Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 232 | 618 | 2.66 | 107 | 46.12% | 72 | 31.03% | 53 | 22.84% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New England Revolution | 18 | 11 | 4 | 3 | 33 | 21 | +12 | 37 | OWWW | 8 | 6 | 1 | 1 | 14 | 8 | 10 | 5 | 3 | 2 | 19 | 13 | ||
| 2 | Orlando City | 18 | 8 | 6 | 4 | 28 | 23 | +5 | 30 | XXWL | 9 | 5 | 3 | 1 | 17 | 7 | 9 | 3 | 3 | 3 | 11 | 16 | ||
| 3 | 2 | New York City | 17 | 8 | 4 | 5 | 32 | 18 | +14 | 28 | XOWW | 9 | 6 | 1 | 2 | 22 | 8 | 8 | 2 | 3 | 3 | 10 | 10 | |
| 4 | 1 | Philadelphia Union | 18 | 7 | 7 | 4 | 24 | 17 | +7 | 28 | WXXL | 9 | 5 | 2 | 2 | 13 | 7 | 9 | 2 | 5 | 2 | 11 | 10 | |
| 5 | 1 | Nashville | 17 | 6 | 10 | 1 | 25 | 15 | +10 | 28 | OXWO | 11 | 6 | 5 | 0 | 22 | 10 | 6 | 0 | 5 | 1 | 3 | 5 | |
| 6 | D.C. United | 17 | 7 | 3 | 7 | 25 | 20 | +5 | 24 | WOWX | 7 | 5 | 0 | 2 | 12 | 4 | 10 | 2 | 3 | 5 | 13 | 16 | ||
| 7 | Columbus Crew | 18 | 6 | 6 | 6 | 21 | 23 | -2 | 24 | LLLW | 9 | 4 | 3 | 2 | 15 | 12 | 9 | 2 | 3 | 4 | 6 | 11 | ||
| 8 | CF Montréal | 17 | 6 | 5 | 6 | 23 | 22 | +1 | 23 | XLLL | 8 | 4 | 3 | 1 | 15 | 11 | 9 | 2 | 2 | 5 | 8 | 11 | ||
| 9 | New York Red Bulls | 16 | 5 | 4 | 7 | 20 | 20 | +0 | 19 | OLLX | 8 | 4 | 2 | 2 | 12 | 7 | 8 | 1 | 2 | 5 | 8 | 13 | ||
| 10 | 1 | Atlanta United | 18 | 3 | 9 | 6 | 21 | 25 | -4 | 18 | WXLL | 7 | 2 | 3 | 2 | 8 | 7 | 11 | 1 | 6 | 4 | 13 | 18 | |
| 11 | 1 | FC Cincinnati | 17 | 3 | 7 | 7 | 18 | 30 | -12 | 16 | XOOL | 7 | 0 | 4 | 3 | 6 | 10 | 10 | 3 | 3 | 4 | 12 | 20 | |
| 12 | 1 | Toronto FC | 18 | 3 | 6 | 9 | 23 | 38 | -15 | 15 | XLXW | 8 | 1 | 5 | 2 | 11 | 12 | 10 | 2 | 1 | 7 | 12 | 26 | |
| 13 | 1 | Chicago Fire | 17 | 3 | 5 | 9 | 18 | 28 | -10 | 14 | OXLX | 11 | 3 | 4 | 4 | 15 | 14 | 6 | 0 | 1 | 5 | 3 | 14 | |
| 14 | Inter Miami | 15 | 3 | 4 | 8 | 13 | 25 | -12 | 13 | XWXL | 8 | 1 | 2 | 5 | 7 | 18 | 7 | 2 | 2 | 3 | 6 | 7 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Sporting Kansas City | 18 | 10 | 4 | 4 | 33 | 20 | +13 | 34 | OWLW | 9 | 5 | 3 | 1 | 17 | 10 | 9 | 5 | 1 | 3 | 16 | 10 | ||
| 2 | Seattle Sounders | 18 | 9 | 6 | 3 | 26 | 14 | +12 | 33 | XLLW | 11 | 5 | 4 | 2 | 18 | 9 | 7 | 4 | 2 | 1 | 8 | 5 | ||
| 3 | LA Galaxy | 17 | 10 | 1 | 6 | 28 | 27 | +1 | 31 | WWLX | 9 | 7 | 0 | 2 | 17 | 9 | 8 | 3 | 1 | 4 | 11 | 18 | ||
| 4 | Colorado Rapids | 16 | 8 | 4 | 4 | 22 | 16 | +6 | 28 | OWLW | 9 | 5 | 3 | 1 | 16 | 8 | 7 | 3 | 1 | 3 | 6 | 8 | ||
| 5 | 1 | Minnesota United | 17 | 7 | 5 | 5 | 21 | 21 | +0 | 26 | WXXW | 9 | 6 | 1 | 2 | 12 | 6 | 8 | 1 | 4 | 3 | 9 | 15 | |
| 6 | 2 | Portland Timbers | 17 | 7 | 2 | 8 | 23 | 29 | -6 | 23 | WXLL | 9 | 6 | 1 | 2 | 15 | 9 | 8 | 1 | 1 | 6 | 8 | 20 | |
| 7 | 2 | Los Angeles | 17 | 6 | 5 | 6 | 23 | 23 | +0 | 23 | LXXL | 10 | 4 | 4 | 2 | 16 | 14 | 7 | 2 | 1 | 4 | 7 | 9 | |
| 8 | 1 | Real Salt Lake | 17 | 5 | 6 | 6 | 26 | 20 | +6 | 21 | LLOW | 9 | 3 | 4 | 2 | 14 | 9 | 8 | 2 | 2 | 4 | 12 | 11 | |
| 9 | FC Dallas | 18 | 5 | 6 | 7 | 23 | 25 | -2 | 21 | WXWW | 9 | 4 | 5 | 0 | 18 | 8 | 9 | 1 | 1 | 7 | 5 | 17 | ||
| 10 | San Jose Earthquakes | 17 | 4 | 6 | 7 | 19 | 26 | -7 | 18 | XWXX | 7 | 2 | 1 | 4 | 10 | 12 | 10 | 2 | 5 | 3 | 9 | 14 | ||
| 11 | Houston Dynamo | 18 | 3 | 9 | 6 | 19 | 25 | -6 | 18 | LLOX | 7 | 3 | 4 | 0 | 9 | 6 | 11 | 0 | 5 | 6 | 10 | 19 | ||
| 12 | Austin FC | 17 | 4 | 4 | 9 | 13 | 20 | -7 | 16 | LWLL | 7 | 2 | 2 | 3 | 7 | 7 | 10 | 2 | 2 | 6 | 6 | 13 | ||
| 13 | Vancouver Whitecaps | 16 | 3 | 6 | 7 | 18 | 27 | -9 | 15 | XXOW | 8 | 3 | 2 | 3 | 8 | 10 | 8 | 0 | 4 | 4 | 10 | 17 | ||
| 11 | Raúl RUIDÍAZ (Seattle Sounders) | |
| 10 | Dániel SALLÓI (Sporting Kansas City) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Gustavo BOU (New England Revolution) | ||
| 9 | +1 | NANI (Orlando City) |
| Ola KAMARA (D.C. United) | ||
| 8 | Adam BUKSA (New England Revolution) | |
| +1 | Damir KREILACH (Real Salt Lake) | |
| Cristian DÁJOME (Vancouver Whitecaps) | ||
| Ricardo PEPI (FC Dallas) | ||
| 7 | Gonzalo HIGUAÍN (Inter Miami) | |
| Jesús MEDINA (New York City) | ||
| Hany MUKHTAR (Nashville) | ||
| +1 | Ismaël TAJOURI-SHRADI (New York City) | |
| Alan PULIDO (Sporting Kansas City) | ||
| Mason TOYE (CF Montréal) | ||
| 6 | +1 | Robin LOD (Minnesota United) |
| +1 | Marcelino MORENO (Atlanta United) | |
| +1 | Felipe MORA (Portland Timbers) | |
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Valentín CASTELLANOS (New York City) | ||
| Kacper PRZYBYŁKO (Philadelphia Union) | ||
| Maximiliano URRUTI (Houston Dynamo) | ||
| 5 | José CIFUENTES (Los Angeles) | |
| Carlos VELA (Los Angeles) | ||
| C.J. SAPONG (Nashville) | ||
| Rubio RUBIN (Real Salt Lake) | ||
| Diego ROSSI (Los Angeles) |
| Saturday, 7 August 2021 | |||||
| FC Dallas | 2-0 | Austin FC | |||
| 50 | Hollingshead | ||||
| 63 | Ferreira | ||||
| Colorado Rapids | 0-0 | Sporting Kansas City | |||
| Columbus Crew | 2-3 | Atlanta United | |||
| 37 | Mensah | 5 | Barco | ||
| 90(p) | Pedro Santos | 35(p) | Barco | ||
| 65(p) | Moreno | ||||
| Portland Timbers | 3-2 | Real Salt Lake | |||
| 10(p) | Asprilla | 40 | Rusnák | ||
| 29 | Chará | 80 | Kreilach | ||
| 62 | Mora | ||||
| Toronto FC | 2-2 | New York City | |||
| 49 | Laryea | 12 | Rodríguez | ||
| 55 | Pozuelo | 21 | Tajouri-Shradi | ||
| Minnesota United | 2-0 | Houston Dynamo | |||
| 14 | Lod | ||||
| 71 | Kallman | ||||
| FC Cincinnati | 1-1 | Orlando City | |||
| 42 | Brenner | 56 | Nani | ||
