Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 193 | 541 | 2.80 | 95 | 49.22% | 46 | 23.83% | 52 | 26.94% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | New York City | 13 | 8 | 2 | 3 | 25 | 10 | +15 | 26 | WWWW | 8 | 6 | 1 | 1 | 21 | 7 | 5 | 2 | 1 | 2 | 4 | 3 | |
| 2 | 1 | Philadelphia Union | 14 | 6 | 7 | 1 | 19 | 10 | +9 | 25 | XWOX | 7 | 3 | 4 | 0 | 8 | 3 | 7 | 3 | 3 | 1 | 11 | 7 | |
| 3 | 1 | CF Montréal | 14 | 7 | 2 | 5 | 28 | 26 | +2 | 23 | WLLW | 6 | 4 | 0 | 2 | 14 | 10 | 8 | 3 | 2 | 3 | 14 | 16 | |
| 4 | 1 | New York Red Bulls | 14 | 6 | 5 | 3 | 24 | 15 | +9 | 23 | WLXX | 7 | 1 | 4 | 2 | 10 | 9 | 7 | 5 | 1 | 1 | 14 | 6 | |
| 5 | 2 | Orlando City | 14 | 6 | 3 | 5 | 17 | 20 | -3 | 21 | LXWL | 7 | 3 | 0 | 4 | 9 | 13 | 7 | 3 | 3 | 1 | 8 | 7 | |
| 6 | FC Cincinnati | 14 | 6 | 1 | 7 | 21 | 25 | -4 | 19 | LLWW | 6 | 2 | 0 | 4 | 11 | 11 | 8 | 4 | 1 | 3 | 10 | 14 | ||
| 7 | 3 | Inter Miami | 14 | 5 | 3 | 6 | 15 | 22 | -7 | 18 | WWOX | 8 | 4 | 2 | 2 | 12 | 11 | 6 | 1 | 1 | 4 | 3 | 11 | |
| 8 | 1 | Charlotte FC | 14 | 5 | 1 | 8 | 13 | 18 | -5 | 16 | LWLW | 7 | 5 | 0 | 2 | 9 | 5 | 7 | 0 | 1 | 6 | 4 | 13 | |
| 9 | 3 | Columbus Crew | 13 | 4 | 4 | 5 | 17 | 16 | +1 | 16 | WLLX | 6 | 3 | 0 | 3 | 9 | 6 | 7 | 1 | 4 | 2 | 8 | 10 | |
| 10 | 2 | Atlanta United | 13 | 4 | 4 | 5 | 20 | 20 | +0 | 16 | LXXW | 7 | 3 | 3 | 1 | 15 | 10 | 6 | 1 | 1 | 4 | 5 | 10 | |
| 11 | 2 | New England Revolution | 13 | 4 | 4 | 5 | 22 | 23 | -1 | 16 | XWXX | 7 | 3 | 2 | 2 | 10 | 8 | 6 | 1 | 2 | 3 | 12 | 15 | |
| 12 | 1 | Toronto FC | 14 | 4 | 3 | 7 | 21 | 27 | -6 | 15 | WXLL | 7 | 4 | 0 | 3 | 11 | 12 | 7 | 0 | 3 | 4 | 10 | 15 | |
| 13 | 2 | D.C. United | 13 | 4 | 2 | 7 | 17 | 23 | -6 | 14 | LXLX | 8 | 3 | 1 | 4 | 12 | 12 | 5 | 1 | 1 | 3 | 5 | 11 | |
| 14 | Chicago Fire | 14 | 2 | 5 | 7 | 13 | 20 | -7 | 11 | LLXL | 6 | 1 | 3 | 2 | 5 | 5 | 8 | 1 | 2 | 5 | 8 | 15 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 14 | 9 | 2 | 3 | 29 | 16 | +13 | 29 | WWLL | 8 | 5 | 2 | 1 | 18 | 9 | 6 | 4 | 0 | 2 | 11 | 7 | ||
| 2 | 1 | FC Dallas | 14 | 7 | 4 | 3 | 24 | 13 | +11 | 25 | WLLW | 7 | 5 | 1 | 1 | 15 | 6 | 7 | 2 | 3 | 2 | 9 | 7 | |
| 3 | 1 | Real Salt Lake | 14 | 7 | 4 | 3 | 17 | 17 | +0 | 25 | WWWL | 6 | 5 | 1 | 0 | 11 | 4 | 8 | 2 | 3 | 3 | 6 | 13 | |
| 4 | 2 | Austin FC | 14 | 7 | 3 | 4 | 28 | 18 | +10 | 24 | LXWL | 7 | 4 | 2 | 1 | 17 | 5 | 7 | 3 | 1 | 3 | 11 | 13 | |
| 5 | LA Galaxy | 14 | 7 | 2 | 5 | 17 | 15 | +2 | 23 | WLXL | 7 | 4 | 0 | 3 | 9 | 9 | 7 | 3 | 2 | 2 | 8 | 6 | ||
| 6 | Nashville | 14 | 6 | 4 | 4 | 18 | 16 | +2 | 22 | WXWL | 4 | 2 | 2 | 0 | 7 | 4 | 10 | 4 | 2 | 4 | 11 | 12 | ||
| 7 | Houston Dynamo | 14 | 5 | 3 | 6 | 17 | 17 | +0 | 18 | LWLW | 8 | 3 | 3 | 2 | 10 | 8 | 6 | 2 | 0 | 4 | 7 | 9 | ||
| 8 | Minnesota United | 14 | 5 | 3 | 6 | 15 | 15 | +0 | 18 | LWXL | 8 | 3 | 2 | 3 | 10 | 7 | 6 | 2 | 1 | 3 | 5 | 8 | ||
| 9 | Colorado Rapids | 14 | 5 | 3 | 6 | 16 | 17 | -1 | 18 | LWLW | 8 | 5 | 2 | 1 | 12 | 4 | 6 | 0 | 1 | 5 | 4 | 13 | ||
| 10 | 2 | Seattle Sounders | 12 | 5 | 1 | 6 | 15 | 16 | -1 | 16 | WLWW | 5 | 3 | 0 | 2 | 8 | 6 | 7 | 2 | 1 | 4 | 7 | 10 | |
| 11 | 1 | Portland Timbers | 15 | 3 | 6 | 6 | 21 | 25 | -4 | 15 | LLLW | 7 | 2 | 3 | 2 | 12 | 10 | 8 | 1 | 3 | 4 | 9 | 15 | |
| 12 | 2 | Vancouver Whitecaps | 13 | 4 | 2 | 7 | 14 | 23 | -9 | 14 | WLWX | 6 | 3 | 2 | 1 | 9 | 7 | 7 | 1 | 0 | 6 | 5 | 16 | |
| 13 | 2 | San Jose Earthquakes | 14 | 3 | 5 | 6 | 25 | 32 | -7 | 14 | LXWX | 8 | 3 | 4 | 1 | 17 | 16 | 6 | 0 | 1 | 5 | 8 | 16 | |
| 14 | 1 | Sporting Kansas City | 15 | 3 | 4 | 8 | 13 | 26 | -13 | 13 | LXWL | 7 | 3 | 2 | 2 | 7 | 6 | 8 | 0 | 2 | 6 | 6 | 20 | |
| 9 | +2 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| Jesús FERREIRA (FC Dallas) | ||
| 8 | Sebastián DRIUSSI (Austin FC, 2p) | |
| 7 | Dániel GAZDAG (Philadelphia Union, 1p) | |
| Valentín CASTELLANOS (New York City, 3p) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| +2 | Paul ARRIOLA (FC Dallas) | |
| Adam BUKSA (New England Revolution) | ||
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| +1 | Leonardo CAMPANA (Inter Miami) | |
| +1 | Diego RUBIO (Colorado Rapids, 1p) | |
| Jesús JIMÉNEZ (Toronto FC) | ||
| 6 | +1 | Lewis MORGAN (New York Red Bulls, 2p) |
| +1 | Javier HERNÁNDEZ (LA Galaxy) | |
| +2 | Hany MUKHTAR (Nashville) | |
| +1 | Ola KAMARA (D.C. United, 1p) | |
| Carlos VELA (Los Angeles, 2p) | ||
| Robin LOD (Minnesota United) | ||
| 5 | +1 | Bill TUILOMA (Portland Timbers) |
| Sebastián FERREIRA (Houston Dynamo) | ||
| +2 | Rommel QUIOTO (CF Montréal, 2p) | |
| Darwin QUINTERO (Houston Dynamo, 1p) | ||
| Taxiarchis FOUNTAS (D.C. United) | ||
| Luciano ACOSTA (FC Cincinnati, 2p) | ||
| +1 | C.J. SAPONG (Nashville) |
| Saturday, 28 May 2022 | |||||
| Colorado Rapids | 1-3 | Nashville | |||
| 78 | Rubio | 8 | Sapong | ||
| 15 | Mukhtar | ||||
| 17 | Mukhtar | ||||
| New York Red Bulls | 4-1 | D.C. United | |||
| 54 | Luquinhas | 87 | Kamara | ||
| 58 | Luquinhas | ||||
| 63 | Morgan | ||||
| 90(og) | Alfaro | ||||
| New England Revolution | 1-1 | Philadelphia Union | |||
| 75(p) | Bou | 77 | Uhre | ||
| Sporting Kansas City | 0-1 | Vancouver Whitecaps | |||
| 24(p) | Cavallini | ||||
| CF Montréal | 4-3 | FC Cincinnati | |||
| 21 | Waterman | 12 | Moreno | ||
| 45 | Quioto | 52 | Barreal | ||
| 46 | Choinière | 63 | Moreno | ||
| 59(p) | Quioto | ||||
| Real Salt Lake | 3-0 | Houston Dynamo | |||
| 29 | Wood | ||||
| 57 | Córdova | ||||
| 90 | Glad | ||||
| Toronto FC | 3-2 | Chicago Fire | |||
| 13 | Kerr | 52 | Terán | ||
| 71(p) | Pozuelo | 66 | Przybyłko | ||
| 78 | Pozuelo | ||||
| Orlando City | 1-3 | FC Dallas | |||
| 45 | Kara | 67 | Arriola | ||
| 70 | Jara | ||||
| 84 | Arriola | ||||
| Minnesota United | 0-1 | New York City | |||
| 29 | Callens | ||||
| Los Angeles | 3-2 | San Jose Earthquakes | |||
| 8(p) | Arango | 16 | Ebobisse | ||
| 13 | Hollingshead | 31 | Ebobisse | ||
| 47 | Rodríguez | ||||
| Atlanta United | 1-2 | Columbus Crew | |||
| 90 | Dwyer | 1 | Mensah | ||
| 45 | Hurtado | ||||
| Inter Miami | 2-1 | Portland Timbers | |||
| 27 | Campana | 78 | Tuiloma | ||
| 59 | Taylor | ||||
| Sunday, 29 May 2022 | |||||
| LA Galaxy | 4-1 | Austin FC | |||
| 61 | Hernández | 53 | Fagúndez | ||
| 64 | Joveljić | ||||
| 88 | Joveljić | ||||
| 90 | Álvarez | ||||
| Seattle Sounders | 2-1 | Charlotte FC | |||
| 72 | Morris | 21 | Bender | ||
| 80 | Ruidíaz | ||||
