Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 184 | 486 | 2.64 | 89 | 48.37% | 53 | 28.80% | 42 | 22.83% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 15 | 9 | 3 | 3 | 28 | 18 | +10 | 30 | WWLX | 6 | 5 | 0 | 1 | 12 | 7 | 9 | 4 | 3 | 2 | 16 | 11 | ||
| 2 | Philadelphia Union | 14 | 6 | 5 | 3 | 18 | 13 | +5 | 23 | WXLX | 7 | 4 | 1 | 2 | 9 | 6 | 7 | 2 | 4 | 1 | 9 | 7 | ||
| 3 | 2 | Nashville | 14 | 5 | 8 | 1 | 21 | 14 | +7 | 23 | OWXW | 10 | 5 | 5 | 0 | 19 | 10 | 4 | 0 | 3 | 1 | 2 | 4 | |
| 4 | 1 | Orlando City | 13 | 6 | 4 | 3 | 21 | 13 | +8 | 22 | XLLW | 6 | 3 | 2 | 1 | 11 | 3 | 7 | 3 | 2 | 2 | 10 | 10 | |
| 5 | 1 | CF Montréal | 14 | 6 | 4 | 4 | 19 | 16 | +3 | 22 | LWWW | 7 | 4 | 2 | 1 | 13 | 9 | 7 | 2 | 2 | 3 | 6 | 7 | |
| 6 | Columbus Crew | 14 | 5 | 6 | 3 | 15 | 12 | +3 | 21 | OWXX | 7 | 4 | 3 | 0 | 11 | 5 | 7 | 1 | 3 | 3 | 4 | 7 | ||
| 7 | New York City | 13 | 6 | 2 | 5 | 21 | 15 | +6 | 20 | WLLW | 7 | 4 | 1 | 2 | 13 | 7 | 6 | 2 | 1 | 3 | 8 | 8 | ||
| 8 | New York Red Bulls | 13 | 5 | 3 | 5 | 18 | 16 | +2 | 18 | XXWO | 6 | 4 | 1 | 1 | 10 | 4 | 7 | 1 | 2 | 4 | 8 | 12 | ||
| 9 | D.C. United | 14 | 5 | 2 | 7 | 20 | 18 | +2 | 17 | XLWL | 6 | 4 | 0 | 2 | 11 | 4 | 8 | 1 | 2 | 5 | 9 | 14 | ||
| 10 | Atlanta United | 14 | 2 | 8 | 4 | 14 | 17 | -3 | 14 | XLXL | 6 | 2 | 3 | 1 | 8 | 6 | 8 | 0 | 5 | 3 | 6 | 11 | ||
| 11 | FC Cincinnati | 13 | 3 | 4 | 6 | 17 | 26 | -9 | 13 | XLXX | 5 | 0 | 2 | 3 | 5 | 9 | 8 | 3 | 2 | 3 | 12 | 17 | ||
| 12 | Chicago Fire | 14 | 3 | 3 | 8 | 16 | 25 | -9 | 12 | XLWW | 9 | 3 | 3 | 3 | 14 | 12 | 5 | 0 | 0 | 5 | 2 | 13 | ||
| 13 | Toronto FC | 14 | 2 | 4 | 8 | 18 | 31 | -13 | 10 | XXWL | 6 | 1 | 3 | 2 | 8 | 9 | 8 | 1 | 1 | 6 | 10 | 22 | ||
| 14 | Inter Miami | 12 | 2 | 2 | 8 | 9 | 22 | -13 | 8 | LLLL | 6 | 0 | 1 | 5 | 4 | 16 | 6 | 2 | 1 | 3 | 5 | 6 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 14 | 8 | 5 | 1 | 23 | 9 | +14 | 29 | LWXX | 8 | 5 | 3 | 0 | 16 | 4 | 6 | 3 | 2 | 1 | 7 | 5 | ||
| 2 | Sporting Kansas City | 14 | 8 | 3 | 3 | 25 | 16 | +9 | 27 | XWWW | 8 | 5 | 3 | 0 | 16 | 8 | 6 | 3 | 0 | 3 | 9 | 8 | ||
| 3 | LA Galaxy | 14 | 8 | 1 | 5 | 23 | 22 | +1 | 25 | XLWL | 7 | 5 | 0 | 2 | 12 | 8 | 7 | 3 | 1 | 3 | 11 | 14 | ||
| 4 | Colorado Rapids | 13 | 7 | 3 | 3 | 21 | 13 | +8 | 24 | WXWX | 8 | 5 | 2 | 1 | 16 | 8 | 5 | 2 | 1 | 2 | 5 | 5 | ||
| 5 | Los Angeles | 14 | 6 | 3 | 5 | 18 | 15 | +3 | 21 | LWWW | 7 | 4 | 2 | 1 | 11 | 6 | 7 | 2 | 1 | 4 | 7 | 9 | ||
| 6 | Portland Timbers | 13 | 6 | 1 | 6 | 17 | 20 | -3 | 19 | WWLL | 7 | 5 | 0 | 2 | 11 | 6 | 6 | 1 | 1 | 4 | 6 | 14 | ||
| 7 | 1 | Minnesota United | 13 | 5 | 3 | 5 | 13 | 16 | -3 | 18 | WLXW | 7 | 4 | 1 | 2 | 8 | 5 | 6 | 1 | 2 | 3 | 5 | 11 | |
| 8 | 1 | Real Salt Lake | 13 | 4 | 5 | 4 | 21 | 16 | +5 | 17 | XLWL | 8 | 2 | 4 | 2 | 11 | 9 | 5 | 2 | 1 | 2 | 10 | 7 | |
| 9 | Houston Dynamo | 14 | 3 | 7 | 4 | 16 | 19 | -3 | 16 | OLXX | 6 | 3 | 3 | 0 | 9 | 6 | 8 | 0 | 4 | 4 | 7 | 13 | ||
| 10 | Austin FC | 13 | 3 | 4 | 6 | 10 | 14 | -4 | 13 | LWOL | 4 | 1 | 2 | 1 | 4 | 3 | 9 | 2 | 2 | 5 | 6 | 11 | ||
| 11 | San Jose Earthquakes | 14 | 3 | 4 | 7 | 16 | 24 | -8 | 13 | XXXL | 6 | 2 | 0 | 4 | 9 | 11 | 8 | 1 | 4 | 3 | 7 | 13 | ||
| 12 | Vancouver Whitecaps | 14 | 3 | 4 | 7 | 14 | 23 | -9 | 13 | OWLX | 7 | 3 | 1 | 3 | 6 | 8 | 7 | 0 | 3 | 4 | 8 | 15 | ||
| 13 | FC Dallas | 14 | 2 | 5 | 7 | 14 | 23 | -9 | 11 | LLLX | 7 | 2 | 5 | 0 | 12 | 8 | 7 | 0 | 0 | 7 | 2 | 15 | ||
| 10 | Javier HERNÁNDEZ (LA Galaxy) | |
| Raúl RUIDÍAZ (Seattle Sounders) | ||
| 8 | +1 | Dániel SALLÓI (Sporting Kansas City) |
| 7 | NANI (Orlando City) | |
| +2 | Adam BUKSA (New England Revolution) | |
| Damir KREILACH (Real Salt Lake) | ||
| Hany MUKHTAR (Nashville) | ||
| Gustavo BOU (New England Revolution) | ||
| 6 | Jesús MEDINA (New York City) | |
| +1 | Ola KAMARA (D.C. United) | |
| Alan PULIDO (Sporting Kansas City) | ||
| Mason TOYE (CF Montréal) | ||
| Maximiliano URRUTI (Houston Dynamo) | ||
| 5 | Gonzalo HIGUAÍN (Inter Miami) | |
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| Ricardo PEPI (FC Dallas) | ||
| +1 | Ismaël TAJOURI-SHRADI (New York City) | |
| Diego ROSSI (Los Angeles) | ||
| 4 | Caden CLARK (New York Red Bulls) | |
| José CIFUENTES (Los Angeles) | ||
| Cory BURKE (Philadelphia Union) | ||
| +1 | Luciano ACOSTA (FC Cincinnati) | |
| +1 | Michael BARRIOS (Colorado Rapids) | |
| Rubio RUBIN (Real Salt Lake) | ||
| Cade COWELL (San Jose Earthquakes) | ||
| Valentín CASTELLANOS (New York City) | ||
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| Gyasi ZARDES (Columbus Crew) | ||
| Cristian CÁSSERES (New York Red Bulls) |
| Sunday, 18 July 2021 | |||||
| Minnesota United | 1-0 | Seattle Sounders | |||
| 81 | Lod | ||||
| Tuesday, 20 July 2021 | |||||
| Vancouver Whitecaps | 0-0 | Houston Dynamo | |||
| Wednesday, 21 July 2021 | |||||
| Colorado Rapids | 2-0 | FC Dallas | |||
| 48 | Abubakar | ||||
| 55 | Barrios | ||||
| Columbus Crew | 0-0 | Nashville | |||
| Sporting Kansas City | 1-1 | San Jose Earthquakes | |||
| 90 | Sallói | 53 | Nathan | ||
| Chicago Fire | 2-2 | D.C. United | |||
| 32 | Giménez | 82 | Paredes | ||
| 61(og) | Najar | 87(p) | Kamara | ||
| Portland Timbers | 2-1 | Los Angeles | |||
| 2 | Valeri | 17 | Vela | ||
| 90 | Mora | ||||
| Real Salt Lake | 2-2 | LA Galaxy | |||
| 9 | Rusnák | 33 | Víctor Vázquez | ||
| 26 | Chang | 77 | Raveloson | ||
| Toronto FC | 1-1 | New York Red Bulls | |||
| 62 | Priso-Mbongue | 46 | Klimala | ||
| New York City | 1-0 | CF Montréal | |||
| 29 | Tajouri-Shradi | ||||
| FC Cincinnati | 1-1 | Atlanta United | |||
| 61 | Acosta | 70 | Hernández | ||
| Inter Miami | 0-5 | New England Revolution | |||
| 15 | Traustason | ||||
| 27 | Bunbury | ||||
| 36 | Traustason | ||||
| 45 | Buksa | ||||
| 83 | Buksa | ||||
