Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 350 | 961 | 2.74 | 169 | 48.29% | 95 | 27.14% | 86 | 24.57% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 28 | 19 | 5 | 4 | 53 | 33 | +20 | 62 | WWXW | 14 | 11 | 2 | 1 | 28 | 15 | 14 | 8 | 3 | 3 | 25 | 18 | ||
| 2 | Nashville | 26 | 11 | 12 | 3 | 44 | 24 | +20 | 45 | OWLW | 14 | 8 | 6 | 0 | 31 | 14 | 12 | 3 | 6 | 3 | 13 | 10 | ||
| 3 | New York City | 26 | 11 | 6 | 9 | 44 | 30 | +14 | 39 | LXWX | 13 | 8 | 2 | 3 | 29 | 12 | 13 | 3 | 4 | 6 | 15 | 18 | ||
| 4 | 3 | Philadelphia Union | 25 | 10 | 8 | 7 | 32 | 25 | +7 | 38 | WWLL | 14 | 8 | 3 | 3 | 19 | 10 | 11 | 2 | 5 | 4 | 13 | 15 | |
| 5 | 1 | Orlando City | 26 | 10 | 8 | 8 | 37 | 38 | -1 | 38 | LLLL | 13 | 7 | 4 | 2 | 23 | 13 | 13 | 3 | 4 | 6 | 14 | 25 | |
| 6 | 2 | D.C. United | 26 | 11 | 4 | 11 | 45 | 38 | +7 | 37 | WLWX | 12 | 9 | 0 | 3 | 25 | 10 | 14 | 2 | 4 | 8 | 20 | 28 | |
| 7 | 2 | CF Montréal | 26 | 10 | 7 | 9 | 37 | 32 | +5 | 37 | LWWL | 12 | 7 | 3 | 2 | 22 | 14 | 14 | 3 | 4 | 7 | 15 | 18 | |
| 8 | 2 | Atlanta United | 26 | 9 | 9 | 8 | 35 | 31 | +4 | 36 | LWWW | 13 | 7 | 3 | 3 | 20 | 11 | 13 | 2 | 6 | 5 | 15 | 20 | |
| 9 | 1 | Columbus Crew | 27 | 9 | 7 | 11 | 32 | 36 | -4 | 34 | WXWL | 13 | 7 | 3 | 3 | 23 | 18 | 14 | 2 | 4 | 8 | 9 | 18 | |
| 10 | 1 | Inter Miami | 25 | 9 | 5 | 11 | 25 | 40 | -15 | 32 | LLWW | 14 | 5 | 2 | 7 | 17 | 31 | 11 | 4 | 3 | 4 | 8 | 9 | |
| 11 | New York Red Bulls | 25 | 8 | 6 | 11 | 31 | 29 | +2 | 30 | WXWL | 12 | 5 | 4 | 3 | 15 | 10 | 13 | 3 | 2 | 8 | 16 | 19 | ||
| 12 | Chicago Fire | 27 | 6 | 6 | 15 | 26 | 43 | -17 | 24 | OLLL | 15 | 5 | 5 | 5 | 20 | 18 | 12 | 1 | 1 | 10 | 6 | 25 | ||
| 13 | FC Cincinnati | 25 | 4 | 8 | 13 | 26 | 48 | -22 | 20 | LLLW | 11 | 1 | 5 | 5 | 9 | 13 | 14 | 3 | 3 | 8 | 17 | 35 | ||
| 14 | Toronto FC | 26 | 4 | 7 | 15 | 28 | 51 | -23 | 19 | OWLL | 11 | 2 | 5 | 4 | 14 | 16 | 15 | 2 | 2 | 11 | 14 | 35 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Seattle Sounders | 25 | 14 | 6 | 5 | 38 | 21 | +17 | 48 | WLWL | 13 | 6 | 4 | 3 | 19 | 11 | 12 | 8 | 2 | 2 | 19 | 10 | |
| 2 | 1 | Sporting Kansas City | 26 | 13 | 7 | 6 | 44 | 28 | +16 | 46 | LWWL | 14 | 7 | 5 | 2 | 26 | 14 | 12 | 6 | 2 | 4 | 18 | 14 | |
| 3 | Colorado Rapids | 25 | 12 | 9 | 4 | 35 | 24 | +11 | 45 | OXXX | 13 | 6 | 6 | 1 | 20 | 11 | 12 | 6 | 3 | 3 | 15 | 13 | ||
| 4 | 1 | Portland Timbers | 26 | 12 | 4 | 10 | 42 | 43 | -1 | 40 | WWXW | 13 | 8 | 2 | 3 | 27 | 19 | 13 | 4 | 2 | 7 | 15 | 24 | |
| 5 | 1 | LA Galaxy | 26 | 11 | 5 | 10 | 37 | 42 | -5 | 38 | LLXX | 13 | 7 | 2 | 4 | 21 | 15 | 13 | 4 | 3 | 6 | 16 | 27 | |
| 6 | 1 | Minnesota United | 25 | 10 | 7 | 8 | 29 | 29 | +0 | 37 | WWLL | 13 | 8 | 2 | 3 | 17 | 7 | 12 | 2 | 5 | 5 | 12 | 22 | |
| 7 | 1 | Real Salt Lake | 26 | 10 | 6 | 10 | 42 | 41 | +1 | 36 | LWWL | 13 | 7 | 4 | 2 | 21 | 12 | 13 | 3 | 2 | 8 | 21 | 29 | |
| 8 | Los Angeles | 26 | 9 | 6 | 11 | 38 | 38 | +0 | 33 | LLWW | 13 | 6 | 5 | 2 | 26 | 19 | 13 | 3 | 1 | 9 | 12 | 19 | ||
| 9 | Vancouver Whitecaps | 25 | 8 | 9 | 8 | 31 | 34 | -3 | 33 | WXLW | 13 | 7 | 2 | 4 | 17 | 14 | 12 | 1 | 7 | 4 | 14 | 20 | ||
| 10 | San Jose Earthquakes | 26 | 8 | 9 | 9 | 34 | 38 | -4 | 33 | WWLX | 13 | 4 | 3 | 6 | 18 | 19 | 13 | 4 | 6 | 3 | 16 | 19 | ||
| 11 | FC Dallas | 27 | 6 | 9 | 12 | 38 | 44 | -6 | 27 | LLXX | 12 | 4 | 6 | 2 | 19 | 12 | 15 | 2 | 3 | 10 | 19 | 32 | ||
| 12 | Houston Dynamo | 27 | 5 | 11 | 11 | 31 | 41 | -10 | 26 | LWXW | 13 | 5 | 5 | 3 | 19 | 17 | 14 | 0 | 6 | 8 | 12 | 24 | ||
| 13 | Austin FC | 26 | 6 | 4 | 16 | 27 | 40 | -13 | 22 | WLLL | 13 | 4 | 2 | 7 | 20 | 21 | 13 | 2 | 2 | 9 | 7 | 19 | ||
| 16 | Ola KAMARA (D.C. United) | |
| 14 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 13 | Dániel SALLÓI (Sporting Kansas City) | |
| Valentín CASTELLANOS (New York City) | ||
| 12 | Ricardo PEPI (FC Dallas) | |
| Gustavo BOU (New England Revolution) | ||
| +1 | Adam BUKSA (New England Revolution) | |
| Hany MUKHTAR (Nashville) | ||
| 11 | +1 | Damir KREILACH (Real Salt Lake) |
| +1 | Felipe MORA (Portland Timbers) | |
| +1 | Javier LÓPEZ (San Jose Earthquakes) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| 10 | Gonzalo HIGUAÍN (Inter Miami) | |
| C.J. SAPONG (Nashville) | ||
| Fabrice PICAULT (Houston Dynamo) | ||
| 9 | Josef MARTÍNEZ (Atlanta United) | |
| +1 | Kacper PRZYBYŁKO (Philadelphia Union) | |
| NANI (Orlando City) | ||
| 8 | Jesús MEDINA (New York City) | |
| Alan PULIDO (Sporting Kansas City) | ||
| Jáder OBRIAN (FC Dallas) | ||
| Cristian DÁJOME (Vancouver Whitecaps) |
| Saturday, 25 September 2021 | |||||
| D.C. United | 4-2 | FC Cincinnati | |||
| 7 | Arriola | 80 | Vázquez | ||
| 21 | Birnbaum | 84 | Acosta | ||
| 41 | Arriola | ||||
| 72 | Robertha | ||||
| Colorado Rapids | 0-0 | Toronto FC | |||
| Columbus Crew | 2-1 | CF Montréal | |||
| 44 | Zardes | 90 | Quioto | ||
| 62 | Zardes | ||||
| New England Revolution | 2-1 | Orlando City | |||
| 9 | Buksa | 18 | Dike | ||
| 35(og) | Schlegel | ||||
| Vancouver Whitecaps | 1-0 | FC Dallas | |||
| 20 | White | ||||
| Portland Timbers | 6-1 | Real Salt Lake | |||
| 27 | Mora | 41 | Kreilach | ||
| 36 | Asprilla | ||||
| 48 | Chará | ||||
| 68 | Chará | ||||
| 85 | Niezgoda | ||||
| 88 | Paredes | ||||
| San Jose Earthquakes | 2-0 | Los Angeles | |||
| 3 | Kikanovic | ||||
| 47 | López | ||||
| Philadelphia Union | 1-0 | Atlanta United | |||
| 71 | Przybyłko | ||||
| Minnesota United | 2-0 | Houston Dynamo | |||
| 1 | Lod | ||||
| 17 | Finlay | ||||
| New York City | 0-1 | New York Red Bulls | |||
| 43 | Fernandez | ||||
| Sunday, 26 September 2021 | |||||
| Sporting Kansas City | 1-2 | Seattle Sounders | |||
| 60 | Russell | 31 | Roldan | ||
| 55 | Bruin | ||||
| Chicago Fire | 0-0 | Nashville | |||
| Austin FC | 2-0 | LA Galaxy | |||
| 64 | Djitté | ||||
| 79 | McKinze Gaines | ||||
