| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 393 | 1,165 | 2.96 | 186 | 47.33% | 99 | 25.19% | 108 | 27.48% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 29 | 16 | 9 | 4 | 61 | 21 | +40 | 57 | WWWL | 15 | 10 | 5 | 0 | 40 | 8 | 14 | 6 | 4 | 4 | 21 | 13 | ||
| 2 | CF Montréal | 28 | 15 | 4 | 9 | 49 | 42 | +7 | 49 | LWWW | 14 | 7 | 2 | 5 | 24 | 17 | 14 | 8 | 2 | 4 | 25 | 25 | ||
| 3 | 1 | New York Red Bulls | 29 | 13 | 8 | 8 | 45 | 34 | +11 | 47 | WWXW | 14 | 4 | 5 | 5 | 22 | 19 | 15 | 9 | 3 | 3 | 23 | 15 | |
| 4 | 1 | New York City | 28 | 13 | 6 | 9 | 50 | 34 | +16 | 45 | LLWL | 14 | 8 | 3 | 3 | 32 | 17 | 14 | 5 | 3 | 6 | 18 | 17 | |
| 5 | Orlando City | 28 | 12 | 6 | 10 | 35 | 40 | -5 | 42 | WWWW | 14 | 7 | 0 | 7 | 20 | 26 | 14 | 5 | 6 | 3 | 15 | 14 | ||
| 6 | 1 | Columbus Crew | 27 | 9 | 12 | 6 | 37 | 31 | +6 | 39 | WXXX | 14 | 6 | 4 | 4 | 19 | 13 | 13 | 3 | 8 | 2 | 18 | 18 | |
| 7 | 1 | Inter Miami | 28 | 10 | 6 | 12 | 35 | 46 | -11 | 36 | LLWW | 14 | 8 | 3 | 3 | 27 | 23 | 14 | 2 | 3 | 9 | 8 | 23 | |
| 8 | FC Cincinnati | 27 | 8 | 11 | 8 | 45 | 48 | -3 | 35 | XXXW | 14 | 4 | 6 | 4 | 27 | 24 | 13 | 4 | 5 | 4 | 18 | 24 | ||
| 9 | New England Revolution | 28 | 8 | 11 | 9 | 39 | 42 | -3 | 35 | OLLX | 14 | 5 | 6 | 3 | 17 | 14 | 14 | 3 | 5 | 6 | 22 | 28 | ||
| 10 | Toronto FC | 29 | 9 | 7 | 13 | 44 | 49 | -5 | 34 | XWLX | 15 | 7 | 3 | 5 | 27 | 24 | 14 | 2 | 4 | 8 | 17 | 25 | ||
| 11 | 2 | Atlanta United | 28 | 8 | 9 | 11 | 40 | 46 | -6 | 33 | LWXL | 14 | 7 | 4 | 3 | 26 | 20 | 14 | 1 | 5 | 8 | 14 | 26 | |
| 12 | 1 | Charlotte FC | 28 | 10 | 2 | 16 | 34 | 44 | -10 | 32 | LLWL | 14 | 8 | 0 | 6 | 21 | 14 | 14 | 2 | 2 | 10 | 13 | 30 | |
| 13 | 1 | Chicago Fire | 28 | 8 | 7 | 13 | 28 | 38 | -10 | 31 | OLLL | 14 | 5 | 4 | 5 | 12 | 12 | 14 | 3 | 3 | 8 | 16 | 26 | |
| 14 | D.C. United | 28 | 7 | 4 | 17 | 32 | 59 | -27 | 25 | WLLL | 14 | 4 | 3 | 7 | 18 | 26 | 14 | 3 | 1 | 10 | 14 | 33 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 28 | 18 | 3 | 7 | 57 | 32 | +25 | 57 | LLLW | 14 | 11 | 2 | 1 | 34 | 13 | 14 | 7 | 1 | 6 | 23 | 19 | ||
| 2 | Austin FC | 28 | 15 | 6 | 7 | 60 | 39 | +21 | 51 | LWLW | 14 | 7 | 4 | 3 | 37 | 21 | 14 | 8 | 2 | 4 | 23 | 18 | ||
| 3 | Minnesota United | 28 | 13 | 5 | 10 | 44 | 40 | +4 | 44 | LWWW | 14 | 7 | 4 | 3 | 24 | 16 | 14 | 6 | 1 | 7 | 20 | 24 | ||
| 4 | FC Dallas | 29 | 11 | 10 | 8 | 40 | 33 | +7 | 43 | XLWW | 15 | 8 | 4 | 3 | 24 | 13 | 14 | 3 | 6 | 5 | 16 | 20 | ||
| 5 | Nashville | 29 | 11 | 9 | 9 | 45 | 37 | +8 | 42 | WWWL | 14 | 5 | 5 | 4 | 25 | 18 | 15 | 6 | 4 | 5 | 20 | 19 | ||
| 6 | Real Salt Lake | 28 | 11 | 9 | 8 | 38 | 36 | +2 | 42 | WXXW | 14 | 8 | 4 | 2 | 23 | 12 | 14 | 3 | 5 | 6 | 15 | 24 | ||
| 7 | Portland Timbers | 29 | 9 | 12 | 8 | 47 | 46 | +1 | 39 | WWLL | 14 | 6 | 6 | 2 | 24 | 16 | 15 | 3 | 6 | 6 | 23 | 30 | ||
| 8 | LA Galaxy | 27 | 11 | 5 | 11 | 44 | 40 | +4 | 38 | XWXW | 14 | 7 | 2 | 5 | 28 | 21 | 13 | 4 | 3 | 6 | 16 | 19 | ||
| 9 | Vancouver Whitecaps | 28 | 9 | 7 | 12 | 32 | 49 | -17 | 34 | LXWL | 14 | 7 | 3 | 4 | 18 | 19 | 14 | 2 | 4 | 8 | 14 | 30 | ||
| 10 | Seattle Sounders | 28 | 10 | 3 | 15 | 38 | 39 | -1 | 33 | LLXL | 13 | 7 | 1 | 5 | 21 | 15 | 15 | 3 | 2 | 10 | 17 | 24 | ||
| 11 | Colorado Rapids | 28 | 8 | 8 | 12 | 38 | 50 | -12 | 32 | LLXL | 14 | 7 | 5 | 2 | 23 | 13 | 14 | 1 | 3 | 10 | 15 | 37 | ||
| 12 | 2 | Houston Dynamo | 28 | 8 | 5 | 15 | 35 | 46 | -11 | 29 | WLXL | 14 | 5 | 4 | 5 | 20 | 18 | 14 | 3 | 1 | 10 | 15 | 28 | |
| 13 | 1 | Sporting Kansas City | 28 | 8 | 5 | 15 | 31 | 49 | -18 | 29 | WWLW | 14 | 6 | 2 | 6 | 17 | 16 | 14 | 2 | 3 | 9 | 14 | 33 | |
| 14 | 1 | San Jose Earthquakes | 27 | 6 | 9 | 12 | 42 | 55 | -13 | 27 | LWLX | 13 | 5 | 5 | 3 | 24 | 23 | 14 | 1 | 4 | 9 | 18 | 32 | |
| 20 | +1 | Sebastián DRIUSSI (Austin FC, 3p) |
| 19 | +3 | Hany MUKHTAR (Nashville, 4p) |
| 17 | +1 | Dániel GAZDAG (Philadelphia Union, 5p) |
| 16 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 15 | Jesús FERREIRA (FC Dallas) | |
| Rommel QUIOTO (CF Montréal, 4p) | ||
| 14 | +1 | Julián CARRANZA (Philadelphia Union, 2p) |
| Jeremy EBOBISSE (San Jose Earthquakes, 1p) | ||
| +1 | Cristian ARANGO (Los Angeles, 1p) | |
| 13 | +1 | Lewis MORGAN (New York Red Bulls, 5p) |
| Valentín CASTELLANOS (New York City, 5p) | ||
| 12 | +1 | Javier HERNÁNDEZ (LA Galaxy, 2p) |
| Diego RUBIO (Colorado Rapids, 3p) | ||
| 11 | Taxiarchis FOUNTAS (D.C. United) | |
| 10 | Dejan JOVELJIĆ (LA Galaxy, 2p) | |
| +1 | Sebastián FERREIRA (Houston Dynamo, 1p) | |
| Emanuel REYNOSO (Minnesota United, 3p) | ||
| +1 | Mikael UHRE (Philadelphia Union) | |
| 9 | Jarosław NIEZGODA (Portland Timbers) | |
| Maximiliano URRUTI (Austin FC) | ||
| BRENNER Souza (FC Cincinnati) | ||
| +1 | Ercan KARA (Orlando City, 1p) | |
| Luis AMARILLA (Minnesota United) | ||
| Paul ARRIOLA (FC Dallas) | ||
| +2 | Ola KAMARA (D.C. United, 1p) | |
| +1 | Gyasi ZARDES (Colorado Rapids, 1p) | |
| Jonathan OSORIO (Toronto FC) | ||
| +1 | Jesús JIMÉNEZ (Toronto FC) | |
| Gonzalo HIGUAÍN (Inter Miami, 3p) |
| Sunday, 28 August 2022 | |||||
| New England Revolution | 1-2 | LA Galaxy | |||
| 82 | Carles Gil | 4 | Aguirre | ||
| 15 | Hernández | ||||
| Orlando City | 2-1 | New York City | |||
| 7 | Júnior Urso | 53 | Moralez | ||
| 90 | Akindele | ||||
| Atlanta United | 3-2 | D.C. United | |||
| 49 | Franco | 47 | Morrison | ||
| 62 | Martínez | 55 | Kamara | ||
| 70 | Sánchez | ||||
| Wednesday, 31 August 2022 | |||||
| Houston Dynamo | 2-1 | Los Angeles | |||
| 13(p) | Ferreira | 19 | Arango | ||
| 75 | Dorsey | ||||
| Columbus Crew | 1-0 | Inter Miami | |||
| 64 | Díaz | ||||
| New England Revolution | 0-0 | Chicago Fire | |||
| CF Montréal | 0-1 | New York Red Bulls | |||
| 43 | Morgan | ||||
| Real Salt Lake | 3-0 | Minnesota United | |||
| 7 | Córdova | ||||
| 23 | Savarino | ||||
| 79 | Julio | ||||
| Toronto FC | 2-2 | LA Galaxy | |||
| 62 | Jiménez | 24 | Douglas Costa | ||
| 81(p) | Bernardeschi | 89 | Riqui Puig | ||
| Orlando City | 3-2 | Seattle Sounders | |||
| 53 | Torres | 26 | Rusnák | ||
| 68(p) | Kara | 52 | Ruidíaz | ||
| 90 | Smith | ||||
| Philadelphia Union | 4-1 | Atlanta United | |||
| 18 | Carranza | 24 | Gutman | ||
| 45 | Uhre | ||||
| 67 | Gazdag | ||||
| 90 | Harriel | ||||
| Austin FC | 1-2 | Portland Timbers | |||
| 79 | Driussi | 16 | Tuiloma | ||
| 73 | McGraw | ||||
| Nashville | 4-1 | Colorado Rapids | |||
| 29(p) | Mukhtar | 35 | Zardes | ||
| 54 | Mukhtar | ||||
| 61 | Shaffelburg | ||||
| 75 | Mukhtar | ||||
| New York City | 1-2 | D.C. United | |||
| 27 | Héber | 24 | Kamara | ||
| 57 | Birnbaum | ||||