Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 97 | 256 | 2.63 | 46 | 47.42% | 24 | 24.74% | 27 | 27.84% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 7 | 5 | 1 | 1 | 11 | 4 | +7 | 16 | LWWW | 4 | 3 | 1 | 0 | 6 | 1 | 3 | 2 | 0 | 1 | 5 | 3 | ||
| 2 | Orlando City | 8 | 4 | 2 | 2 | 10 | 7 | +3 | 14 | WWLX | 4 | 2 | 0 | 2 | 6 | 6 | 4 | 2 | 2 | 0 | 4 | 1 | ||
| 3 | New York Red Bulls | 7 | 3 | 2 | 2 | 10 | 6 | +4 | 11 | OLWX | 4 | 0 | 2 | 2 | 2 | 4 | 3 | 3 | 0 | 0 | 8 | 2 | ||
| 4 | Atlanta United | 7 | 3 | 2 | 2 | 9 | 9 | +0 | 11 | OLWX | 4 | 2 | 2 | 0 | 8 | 5 | 3 | 1 | 0 | 2 | 1 | 4 | ||
| 5 | 2 | Toronto FC | 7 | 3 | 2 | 2 | 11 | 12 | -1 | 11 | WXWW | 4 | 3 | 0 | 1 | 7 | 7 | 3 | 0 | 2 | 1 | 4 | 5 | |
| 6 | 2 | CF Montréal | 7 | 3 | 1 | 3 | 13 | 16 | -3 | 10 | WWWX | 2 | 1 | 0 | 1 | 3 | 3 | 5 | 2 | 1 | 2 | 10 | 13 | |
| 7 | 2 | Chicago Fire | 7 | 2 | 4 | 1 | 5 | 2 | +3 | 10 | OLOW | 4 | 1 | 3 | 0 | 3 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | |
| 8 | 2 | Charlotte FC | 8 | 3 | 0 | 5 | 8 | 11 | -3 | 9 | LWLW | 4 | 3 | 0 | 1 | 6 | 2 | 4 | 0 | 0 | 4 | 2 | 9 | |
| 9 | 3 | Columbus Crew | 7 | 2 | 2 | 3 | 10 | 9 | +1 | 8 | LLLX | 4 | 2 | 0 | 2 | 6 | 4 | 3 | 0 | 2 | 1 | 4 | 5 | |
| 10 | 3 | New England Revolution | 7 | 2 | 1 | 4 | 10 | 13 | -3 | 7 | WLLL | 4 | 2 | 0 | 2 | 5 | 5 | 3 | 0 | 1 | 2 | 5 | 8 | |
| 11 | FC Cincinnati | 7 | 2 | 1 | 4 | 8 | 14 | -6 | 7 | OLLW | 3 | 1 | 0 | 2 | 6 | 6 | 4 | 1 | 1 | 2 | 2 | 8 | ||
| 12 | 2 | Inter Miami | 7 | 2 | 1 | 4 | 7 | 15 | -8 | 7 | WWLL | 4 | 1 | 1 | 2 | 4 | 7 | 3 | 1 | 0 | 2 | 3 | 8 | |
| 13 | 4 | D.C. United | 6 | 2 | 0 | 4 | 7 | 8 | -1 | 6 | LLLL | 4 | 1 | 0 | 3 | 5 | 6 | 2 | 1 | 0 | 1 | 2 | 2 | |
| 14 | 2 | New York City | 5 | 1 | 1 | 3 | 5 | 6 | -1 | 4 | LLWO | 2 | 1 | 0 | 1 | 4 | 3 | 3 | 0 | 1 | 2 | 1 | 3 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 7 | Austin FC | 7 | 4 | 2 | 1 | 17 | 7 | +10 | 14 | WWXX | 4 | 3 | 1 | 0 | 12 | 2 | 3 | 1 | 1 | 1 | 5 | 5 | |
| 2 | 1 | Los Angeles | 6 | 4 | 1 | 1 | 14 | 6 | +8 | 13 | LWWW | 3 | 2 | 1 | 0 | 7 | 2 | 3 | 2 | 0 | 1 | 7 | 4 | |
| 3 | 1 | LA Galaxy | 7 | 4 | 1 | 2 | 9 | 6 | +3 | 13 | OWWL | 3 | 2 | 0 | 1 | 3 | 2 | 4 | 2 | 1 | 1 | 6 | 4 | |
| 4 | FC Dallas | 7 | 3 | 3 | 1 | 10 | 4 | +6 | 12 | OWOW | 4 | 3 | 1 | 0 | 10 | 3 | 3 | 0 | 2 | 1 | 0 | 1 | ||
| 5 | Houston Dynamo | 7 | 3 | 3 | 1 | 10 | 7 | +3 | 12 | OWWX | 5 | 2 | 3 | 0 | 7 | 5 | 2 | 1 | 0 | 1 | 3 | 2 | ||
| 6 | 3 | Real Salt Lake | 7 | 3 | 3 | 1 | 9 | 7 | +2 | 12 | XXLW | 3 | 2 | 1 | 0 | 5 | 3 | 4 | 1 | 2 | 1 | 4 | 4 | |
| 7 | 2 | Minnesota United | 7 | 3 | 2 | 2 | 8 | 6 | +2 | 11 | WLLW | 4 | 2 | 1 | 1 | 6 | 4 | 3 | 1 | 1 | 1 | 2 | 2 | |
| 8 | 2 | Nashville | 7 | 3 | 2 | 2 | 8 | 8 | +0 | 11 | XWWL | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 2 | 8 | 8 | |
| 9 | 2 | Portland Timbers | 8 | 2 | 4 | 2 | 10 | 13 | -3 | 10 | OWLX | 4 | 1 | 2 | 1 | 5 | 6 | 4 | 1 | 2 | 1 | 5 | 7 | |
| 10 | Colorado Rapids | 7 | 2 | 2 | 3 | 9 | 11 | -2 | 8 | LLXX | 3 | 2 | 1 | 0 | 6 | 1 | 4 | 0 | 1 | 3 | 3 | 10 | ||
| 11 | Seattle Sounders | 6 | 2 | 1 | 3 | 6 | 7 | -1 | 7 | LWXW | 3 | 1 | 0 | 2 | 3 | 4 | 3 | 1 | 1 | 1 | 3 | 3 | ||
| 12 | Sporting Kansas City | 7 | 2 | 0 | 5 | 5 | 11 | -6 | 6 | LLWL | 3 | 2 | 0 | 1 | 3 | 2 | 4 | 0 | 0 | 4 | 2 | 9 | ||
| 13 | Vancouver Whitecaps | 7 | 1 | 1 | 5 | 6 | 14 | -8 | 4 | LLWL | 3 | 1 | 1 | 1 | 3 | 3 | 4 | 0 | 0 | 4 | 3 | 11 | ||
| 14 | San Jose Earthquakes | 7 | 0 | 3 | 4 | 11 | 17 | -6 | 3 | XLXL | 4 | 0 | 3 | 1 | 8 | 10 | 3 | 0 | 0 | 3 | 3 | 7 | ||
| 5 | +2 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Jesús FERREIRA (FC Dallas) | ||
| +1 | Sebastián DRIUSSI (Austin FC, 1p) | |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 4 | Karol ŚWIDERSKI (Charlotte FC) | |
| Dániel GAZDAG (Philadelphia Union, 1p) | ||
| +1 | Djordje MIHAILOVIC (CF Montréal) | |
| Lucas ZELARAYÁN (Columbus Crew) | ||
| +2 | Ola KAMARA (D.C. United, 1p) | |
| Carlos VELA (Los Angeles, 1p) | ||
| Darwin QUINTERO (Houston Dynamo) | ||
| Leonardo CAMPANA (Inter Miami) | ||
| +1 | Diego RUBIO (Colorado Rapids) | |
| +1 | Jesús JIMÉNEZ (Toronto FC) | |
| 3 | Lewis MORGAN (New York Red Bulls) | |
| +1 | Rommel QUIOTO (CF Montréal, 1p) | |
| CARLES GIL de Pareja (New England Revolution, 3p) | ||
| Yimmi CHARÁ (Portland Timbers) |
| Sunday, 10 April 2022 | |||||
| Austin FC | 1-0 | Minnesota United | |||
| 58 | Urruti | ||||
| Charlotte FC | 1-0 | Atlanta United | |||
| 11 | Alcivar | ||||
| Saturday, 16 April 2022 | |||||
| D.C. United | 2-3 | Austin FC | |||
| 26 | Kamara | 80 | Hoesen | ||
| 40 | Kamara | 85 | Driussi | ||
| 90 | Gabrielsen | ||||
| Houston Dynamo | 0-0 | Portland Timbers | |||
| New York Red Bulls | 0-0 | FC Dallas | |||
| Columbus Crew | 0-2 | Orlando City | |||
| 37 | Schlegel | ||||
| 51 | Kara | ||||
| New England Revolution | 2-1 | Charlotte FC | |||
| 8 | Buksa | 85 | Ortiz | ||
| 72 | Polster | ||||
| Chicago Fire | 0-0 | LA Galaxy | |||
| CF Montréal | 2-1 | Vancouver Whitecaps | |||
| 1 | Mihailovic | 65 | White | ||
| 47 | Quioto | ||||
| Seattle Sounders | 0-1 | Inter Miami | |||
| 41 | Robinson | ||||
| Toronto FC | 2-1 | Philadelphia Union | |||
| 39 | Jiménez | 34 | Carranza | ||
| 51 | Pozuelo | ||||
| San Jose Earthquakes | 2-2 | Nashville | |||
| 52 | Ebobisse | 38 | Mukhtar | ||
| 72 | Ebobisse | 63 | Mukhtar | ||
| Minnesota United | 3-1 | Colorado Rapids | |||
| 42 | Dibassy | 45 | Rubio | ||
| 77 | Lod | ||||
| 79 | Danladi | ||||
| Atlanta United | 0-0 | FC Cincinnati | |||
