Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 406 | 1,199 | 2.95 | 193 | 47.54% | 102 | 25.12% | 111 | 27.34% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 30 | 17 | 9 | 4 | 63 | 21 | +42 | 60 | WWWW | 15 | 10 | 5 | 0 | 40 | 8 | 15 | 7 | 4 | 4 | 23 | 13 | ||
| 2 | CF Montréal | 29 | 16 | 4 | 9 | 53 | 45 | +8 | 52 | WLWW | 14 | 7 | 2 | 5 | 24 | 17 | 15 | 9 | 2 | 4 | 29 | 28 | ||
| 3 | New York Red Bulls | 30 | 13 | 8 | 9 | 45 | 36 | +9 | 47 | LWWX | 15 | 4 | 5 | 6 | 22 | 21 | 15 | 9 | 3 | 3 | 23 | 15 | ||
| 4 | New York City | 29 | 13 | 6 | 10 | 50 | 37 | +13 | 45 | LLLW | 14 | 8 | 3 | 3 | 32 | 17 | 15 | 5 | 3 | 7 | 18 | 20 | ||
| 5 | Orlando City | 28 | 12 | 6 | 10 | 35 | 40 | -5 | 42 | WWWW | 14 | 7 | 0 | 7 | 20 | 26 | 14 | 5 | 6 | 3 | 15 | 14 | ||
| 6 | Columbus Crew | 28 | 9 | 13 | 6 | 37 | 31 | +6 | 40 | OWXX | 15 | 6 | 5 | 4 | 19 | 13 | 13 | 3 | 8 | 2 | 18 | 18 | ||
| 7 | 2 | New England Revolution | 29 | 9 | 11 | 9 | 42 | 42 | +0 | 38 | WOLL | 15 | 6 | 6 | 3 | 20 | 14 | 14 | 3 | 5 | 6 | 22 | 28 | |
| 8 | FC Cincinnati | 28 | 9 | 11 | 8 | 47 | 48 | -1 | 38 | WXXX | 15 | 5 | 6 | 4 | 29 | 24 | 13 | 4 | 5 | 4 | 18 | 24 | ||
| 9 | 2 | Inter Miami | 28 | 10 | 6 | 12 | 35 | 46 | -11 | 36 | LLWW | 14 | 8 | 3 | 3 | 27 | 23 | 14 | 2 | 3 | 9 | 8 | 23 | |
| 10 | Toronto FC | 30 | 9 | 7 | 14 | 47 | 53 | -6 | 34 | LXWL | 16 | 7 | 3 | 6 | 30 | 28 | 14 | 2 | 4 | 8 | 17 | 25 | ||
| 11 | Atlanta United | 29 | 8 | 9 | 12 | 41 | 48 | -7 | 33 | LLWX | 14 | 7 | 4 | 3 | 26 | 20 | 15 | 1 | 5 | 9 | 15 | 28 | ||
| 12 | Charlotte FC | 29 | 10 | 2 | 17 | 34 | 46 | -12 | 32 | LLLW | 14 | 8 | 0 | 6 | 21 | 14 | 15 | 2 | 2 | 11 | 13 | 32 | ||
| 13 | Chicago Fire | 29 | 8 | 8 | 13 | 28 | 38 | -10 | 32 | OOLL | 14 | 5 | 4 | 5 | 12 | 12 | 15 | 3 | 4 | 8 | 16 | 26 | ||
| 14 | D.C. United | 29 | 7 | 5 | 17 | 32 | 59 | -27 | 26 | OWLL | 15 | 4 | 4 | 7 | 18 | 26 | 14 | 3 | 1 | 10 | 14 | 33 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 29 | 19 | 3 | 7 | 59 | 32 | +27 | 60 | WLLL | 15 | 12 | 2 | 1 | 36 | 13 | 14 | 7 | 1 | 6 | 23 | 19 | ||
| 2 | Austin FC | 29 | 15 | 6 | 8 | 60 | 42 | +18 | 51 | LLWL | 14 | 7 | 4 | 3 | 37 | 21 | 15 | 8 | 2 | 5 | 23 | 21 | ||
| 3 | 1 | FC Dallas | 30 | 12 | 10 | 8 | 43 | 33 | +10 | 46 | WXLW | 15 | 8 | 4 | 3 | 24 | 13 | 15 | 4 | 6 | 5 | 19 | 20 | |
| 4 | 1 | Nashville | 30 | 12 | 9 | 9 | 48 | 37 | +11 | 45 | WWWW | 15 | 6 | 5 | 4 | 28 | 18 | 15 | 6 | 4 | 5 | 20 | 19 | |
| 5 | 2 | Minnesota United | 29 | 13 | 5 | 11 | 44 | 43 | +1 | 44 | LLWW | 15 | 7 | 4 | 4 | 24 | 19 | 14 | 6 | 1 | 7 | 20 | 24 | |
| 6 | Real Salt Lake | 29 | 11 | 9 | 9 | 38 | 38 | +0 | 42 | LWXX | 14 | 8 | 4 | 2 | 23 | 12 | 15 | 3 | 5 | 7 | 15 | 26 | ||
| 7 | Portland Timbers | 30 | 10 | 12 | 8 | 49 | 47 | +2 | 42 | WWWL | 15 | 7 | 6 | 2 | 26 | 17 | 15 | 3 | 6 | 6 | 23 | 30 | ||
| 8 | LA Galaxy | 28 | 11 | 6 | 11 | 46 | 42 | +4 | 39 | XXWX | 15 | 7 | 3 | 5 | 30 | 23 | 13 | 4 | 3 | 6 | 16 | 19 | ||
| 9 | 1 | Seattle Sounders | 29 | 11 | 3 | 15 | 40 | 40 | +0 | 36 | WLLX | 14 | 8 | 1 | 5 | 23 | 16 | 15 | 3 | 2 | 10 | 17 | 24 | |
| 10 | 1 | Vancouver Whitecaps | 29 | 9 | 7 | 13 | 32 | 51 | -19 | 34 | LLXW | 14 | 7 | 3 | 4 | 18 | 19 | 15 | 2 | 4 | 9 | 14 | 32 | |
| 11 | Colorado Rapids | 29 | 8 | 9 | 12 | 38 | 50 | -12 | 33 | OLLX | 14 | 7 | 5 | 2 | 23 | 13 | 15 | 1 | 4 | 10 | 15 | 37 | ||
| 12 | 1 | Sporting Kansas City | 29 | 8 | 6 | 15 | 33 | 51 | -18 | 30 | XWWL | 14 | 6 | 2 | 6 | 17 | 16 | 15 | 2 | 4 | 9 | 16 | 35 | |
| 13 | 1 | San Jose Earthquakes | 28 | 7 | 9 | 12 | 44 | 55 | -11 | 30 | WLWL | 14 | 6 | 5 | 3 | 26 | 23 | 14 | 1 | 4 | 9 | 18 | 32 | |
| 14 | 2 | Houston Dynamo | 29 | 8 | 5 | 16 | 36 | 48 | -12 | 29 | LWLX | 14 | 5 | 4 | 5 | 20 | 18 | 15 | 3 | 1 | 11 | 16 | 30 | |
| 21 | +2 | Hany MUKHTAR (Nashville, 4p) |
| 20 | Sebastián DRIUSSI (Austin FC, 3p) | |
| 18 | +1 | Dániel GAZDAG (Philadelphia Union, 5p) |
| 16 | +1 | Jesús FERREIRA (FC Dallas) |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 15 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| +1 | Cristian ARANGO (Los Angeles, 1p) | |
| Rommel QUIOTO (CF Montréal, 4p) | ||
| 14 | Julián CARRANZA (Philadelphia Union, 2p) | |
| +2 | Javier HERNÁNDEZ (LA Galaxy, 3p) | |
| 13 | Lewis MORGAN (New York Red Bulls, 5p) | |
| Valentín CASTELLANOS (New York City, 5p) | ||
| 12 | Diego RUBIO (Colorado Rapids, 3p) | |
| 11 | Taxiarchis FOUNTAS (D.C. United) | |
| +1 | Mikael UHRE (Philadelphia Union) | |
| 10 | Dejan JOVELJIĆ (LA Galaxy, 2p) | |
| Sebastián FERREIRA (Houston Dynamo, 1p) | ||
| Emanuel REYNOSO (Minnesota United, 3p) | ||
| 9 | Jarosław NIEZGODA (Portland Timbers) | |
| Maximiliano URRUTI (Austin FC) | ||
| BRENNER Souza (FC Cincinnati) | ||
| Ercan KARA (Orlando City, 1p) | ||
| Luis AMARILLA (Minnesota United) | ||
| Paul ARRIOLA (FC Dallas) | ||
| Ola KAMARA (D.C. United, 1p) | ||
| Gyasi ZARDES (Colorado Rapids, 1p) | ||
| Jonathan OSORIO (Toronto FC) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| Gonzalo HIGUAÍN (Inter Miami, 3p) |
| Saturday, 3 September 2022 | |||||
| New York Red Bulls | 0-2 | Philadelphia Union | |||
| 48 | Uhre | ||||
| 74 | Gazdag | ||||
| Columbus Crew | 0-0 | Chicago Fire | |||
| Minnesota United | 0-3 | FC Dallas | |||
| 55(og) | Boxall | ||||
| 56 | Velasco | ||||
| 58 | Ferreira | ||||
| Nashville | 3-0 | Austin FC | |||
| 49 | Zimmerman | ||||
| 82 | Mukhtar | ||||
| 90 | Mukhtar | ||||
| FC Cincinnati | 2-0 | Charlotte FC | |||
| 38 | Hagglund | ||||
| 81 | Acosta | ||||
| Sunday, 4 September 2022 | |||||
| D.C. United | 0-0 | Colorado Rapids | |||
| New England Revolution | 3-0 | New York City | |||
| 12 | Bell | ||||
| 33 | Buck | ||||
| 66 | McNamara | ||||
| LA Galaxy | 2-2 | Sporting Kansas City | |||
| 4 | Hernández | 67(p) | Russell | ||
| 88(p) | Hernández | 76 | Hernández | ||
| Portland Timbers | 2-1 | Atlanta United | |||
| 38(p) | Moreno | 88 | Martínez | ||
| 82(p) | Asprilla | ||||
| Seattle Sounders | 2-1 | Houston Dynamo | |||
| 59 | Tolo | 26 | Steres | ||
| 76 | Montero | ||||
| Toronto FC | 3-4 | CF Montréal | |||
| 5(p) | Bernardeschi | 19 | Miller | ||
| 7 | Insigne | 21 | Mihailovic | ||
| 90 | Insigne | 43 | Kamara | ||
| 54 | Johnston | ||||
| San Jose Earthquakes | 2-0 | Vancouver Whitecaps | |||
| 4 | Ebobisse | ||||
| 34 | Monteiro | ||||
| Los Angeles | 2-0 | Real Salt Lake | |||
| 49 | Hollingshead | ||||
| 68 | Arango | ||||
