Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 444 | 1,314 | 2.95 | 216 | 48.65% | 112 | 25.23% | 116 | 26.13% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 32 | 18 | 10 | 4 | 68 | 22 | +46 | 64 | OWWW | 16 | 11 | 5 | 0 | 45 | 9 | 16 | 7 | 5 | 4 | 23 | 13 | ||
| 2 | CF Montréal | 32 | 18 | 5 | 9 | 59 | 49 | +10 | 59 | WWXW | 16 | 8 | 3 | 5 | 29 | 21 | 16 | 10 | 2 | 4 | 30 | 28 | ||
| 3 | New York Red Bulls | 32 | 14 | 8 | 10 | 47 | 39 | +8 | 50 | LWLW | 16 | 5 | 5 | 6 | 24 | 22 | 16 | 9 | 3 | 4 | 23 | 17 | ||
| 4 | New York City | 32 | 14 | 7 | 11 | 53 | 39 | +14 | 49 | WLXL | 16 | 9 | 4 | 3 | 35 | 18 | 16 | 5 | 3 | 8 | 18 | 21 | ||
| 5 | Orlando City | 31 | 13 | 6 | 12 | 40 | 46 | -6 | 45 | WLLW | 16 | 8 | 0 | 8 | 24 | 27 | 15 | 5 | 6 | 4 | 16 | 19 | ||
| 6 | FC Cincinnati | 31 | 11 | 12 | 8 | 56 | 50 | +6 | 45 | WWXW | 16 | 6 | 6 | 4 | 35 | 24 | 15 | 5 | 6 | 4 | 21 | 26 | ||
| 7 | 1 | Inter Miami | 31 | 12 | 6 | 13 | 41 | 52 | -11 | 42 | WWLL | 15 | 9 | 3 | 3 | 29 | 24 | 16 | 3 | 3 | 10 | 12 | 28 | |
| 8 | 1 | Columbus Crew | 31 | 9 | 15 | 7 | 41 | 36 | +5 | 42 | XLXO | 16 | 6 | 6 | 4 | 20 | 14 | 15 | 3 | 9 | 3 | 21 | 22 | |
| 9 | Atlanta United | 32 | 10 | 10 | 12 | 46 | 50 | -4 | 40 | OWWL | 16 | 8 | 5 | 3 | 30 | 22 | 16 | 2 | 5 | 9 | 16 | 28 | ||
| 10 | 1 | Charlotte FC | 31 | 12 | 2 | 17 | 38 | 48 | -10 | 38 | WWLL | 15 | 9 | 0 | 6 | 22 | 14 | 16 | 3 | 2 | 11 | 16 | 34 | |
| 11 | 1 | New England Revolution | 32 | 9 | 11 | 12 | 44 | 48 | -4 | 38 | LLLW | 16 | 6 | 6 | 4 | 20 | 15 | 16 | 3 | 5 | 8 | 24 | 33 | |
| 12 | Chicago Fire | 32 | 9 | 8 | 15 | 35 | 45 | -10 | 35 | LLWO | 16 | 6 | 4 | 6 | 17 | 16 | 16 | 3 | 4 | 9 | 18 | 29 | ||
| 13 | Toronto FC | 32 | 9 | 7 | 16 | 49 | 61 | -12 | 34 | LLLX | 16 | 7 | 3 | 6 | 30 | 28 | 16 | 2 | 4 | 10 | 19 | 33 | ||
| 14 | D.C. United | 32 | 7 | 6 | 19 | 34 | 65 | -31 | 27 | LLOO | 16 | 4 | 4 | 8 | 20 | 29 | 16 | 3 | 2 | 11 | 14 | 36 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 32 | 20 | 4 | 8 | 64 | 36 | +28 | 64 | WXLW | 16 | 13 | 2 | 1 | 39 | 14 | 16 | 7 | 2 | 7 | 25 | 22 | ||
| 2 | Austin FC | 32 | 16 | 7 | 9 | 64 | 46 | +18 | 55 | XWLL | 16 | 8 | 5 | 3 | 41 | 22 | 16 | 8 | 2 | 6 | 23 | 24 | ||
| 3 | FC Dallas | 32 | 13 | 11 | 8 | 46 | 35 | +11 | 50 | XWWX | 16 | 9 | 4 | 3 | 26 | 14 | 16 | 4 | 7 | 5 | 20 | 21 | ||
| 4 | Nashville | 32 | 12 | 11 | 9 | 50 | 39 | +11 | 47 | XXWW | 16 | 6 | 6 | 4 | 29 | 19 | 16 | 6 | 5 | 5 | 21 | 20 | ||
| 5 | 1 | Portland Timbers | 32 | 11 | 13 | 8 | 51 | 48 | +3 | 46 | XWWW | 16 | 8 | 6 | 2 | 27 | 17 | 16 | 3 | 7 | 6 | 24 | 31 | |
| 6 | 1 | Minnesota United | 32 | 13 | 6 | 13 | 46 | 49 | -3 | 45 | LXLL | 16 | 7 | 5 | 4 | 25 | 20 | 16 | 6 | 1 | 9 | 21 | 29 | |
| 7 | 1 | LA Galaxy | 31 | 12 | 7 | 12 | 51 | 47 | +4 | 43 | WLXX | 16 | 8 | 3 | 5 | 34 | 24 | 15 | 4 | 4 | 7 | 17 | 23 | |
| 8 | 1 | Real Salt Lake | 32 | 11 | 10 | 11 | 39 | 43 | -4 | 43 | LLOL | 16 | 8 | 5 | 3 | 24 | 14 | 16 | 3 | 5 | 8 | 15 | 29 | |
| 9 | 2 | Vancouver Whitecaps | 32 | 11 | 7 | 14 | 38 | 55 | -17 | 40 | WWLL | 16 | 9 | 3 | 4 | 23 | 20 | 16 | 2 | 4 | 10 | 15 | 35 | |
| 10 | 1 | Seattle Sounders | 31 | 12 | 3 | 16 | 44 | 42 | +2 | 39 | LWWL | 15 | 9 | 1 | 5 | 26 | 16 | 16 | 3 | 2 | 11 | 18 | 26 | |
| 11 | 1 | Colorado Rapids | 32 | 10 | 9 | 13 | 44 | 56 | -12 | 39 | LWWO | 16 | 9 | 5 | 2 | 28 | 15 | 16 | 1 | 4 | 11 | 16 | 41 | |
| 12 | Sporting Kansas City | 32 | 10 | 7 | 15 | 40 | 52 | -12 | 37 | WWOX | 16 | 8 | 2 | 6 | 24 | 17 | 16 | 2 | 5 | 9 | 16 | 35 | ||
| 13 | Houston Dynamo | 32 | 9 | 6 | 17 | 40 | 52 | -12 | 33 | LWOL | 16 | 6 | 5 | 5 | 23 | 19 | 16 | 3 | 1 | 12 | 17 | 33 | ||
| 14 | San Jose Earthquakes | 31 | 7 | 10 | 14 | 46 | 64 | -18 | 31 | XLLW | 15 | 6 | 6 | 3 | 27 | 24 | 16 | 1 | 4 | 11 | 19 | 40 | ||
| 23 | +1 | Hany MUKHTAR (Nashville, 6p) |
| 21 | +1 | Sebastián DRIUSSI (Austin FC, 3p) |
| 19 | Dániel GAZDAG (Philadelphia Union, 6p) | |
| 18 | Jesús FERREIRA (FC Dallas) | |
| 16 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 2p) |
| Cristian ARANGO (Los Angeles, 1p) | ||
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 15 | +1 | Javier HERNÁNDEZ (LA Galaxy, 3p) |
| Rommel QUIOTO (CF Montréal, 4p) | ||
| 14 | Julián CARRANZA (Philadelphia Union, 2p) | |
| +2 | BRENNER Souza (FC Cincinnati, 1p) | |
| Lewis MORGAN (New York Red Bulls, 6p) | ||
| Diego RUBIO (Colorado Rapids, 4p) | ||
| 13 | Valentín CASTELLANOS (New York City, 5p) | |
| +1 | Gonzalo HIGUAÍN (Inter Miami, 4p) | |
| 12 | +1 | Taxiarchis FOUNTAS (D.C. United) |
| Mikael UHRE (Philadelphia Union) | ||
| 11 | +2 | Carlos VELA (Los Angeles, 4p) |
| 10 | Dejan JOVELJIĆ (LA Galaxy, 2p) | |
| +2 | Karol ŚWIDERSKI (Charlotte FC) | |
| Sebastián FERREIRA (Houston Dynamo, 1p) | ||
| +1 | Ercan KARA (Orlando City, 1p) | |
| Gyasi ZARDES (Colorado Rapids, 1p) | ||
| Emanuel REYNOSO (Minnesota United, 3p) | ||
| +2 | Leonardo CAMPANA (Inter Miami) |
| Saturday, 17 September 2022 | |||||
| New England Revolution | 0-1 | CF Montréal | |||
| 72 | Johnston | ||||
| Sporting Kansas City | 4-1 | Minnesota United | |||
| 31(og) | Boxall | 57 | García | ||
| 41 | Thommy | ||||
| 45 | Agada | ||||
| 81 | Agada | ||||
| LA Galaxy | 4-1 | Colorado Rapids | |||
| 22 | Brugman | 90 | Nicholson | ||
| 28 | Edwards | ||||
| 31 | Hernández | ||||
| 52 | Brugman | ||||
| Chicago Fire | 2-3 | Charlotte FC | |||
| 3 | Pineda | 68 | Świderski | ||
| 30 | Durán | 76 | Nuno Santos | ||
| 90 | Świderski | ||||
| Vancouver Whitecaps | 2-1 | Seattle Sounders | |||
| 29 | Vite | 89 | Bruin | ||
| 37 | Gressel | ||||
| Real Salt Lake | 1-2 | FC Cincinnati | |||
| 35 | Chang | 44 | Brenner | ||
| 76 | Brenner | ||||
| San Jose Earthquakes | 1-1 | FC Dallas | |||
| 24(p) | Ebobisse | 16 | Obrian | ||
| Orlando City | 4-0 | Toronto FC | |||
| 9 | Torres | ||||
| 22 | Kara | ||||
| 47(og) | MacNaughton | ||||
| 84 | Akindele | ||||
| Austin FC | 1-1 | Nashville | |||
| 61 | Driussi | 56(p) | Mukhtar | ||
| New York City | 2-0 | New York Red Bulls | |||
| 1 | Callens | ||||
| 23 | Rodríguez | ||||
| Atlanta United | 0-0 | Philadelphia Union | |||
| Sunday, 18 September 2022 | |||||
| D.C. United | 2-3 | Inter Miami | |||
| 22 | Benteke | 39 | Campana | ||
| 57 | Fountas | 53 | Campana | ||
| 90 | Higuaín | ||||
| Columbus Crew | 1-1 | Portland Timbers | |||
| 36 | Molino | 90 | Moreno | ||
| Los Angeles | 3-1 | Houston Dynamo | |||
| 8(p) | Vela | 24 | Baird | ||
| 45(p) | Vela | ||||
| 52 | Hollingshead | ||||
