Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 302 | 848 | 2.80 | 143 | 47.35% | 75 | 24.83% | 84 | 27.81% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 22 | 11 | 9 | 2 | 34 | 15 | +19 | 42 | WWWW | 11 | 6 | 5 | 0 | 20 | 6 | 11 | 5 | 4 | 2 | 14 | 9 | ||
| 2 | New York City | 21 | 12 | 5 | 4 | 41 | 21 | +20 | 41 | WWWW | 12 | 8 | 3 | 1 | 30 | 12 | 9 | 4 | 2 | 3 | 11 | 9 | ||
| 3 | New York Red Bulls | 22 | 10 | 6 | 6 | 34 | 25 | +9 | 36 | WLXW | 10 | 3 | 4 | 3 | 14 | 11 | 12 | 7 | 2 | 3 | 20 | 14 | ||
| 4 | CF Montréal | 21 | 11 | 2 | 8 | 36 | 36 | +0 | 35 | WWLL | 10 | 6 | 0 | 4 | 18 | 14 | 11 | 5 | 2 | 4 | 18 | 22 | ||
| 5 | Orlando City | 22 | 8 | 6 | 8 | 26 | 31 | -5 | 30 | LXXW | 11 | 5 | 0 | 6 | 15 | 20 | 11 | 3 | 6 | 2 | 11 | 11 | ||
| 6 | Columbus Crew | 21 | 7 | 9 | 5 | 27 | 22 | +5 | 30 | OWXW | 10 | 4 | 3 | 3 | 12 | 7 | 11 | 3 | 6 | 2 | 15 | 15 | ||
| 7 | FC Cincinnati | 22 | 7 | 7 | 8 | 33 | 38 | -5 | 28 | XLXX | 11 | 3 | 4 | 4 | 20 | 19 | 11 | 4 | 3 | 4 | 13 | 19 | ||
| 8 | Charlotte FC | 22 | 8 | 2 | 12 | 25 | 31 | -6 | 26 | LLWW | 10 | 7 | 0 | 3 | 15 | 7 | 12 | 1 | 2 | 9 | 10 | 24 | ||
| 9 | 3 | Chicago Fire | 22 | 7 | 5 | 10 | 24 | 28 | -4 | 26 | WWWL | 11 | 5 | 3 | 3 | 12 | 8 | 11 | 2 | 2 | 7 | 12 | 20 | |
| 10 | New England Revolution | 21 | 6 | 8 | 7 | 32 | 34 | -2 | 26 | OLLX | 10 | 4 | 4 | 2 | 15 | 12 | 11 | 2 | 4 | 5 | 17 | 22 | ||
| 11 | 2 | Inter Miami | 21 | 7 | 4 | 10 | 22 | 33 | -11 | 25 | LWLL | 11 | 6 | 2 | 3 | 18 | 16 | 10 | 1 | 2 | 7 | 4 | 17 | |
| 12 | 1 | Atlanta United | 21 | 6 | 6 | 9 | 29 | 33 | -4 | 24 | LXWL | 11 | 5 | 4 | 2 | 20 | 15 | 10 | 1 | 2 | 7 | 9 | 18 | |
| 13 | Toronto FC | 22 | 6 | 4 | 12 | 30 | 39 | -9 | 22 | WLLX | 12 | 6 | 1 | 5 | 20 | 19 | 10 | 0 | 3 | 7 | 10 | 20 | ||
| 14 | D.C. United | 20 | 5 | 3 | 12 | 26 | 43 | -17 | 18 | LLXL | 11 | 3 | 2 | 6 | 16 | 19 | 9 | 2 | 1 | 6 | 10 | 24 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 21 | 14 | 3 | 4 | 42 | 22 | +20 | 45 | WWWL | 11 | 8 | 2 | 1 | 26 | 12 | 10 | 6 | 1 | 3 | 16 | 10 | ||
| 2 | Austin FC | 22 | 12 | 5 | 5 | 45 | 28 | +17 | 41 | LXWW | 10 | 5 | 3 | 2 | 25 | 12 | 12 | 7 | 2 | 3 | 20 | 16 | ||
| 3 | 1 | Minnesota United | 22 | 10 | 4 | 8 | 31 | 26 | +5 | 34 | WWXW | 11 | 5 | 3 | 3 | 16 | 10 | 11 | 5 | 1 | 5 | 15 | 16 | |
| 4 | 1 | Real Salt Lake | 22 | 9 | 6 | 7 | 28 | 27 | +1 | 33 | LWLX | 11 | 7 | 3 | 1 | 18 | 7 | 11 | 2 | 3 | 6 | 10 | 20 | |
| 5 | 1 | FC Dallas | 22 | 8 | 8 | 6 | 32 | 25 | +7 | 32 | WXLX | 11 | 5 | 3 | 3 | 17 | 11 | 11 | 3 | 5 | 3 | 15 | 14 | |
| 6 | 1 | Nashville | 22 | 8 | 7 | 7 | 28 | 28 | +0 | 31 | XLWL | 9 | 3 | 4 | 2 | 12 | 10 | 13 | 5 | 3 | 5 | 16 | 18 | |
| 7 | LA Galaxy | 21 | 9 | 3 | 9 | 30 | 27 | +3 | 30 | WLLL | 12 | 6 | 1 | 5 | 20 | 16 | 9 | 3 | 2 | 4 | 10 | 11 | ||
| 8 | Portland Timbers | 22 | 7 | 9 | 6 | 35 | 31 | +4 | 30 | WXWX | 11 | 5 | 4 | 2 | 20 | 13 | 11 | 2 | 5 | 4 | 15 | 18 | ||
| 9 | Seattle Sounders | 21 | 9 | 2 | 10 | 28 | 25 | +3 | 29 | WLLL | 11 | 6 | 1 | 4 | 19 | 13 | 10 | 3 | 1 | 6 | 9 | 12 | ||
| 10 | Vancouver Whitecaps | 22 | 7 | 5 | 10 | 24 | 37 | -13 | 26 | LXXL | 11 | 5 | 3 | 3 | 14 | 14 | 11 | 2 | 2 | 7 | 10 | 23 | ||
| 11 | Houston Dynamo | 22 | 7 | 4 | 11 | 28 | 31 | -3 | 25 | LWLX | 12 | 4 | 4 | 4 | 16 | 14 | 10 | 3 | 0 | 7 | 12 | 17 | ||
| 12 | Colorado Rapids | 21 | 6 | 6 | 9 | 25 | 29 | -4 | 24 | LWXX | 11 | 6 | 3 | 2 | 17 | 8 | 10 | 0 | 3 | 7 | 8 | 21 | ||
| 13 | San Jose Earthquakes | 21 | 5 | 7 | 9 | 34 | 43 | -9 | 22 | LLWX | 10 | 4 | 4 | 2 | 20 | 19 | 11 | 1 | 3 | 7 | 14 | 24 | ||
| 14 | Sporting Kansas City | 23 | 5 | 5 | 13 | 19 | 40 | -21 | 20 | LLXW | 10 | 3 | 2 | 5 | 8 | 11 | 13 | 2 | 3 | 8 | 11 | 29 | ||
| 13 | Valentín CASTELLANOS (New York City, 5p) | |
| +2 | Sebastián DRIUSSI (Austin FC, 2p) | |
| 12 | Hany MUKHTAR (Nashville, 2p) | |
| +1 | Jesús FERREIRA (FC Dallas) | |
| 11 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| +1 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 10 | +1 | Dániel GAZDAG (Philadelphia Union, 3p) |
| Taxiarchis FOUNTAS (D.C. United) | ||
| 9 | +1 | Dejan JOVELJIĆ (LA Galaxy, 1p) |
| Lewis MORGAN (New York Red Bulls, 4p) | ||
| +1 | Cristian ARANGO (Los Angeles, 1p) | |
| Paul ARRIOLA (FC Dallas) | ||
| +2 | Rommel QUIOTO (CF Montréal, 2p) | |
| Emanuel REYNOSO (Minnesota United, 2p) | ||
| Diego RUBIO (Colorado Rapids, 2p) | ||
| 8 | +1 | Jarosław NIEZGODA (Portland Timbers) |
| Leonardo CAMPANA (Inter Miami) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| 7 | Maximiliano URRUTI (Austin FC) | |
| Julián CARRANZA (Philadelphia Union, 1p) | ||
| +1 | Lucas CAVALLINI (Vancouver Whitecaps, 2p) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| Sebastián FERREIRA (Houston Dynamo) | ||
| Ercan KARA (Orlando City) | ||
| Adam BUKSA (New England Revolution) | ||
| Ola KAMARA (D.C. United, 1p) | ||
| Gustavo BOU (New England Revolution, 1p) | ||
| Darwin QUINTERO (Houston Dynamo, 1p) |
| Saturday, 23 July 2022 | |||||
| D.C. United | 1-2 | CF Montréal | |||
| 56 | Birnbaum | 1 | Quioto | ||
| 35 | Quioto | ||||
| Houston Dynamo | 1-2 | Minnesota United | |||
| 85 | Picault | 45 | Fragapane | ||
| 72 | Hlongwane | ||||
| Columbus Crew | 0-0 | New England Revolution | |||
| Sporting Kansas City | 0-2 | Los Angeles | |||
| 56 | Arango | ||||
| 83 | Bale | ||||
| Vancouver Whitecaps | 1-3 | Chicago Fire | |||
| 54 | Cavallini | 13 | Shaqiri | ||
| 76 | Czichos | ||||
| 90 | Mueller | ||||
| Portland Timbers | 2-1 | San Jose Earthquakes | |||
| 53 | Niezgoda | 42 | Kikanovic | ||
| 71 | Asprilla | ||||
| Seattle Sounders | 2-1 | Colorado Rapids | |||
| 43 | Morris | 3 | Lewis | ||
| 71(p) | Lodeiro | ||||
| Real Salt Lake | 0-1 | FC Dallas | |||
| 14 | Ferreira | ||||
| Toronto FC | 4-0 | Charlotte FC | |||
| 4 | Osorio | ||||
| 10 | Bradley | ||||
| 31 | Bernardeschi | ||||
| 45 | Bradley | ||||
| Orlando City | 0-1 | Philadelphia Union | |||
| 39 | Gazdag | ||||
| New York City | 2-0 | Inter Miami | |||
| 12 | Moralez | ||||
| 75 | Héber | ||||
| FC Cincinnati | 1-1 | Nashville | |||
| 52 | Vázquez | 6 | Bunbury | ||
| Sunday, 24 July 2022 | |||||
| LA Galaxy | 2-0 | Atlanta United | |||
| 7 | Cabral | ||||
| 90 | Joveljić | ||||
| Austin FC | 3-4 | New York Red Bulls | |||
| 45 | Driussi | 14 | Ngoma | ||
| 69 | Driussi | 26 | Yearwood | ||
| 81 | Finlay | 51 | Harper | ||
| 65 | Barlow | ||||
