Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 334 | 964 | 2.88 | 155 | 46.41% | 87 | 26.05% | 92 | 27.54% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 24 | 12 | 9 | 3 | 41 | 18 | +23 | 45 | LWWW | 12 | 7 | 5 | 0 | 26 | 6 | 12 | 5 | 4 | 3 | 15 | 12 | ||
| 2 | New York City | 23 | 12 | 6 | 5 | 43 | 24 | +19 | 42 | LOWW | 12 | 8 | 3 | 1 | 30 | 12 | 11 | 4 | 3 | 4 | 13 | 12 | ||
| 3 | CF Montréal | 24 | 12 | 4 | 8 | 40 | 39 | +1 | 40 | XWOW | 12 | 6 | 2 | 4 | 20 | 16 | 12 | 6 | 2 | 4 | 20 | 23 | ||
| 4 | New York Red Bulls | 24 | 10 | 7 | 7 | 38 | 30 | +8 | 37 | OLWL | 11 | 3 | 4 | 4 | 18 | 16 | 13 | 7 | 3 | 3 | 20 | 14 | ||
| 5 | 1 | Columbus Crew | 23 | 8 | 9 | 6 | 31 | 26 | +5 | 33 | WLOW | 12 | 5 | 3 | 4 | 16 | 11 | 11 | 3 | 6 | 2 | 15 | 15 | |
| 6 | 1 | FC Cincinnati | 24 | 8 | 8 | 8 | 40 | 43 | -3 | 32 | WXXL | 12 | 4 | 4 | 4 | 23 | 20 | 12 | 4 | 4 | 4 | 17 | 23 | |
| 7 | 1 | Chicago Fire | 24 | 8 | 6 | 10 | 27 | 30 | -3 | 30 | WOWW | 12 | 5 | 4 | 3 | 12 | 8 | 12 | 3 | 2 | 7 | 15 | 22 | |
| 8 | 3 | Orlando City | 24 | 8 | 6 | 10 | 27 | 36 | -9 | 30 | LLLX | 12 | 5 | 0 | 7 | 15 | 23 | 12 | 3 | 6 | 3 | 12 | 13 | |
| 9 | 2 | Inter Miami | 24 | 8 | 6 | 10 | 29 | 39 | -10 | 30 | XWXL | 12 | 6 | 3 | 3 | 22 | 20 | 12 | 2 | 3 | 7 | 7 | 19 | |
| 10 | 1 | New England Revolution | 23 | 7 | 9 | 7 | 35 | 34 | +1 | 30 | WOOL | 11 | 4 | 5 | 2 | 15 | 12 | 12 | 3 | 4 | 5 | 20 | 22 | |
| 11 | 1 | Charlotte FC | 24 | 9 | 2 | 13 | 30 | 34 | -4 | 29 | LWLL | 12 | 8 | 0 | 4 | 20 | 10 | 12 | 1 | 2 | 9 | 10 | 24 | |
| 12 | Atlanta United | 23 | 7 | 7 | 9 | 31 | 34 | -3 | 28 | WOLX | 12 | 6 | 4 | 2 | 22 | 16 | 11 | 1 | 3 | 7 | 9 | 18 | ||
| 13 | Toronto FC | 24 | 7 | 5 | 12 | 34 | 42 | -8 | 26 | WOWL | 12 | 6 | 1 | 5 | 20 | 19 | 12 | 1 | 4 | 7 | 14 | 23 | ||
| 14 | D.C. United | 23 | 6 | 4 | 13 | 28 | 47 | -19 | 22 | OLWL | 13 | 4 | 3 | 6 | 18 | 20 | 10 | 2 | 1 | 7 | 10 | 27 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 23 | 16 | 3 | 4 | 48 | 24 | +24 | 51 | WWWW | 12 | 9 | 2 | 1 | 28 | 13 | 11 | 7 | 1 | 3 | 20 | 11 | ||
| 2 | Austin FC | 24 | 13 | 6 | 5 | 50 | 31 | +19 | 45 | XWLX | 11 | 5 | 4 | 2 | 28 | 15 | 13 | 8 | 2 | 3 | 22 | 16 | ||
| 3 | 1 | FC Dallas | 25 | 9 | 9 | 7 | 34 | 27 | +7 | 36 | XLWW | 12 | 6 | 3 | 3 | 18 | 11 | 13 | 3 | 6 | 4 | 16 | 16 | |
| 4 | 1 | Minnesota United | 24 | 10 | 5 | 9 | 38 | 34 | +4 | 35 | LXWW | 12 | 5 | 4 | 3 | 20 | 14 | 12 | 5 | 1 | 6 | 18 | 20 | |
| 5 | Real Salt Lake | 24 | 9 | 7 | 8 | 31 | 33 | -2 | 34 | LXLW | 12 | 7 | 3 | 2 | 19 | 11 | 12 | 2 | 4 | 6 | 12 | 22 | ||
| 6 | 1 | Nashville | 25 | 8 | 9 | 8 | 33 | 34 | -1 | 33 | LXXX | 11 | 3 | 5 | 3 | 16 | 15 | 14 | 5 | 4 | 5 | 17 | 19 | |
| 7 | 1 | Portland Timbers | 25 | 7 | 12 | 6 | 41 | 37 | +4 | 33 | XXXW | 13 | 5 | 6 | 2 | 22 | 15 | 12 | 2 | 6 | 4 | 19 | 22 | |
| 8 | 2 | Seattle Sounders | 24 | 10 | 2 | 12 | 31 | 29 | +2 | 32 | LWLW | 12 | 7 | 1 | 4 | 20 | 13 | 12 | 3 | 1 | 8 | 11 | 16 | |
| 9 | LA Galaxy | 23 | 9 | 3 | 11 | 32 | 32 | +0 | 30 | LLWL | 12 | 6 | 1 | 5 | 20 | 16 | 11 | 3 | 2 | 6 | 12 | 16 | ||
| 10 | Colorado Rapids | 23 | 8 | 6 | 9 | 34 | 36 | -2 | 30 | WWLW | 12 | 7 | 3 | 2 | 21 | 11 | 11 | 1 | 3 | 7 | 13 | 25 | ||
| 11 | Vancouver Whitecaps | 24 | 8 | 6 | 10 | 27 | 39 | -12 | 30 | WXLX | 12 | 6 | 3 | 3 | 16 | 15 | 12 | 2 | 3 | 7 | 11 | 24 | ||
| 12 | Houston Dynamo | 24 | 7 | 4 | 13 | 29 | 39 | -10 | 25 | LLLW | 12 | 4 | 4 | 4 | 16 | 14 | 12 | 3 | 0 | 9 | 13 | 25 | ||
| 13 | San Jose Earthquakes | 24 | 5 | 9 | 10 | 39 | 49 | -10 | 24 | XLXL | 12 | 4 | 5 | 3 | 22 | 22 | 12 | 1 | 4 | 7 | 17 | 27 | ||
| 14 | Sporting Kansas City | 25 | 6 | 5 | 14 | 23 | 44 | -21 | 23 | WLLL | 12 | 4 | 2 | 6 | 12 | 15 | 13 | 2 | 3 | 8 | 11 | 29 | ||
| 16 | +2 | Sebastián DRIUSSI (Austin FC, 2p) |
| 14 | +1 | Brandon VÁZQUEZ (FC Cincinnati) |
| 13 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| Valentín CASTELLANOS (New York City, 5p) | ||
| +1 | Hany MUKHTAR (Nashville, 3p) | |
| 12 | Jesús FERREIRA (FC Dallas) | |
| 11 | +2 | Cristian ARANGO (Los Angeles, 1p) |
| Dániel GAZDAG (Philadelphia Union, 3p) | ||
| +2 | Rommel QUIOTO (CF Montréal, 3p) | |
| Taxiarchis FOUNTAS (D.C. United) | ||
| +1 | Diego RUBIO (Colorado Rapids, 2p) | |
| 10 | Lewis MORGAN (New York Red Bulls, 5p) | |
| 9 | Jarosław NIEZGODA (Portland Timbers) | |
| Dejan JOVELJIĆ (LA Galaxy, 1p) | ||
| +2 | Javier HERNÁNDEZ (LA Galaxy, 1p) | |
| Paul ARRIOLA (FC Dallas) | ||
| Emanuel REYNOSO (Minnesota United, 2p) | ||
| 8 | Julián CARRANZA (Philadelphia Union, 1p) | |
| +1 | Lucas CAVALLINI (Vancouver Whitecaps, 2p) | |
| +1 | BRENNER Souza (FC Cincinnati) | |
| +3 | Lucas ZELARAYÁN (Columbus Crew, 1p) | |
| +1 | Luis AMARILLA (Minnesota United) | |
| +2 | Jonathan OSORIO (Toronto FC) | |
| Leonardo CAMPANA (Inter Miami) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| +1 | Gonzalo HIGUAÍN (Inter Miami, 3p) | |
| Mikael UHRE (Philadelphia Union) |
| Wednesday, 3 August 2022 | |||||
| Columbus Crew | 1-2 | CF Montréal | |||
| 14 | Zelarayán | 88 | Kamara | ||
| 90 | Waterman | ||||
| Portland Timbers | 1-1 | Nashville | |||
| 27 | Moreno | 20 | Bunbury | ||
| San Jose Earthquakes | 0-1 | Inter Miami | |||
| 12 | Jean Mota | ||||
| Charlotte FC | 3-0 | D.C. United | |||
| 13(og) | Birnbaum | ||||
| 64 | Świderski | ||||
| 67 | McNeill | ||||
| Friday, 5 August 2022 | |||||
| Vancouver Whitecaps | 2-1 | Houston Dynamo | |||
| 88 | Becher | 6 | Picault | ||
| 90 | Cavallini | ||||
| Saturday, 6 August 2022 | |||||
| D.C. United | 0-0 | New York Red Bulls | |||
| Colorado Rapids | 4-3 | Minnesota United | |||
| 7 | Zardes | 4 | Danladi | ||
| 11 | Rubio | 43 | Amarilla | ||
| 15 | Zardes | 81 | Kallman | ||
| 61 | Zardes | ||||
| Columbus Crew | 3-2 | New York City | |||
| 20 | Cucho | 3(og) | Mensah | ||
| 27 | Zelarayán | 64 | Gabriel Pereira | ||
| 75 | Zelarayán | ||||
| Sporting Kansas City | 4-2 | LA Galaxy | |||
| 10 | Thommy | 83 | Hernández | ||
| 40 | Agada | 90(p) | Hernández | ||
| 45 | Agada | ||||
| 90 | Sallói | ||||
| CF Montréal | 2-2 | Inter Miami | |||
| 5 | Quioto | 6 | Higuaín | ||
| 21(p) | Quioto | 79 | Rodríguez | ||
| Portland Timbers | 1-1 | FC Dallas | |||
| 90 | Loría | 90(og) | Chará | ||
| Real Salt Lake | 1-4 | Los Angeles | |||
| 12 | Córdova | 9 | Arango | ||
| 17 | Acosta | ||||
| 60 | Arango | ||||
| 87 | Bale | ||||
| Orlando City | 0-3 | New England Revolution | |||
| 20 | Polster | ||||
| 51 | Kaptoum | ||||
| 75 | Kessler | ||||
| Austin FC | 3-3 | San Jose Earthquakes | |||
| 6 | Cascante | 8 | Kikanovic | ||
| 26 | Driussi | 20 | Marie | ||
| 44 | Driussi | 88 | Ebobisse | ||
| Nashville | 3-4 | Toronto FC | |||
| 41(p) | Mukhtar | 19 | Osorio | ||
| 45 | Bunbury | 44 | Osorio | ||
| 84 | Zimmerman | 54(p) | Bernardeschi | ||
| 77 | Insigne | ||||
| Atlanta United | 2-1 | Seattle Sounders | |||
| 23 | Cisneros | 68 | Roldan | ||
| 90 | Gutman | ||||
| FC Cincinnati | 3-1 | Philadelphia Union | |||
| 50 | Vázquez | 77 | Aaronson | ||
| 55 | Brenner | ||||
| 71 | Barreal | ||||
| Charlotte FC | 2-3 | Chicago Fire | |||
| 1 | Reyna | 21 | Przybyłko | ||
| 45 | Świderski | 24 | Navarro | ||
| 52 | Przybyłko | ||||
