Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 297 | 802 | 2.70 | 140 | 47.14% | 84 | 28.28% | 73 | 24.58% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 24 | 16 | 4 | 4 | 45 | 28 | +17 | 52 | WLWW | 11 | 9 | 1 | 1 | 23 | 12 | 13 | 7 | 3 | 3 | 22 | 16 | ||
| 2 | Orlando City | 22 | 10 | 8 | 4 | 33 | 26 | +7 | 38 | WOWX | 12 | 7 | 4 | 1 | 21 | 9 | 10 | 3 | 4 | 3 | 12 | 17 | ||
| 3 | Nashville | 22 | 9 | 11 | 2 | 37 | 21 | +16 | 38 | WWXW | 14 | 8 | 6 | 0 | 31 | 14 | 8 | 1 | 5 | 2 | 6 | 7 | ||
| 4 | New York City | 21 | 10 | 4 | 7 | 37 | 22 | +15 | 34 | LWLW | 11 | 8 | 1 | 2 | 26 | 8 | 10 | 2 | 3 | 5 | 11 | 14 | ||
| 5 | Philadelphia Union | 23 | 8 | 8 | 7 | 28 | 24 | +4 | 32 | LLXW | 12 | 6 | 3 | 3 | 15 | 9 | 11 | 2 | 5 | 4 | 13 | 15 | ||
| 6 | CF Montréal | 22 | 8 | 7 | 7 | 30 | 27 | +3 | 31 | WXOW | 10 | 6 | 3 | 1 | 20 | 13 | 12 | 2 | 4 | 6 | 10 | 14 | ||
| 7 | D.C. United | 22 | 9 | 3 | 10 | 35 | 32 | +3 | 30 | WLLL | 10 | 7 | 0 | 3 | 18 | 8 | 12 | 2 | 3 | 7 | 17 | 24 | ||
| 8 | Columbus Crew | 23 | 7 | 6 | 10 | 27 | 32 | -5 | 27 | LWLL | 11 | 5 | 3 | 3 | 19 | 16 | 12 | 2 | 3 | 7 | 8 | 16 | ||
| 9 | Atlanta United | 22 | 6 | 9 | 7 | 25 | 28 | -3 | 27 | LWWW | 10 | 4 | 3 | 3 | 10 | 9 | 12 | 2 | 6 | 4 | 15 | 19 | ||
| 10 | 1 | Inter Miami | 21 | 7 | 5 | 9 | 22 | 31 | -9 | 26 | WOWW | 11 | 4 | 2 | 5 | 15 | 22 | 10 | 3 | 3 | 4 | 7 | 9 | |
| 11 | 1 | Chicago Fire | 22 | 6 | 5 | 11 | 24 | 33 | -9 | 23 | WLLW | 13 | 5 | 4 | 4 | 18 | 15 | 9 | 1 | 1 | 7 | 6 | 18 | |
| 12 | New York Red Bulls | 20 | 6 | 4 | 10 | 23 | 25 | -2 | 22 | LWLL | 10 | 5 | 2 | 3 | 13 | 8 | 10 | 1 | 2 | 7 | 10 | 17 | ||
| 13 | FC Cincinnati | 21 | 3 | 8 | 10 | 21 | 38 | -17 | 17 | LLLO | 9 | 0 | 5 | 4 | 6 | 11 | 12 | 3 | 3 | 6 | 15 | 27 | ||
| 14 | Toronto FC | 22 | 3 | 6 | 13 | 26 | 47 | -21 | 15 | LLLL | 9 | 1 | 5 | 3 | 12 | 14 | 13 | 2 | 1 | 10 | 14 | 33 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Seattle Sounders | 22 | 12 | 6 | 4 | 35 | 19 | +16 | 42 | LWWW | 12 | 5 | 4 | 3 | 18 | 11 | 10 | 7 | 2 | 1 | 17 | 8 | ||
| 2 | 1 | Colorado Rapids | 21 | 12 | 5 | 4 | 31 | 20 | +11 | 41 | WXWW | 10 | 6 | 3 | 1 | 18 | 9 | 11 | 6 | 2 | 3 | 13 | 11 | |
| 3 | 1 | Sporting Kansas City | 23 | 11 | 7 | 5 | 37 | 26 | +11 | 40 | LXOX | 11 | 5 | 5 | 1 | 19 | 12 | 12 | 6 | 2 | 4 | 18 | 14 | |
| 4 | LA Galaxy | 22 | 11 | 3 | 8 | 35 | 35 | +0 | 36 | XLLW | 12 | 7 | 1 | 4 | 20 | 14 | 10 | 4 | 2 | 4 | 15 | 21 | ||
| 5 | Minnesota United | 21 | 8 | 7 | 6 | 24 | 24 | +0 | 31 | WOXL | 11 | 6 | 2 | 3 | 12 | 7 | 10 | 2 | 5 | 3 | 12 | 17 | ||
| 6 | 2 | Portland Timbers | 22 | 9 | 3 | 10 | 31 | 39 | -8 | 30 | WWLX | 10 | 6 | 1 | 3 | 17 | 15 | 12 | 3 | 2 | 7 | 14 | 24 | |
| 7 | 1 | Real Salt Lake | 22 | 8 | 6 | 8 | 34 | 29 | +5 | 30 | WLLW | 12 | 6 | 4 | 2 | 20 | 12 | 10 | 2 | 2 | 6 | 14 | 17 | |
| 8 | 2 | Vancouver Whitecaps | 22 | 7 | 8 | 7 | 29 | 32 | -3 | 29 | WWWW | 11 | 6 | 2 | 3 | 16 | 13 | 11 | 1 | 6 | 4 | 13 | 19 | |
| 9 | Los Angeles | 22 | 7 | 6 | 9 | 32 | 31 | +1 | 27 | WXLL | 12 | 5 | 5 | 2 | 23 | 17 | 10 | 2 | 1 | 7 | 9 | 14 | ||
| 10 | 3 | San Jose Earthquakes | 22 | 6 | 8 | 8 | 24 | 30 | -6 | 26 | LWXO | 11 | 3 | 3 | 5 | 13 | 15 | 11 | 3 | 5 | 3 | 11 | 15 | |
| 11 | FC Dallas | 23 | 6 | 7 | 10 | 32 | 36 | -4 | 25 | LWXL | 11 | 4 | 5 | 2 | 18 | 11 | 12 | 2 | 2 | 8 | 14 | 25 | ||
| 12 | Austin FC | 22 | 5 | 4 | 13 | 21 | 31 | -10 | 19 | LLWL | 10 | 3 | 2 | 5 | 14 | 15 | 12 | 2 | 2 | 8 | 7 | 16 | ||
| 13 | Houston Dynamo | 23 | 3 | 10 | 10 | 24 | 36 | -12 | 19 | LLXL | 11 | 3 | 5 | 3 | 13 | 15 | 12 | 0 | 5 | 7 | 11 | 21 | ||
| 14 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 12 | Gustavo BOU (New England Revolution) | |
| Dániel SALLÓI (Sporting Kansas City) | ||
| Ola KAMARA (D.C. United) | ||
| 11 | +2 | Ricardo PEPI (FC Dallas) |
| +1 | Valentín CASTELLANOS (New York City) | |
| 10 | Adam BUKSA (New England Revolution) | |
| +2 | Hany MUKHTAR (Nashville) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| 9 | C.J. SAPONG (Nashville) | |
| +2 | Felipe MORA (Portland Timbers) | |
| NANI (Orlando City) | ||
| 8 | Gonzalo HIGUAÍN (Inter Miami) | |
| Damir KREILACH (Real Salt Lake) | ||
| Alan PULIDO (Sporting Kansas City) | ||
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| 7 | Jesús MEDINA (New York City) | |
| Luka STOJANOVIĆ (Chicago Fire) | ||
| Marcelino MORENO (Atlanta United) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Ismaël TAJOURI-SHRADI (New York City) | ||
| Mason TOYE (CF Montréal) |
| Sunday, 29 August 2021 | |||||
| Vancouver Whitecaps | 4-1 | Real Salt Lake | |||
| 33(og) | Silva | 90 | Julio | ||
| 53 | White | ||||
| 64 | Gauld | ||||
| 69 | Jungwirth | ||||
| Seattle Sounders | 0-2 | Portland Timbers | |||
| 58 | Blanco | ||||
| 90 | Mora | ||||
| Austin FC | 3-5 | FC Dallas | |||
| 13 | Cascante | 5 | Ferreira | ||
| 59 | Fagúndez | 36 | Pepi | ||
| 68 | Ring | 38 | Ferreira | ||
| 40 | Pepi | ||||
| 53 | Obrian | ||||
| Friday, 3 September 2021 | |||||
| Houston Dynamo | 0-2 | Portland Timbers | |||
| 15 | Chará | ||||
| 20(p) | Mora | ||||
| Philadelphia Union | 0-1 | New England Revolution | |||
| 33 | Polster | ||||
| Los Angeles | 4-0 | Sporting Kansas City | |||
| 18 | Fall | ||||
| 61 | Fall | ||||
| 71 | Arango | ||||
| 87(p) | Atuesta | ||||
| Nashville | 3-1 | New York City | |||
| 30 | Mukhtar | 90 | Castellanos | ||
| 32(og) | Latinovich | ||||
| 68 | Mukhtar | ||||
| Saturday, 4 September 2021 | |||||
| Vancouver Whitecaps | 2-1 | Austin FC | |||
| 70 | Godoy | 45 | Driussi | ||
| 83 | Caicedo | ||||
| Real Salt Lake | 3-2 | FC Dallas | |||
| 42 | Glad | 19 | Jara | ||
| 54 | Menéndez | 80 | Ferreira | ||
| 72 | Rusnák | ||||
| San Jose Earthquakes | 0-1 | Colorado Rapids | |||
| 89 | Badji | ||||
| Orlando City | 3-2 | Columbus Crew | |||
| 26 | Dike | 52(og) | Antônio Carlos | ||
| 29 | van Der Water | 54 | Berry | ||
| 69 | Júnior Urso | ||||
| FC Cincinnati | 0-1 | Inter Miami | |||
| 90 | Shea | ||||
