| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 |
| 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 252 | 855 | 3.39 | 119 | 47.22% | 49 | 19.44% | 84 | 33.33% |
| 2022 | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew 2 | 24 | 16 | 5 | 3 | 62 | 22 | +40 | 55 | WXWW | 12 | 11 | 0 | 1 | 44 | 10 | 12 | 5 | 5 | 2 | 18 | 12 | ||
| 2 | 1 | St. Louis CITY SC 2 | 24 | 15 | 3 | 6 | 51 | 34 | +17 | 49 | XLLW | 12 | 7 | 2 | 3 | 21 | 15 | 12 | 8 | 1 | 3 | 30 | 19 | |
| 3 | 2 | Houston Dynamo 2 | 24 | 14 | 5 | 5 | 38 | 22 | +16 | 49 | WLWW | 12 | 10 | 1 | 1 | 21 | 4 | 12 | 4 | 4 | 4 | 17 | 18 | |
| 4 | 2 | Tacoma Defiance | 24 | 14 | 4 | 6 | 57 | 25 | +32 | 48 | LWLW | 12 | 9 | 1 | 2 | 34 | 11 | 12 | 5 | 3 | 4 | 23 | 14 | |
| 5 | 1 | North Texas | 24 | 13 | 5 | 6 | 48 | 31 | +17 | 46 | LWWX | 12 | 8 | 2 | 2 | 30 | 14 | 12 | 5 | 3 | 4 | 18 | 17 | |
| 6 | 1 | San Jose Earthquakes II | 24 | 12 | 4 | 8 | 48 | 37 | +11 | 41 | WXWW | 12 | 5 | 3 | 4 | 26 | 19 | 12 | 7 | 1 | 4 | 22 | 18 | |
| 7 | 1 | Toronto FC 2 | 24 | 12 | 3 | 9 | 44 | 38 | +6 | 41 | WLLW | 12 | 6 | 2 | 4 | 23 | 19 | 12 | 6 | 1 | 5 | 21 | 19 | |
| 8 | 2 | Rochester New York | 24 | 10 | 6 | 8 | 37 | 30 | +7 | 40 | XWWW | 12 | 5 | 4 | 3 | 22 | 14 | 12 | 5 | 2 | 5 | 15 | 16 | |
| 9 | Philadelphia Union 2 | 24 | 11 | 4 | 9 | 42 | 39 | +3 | 40 | WWLL | 12 | 6 | 2 | 4 | 23 | 17 | 12 | 5 | 2 | 5 | 19 | 22 | ||
| 10 | 2 | New York City II | 24 | 9 | 6 | 9 | 49 | 35 | +14 | 37 | XWOL | 12 | 4 | 3 | 5 | 24 | 14 | 12 | 5 | 3 | 4 | 25 | 21 | |
| 11 | 1 | Minnesota United 2 | 24 | 9 | 5 | 10 | 43 | 39 | +4 | 36 | LWLL | 12 | 5 | 2 | 5 | 21 | 16 | 12 | 4 | 3 | 5 | 22 | 23 | |
| 12 | 1 | Inter Miami II | 24 | 10 | 5 | 9 | 40 | 49 | -9 | 36 | LWXL | 12 | 7 | 2 | 3 | 26 | 16 | 12 | 3 | 3 | 6 | 14 | 33 | |
| 13 | New England Revolution 2 | 24 | 9 | 5 | 10 | 27 | 42 | -15 | 33 | LOWL | 12 | 7 | 1 | 4 | 15 | 18 | 12 | 2 | 4 | 6 | 12 | 24 | ||
| 14 | Vancouver Whitecaps 2 | 24 | 7 | 8 | 9 | 40 | 40 | +0 | 32 | XLLL | 12 | 4 | 4 | 4 | 25 | 20 | 12 | 3 | 4 | 5 | 15 | 20 | ||
| 15 | 2 | Chicago Fire II | 24 | 8 | 5 | 11 | 41 | 44 | -3 | 31 | WWLW | 12 | 5 | 3 | 4 | 23 | 22 | 12 | 3 | 2 | 7 | 18 | 22 | |
| 16 | Sporting Kansas City 2 | 24 | 9 | 3 | 12 | 31 | 38 | -7 | 31 | XWLL | 12 | 4 | 1 | 7 | 19 | 22 | 12 | 5 | 2 | 5 | 12 | 16 | ||
| 17 | 2 | Colorado Rapids 2 | 24 | 7 | 6 | 11 | 33 | 56 | -23 | 31 | LWLW | 12 | 4 | 5 | 3 | 19 | 19 | 12 | 3 | 1 | 8 | 14 | 37 | |
| 18 | Orlando City B | 24 | 6 | 5 | 13 | 40 | 53 | -13 | 24 | LLLX | 12 | 3 | 5 | 4 | 26 | 22 | 12 | 3 | 0 | 9 | 14 | 31 | ||
| 19 | Real Monarchs | 24 | 6 | 4 | 14 | 28 | 50 | -22 | 23 | WXWW | 12 | 6 | 1 | 5 | 19 | 16 | 12 | 0 | 3 | 9 | 9 | 34 | ||
| 20 | FC Cincinnati 2 | 24 | 4 | 3 | 17 | 27 | 65 | -38 | 17 | LLLX | 12 | 2 | 2 | 8 | 11 | 24 | 12 | 2 | 1 | 9 | 16 | 41 | ||
| 21 | Portland Timbers 2 | 24 | 2 | 4 | 18 | 29 | 66 | -37 | 14 | WXLL | 12 | 1 | 3 | 8 | 18 | 33 | 12 | 1 | 1 | 10 | 11 | 33 | ||
| Sunday, 18 September 2022 | ||||||
| Rochester New York | 2-2 | New York City II | ||||
| Real Monarchs | 2-1 | Colorado Rapids 2 | ||||
| Tacoma Defiance | 0-2 | Portland Timbers 2 | ||||
| Orlando City B | 1-2 | Toronto FC 2 | ||||
| New England Revolution 2 | 1-3 | Philadelphia Union 2 | ||||
| Chicago Fire II | 1-0 | Inter Miami II | ||||
| Houston Dynamo 2 | 2-0 | North Texas | ||||
| St. Louis CITY SC 2 | 1-1 | Sporting Kansas City 2 | ||||
| Columbus Crew 2 | 9-0 | FC Cincinnati 2 | ||||
| Minnesota United 2 | 1-4 | San Jose Earthquakes II | ||||
| Play-offs | ||||||
| Saturday, 24 September 2022 | ||||||
| sf | Toronto FC 2 | 1-0 | Philadelphia Union 2 | |||
| sf | Columbus Crew 2 | 4-1 | Rochester New York | |||
| Sunday, 25 September 2022 | ||||||
| sf | Tacoma Defiance | 2-2 | Houston Dynamo 2 | p5-4 | ||
| sf | St. Louis CITY SC 2 | 2-0 | North Texas | |||
| Sunday, 2 October 2022 | ||||||
| f | St. Louis CITY SC 2 | 2-1 | Tacoma Defiance | |||
| f | Columbus Crew 2 | 4-3 | Toronto FC 2 | aet | ||
| Friday, 7 October 2022 | ||||||
| ff | Columbus Crew 2 | 4-1 | St. Louis CITY SC 2 | |||
| 21 | Jacen RUSSELL-ROWE (Columbus Crew 2, 1p) |
| 16 | Bernard KAMUNGO (North Texas, 3p) |
| 15 | Jack LYNN (Orlando City B, 1p) |
| 14 | Shanyder BORGELIN (Inter Miami II, 1p) |
| John DENIS (New York City II, 6p) | |
| 13 | Gibran RAYO (Rochester New York, 3p) |
| 12 | Marlon VARGAS (Tacoma Defiance, 3p) |
| Rudi CASTRO (San Jose Earthquakes II) | |
| 10 | Jonathan JIMÉNEZ (New York City II) |
| Aziel JACKSON (Minnesota United 2) | |
| 9 | Max ARFSTEN (San Jose Earthquakes II, 1p) |
| Noah FUSON (Columbus Crew 2) | |
| José MULATO (North Texas, 1p) | |
| Alfonso OCAMPO-CHAVEZ (Tacoma Defiance, 1p) | |
| Tommy WILLIAMSON (Minnesota United 2, 3p) | |
| 8 | Victor BEZERRA (Chicago Fire II, 1p) |
| Chris DONOVAN (Philadelphia Union 2) | |
| Dantouma TOURÉ (Colorado Rapids 2, 2p) | |
| Simon BECHER (Vancouver Whitecaps 2, 1p) | |
| Josh DOLLING (St. Louis CITY SC 2) | |
| Tyrone MONDI (Real Monarchs) | |
| Marco MICALETTO (Columbus Crew 2, 1p) |