Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 179 | 490 | 2.73 | 87 | 48.60% | 45 | 25.14% | 47 | 26.26% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 13 | 6 | 6 | 1 | 18 | 9 | +9 | 24 | WOXX | 7 | 3 | 4 | 0 | 8 | 3 | 6 | 3 | 2 | 1 | 10 | 6 | ||
| 2 | New York City | 12 | 7 | 2 | 3 | 24 | 10 | +14 | 23 | WWWO | 8 | 6 | 1 | 1 | 21 | 7 | 4 | 1 | 1 | 2 | 3 | 3 | ||
| 3 | 1 | Orlando City | 13 | 6 | 3 | 4 | 16 | 17 | -1 | 21 | XWLW | 6 | 3 | 0 | 3 | 8 | 10 | 7 | 3 | 3 | 1 | 8 | 7 | |
| 4 | 1 | CF Montréal | 13 | 6 | 2 | 5 | 24 | 23 | +1 | 20 | LLWW | 5 | 3 | 0 | 2 | 10 | 7 | 8 | 3 | 2 | 3 | 14 | 16 | |
| 5 | New York Red Bulls | 13 | 5 | 5 | 3 | 20 | 14 | +6 | 20 | LXXX | 6 | 0 | 4 | 2 | 6 | 8 | 7 | 5 | 1 | 1 | 14 | 6 | ||
| 6 | FC Cincinnati | 13 | 6 | 1 | 6 | 18 | 21 | -3 | 19 | LWWW | 6 | 2 | 0 | 4 | 11 | 11 | 7 | 4 | 1 | 2 | 7 | 10 | ||
| 7 | 2 | Charlotte FC | 13 | 5 | 1 | 7 | 12 | 16 | -4 | 16 | WLWL | 7 | 5 | 0 | 2 | 9 | 5 | 6 | 0 | 1 | 5 | 3 | 11 | |
| 8 | 1 | Atlanta United | 12 | 4 | 4 | 4 | 19 | 18 | +1 | 16 | XXWL | 6 | 3 | 3 | 0 | 14 | 8 | 6 | 1 | 1 | 4 | 5 | 10 | |
| 9 | 2 | New England Revolution | 12 | 4 | 3 | 5 | 21 | 22 | -1 | 15 | WXXW | 6 | 3 | 1 | 2 | 9 | 7 | 6 | 1 | 2 | 3 | 12 | 15 | |
| 10 | 2 | Inter Miami | 13 | 4 | 3 | 6 | 13 | 21 | -8 | 15 | WOXL | 7 | 3 | 2 | 2 | 10 | 10 | 6 | 1 | 1 | 4 | 3 | 11 | |
| 11 | 3 | D.C. United | 12 | 4 | 2 | 6 | 16 | 19 | -3 | 14 | XLXW | 8 | 3 | 1 | 4 | 12 | 12 | 4 | 1 | 1 | 2 | 4 | 7 | |
| 12 | 2 | Columbus Crew | 12 | 3 | 4 | 5 | 15 | 15 | +0 | 13 | LLXW | 6 | 3 | 0 | 3 | 9 | 6 | 6 | 0 | 4 | 2 | 6 | 9 | |
| 13 | Toronto FC | 13 | 3 | 3 | 7 | 18 | 25 | -7 | 12 | XLLL | 6 | 3 | 0 | 3 | 8 | 10 | 7 | 0 | 3 | 4 | 10 | 15 | ||
| 14 | Chicago Fire | 13 | 2 | 5 | 6 | 11 | 17 | -6 | 11 | LXLL | 6 | 1 | 3 | 2 | 5 | 5 | 7 | 1 | 2 | 4 | 6 | 12 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Los Angeles | 13 | 8 | 2 | 3 | 26 | 14 | +12 | 26 | WLLX | 7 | 4 | 2 | 1 | 15 | 7 | 6 | 4 | 0 | 2 | 11 | 7 | |
| 2 | 1 | Austin FC | 13 | 7 | 3 | 3 | 27 | 14 | +13 | 24 | XWLL | 7 | 4 | 2 | 1 | 17 | 5 | 6 | 3 | 1 | 2 | 10 | 9 | |
| 3 | FC Dallas | 13 | 6 | 4 | 3 | 21 | 12 | +9 | 22 | LLWW | 7 | 5 | 1 | 1 | 15 | 6 | 6 | 1 | 3 | 2 | 6 | 6 | ||
| 4 | 1 | Real Salt Lake | 13 | 6 | 4 | 3 | 14 | 17 | -3 | 22 | WWLW | 5 | 4 | 1 | 0 | 8 | 4 | 8 | 2 | 3 | 3 | 6 | 13 | |
| 5 | 1 | LA Galaxy | 13 | 6 | 2 | 5 | 13 | 14 | -1 | 20 | LXLW | 6 | 3 | 0 | 3 | 5 | 8 | 7 | 3 | 2 | 2 | 8 | 6 | |
| 6 | Nashville | 13 | 5 | 4 | 4 | 15 | 15 | +0 | 19 | XWLW | 4 | 2 | 2 | 0 | 7 | 4 | 9 | 3 | 2 | 4 | 8 | 11 | ||
| 7 | Houston Dynamo | 13 | 5 | 3 | 5 | 17 | 14 | +3 | 18 | WLWL | 8 | 3 | 3 | 2 | 10 | 8 | 5 | 2 | 0 | 3 | 7 | 6 | ||
| 8 | 1 | Minnesota United | 13 | 5 | 3 | 5 | 15 | 14 | +1 | 18 | WXLL | 7 | 3 | 2 | 2 | 10 | 6 | 6 | 2 | 1 | 3 | 5 | 8 | |
| 9 | 1 | Colorado Rapids | 13 | 5 | 3 | 5 | 15 | 14 | +1 | 18 | WLWL | 7 | 5 | 2 | 0 | 11 | 1 | 6 | 0 | 1 | 5 | 4 | 13 | |
| 10 | Portland Timbers | 14 | 3 | 6 | 5 | 20 | 23 | -3 | 15 | LLWX | 7 | 2 | 3 | 2 | 12 | 10 | 7 | 1 | 3 | 3 | 8 | 13 | ||
| 11 | 1 | San Jose Earthquakes | 13 | 3 | 5 | 5 | 23 | 29 | -6 | 14 | XWXW | 8 | 3 | 4 | 1 | 17 | 16 | 5 | 0 | 1 | 4 | 6 | 13 | |
| 12 | 1 | Seattle Sounders | 11 | 4 | 1 | 6 | 13 | 15 | -2 | 13 | LWWL | 4 | 2 | 0 | 2 | 6 | 5 | 7 | 2 | 1 | 4 | 7 | 10 | |
| 13 | Sporting Kansas City | 14 | 3 | 4 | 7 | 13 | 25 | -12 | 13 | XWLO | 6 | 3 | 2 | 1 | 7 | 5 | 8 | 0 | 2 | 6 | 6 | 20 | ||
| 14 | Vancouver Whitecaps | 12 | 3 | 2 | 7 | 13 | 23 | -10 | 11 | LWXW | 6 | 3 | 2 | 1 | 9 | 7 | 6 | 0 | 0 | 6 | 4 | 16 | ||
| 9 | Jesús FERREIRA (FC Dallas) | |
| 8 | +1 | Sebastián DRIUSSI (Austin FC, 2p) |
| 7 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| +1 | Dániel GAZDAG (Philadelphia Union, 1p) | |
| Valentín CASTELLANOS (New York City, 3p) | ||
| +1 | Djordje MIHAILOVIC (CF Montréal) | |
| +1 | Adam BUKSA (New England Revolution) | |
| +1 | Brandon VÁZQUEZ (FC Cincinnati) | |
| Jesús JIMÉNEZ (Toronto FC) | ||
| 6 | +1 | Carlos VELA (Los Angeles, 2p) |
| +1 | Robin LOD (Minnesota United) | |
| Leonardo CAMPANA (Inter Miami) | ||
| Diego RUBIO (Colorado Rapids, 1p) | ||
| 5 | Lewis MORGAN (New York Red Bulls, 2p) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| +1 | Sebastián FERREIRA (Houston Dynamo) | |
| +1 | Paul ARRIOLA (FC Dallas) | |
| Ola KAMARA (D.C. United, 1p) | ||
| Darwin QUINTERO (Houston Dynamo, 1p) | ||
| Taxiarchis FOUNTAS (D.C. United) | ||
| Luciano ACOSTA (FC Cincinnati, 2p) |
| Saturday, 21 May 2022 | |||||
| D.C. United | 2-2 | Toronto FC | |||
| 7 | Flores | 36 | Akinola | ||
| 56 | Estrada | 89 | Osorio | ||
| Columbus Crew | 0-2 | Los Angeles | |||
| 62 | Vela | ||||
| 73 | Cifuentes | ||||
| Nashville | 2-2 | Atlanta United | |||
| 24 | Sapong | 26 | Almada | ||
| 31 | Mukhtar | 88 | Dwyer | ||
| FC Cincinnati | 2-3 | New England Revolution | |||
| 26 | Vázquez | 17 | Lletget | ||
| 58 | Barreal | 43 | Buksa | ||
| 89 | McNamara | ||||
| Sunday, 22 May 2022 | |||||
| FC Dallas | 1-2 | Minnesota United | |||
| 59 | Arriola | 20 | Lod | ||
| 55 | Taylor | ||||
| Colorado Rapids | 1-0 | Seattle Sounders | |||
| 50 | Lewis | ||||
| LA Galaxy | 0-3 | Houston Dynamo | |||
| 11 | Ferreira | ||||
| 58 | Pasher | ||||
| 62 | Úlfarsson | ||||
| CF Montréal | 1-2 | Real Salt Lake | |||
| 1 | Mihailovic | 54 | Glad | ||
| 66 | Córdova | ||||
| Portland Timbers | 0-2 | Philadelphia Union | |||
| 5 | Gazdag | ||||
| 48 | Santos | ||||
| San Jose Earthquakes | 1-1 | Sporting Kansas City | |||
| 46 | Yueill | 45 | Russell | ||
| Austin FC | 2-2 | Orlando City | |||
| 63(p) | Driussi | 2 | Kara | ||
| 90 | Djitté | 22 | Ruan | ||
| New York City | 1-0 | Chicago Fire | |||
| 23(p) | Héber | ||||
| Inter Miami | 2-0 | New York Red Bulls | |||
| 29 | Lassiter | ||||
| 88 | Taylor | ||||
| Charlotte FC | 2-1 | Vancouver Whitecaps | |||
| 8 | André Bava | 2 | Ricketts | ||
| 85 | Rios | ||||
