Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 456 | 1,345 | 2.94 | 223 | 48.90% | 114 | 25.00% | 119 | 26.10% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 33 | 18 | 10 | 5 | 68 | 26 | +42 | 64 | LOWW | 16 | 11 | 5 | 0 | 45 | 9 | 17 | 7 | 5 | 5 | 23 | 17 | ||
| 2 | CF Montréal | 33 | 19 | 5 | 9 | 60 | 49 | +11 | 62 | WWWX | 17 | 9 | 3 | 5 | 30 | 21 | 16 | 10 | 2 | 4 | 30 | 28 | ||
| 3 | New York Red Bulls | 33 | 14 | 8 | 11 | 48 | 41 | +7 | 50 | LLWL | 16 | 5 | 5 | 6 | 24 | 22 | 17 | 9 | 3 | 5 | 24 | 19 | ||
| 4 | New York City | 32 | 14 | 7 | 11 | 53 | 39 | +14 | 49 | WLXL | 16 | 9 | 4 | 3 | 35 | 18 | 16 | 5 | 3 | 8 | 18 | 21 | ||
| 5 | 1 | FC Cincinnati | 33 | 11 | 13 | 9 | 59 | 54 | +5 | 46 | LXWW | 17 | 6 | 6 | 5 | 37 | 27 | 16 | 5 | 7 | 4 | 22 | 27 | |
| 6 | 1 | Orlando City | 31 | 13 | 6 | 12 | 40 | 46 | -6 | 45 | WLLW | 16 | 8 | 0 | 8 | 24 | 27 | 15 | 5 | 6 | 4 | 16 | 19 | |
| 7 | Inter Miami | 32 | 13 | 6 | 13 | 42 | 52 | -10 | 45 | WWWL | 15 | 9 | 3 | 3 | 29 | 24 | 17 | 4 | 3 | 10 | 13 | 28 | ||
| 8 | Columbus Crew | 32 | 10 | 15 | 7 | 43 | 37 | +6 | 45 | WXLX | 17 | 7 | 6 | 4 | 22 | 15 | 15 | 3 | 9 | 3 | 21 | 22 | ||
| 9 | 1 | Charlotte FC | 32 | 13 | 2 | 17 | 42 | 48 | -6 | 41 | WWWL | 16 | 10 | 0 | 6 | 26 | 14 | 16 | 3 | 2 | 11 | 16 | 34 | |
| 10 | 1 | New England Revolution | 33 | 10 | 11 | 12 | 46 | 49 | -3 | 41 | WLLL | 17 | 7 | 6 | 4 | 22 | 16 | 16 | 3 | 5 | 8 | 24 | 33 | |
| 11 | 2 | Atlanta United | 33 | 10 | 10 | 13 | 47 | 52 | -5 | 40 | LOWW | 16 | 8 | 5 | 3 | 30 | 22 | 17 | 2 | 5 | 10 | 17 | 30 | |
| 12 | Chicago Fire | 33 | 10 | 8 | 15 | 38 | 47 | -9 | 38 | WLLW | 16 | 6 | 4 | 6 | 17 | 16 | 17 | 4 | 4 | 9 | 21 | 31 | ||
| 13 | Toronto FC | 33 | 9 | 7 | 17 | 49 | 62 | -13 | 34 | LLLL | 17 | 7 | 3 | 7 | 30 | 29 | 16 | 2 | 4 | 10 | 19 | 33 | ||
| 14 | D.C. United | 33 | 7 | 6 | 20 | 34 | 66 | -32 | 27 | LLLO | 16 | 4 | 4 | 8 | 20 | 29 | 17 | 3 | 2 | 12 | 14 | 37 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 32 | 20 | 4 | 8 | 64 | 36 | +28 | 64 | WXLW | 16 | 13 | 2 | 1 | 39 | 14 | 16 | 7 | 2 | 7 | 25 | 22 | ||
| 2 | Austin FC | 33 | 16 | 7 | 10 | 64 | 48 | +16 | 55 | LXWL | 16 | 8 | 5 | 3 | 41 | 22 | 17 | 8 | 2 | 7 | 23 | 26 | ||
| 3 | FC Dallas | 33 | 13 | 11 | 9 | 46 | 36 | +10 | 50 | LXWW | 16 | 9 | 4 | 3 | 26 | 14 | 17 | 4 | 7 | 6 | 20 | 22 | ||
| 4 | 3 | LA Galaxy | 33 | 13 | 8 | 12 | 55 | 50 | +5 | 47 | XWWL | 17 | 8 | 4 | 5 | 35 | 25 | 16 | 5 | 4 | 7 | 20 | 25 | |
| 5 | 1 | Nashville | 32 | 12 | 11 | 9 | 50 | 39 | +11 | 47 | XXWW | 16 | 6 | 6 | 4 | 29 | 19 | 16 | 6 | 5 | 5 | 21 | 20 | |
| 6 | 1 | Portland Timbers | 32 | 11 | 13 | 8 | 51 | 48 | +3 | 46 | XWWW | 16 | 8 | 6 | 2 | 27 | 17 | 16 | 3 | 7 | 6 | 24 | 31 | |
| 7 | 1 | Minnesota United | 33 | 13 | 6 | 14 | 46 | 51 | -5 | 45 | LLXL | 16 | 7 | 5 | 4 | 25 | 20 | 17 | 6 | 1 | 10 | 21 | 31 | |
| 8 | Real Salt Lake | 33 | 11 | 11 | 11 | 40 | 44 | -4 | 44 | XLLO | 16 | 8 | 5 | 3 | 24 | 14 | 17 | 3 | 6 | 8 | 16 | 30 | ||
| 9 | Vancouver Whitecaps | 33 | 12 | 7 | 14 | 40 | 55 | -15 | 43 | WWWL | 17 | 10 | 3 | 4 | 25 | 20 | 16 | 2 | 4 | 10 | 15 | 35 | ||
| 10 | 1 | Colorado Rapids | 33 | 11 | 9 | 13 | 45 | 56 | -11 | 42 | WLWW | 17 | 10 | 5 | 2 | 29 | 15 | 16 | 1 | 4 | 11 | 16 | 41 | |
| 11 | 1 | Seattle Sounders | 32 | 12 | 4 | 16 | 45 | 43 | +2 | 40 | XLWW | 16 | 9 | 2 | 5 | 27 | 17 | 16 | 3 | 2 | 11 | 18 | 26 | |
| 12 | Sporting Kansas City | 32 | 10 | 7 | 15 | 40 | 52 | -12 | 37 | WWOX | 16 | 8 | 2 | 6 | 24 | 17 | 16 | 2 | 5 | 9 | 16 | 35 | ||
| 13 | 1 | San Jose Earthquakes | 33 | 8 | 10 | 15 | 50 | 67 | -17 | 34 | WLXL | 17 | 7 | 6 | 4 | 31 | 27 | 16 | 1 | 4 | 11 | 19 | 40 | |
| 14 | 1 | Houston Dynamo | 32 | 9 | 6 | 17 | 40 | 52 | -12 | 33 | LWOL | 16 | 6 | 5 | 5 | 23 | 19 | 16 | 3 | 1 | 12 | 17 | 33 | |
| 23 | Hany MUKHTAR (Nashville, 6p) | |
| 21 | Sebastián DRIUSSI (Austin FC, 3p) | |
| 19 | Dániel GAZDAG (Philadelphia Union, 6p) | |
| 18 | Jesús FERREIRA (FC Dallas) | |
| 17 | +2 | Javier HERNÁNDEZ (LA Galaxy, 3p) |
| +1 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 16 | Jeremy EBOBISSE (San Jose Earthquakes, 2p) | |
| Cristian ARANGO (Los Angeles, 1p) | ||
| 15 | +1 | BRENNER Souza (FC Cincinnati, 1p) |
| Rommel QUIOTO (CF Montréal, 4p) | ||
| +1 | Diego RUBIO (Colorado Rapids, 4p) | |
| 14 | Julián CARRANZA (Philadelphia Union, 2p) | |
| Lewis MORGAN (New York Red Bulls, 6p) | ||
| +1 | Gonzalo HIGUAÍN (Inter Miami, 4p) | |
| 13 | Valentín CASTELLANOS (New York City, 5p) | |
| 12 | Taxiarchis FOUNTAS (D.C. United) | |
| Mikael UHRE (Philadelphia Union) | ||
| 11 | Carlos VELA (Los Angeles, 4p) | |
| 10 | Dejan JOVELJIĆ (LA Galaxy, 2p) | |
| Karol ŚWIDERSKI (Charlotte FC) | ||
| Sebastián FERREIRA (Houston Dynamo, 1p) | ||
| Ercan KARA (Orlando City, 1p) | ||
| Gyasi ZARDES (Colorado Rapids, 1p) | ||
| Emanuel REYNOSO (Minnesota United, 3p) | ||
| Leonardo CAMPANA (Inter Miami) |
| Saturday, 24 September 2022 | |||||
| San Jose Earthquakes | 2-3 | LA Galaxy | |||
| 74(p) | Espinoza | 12 | Hernández | ||
| 90 | Nathan | 42 | Brugman | ||
| 69 | Hernández | ||||
| Tuesday, 27 September 2022 | |||||
| Seattle Sounders | 1-1 | FC Cincinnati | |||
| 58 | Montero | 24 | Brenner | ||
| Friday, 30 September 2022 | |||||
| Toronto FC | 0-1 | Inter Miami | |||
| 86 | Higuaín | ||||
| Saturday, 1 October 2022 | |||||
| Colorado Rapids | 1-0 | FC Dallas | |||
| 66 | Rubio | ||||
| Columbus Crew | 2-1 | New York Red Bulls | |||
| 89 | Etienne | 53 | Amaya | ||
| 90 | Etienne | ||||
| New England Revolution | 2-1 | Atlanta United | |||
| 32(p) | Vrioni | 81 | Martínez | ||
| 85 | Bou | ||||
| LA Galaxy | 1-1 | Real Salt Lake | |||
| 68(p) | Douglas Costa | 25 | Córdova | ||
| Vancouver Whitecaps | 2-0 | Austin FC | |||
| 7 | Gauld | ||||
| 62 | Cavallini | ||||
| CF Montréal | 1-0 | D.C. United | |||
| 41(og) | Pines | ||||
| San Jose Earthquakes | 2-0 | Minnesota United | |||
| 52 | Salinas | ||||
| 71 | Kikanovic | ||||
| FC Cincinnati | 2-3 | Chicago Fire | |||
| 78 | Acosta | 56 | Durán | ||
| 89 | Vázquez | 59 | Gutiérrez | ||
| 75 | Durán | ||||
| Charlotte FC | 4-0 | Philadelphia Union | |||
| 24 | Rios | ||||
| 54 | Rios | ||||
| 72(p) | Rios | ||||
| 90 | Rios | ||||
