Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 138 | 371 | 2.68 | 71 | 51.45% | 34 | 24.64% | 33 | 23.91% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Philadelphia Union | 10 | 5 | 4 | 1 | 15 | 8 | +7 | 19 | XXXL | 5 | 3 | 2 | 0 | 7 | 2 | 5 | 2 | 2 | 1 | 8 | 6 | |
| 2 | 1 | New York Red Bulls | 10 | 5 | 3 | 2 | 16 | 8 | +8 | 18 | XWWO | 5 | 0 | 3 | 2 | 3 | 5 | 5 | 5 | 0 | 0 | 13 | 3 | |
| 3 | 1 | CF Montréal | 10 | 5 | 2 | 3 | 20 | 19 | +1 | 17 | WWXW | 4 | 3 | 0 | 1 | 9 | 5 | 6 | 2 | 2 | 2 | 11 | 14 | |
| 4 | 1 | Orlando City | 11 | 5 | 2 | 4 | 13 | 15 | -2 | 17 | LWLW | 6 | 3 | 0 | 3 | 8 | 10 | 5 | 2 | 2 | 1 | 5 | 5 | |
| 5 | 6 | FC Cincinnati | 11 | 5 | 1 | 5 | 14 | 17 | -3 | 16 | WWWL | 5 | 2 | 0 | 3 | 9 | 8 | 6 | 3 | 1 | 2 | 5 | 9 | |
| 6 | 2 | New York City | 9 | 4 | 2 | 3 | 19 | 10 | +9 | 14 | OWWW | 6 | 4 | 1 | 1 | 18 | 7 | 3 | 0 | 1 | 2 | 1 | 3 | |
| 7 | 1 | Atlanta United | 10 | 4 | 2 | 4 | 15 | 14 | +1 | 14 | WLLO | 5 | 3 | 2 | 0 | 12 | 6 | 5 | 1 | 0 | 4 | 3 | 8 | |
| 8 | 2 | Charlotte FC | 11 | 4 | 1 | 6 | 10 | 13 | -3 | 13 | WLOL | 5 | 4 | 0 | 1 | 7 | 2 | 6 | 0 | 1 | 5 | 3 | 11 | |
| 9 | 4 | Columbus Crew | 10 | 3 | 4 | 3 | 15 | 11 | +4 | 13 | XWOL | 5 | 3 | 0 | 2 | 9 | 4 | 5 | 0 | 4 | 1 | 6 | 7 | |
| 10 | 4 | D.C. United | 9 | 4 | 0 | 5 | 12 | 13 | -1 | 12 | WLWL | 6 | 3 | 0 | 3 | 10 | 8 | 3 | 1 | 0 | 2 | 2 | 5 | |
| 11 | 2 | New England Revolution | 10 | 3 | 2 | 5 | 16 | 18 | -2 | 11 | XWLW | 6 | 3 | 1 | 2 | 9 | 7 | 4 | 0 | 1 | 3 | 7 | 11 | |
| 12 | 5 | Toronto FC | 10 | 3 | 2 | 5 | 16 | 21 | -5 | 11 | LLLW | 5 | 3 | 0 | 2 | 8 | 9 | 5 | 0 | 2 | 3 | 8 | 12 | |
| 13 | 1 | Inter Miami | 10 | 3 | 1 | 6 | 9 | 19 | -10 | 10 | LLWW | 5 | 2 | 1 | 2 | 6 | 8 | 5 | 1 | 0 | 4 | 3 | 11 | |
| 14 | 1 | Chicago Fire | 10 | 2 | 4 | 4 | 7 | 11 | -4 | 10 | LLLO | 5 | 1 | 3 | 1 | 4 | 3 | 5 | 1 | 1 | 3 | 3 | 8 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Los Angeles | 10 | 7 | 2 | 1 | 23 | 10 | +13 | 23 | XWWW | 6 | 4 | 2 | 0 | 14 | 5 | 4 | 3 | 0 | 1 | 9 | 5 | |
| 2 | 1 | Austin FC | 9 | 6 | 2 | 1 | 22 | 8 | +14 | 20 | WWWW | 5 | 4 | 1 | 0 | 15 | 2 | 4 | 2 | 1 | 1 | 7 | 6 | |
| 3 | 1 | FC Dallas | 10 | 5 | 4 | 1 | 16 | 7 | +9 | 19 | WXWO | 6 | 5 | 1 | 0 | 14 | 4 | 4 | 0 | 3 | 1 | 2 | 3 | |
| 4 | 1 | LA Galaxy | 9 | 5 | 1 | 3 | 10 | 7 | +3 | 16 | LWOW | 4 | 3 | 0 | 1 | 4 | 2 | 5 | 2 | 1 | 2 | 6 | 5 | |
| 5 | Real Salt Lake | 10 | 4 | 4 | 2 | 10 | 13 | -3 | 16 | WOLX | 4 | 3 | 1 | 0 | 6 | 3 | 6 | 1 | 3 | 2 | 4 | 10 | ||
| 6 | Minnesota United | 10 | 4 | 2 | 4 | 11 | 9 | +2 | 14 | LLWW | 6 | 3 | 1 | 2 | 9 | 5 | 4 | 1 | 1 | 2 | 2 | 4 | ||
| 7 | Houston Dynamo | 10 | 3 | 3 | 4 | 12 | 13 | -1 | 12 | LLLO | 6 | 2 | 3 | 1 | 8 | 7 | 4 | 1 | 0 | 3 | 4 | 6 | ||
| 8 | Colorado Rapids | 10 | 3 | 3 | 4 | 11 | 12 | -1 | 12 | LWOL | 5 | 3 | 2 | 0 | 8 | 1 | 5 | 0 | 1 | 4 | 3 | 11 | ||
| 9 | Nashville | 9 | 3 | 3 | 3 | 9 | 10 | -1 | 12 | XLXW | 1 | 0 | 1 | 0 | 1 | 1 | 8 | 3 | 2 | 3 | 8 | 9 | ||
| 10 | Portland Timbers | 11 | 2 | 6 | 3 | 11 | 16 | -5 | 12 | XLOO | 5 | 1 | 3 | 1 | 5 | 6 | 6 | 1 | 3 | 2 | 6 | 10 | ||
| 11 | 2 | San Jose Earthquakes | 10 | 2 | 3 | 5 | 16 | 23 | -7 | 9 | WLWX | 6 | 2 | 3 | 1 | 13 | 13 | 4 | 0 | 0 | 4 | 3 | 10 | |
| 12 | 1 | Sporting Kansas City | 11 | 2 | 3 | 6 | 8 | 16 | -8 | 9 | OXOL | 5 | 2 | 2 | 1 | 5 | 4 | 6 | 0 | 1 | 5 | 3 | 12 | |
| 13 | 1 | Seattle Sounders | 8 | 2 | 1 | 5 | 9 | 13 | -4 | 7 | LLLW | 3 | 1 | 0 | 2 | 3 | 4 | 5 | 1 | 1 | 3 | 6 | 9 | |
| 14 | Vancouver Whitecaps | 8 | 1 | 1 | 6 | 6 | 17 | -11 | 4 | LLLW | 3 | 1 | 1 | 1 | 3 | 3 | 5 | 0 | 0 | 5 | 3 | 14 | ||
| 7 | +1 | Jesús FERREIRA (FC Dallas) |
| Sebastián DRIUSSI (Austin FC, 1p) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| 6 | +1 | Brandon VÁZQUEZ (FC Cincinnati) |
| 5 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| +1 | Dániel GAZDAG (Philadelphia Union, 1p) | |
| Valentín CASTELLANOS (New York City, 2p) | ||
| Javier HERNÁNDEZ (LA Galaxy) | ||
| +1 | Djordje MIHAILOVIC (CF Montréal) | |
| Leonardo CAMPANA (Inter Miami) | ||
| Diego RUBIO (Colorado Rapids) | ||
| 4 | Maximiliano URRUTI (Austin FC) | |
| +1 | Julián CARRANZA (Philadelphia Union, 1p) | |
| Karol ŚWIDERSKI (Charlotte FC) | ||
| Lewis MORGAN (New York Red Bulls, 1p) | ||
| Cristian ESPINOZA (San Jose Earthquakes, 2p) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Sebastián FERREIRA (Houston Dynamo) | ||
| +1 | Adam BUKSA (New England Revolution) | |
| Ola KAMARA (D.C. United, 1p) | ||
| Carlos VELA (Los Angeles, 1p) | ||
| THIAGO Eduardo ANDRADE (New York City) | ||
| Darwin QUINTERO (Houston Dynamo) | ||
| +2 | Taxiarchis FOUNTAS (D.C. United) | |
| +1 | Luciano ACOSTA (FC Cincinnati, 2p) | |
| +3 | Ronaldo CISNEROS (Atlanta United) |
| Sunday, 1 May 2022 | |||||
| Los Angeles | 2-0 | Minnesota United | |||
| 82 | Hollingshead | ||||
| 90 | Cifuentes | ||||
| Nashville | 1-1 | Philadelphia Union | |||
| 85(p) | Leal | 66 | Uhre | ||
| New York City | 3-0 | San Jose Earthquakes | |||
| 74 | Parks | ||||
| 78 | Gabriel Pereira | ||||
| 88 | Gloster | ||||
| Wednesday, 4 May 2022 | |||||
| FC Cincinnati | 2-0 | Toronto FC | |||
| 2 | Harris | ||||
| 57(p) | Acosta | ||||
| Saturday, 7 May 2022 | |||||
| D.C. United | 2-0 | Houston Dynamo | |||
| 35 | Fountas | ||||
| 43 | Fountas | ||||
| FC Dallas | 2-0 | Seattle Sounders | |||
| 65 | Ferreira | ||||
| 88 | Arriola | ||||
| New York Red Bulls | 1-1 | Portland Timbers | |||
| 67 | Long | 53 | Niezgoda | ||
| New England Revolution | 2-2 | Columbus Crew | |||
| 70 | Jones | 27 | Berry | ||
| 82 | Buksa | 89 | Hurtado | ||
| CF Montréal | 4-1 | Orlando City | |||
| 21 | Waterman | 72 | João Moutinho | ||
| 52 | Mihailovic | ||||
| 81 | Torres | ||||
| 84 | Brault-Guillard | ||||
| San Jose Earthquakes | 1-0 | Colorado Rapids | |||
| 64 | Nathan | ||||
| Minnesota United | 0-1 | FC Cincinnati | |||
| 90 | Vázquez | ||||
| Los Angeles | 2-2 | Philadelphia Union | |||
| 56 | Opoku | 9 | Gazdag | ||
| 82 | Escobar | 67 | Carranza | ||
| New York City | 0-0 | Sporting Kansas City | |||
| Atlanta United | 4-1 | Chicago Fire | |||
| 3 | Cisneros | 11 | Offor | ||
| 27 | Cisneros | ||||
| 36 | Cisneros | ||||
| 90 | Lennon | ||||
| Charlotte FC | 1-0 | Inter Miami | |||
| 68 | André Bava | ||||
