 | 1 | 0 | 4 | 2 | 5 | 0 | 1 | 4 | 4 | 10 | ||
| 13 | Chicago Fire | 7 | 1 | 1 | 5 | 4 | 11 | -7 | 4 | LWLL | 4 | 1 | 1 | 2 | 3 | 5 | 3 | 0 | 0 | 3 | 1 | 6 | ||
| 14 | FC Cincinnati | 6 | 1 | 1 | 4 | 6 | 15 | -9 | 4 | LWLL | 2 | 0 | 0 | 2 | 2 | 4 | 4 | 1 | 1 | 2 | 4 | 11 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 7 | 5 | 2 | 0 | 14 | 3 | +11 | 17 | XWWW | 4 | 3 | 1 | 0 | 10 | 1 | 3 | 2 | 1 | 0 | 4 | 2 | ||
| 2 | Sporting Kansas City | 8 | 5 | 1 | 2 | 15 | 10 | +5 | 16 | WWWL | 4 | 3 | 1 | 0 | 9 | 4 | 4 | 2 | 0 | 2 | 6 | 6 | ||
| 3 | LA Galaxy | 7 | 5 | 0 | 2 | 11 | 11 | +0 | 15 | WLWW | 4 | 4 | 0 | 0 | 8 | 3 | 3 | 1 | 0 | 2 | 3 | 8 | ||
| 4 | 1 | Colorado Rapids | 7 | 4 | 1 | 2 | 12 | 8 | +4 | 13 | WLWW | 4 | 3 | 0 | 1 | 10 | 6 | 3 | 1 | 1 | 1 | 2 | 2 | |
| 5 | 1 | Houston Dynamo | 8 | 3 | 2 | 3 | 11 | 12 | -1 | 11 | LWLW | 4 | 3 | 1 | 0 | 6 | 3 | 4 | 0 | 1 | 3 | 5 | 9 | |
| 6 | Portland Timbers | 6 | 3 | 0 | 3 | 9 | 8 | +1 | 9 | WWLL | 3 | 2 | 0 | 1 | 6 | 3 | 3 | 1 | 0 | 2 | 3 | 5 | ||
| 7 | San Jose Earthquakes | 8 | 3 | 0 | 5 | 11 | 12 | -1 | 9 | LLLL | 5 | 2 | 0 | 3 | 8 | 8 | 3 | 1 | 0 | 2 | 3 | 4 | ||
| 8 | Real Salt Lake | 6 | 2 | 3 | 1 | 9 | 7 | +2 | 9 | XXOL | 4 | 1 | 2 | 1 | 5 | 4 | 2 | 1 | 1 | 0 | 4 | 3 | ||
| 9 | Los Angeles | 7 | 2 | 2 | 3 | 8 | 9 | -1 | 8 | LWLL | 4 | 2 | 1 | 1 | 6 | 4 | 3 | 0 | 1 | 2 | 2 | 5 | ||
| 10 | Vancouver Whitecaps | 7 | 2 | 1 | 4 | 6 | 9 | -3 | 7 | LLLW | 3 | 2 | 0 | 1 | 3 | 1 | 4 | 0 | 1 | 3 | 3 | 8 | ||
| 11 | 1 | Minnesota United | 7 | 2 | 1 | 4 | 6 | 11 | -5 | 7 | XWWL | 4 | 2 | 0 | 2 | 3 | 3 | 3 | 0 | 1 | 2 | 3 | 8 | |
| 12 | 1 | Austin FC | 6 | 2 | 0 | 4 | 5 | 8 | -3 | 6 | LLLW | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 4 | 5 | 8 | |
| 13 | FC Dallas | 7 | 1 | 3 | 3 | 8 | 11 | -3 | 6 | LXLX | 4 | 1 | 3 | 0 | 7 | 4 | 3 | 0 | 0 | 3 | 1 | 7 | ||
| 7 | Javier HERNÁNDEZ (LA Galaxy) | |
| 6 | +1 | Raúl RUIDÍAZ (Seattle Sounders) |
| 5 | +1 | Jesús MEDINA (New York City) |
| +1 | Alan PULIDO (Sporting Kansas City) | |
| 4 | Gonzalo HIGUAÍN (Inter Miami) | |
| +1 | Caden CLARK (New York Red Bulls) | |
| +1 | Adam BUKSA (New England Revolution) | |
| Rubio RUBIN (Real Salt Lake) | ||
| Valentín CASTELLANOS (New York City) | ||
| +1 | Maximiliano URRUTI (Houston Dynamo) | |
| 3 | +1 | Gadi KINDA (Sporting Kansas City) |
| Dániel SALLÓI (Sporting Kansas City) | ||
| NANI (Orlando City) | ||
| +2 | Ola KAMARA (D.C. United) | |
| +1 | Corey BAIRD (Los Angeles) | |
| +1 | Marcelino MORENO (Atlanta United) | |
| +1 | Damir KREILACH (Real Salt Lake) | |
| Lucas ZELARAYÁN (Columbus Crew) | ||
| +2 | Hany MUKHTAR (Nashville) | |
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| +1 | Cristian CÁSSERES (New York Red Bulls) | |
| Brad SMITH (Seattle Sounders) | ||
| +1 | Mason TOYE (CF Montréal) | |
| Luka STOJANOVIĆ (Chicago Fire) | ||
| Diego ROSSI (Los Angeles) |
| Sunday, 23 May 2021 | |||||
| D.C. United | 0-1 | Philadelphia Union | |||
| 45 | Przybyłko | ||||
| Seattle Sounders | 1-1 | Atlanta United | |||
| 6 | Ruidíaz | 86(p) | Martínez | ||
| Nashville | 1-0 | Austin FC | |||
| 35 | Leal | ||||
| Saturday, 29 May 2021 | |||||
| Colorado Rapids | 3-0 | FC Dallas | |||
| 13 | Rosenberry | ||||
| 41(og) | Tessmann | ||||
| 71 | Barrios | ||||
| New York Red Bulls | 2-1 | Orlando City | |||
| 35 | Clark | 84 | van Der Water | ||
| 60 | Cásseres | ||||
| Columbus Crew | 2-1 | Toronto FC | |||
| 12 | Díaz | 52 | Akinola | ||
| 21 | Zardes | ||||
| Sporting Kansas City | 3-2 | Houston Dynamo | |||
| 51 | Busio | 14 | Vera | ||
| 61(p) | Pulido | 90 | Urruti | ||
| 65 | Kinda | ||||
| LA Galaxy | 1-0 | San Jose Earthquakes | |||
| 70(og) | Beason | ||||
| Chicago Fire | 0-1 | CF Montréal | |||
| 87 | Toye | ||||
| Real Salt Lake | 1-1 | Minnesota United | |||
| 13 | Kreilach | 78 | Hansen | ||
| Los Angeles | 1-2 | New York City | |||
| 56 | Baird | 70 | Medina | ||
| 90 | Tajouri-Shradi | ||||
| Atlanta United | 2-2 | Nashville | |||
| 6 | Moreno | 80 | Mukhtar | ||
| 51 | López | 83 | Mukhtar | ||
| FC Cincinnati | 0-1 | New England Revolution | |||
| 70 | Buksa | ||||
| Inter Miami | 0-3 | D.C. United | |||
| 15 | Kamara | ||||
| 22 | Arriola | ||||
| 71 | Kamara | ||||
