Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 83 | 229 | 2.75 | 40 | 48.19% | 19 | 22.89% | 24 | 28.92% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 6 | 5 | 1 | 0 | 10 | 2 | +8 | 16 | WWWW | 4 | 3 | 1 | 0 | 6 | 1 | 2 | 2 | 0 | 0 | 4 | 1 | ||
| 2 | 4 | Orlando City | 7 | 3 | 2 | 2 | 8 | 7 | +1 | 11 | WLXW | 4 | 2 | 0 | 2 | 6 | 6 | 3 | 1 | 2 | 0 | 2 | 1 | |
| 3 | 1 | New York Red Bulls | 6 | 3 | 1 | 2 | 10 | 6 | +4 | 10 | LWXL | 3 | 0 | 1 | 2 | 2 | 4 | 3 | 3 | 0 | 0 | 8 | 2 | |
| 4 | 1 | Atlanta United | 5 | 3 | 1 | 1 | 9 | 8 | +1 | 10 | WXWL | 3 | 2 | 1 | 0 | 8 | 5 | 2 | 1 | 0 | 1 | 1 | 3 | |
| 5 | 1 | Chicago Fire | 6 | 2 | 3 | 1 | 5 | 2 | +3 | 9 | LOWW | 3 | 1 | 2 | 0 | 3 | 1 | 3 | 1 | 1 | 1 | 2 | 1 | |
| 6 | 1 | Columbus Crew | 6 | 2 | 2 | 2 | 10 | 7 | +3 | 8 | LLXW | 3 | 2 | 0 | 1 | 6 | 2 | 3 | 0 | 2 | 1 | 4 | 5 | |
| 7 | Toronto FC | 6 | 2 | 2 | 2 | 9 | 11 | -2 | 8 | XWWL | 3 | 2 | 0 | 1 | 5 | 6 | 3 | 0 | 2 | 1 | 4 | 5 | ||
| 8 | 5 | CF Montréal | 6 | 2 | 1 | 3 | 11 | 15 | -4 | 7 | WWXL | 1 | 0 | 0 | 1 | 1 | 2 | 5 | 2 | 1 | 2 | 10 | 13 | |
| 9 | 1 | D.C. United | 5 | 2 | 0 | 3 | 5 | 5 | +0 | 6 | LLLW | 3 | 1 | 0 | 2 | 3 | 3 | 2 | 1 | 0 | 1 | 2 | 2 | |
| 10 | 1 | Charlotte FC | 6 | 2 | 0 | 4 | 6 | 9 | -3 | 6 | LWWL | 3 | 2 | 0 | 1 | 5 | 2 | 3 | 0 | 0 | 3 | 1 | 7 | |
| 11 | 1 | FC Cincinnati | 6 | 2 | 0 | 4 | 8 | 14 | -6 | 6 | LLWW | 3 | 1 | 0 | 2 | 6 | 6 | 3 | 1 | 0 | 2 | 2 | 8 | |
| 12 | 1 | New York City | 5 | 1 | 1 | 3 | 5 | 6 | -1 | 4 | LLWO | 2 | 1 | 0 | 1 | 4 | 3 | 3 | 0 | 1 | 2 | 1 | 3 | |
| 13 | 1 | New England Revolution | 6 | 1 | 1 | 4 | 8 | 12 | -4 | 4 | LLLL | 3 | 1 | 0 | 2 | 3 | 4 | 3 | 0 | 1 | 2 | 5 | 8 | |
| 14 | Inter Miami | 6 | 1 | 1 | 4 | 6 | 15 | -9 | 4 | WLLL | 4 | 1 | 1 | 2 | 4 | 7 | 2 | 0 | 0 | 2 | 2 | 8 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 6 | 4 | 1 | 1 | 14 | 6 | +8 | 13 | LWWW | 3 | 2 | 1 | 0 | 7 | 2 | 3 | 2 | 0 | 1 | 7 | 4 | ||
| 2 | 8 | LA Galaxy | 6 | 4 | 0 | 2 | 9 | 6 | +3 | 12 | WWLL | 3 | 2 | 0 | 1 | 3 | 2 | 3 | 2 | 0 | 1 | 6 | 4 | |
| 3 | 1 | Real Salt Lake | 7 | 3 | 3 | 1 | 9 | 7 | +2 | 12 | XXLW | 3 | 2 | 1 | 0 | 5 | 3 | 4 | 1 | 2 | 1 | 4 | 4 | |
| 4 | FC Dallas | 6 | 3 | 2 | 1 | 10 | 4 | +6 | 11 | WOWW | 4 | 3 | 1 | 0 | 10 | 3 | 2 | 0 | 1 | 1 | 0 | 1 | ||
| 5 | 1 | Houston Dynamo | 6 | 3 | 2 | 1 | 10 | 7 | +3 | 11 | WWXW | 4 | 2 | 2 | 0 | 7 | 5 | 2 | 1 | 0 | 1 | 3 | 2 | |
| 6 | 3 | Nashville | 6 | 3 | 1 | 2 | 6 | 6 | +0 | 10 | WWLL | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 2 | 6 | 6 | |
| 7 | 5 | Portland Timbers | 7 | 2 | 3 | 2 | 10 | 13 | -3 | 9 | WLXL | 4 | 1 | 2 | 1 | 5 | 6 | 3 | 1 | 1 | 1 | 5 | 7 | |
| 8 | 5 | Austin FC | 5 | 2 | 2 | 1 | 13 | 5 | +8 | 8 | XXLW | 3 | 2 | 1 | 0 | 11 | 2 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 9 | 2 | Minnesota United | 5 | 2 | 2 | 1 | 5 | 4 | +1 | 8 | LWWX | 3 | 1 | 1 | 1 | 3 | 3 | 2 | 1 | 1 | 0 | 2 | 1 | |
| 10 | 5 | Colorado Rapids | 6 | 2 | 2 | 2 | 8 | 8 | +0 | 8 | LXXW | 3 | 2 | 1 | 0 | 6 | 1 | 3 | 0 | 1 | 2 | 2 | 7 | |
| 11 | 3 | Seattle Sounders | 5 | 2 | 1 | 2 | 6 | 6 | +0 | 7 | WXWL | 2 | 1 | 0 | 1 | 3 | 3 | 3 | 1 | 1 | 1 | 3 | 3 | |
| 12 | 1 | Sporting Kansas City | 7 | 2 | 0 | 5 | 5 | 11 | -6 | 6 | LLWL | 3 | 2 | 0 | 1 | 3 | 2 | 4 | 0 | 0 | 4 | 2 | 9 | |
| 13 | Vancouver Whitecaps | 6 | 1 | 1 | 4 | 5 | 12 | -7 | 4 | LWLL | 3 | 1 | 1 | 1 | 3 | 3 | 3 | 0 | 0 | 3 | 2 | 9 | ||
| 14 | San Jose Earthquakes | 6 | 0 | 2 | 4 | 9 | 15 | -6 | 2 | LXLL | 3 | 0 | 2 | 1 | 6 | 8 | 3 | 0 | 0 | 3 | 3 | 7 | ||
| 5 | +3 | Javier HERNÁNDEZ (LA Galaxy) |
| +2 | Jesús FERREIRA (FC Dallas) | |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 4 | Karol ŚWIDERSKI (Charlotte FC) | |
| Dániel GAZDAG (Philadelphia Union, 1p) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Carlos VELA (Los Angeles, 1p) | ||
| Sebastián DRIUSSI (Austin FC, 1p) | ||
| +1 | Darwin QUINTERO (Houston Dynamo) | |
| +3 | Leonardo CAMPANA (Inter Miami) | |
| 3 | +2 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| Lewis MORGAN (New York Red Bulls) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| +1 | Diego RUBIO (Colorado Rapids) | |
| Jesús JIMÉNEZ (Toronto FC) | ||
| +1 | CARLES GIL de Pareja (New England Revolution, 3p) | |
| +1 | Yimmi CHARÁ (Portland Timbers) |
| Sunday, 3 April 2022 | |||||
| Portland Timbers | 1-3 | LA Galaxy | |||
| 51 | Tuiloma | 9 | Hernández | ||
| 16(og) | Tuiloma | ||||
| 59 | Hernández | ||||
| Saturday, 9 April 2022 | |||||
| FC Dallas | 3-1 | Colorado Rapids | |||
| 45 | Servania | 30 | Rubio | ||
| 50 | Ferreira | ||||
| 89 | Ferreira | ||||
| Houston Dynamo | 4-3 | San Jose Earthquakes | |||
| 8 | Ferreira | 25 | Ebobisse | ||
| 43 | Quintero | 28 | Ebobisse | ||
| 57 | Hadebe | 77 | Thompson | ||
| 68 | Ferreira | ||||
| New York Red Bulls | 1-2 | CF Montréal | |||
| 14 | Fernandez | 71 | Camacho | ||
| 81 | Quioto | ||||
| Sporting Kansas City | 1-2 | Nashville | |||
| 25 | Walter | 51 | Romney | ||
| 68 | Sapong | ||||
| LA Galaxy | 2-1 | Los Angeles | |||
| 13 | Hernández | 79 | Arango | ||
| 31 | Coulibaly | ||||
| Vancouver Whitecaps | 2-3 | Portland Timbers | |||
| 76 | Dájome | 42(p) | Asprilla | ||
| 90(p) | Gauld | 60 | Niezgoda | ||
| 78 | Chará | ||||
| Real Salt Lake | 2-2 | Toronto FC | |||
| 7 | Meram | 9 | Thompson | ||
| 43 | Kreilach | 79 | Nelson | ||
| Orlando City | 1-0 | Chicago Fire | |||
| 59 | Kara | ||||
| Philadelphia Union | 1-0 | Columbus Crew | |||
| 2(og) | Room | ||||
| Inter Miami | 3-2 | New England Revolution | |||
| 17 | Campana | 11 | Rennicks | ||
| 23 | Campana | 67(p) | Carles Gil | ||
| 88 | Campana | ||||
