Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 430 | 1,271 | 2.95 | 210 | 48.84% | 108 | 25.12% | 112 | 26.05% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 31 | 18 | 9 | 4 | 68 | 22 | +46 | 63 | WWWW | 16 | 11 | 5 | 0 | 45 | 9 | 15 | 7 | 4 | 4 | 23 | 13 | ||
| 2 | CF Montréal | 31 | 17 | 5 | 9 | 58 | 49 | +9 | 56 | WXWL | 16 | 8 | 3 | 5 | 29 | 21 | 15 | 9 | 2 | 4 | 29 | 28 | ||
| 3 | New York Red Bulls | 31 | 14 | 8 | 9 | 47 | 37 | +10 | 50 | WLWW | 16 | 5 | 5 | 6 | 24 | 22 | 15 | 9 | 3 | 3 | 23 | 15 | ||
| 4 | New York City | 31 | 13 | 7 | 11 | 51 | 39 | +12 | 46 | LXLL | 15 | 8 | 4 | 3 | 33 | 18 | 16 | 5 | 3 | 8 | 18 | 21 | ||
| 5 | Orlando City | 30 | 12 | 6 | 12 | 36 | 46 | -10 | 42 | LLWW | 15 | 7 | 0 | 8 | 20 | 27 | 15 | 5 | 6 | 4 | 16 | 19 | ||
| 6 | FC Cincinnati | 30 | 10 | 12 | 8 | 54 | 49 | +5 | 42 | WXWX | 16 | 6 | 6 | 4 | 35 | 24 | 14 | 4 | 6 | 4 | 19 | 25 | ||
| 7 | Columbus Crew | 30 | 9 | 14 | 7 | 40 | 35 | +5 | 41 | LXOW | 15 | 6 | 5 | 4 | 19 | 13 | 15 | 3 | 9 | 3 | 21 | 22 | ||
| 8 | 1 | Inter Miami | 30 | 11 | 6 | 13 | 38 | 50 | -12 | 39 | WLLL | 15 | 9 | 3 | 3 | 29 | 24 | 15 | 2 | 3 | 10 | 9 | 26 | |
| 9 | 1 | Atlanta United | 31 | 10 | 9 | 12 | 46 | 50 | -4 | 39 | WWLL | 15 | 8 | 4 | 3 | 30 | 22 | 16 | 2 | 5 | 9 | 16 | 28 | |
| 10 | 2 | New England Revolution | 31 | 9 | 11 | 11 | 44 | 47 | -3 | 38 | LLWO | 15 | 6 | 6 | 3 | 20 | 14 | 16 | 3 | 5 | 8 | 24 | 33 | |
| 11 | Charlotte FC | 30 | 11 | 2 | 17 | 35 | 46 | -11 | 35 | WLLL | 15 | 9 | 0 | 6 | 22 | 14 | 15 | 2 | 2 | 11 | 13 | 32 | ||
| 12 | Chicago Fire | 31 | 9 | 8 | 14 | 33 | 42 | -9 | 35 | LWOO | 15 | 6 | 4 | 5 | 15 | 13 | 16 | 3 | 4 | 9 | 18 | 29 | ||
| 13 | Toronto FC | 31 | 9 | 7 | 15 | 49 | 57 | -8 | 34 | LLXW | 16 | 7 | 3 | 6 | 30 | 28 | 15 | 2 | 4 | 9 | 19 | 29 | ||
| 14 | D.C. United | 31 | 7 | 6 | 18 | 32 | 62 | -30 | 27 | LOOW | 15 | 4 | 4 | 7 | 18 | 26 | 16 | 3 | 2 | 11 | 14 | 36 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 31 | 19 | 4 | 8 | 61 | 35 | +26 | 61 | XLWL | 15 | 12 | 2 | 1 | 36 | 13 | 16 | 7 | 2 | 7 | 25 | 22 | ||
| 2 | Austin FC | 31 | 16 | 6 | 9 | 63 | 45 | +18 | 54 | WLLL | 15 | 8 | 4 | 3 | 40 | 21 | 16 | 8 | 2 | 6 | 23 | 24 | ||
| 3 | FC Dallas | 31 | 13 | 10 | 8 | 45 | 34 | +11 | 49 | WWXL | 16 | 9 | 4 | 3 | 26 | 14 | 15 | 4 | 6 | 5 | 19 | 20 | ||
| 4 | Nashville | 31 | 12 | 10 | 9 | 49 | 38 | +11 | 46 | XWWW | 16 | 6 | 6 | 4 | 29 | 19 | 15 | 6 | 4 | 5 | 20 | 19 | ||
| 5 | 1 | Minnesota United | 31 | 13 | 6 | 12 | 45 | 45 | +0 | 45 | XLLL | 16 | 7 | 5 | 4 | 25 | 20 | 15 | 6 | 1 | 8 | 20 | 25 | |
| 6 | 1 | Portland Timbers | 31 | 11 | 12 | 8 | 50 | 47 | +3 | 45 | WWWW | 16 | 8 | 6 | 2 | 27 | 17 | 15 | 3 | 6 | 6 | 23 | 30 | |
| 7 | Real Salt Lake | 31 | 11 | 10 | 10 | 38 | 41 | -3 | 43 | LOLW | 15 | 8 | 5 | 2 | 23 | 12 | 16 | 3 | 5 | 8 | 15 | 29 | ||
| 8 | LA Galaxy | 30 | 11 | 7 | 12 | 47 | 46 | +1 | 40 | LXXX | 15 | 7 | 3 | 5 | 30 | 23 | 15 | 4 | 4 | 7 | 17 | 23 | ||
| 9 | Seattle Sounders | 30 | 12 | 3 | 15 | 43 | 40 | +3 | 39 | WWLL | 15 | 9 | 1 | 5 | 26 | 16 | 15 | 3 | 2 | 10 | 17 | 24 | ||
| 10 | Colorado Rapids | 31 | 10 | 9 | 12 | 43 | 52 | -9 | 39 | WWOL | 16 | 9 | 5 | 2 | 28 | 15 | 15 | 1 | 4 | 10 | 15 | 37 | ||
| 11 | Vancouver Whitecaps | 31 | 10 | 7 | 14 | 36 | 54 | -18 | 37 | WLLL | 15 | 8 | 3 | 4 | 21 | 19 | 16 | 2 | 4 | 10 | 15 | 35 | ||
| 12 | Sporting Kansas City | 31 | 9 | 7 | 15 | 36 | 51 | -15 | 34 | WOXW | 15 | 7 | 2 | 6 | 20 | 16 | 16 | 2 | 5 | 9 | 16 | 35 | ||
| 13 | Houston Dynamo | 31 | 9 | 6 | 16 | 39 | 49 | -10 | 33 | WOLW | 16 | 6 | 5 | 5 | 23 | 19 | 15 | 3 | 1 | 11 | 16 | 30 | ||
| 14 | San Jose Earthquakes | 30 | 7 | 9 | 14 | 45 | 63 | -18 | 30 | LLWL | 14 | 6 | 5 | 3 | 26 | 23 | 16 | 1 | 4 | 11 | 19 | 40 | ||
| 22 | Hany MUKHTAR (Nashville, 5p) | |
| 20 | Sebastián DRIUSSI (Austin FC, 3p) | |
| 19 | Dániel GAZDAG (Philadelphia Union, 6p) | |
| 18 | Jesús FERREIRA (FC Dallas) | |
| 16 | Cristian ARANGO (Los Angeles, 1p) | |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| 15 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| Rommel QUIOTO (CF Montréal, 4p) | ||
| 14 | Julián CARRANZA (Philadelphia Union, 2p) | |
| Lewis MORGAN (New York Red Bulls, 6p) | ||
| Javier HERNÁNDEZ (LA Galaxy, 3p) | ||
| +1 | Diego RUBIO (Colorado Rapids, 4p) | |
| 13 | Valentín CASTELLANOS (New York City, 5p) | |
| 12 | BRENNER Souza (FC Cincinnati, 1p) | |
| +2 | Gonzalo HIGUAÍN (Inter Miami, 4p) | |
| Mikael UHRE (Philadelphia Union) | ||
| 11 | Taxiarchis FOUNTAS (D.C. United) | |
| 10 | Dejan JOVELJIĆ (LA Galaxy, 2p) | |
| Sebastián FERREIRA (Houston Dynamo, 1p) | ||
| Gyasi ZARDES (Colorado Rapids, 1p) | ||
| Emanuel REYNOSO (Minnesota United, 3p) |
| Tuesday, 13 September 2022 | |||||
| Houston Dynamo | 3-1 | New England Revolution | |||
| 37 | Quintero | 63(p) | Carles Gil | ||
| 76(p) | Picault | ||||
| 85 | Picault | ||||
| Sporting Kansas City | 3-0 | D.C. United | |||
| 34 | Shelton | ||||
| 70 | Voloder | ||||
| 87 | Sallói | ||||
| CF Montréal | 3-2 | Chicago Fire | |||
| 21 | Kamara | 39(p) | Shaqiri | ||
| 29 | Kamara | 57(p) | Shaqiri | ||
| 44 | Brault-Guillard | ||||
| Minnesota United | 1-1 | Los Angeles | |||
| 45 | Kallman | 64 | Vela | ||
| Inter Miami | 2-1 | Columbus Crew | |||
| 25 | Higuaín | 41 | Cucho | ||
| 82 | Higuaín | ||||
| Wednesday, 14 September 2022 | |||||
| Colorado Rapids | 2-1 | San Jose Earthquakes | |||
| 21 | Rubio | 37 | Nathan | ||
| 77 | Rosenberry | ||||
| Vancouver Whitecaps | 3-0 | LA Galaxy | |||
| 57 | Gauld | ||||
| 68 | Vite | ||||
| 86 | Ricketts | ||||
| Orlando City | 0-1 | Atlanta United | |||
| 72 | Almada | ||||
| Austin FC | 3-0 | Real Salt Lake | |||
| 60 | Djitté | ||||
| 76 | Djitté | ||||
| 80 | Djitté | ||||
