Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 274 | 779 | 2.84 | 130 | 47.45% | 70 | 25.55% | 74 | 27.01% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Philadelphia Union | 20 | 9 | 9 | 2 | 31 | 14 | +17 | 36 | WWOL | 10 | 5 | 5 | 0 | 18 | 5 | 10 | 4 | 4 | 2 | 13 | 9 | |
| 2 | 1 | New York City | 19 | 10 | 5 | 4 | 38 | 21 | +17 | 35 | WWXX | 11 | 7 | 3 | 1 | 28 | 12 | 8 | 3 | 2 | 3 | 10 | 9 | |
| 3 | 2 | New York Red Bulls | 20 | 9 | 6 | 5 | 30 | 21 | +9 | 33 | XWWL | 9 | 3 | 4 | 2 | 14 | 10 | 11 | 6 | 2 | 3 | 16 | 11 | |
| 4 | CF Montréal | 19 | 9 | 2 | 8 | 33 | 35 | -2 | 29 | LLWW | 9 | 5 | 0 | 4 | 17 | 14 | 10 | 4 | 2 | 4 | 16 | 21 | ||
| 5 | Orlando City | 20 | 8 | 5 | 7 | 25 | 29 | -4 | 29 | XWLL | 10 | 5 | 0 | 5 | 15 | 19 | 10 | 3 | 5 | 2 | 10 | 10 | ||
| 6 | 1 | FC Cincinnati | 20 | 7 | 6 | 7 | 32 | 35 | -3 | 27 | XXXX | 10 | 3 | 3 | 4 | 19 | 18 | 10 | 4 | 3 | 3 | 13 | 17 | |
| 7 | 1 | Charlotte FC | 20 | 8 | 2 | 10 | 23 | 24 | -1 | 26 | WWLL | 10 | 7 | 0 | 3 | 15 | 7 | 10 | 1 | 2 | 7 | 8 | 17 | |
| 8 | Columbus Crew | 19 | 6 | 8 | 5 | 25 | 22 | +3 | 26 | XWOW | 8 | 3 | 2 | 3 | 10 | 7 | 11 | 3 | 6 | 2 | 15 | 15 | ||
| 9 | New England Revolution | 19 | 6 | 7 | 6 | 31 | 32 | -1 | 25 | LXOW | 10 | 4 | 4 | 2 | 15 | 12 | 9 | 2 | 3 | 4 | 16 | 20 | ||
| 10 | 1 | Atlanta United | 19 | 6 | 5 | 8 | 28 | 30 | -2 | 23 | WLXL | 10 | 5 | 3 | 2 | 19 | 14 | 9 | 1 | 2 | 6 | 9 | 16 | |
| 11 | 1 | Inter Miami | 19 | 6 | 4 | 9 | 19 | 29 | -10 | 22 | LLXW | 10 | 5 | 2 | 3 | 15 | 14 | 9 | 1 | 2 | 6 | 4 | 15 | |
| 12 | 2 | Chicago Fire | 20 | 5 | 5 | 10 | 20 | 27 | -7 | 20 | WLLW | 10 | 4 | 3 | 3 | 11 | 8 | 10 | 1 | 2 | 7 | 9 | 19 | |
| 13 | 1 | Toronto FC | 20 | 5 | 4 | 11 | 26 | 38 | -12 | 19 | LXLL | 11 | 5 | 1 | 5 | 16 | 19 | 9 | 0 | 3 | 6 | 10 | 19 | |
| 14 | 1 | D.C. United | 18 | 5 | 3 | 10 | 25 | 39 | -14 | 18 | XLWL | 10 | 3 | 2 | 5 | 15 | 17 | 8 | 2 | 1 | 5 | 10 | 22 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Austin FC | 20 | 12 | 4 | 4 | 41 | 23 | +18 | 40 | WWWW | 9 | 5 | 3 | 1 | 22 | 8 | 11 | 7 | 1 | 3 | 19 | 15 | |
| 2 | 1 | Los Angeles | 19 | 12 | 3 | 4 | 38 | 21 | +17 | 39 | WLWW | 11 | 8 | 2 | 1 | 26 | 12 | 8 | 4 | 1 | 3 | 12 | 9 | |
| 3 | 4 | Nashville | 20 | 8 | 6 | 6 | 26 | 25 | +1 | 30 | WLXW | 8 | 3 | 4 | 1 | 11 | 8 | 12 | 5 | 2 | 5 | 15 | 17 | |
| 4 | 1 | Real Salt Lake | 20 | 8 | 6 | 6 | 25 | 26 | -1 | 30 | LXLO | 9 | 6 | 3 | 0 | 15 | 6 | 11 | 2 | 3 | 6 | 10 | 20 | |
| 5 | 1 | Minnesota United | 20 | 8 | 4 | 8 | 27 | 25 | +2 | 28 | XWWW | 10 | 4 | 3 | 3 | 14 | 10 | 10 | 4 | 1 | 5 | 13 | 15 | |
| 6 | 2 | FC Dallas | 20 | 7 | 7 | 6 | 30 | 24 | +6 | 28 | LXXL | 10 | 5 | 2 | 3 | 16 | 10 | 10 | 2 | 5 | 3 | 14 | 14 | |
| 7 | 2 | LA Galaxy | 19 | 8 | 3 | 8 | 28 | 25 | +3 | 27 | LLWL | 11 | 5 | 1 | 5 | 18 | 16 | 8 | 3 | 2 | 3 | 10 | 9 | |
| 8 | Seattle Sounders | 19 | 8 | 2 | 9 | 26 | 23 | +3 | 26 | LLWL | 10 | 5 | 1 | 4 | 17 | 12 | 9 | 3 | 1 | 5 | 9 | 11 | ||
| 9 | Portland Timbers | 20 | 6 | 8 | 6 | 32 | 29 | +3 | 26 | WXWW | 9 | 4 | 3 | 2 | 17 | 11 | 11 | 2 | 5 | 4 | 15 | 18 | ||
| 10 | Vancouver Whitecaps | 20 | 7 | 4 | 9 | 22 | 33 | -11 | 25 | XLWO | 10 | 5 | 3 | 2 | 13 | 11 | 10 | 2 | 1 | 7 | 9 | 22 | ||
| 11 | Houston Dynamo | 20 | 6 | 4 | 10 | 25 | 28 | -3 | 22 | LXLL | 11 | 4 | 4 | 3 | 15 | 12 | 9 | 2 | 0 | 7 | 10 | 16 | ||
| 12 | 2 | San Jose Earthquakes | 19 | 5 | 7 | 7 | 32 | 39 | -7 | 22 | WXWL | 9 | 4 | 4 | 1 | 19 | 17 | 10 | 1 | 3 | 6 | 13 | 22 | |
| 13 | 1 | Colorado Rapids | 19 | 5 | 6 | 8 | 22 | 27 | -5 | 21 | XXLL | 10 | 5 | 3 | 2 | 15 | 8 | 9 | 0 | 3 | 6 | 7 | 19 | |
| 14 | 1 | Sporting Kansas City | 21 | 5 | 5 | 11 | 19 | 35 | -16 | 20 | XWLL | 9 | 3 | 2 | 4 | 8 | 9 | 12 | 2 | 3 | 7 | 11 | 26 | |
| 12 | Valentín CASTELLANOS (New York City, 5p) | |
| 11 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| +1 | Hany MUKHTAR (Nashville, 1p) | |
| Jesús FERREIRA (FC Dallas) | ||
| Sebastián DRIUSSI (Austin FC, 2p) | ||
| 10 | +1 | Taxiarchis FOUNTAS (D.C. United) |
| +1 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 9 | Lewis MORGAN (New York Red Bulls, 4p) | |
| 8 | +2 | Dejan JOVELJIĆ (LA Galaxy, 1p) |
| +1 | Dániel GAZDAG (Philadelphia Union, 2p) | |
| Paul ARRIOLA (FC Dallas) | ||
| Leonardo CAMPANA (Inter Miami) | ||
| Diego RUBIO (Colorado Rapids, 2p) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| 7 | Jarosław NIEZGODA (Portland Timbers) | |
| +1 | Maximiliano URRUTI (Austin FC) | |
| Julián CARRANZA (Philadelphia Union, 1p) | ||
| Cristian ARANGO (Los Angeles, 1p) | ||
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| Ercan KARA (Orlando City) | ||
| Adam BUKSA (New England Revolution) | ||
| +1 | Ola KAMARA (D.C. United, 1p) | |
| Rommel QUIOTO (CF Montréal, 2p) | ||
| Darwin QUINTERO (Houston Dynamo, 1p) | ||
| Emanuel REYNOSO (Minnesota United, 2p) |
| Tuesday, 12 July 2022 | |||||
| Austin FC | 3-1 | Houston Dynamo | |||
| 15 | Fagúndez | 11 | Carrasquilla | ||
| 57 | Urruti | ||||
| 70 | Ring | ||||
| Wednesday, 13 July 2022 | |||||
| D.C. United | 2-2 | Columbus Crew | |||
| 80 | Fountas | 62 | Cucho | ||
| 90 | Kamara | 81 | Cucho | ||
| FC Dallas | 0-1 | New York City | |||
| 29 | Héber | ||||
| Colorado Rapids | 1-1 | Orlando City | |||
| 65 | Zardes | 22 | Torres | ||
| LA Galaxy | 2-3 | San Jose Earthquakes | |||
| 48 | Joveljić | 13(p) | Espinoza | ||
| 88 | Joveljić | 14 | Ebobisse | ||
| 40 | López | ||||
| Chicago Fire | 2-0 | Toronto FC | |||
| 4 | Durán | ||||
| 16 | Durán | ||||
| Minnesota United | 1-1 | Sporting Kansas City | |||
| 43(og) | Pulskamp | 63 | Russell | ||
| Nashville | 1-0 | Seattle Sounders | |||
| 44 | Mukhtar | ||||
| Atlanta United | 2-1 | Real Salt Lake | |||
| 7 | Cisneros | 37 | Kappelhof | ||
| 33 | Cisneros | ||||
| FC Cincinnati | 2-2 | Vancouver Whitecaps | |||
| 3 | Barreal | 5 | Gauld | ||
| 23 | Vázquez | 82 | Dájome | ||
| Inter Miami | 1-2 | Philadelphia Union | |||
| 82 | Higuaín | 26(p) | Gazdag | ||
| 66 | Burke | ||||
