| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 379 | 1,121 | 2.95 | 178 | 46.97% | 97 | 25.59% | 104 | 27.44% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 28 | 15 | 9 | 4 | 57 | 20 | +37 | 54 | WWLW | 14 | 9 | 5 | 0 | 36 | 7 | 14 | 6 | 4 | 4 | 21 | 13 | ||
| 2 | CF Montréal | 27 | 15 | 4 | 8 | 49 | 41 | +8 | 49 | WWWX | 13 | 7 | 2 | 4 | 24 | 16 | 14 | 8 | 2 | 4 | 25 | 25 | ||
| 3 | New York City | 26 | 13 | 6 | 7 | 48 | 30 | +18 | 45 | WLLL | 13 | 8 | 3 | 2 | 31 | 15 | 13 | 5 | 3 | 5 | 17 | 15 | ||
| 4 | New York Red Bulls | 28 | 12 | 8 | 8 | 44 | 34 | +10 | 44 | WXWL | 14 | 4 | 5 | 5 | 22 | 19 | 14 | 8 | 3 | 3 | 22 | 15 | ||
| 5 | 4 | Orlando City | 26 | 10 | 6 | 10 | 30 | 37 | -7 | 36 | WWLL | 12 | 5 | 0 | 7 | 15 | 23 | 14 | 5 | 6 | 3 | 15 | 14 | |
| 6 | 1 | Inter Miami | 27 | 10 | 6 | 11 | 35 | 45 | -10 | 36 | LWWX | 14 | 8 | 3 | 3 | 27 | 23 | 13 | 2 | 3 | 8 | 8 | 22 | |
| 7 | 1 | Columbus Crew | 26 | 8 | 12 | 6 | 36 | 31 | +5 | 36 | XXXW | 13 | 5 | 4 | 4 | 18 | 13 | 13 | 3 | 8 | 2 | 18 | 18 | |
| 8 | FC Cincinnati | 27 | 8 | 11 | 8 | 45 | 48 | -3 | 35 | XXXW | 14 | 4 | 6 | 4 | 27 | 24 | 13 | 4 | 5 | 4 | 18 | 24 | ||
| 9 | 2 | New England Revolution | 26 | 8 | 10 | 8 | 38 | 40 | -2 | 34 | LXWW | 12 | 5 | 5 | 2 | 16 | 12 | 14 | 3 | 5 | 6 | 22 | 28 | |
| 10 | 2 | Toronto FC | 28 | 9 | 6 | 13 | 42 | 47 | -5 | 33 | WLXW | 14 | 7 | 2 | 5 | 25 | 22 | 14 | 2 | 4 | 8 | 17 | 25 | |
| 11 | 1 | Charlotte FC | 28 | 10 | 2 | 16 | 34 | 44 | -10 | 32 | LLWL | 14 | 8 | 0 | 6 | 21 | 14 | 14 | 2 | 2 | 10 | 13 | 30 | |
| 12 | 1 | Chicago Fire | 27 | 8 | 6 | 13 | 28 | 38 | -10 | 30 | LLLW | 14 | 5 | 4 | 5 | 12 | 12 | 13 | 3 | 2 | 8 | 16 | 26 | |
| 13 | Atlanta United | 26 | 7 | 9 | 10 | 36 | 40 | -4 | 30 | XLXW | 13 | 6 | 4 | 3 | 23 | 18 | 13 | 1 | 5 | 7 | 13 | 22 | ||
| 14 | D.C. United | 26 | 6 | 4 | 16 | 28 | 55 | -27 | 22 | LLLO | 14 | 4 | 3 | 7 | 18 | 26 | 12 | 2 | 1 | 9 | 10 | 29 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 27 | 18 | 3 | 6 | 56 | 30 | +26 | 57 | LLWW | 14 | 11 | 2 | 1 | 34 | 13 | 13 | 7 | 1 | 5 | 22 | 17 | ||
| 2 | Austin FC | 27 | 15 | 6 | 6 | 59 | 37 | +22 | 51 | WLWX | 13 | 7 | 4 | 2 | 36 | 19 | 14 | 8 | 2 | 4 | 23 | 18 | ||
| 3 | 1 | Minnesota United | 27 | 13 | 5 | 9 | 44 | 37 | +7 | 44 | WWWL | 14 | 7 | 4 | 3 | 24 | 16 | 13 | 6 | 1 | 6 | 20 | 21 | |
| 4 | 1 | FC Dallas | 29 | 11 | 10 | 8 | 40 | 33 | +7 | 43 | XLWW | 15 | 8 | 4 | 3 | 24 | 13 | 14 | 3 | 6 | 5 | 16 | 20 | |
| 5 | 4 | Nashville | 28 | 10 | 9 | 9 | 41 | 36 | +5 | 39 | WWLL | 13 | 4 | 5 | 4 | 21 | 17 | 15 | 6 | 4 | 5 | 20 | 19 | |
| 6 | 1 | Real Salt Lake | 27 | 10 | 9 | 8 | 35 | 36 | -1 | 39 | XXWL | 13 | 7 | 4 | 2 | 20 | 12 | 14 | 3 | 5 | 6 | 15 | 24 | |
| 7 | 3 | Portland Timbers | 28 | 8 | 12 | 8 | 45 | 45 | +0 | 36 | WLLX | 14 | 6 | 6 | 2 | 24 | 16 | 14 | 2 | 6 | 6 | 21 | 29 | |
| 8 | 2 | LA Galaxy | 25 | 10 | 4 | 11 | 40 | 37 | +3 | 34 | XWLL | 14 | 7 | 2 | 5 | 28 | 21 | 11 | 3 | 2 | 6 | 12 | 16 | |
| 9 | 2 | Vancouver Whitecaps | 28 | 9 | 7 | 12 | 32 | 49 | -17 | 34 | LXWL | 14 | 7 | 3 | 4 | 18 | 19 | 14 | 2 | 4 | 8 | 14 | 30 | |
| 10 | 2 | Seattle Sounders | 27 | 10 | 3 | 14 | 36 | 36 | +0 | 33 | LXLL | 13 | 7 | 1 | 5 | 21 | 15 | 14 | 3 | 2 | 9 | 15 | 21 | |
| 11 | Colorado Rapids | 27 | 8 | 8 | 11 | 37 | 46 | -9 | 32 | LXLX | 14 | 7 | 5 | 2 | 23 | 13 | 13 | 1 | 3 | 9 | 14 | 33 | ||
| 12 | 2 | Sporting Kansas City | 28 | 8 | 5 | 15 | 31 | 49 | -18 | 29 | WWLW | 14 | 6 | 2 | 6 | 17 | 16 | 14 | 2 | 3 | 9 | 14 | 33 | |
| 13 | 1 | San Jose Earthquakes | 27 | 6 | 9 | 12 | 42 | 55 | -13 | 27 | LWLX | 13 | 5 | 5 | 3 | 24 | 23 | 14 | 1 | 4 | 9 | 18 | 32 | |
| 14 | 1 | Houston Dynamo | 27 | 7 | 5 | 15 | 33 | 45 | -12 | 26 | LXLL | 13 | 4 | 4 | 5 | 18 | 17 | 14 | 3 | 1 | 10 | 15 | 28 | |
| 19 | +1 | Sebastián DRIUSSI (Austin FC, 3p) |
| 16 | +3 | Dániel GAZDAG (Philadelphia Union, 5p) |
| +2 | Hany MUKHTAR (Nashville, 3p) | |
| +1 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 15 | Jesús FERREIRA (FC Dallas) | |
| +1 | Rommel QUIOTO (CF Montréal, 4p) | |
| 14 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| 13 | +1 | Julián CARRANZA (Philadelphia Union, 2p) |
| +1 | Cristian ARANGO (Los Angeles, 1p) | |
| Valentín CASTELLANOS (New York City, 5p) | ||
| 12 | +1 | Lewis MORGAN (New York Red Bulls, 5p) |
| Diego RUBIO (Colorado Rapids, 3p) | ||
| 11 | Javier HERNÁNDEZ (LA Galaxy, 2p) | |
| Taxiarchis FOUNTAS (D.C. United) | ||
| 10 | Dejan JOVELJIĆ (LA Galaxy, 2p) | |
| Emanuel REYNOSO (Minnesota United, 3p) | ||
| 9 | Jarosław NIEZGODA (Portland Timbers) | |
| +2 | Maximiliano URRUTI (Austin FC) | |
| BRENNER Souza (FC Cincinnati) | ||
| Sebastián FERREIRA (Houston Dynamo) | ||
| +1 | Luis AMARILLA (Minnesota United) | |
| Paul ARRIOLA (FC Dallas) | ||
| Jonathan OSORIO (Toronto FC) | ||
| +1 | Gonzalo HIGUAÍN (Inter Miami, 3p) | |
| Mikael UHRE (Philadelphia Union) |
| Sunday, 21 August 2022 | |||||
| Columbus Crew | 2-2 | Atlanta United | |||
| 66 | Cucho | 21 | Sosa | ||
| 72 | Cucho | 77 | Sánchez | ||
| Sporting Kansas City | 4-1 | Portland Timbers | |||
| 31 | Agada | 90 | Blanco | ||
| 40 | Fontás | ||||
| 42 | Thommy | ||||
| 75 | Agada | ||||
| Chicago Fire | 0-2 | New York City | |||
| 16 | Gabriel Pereira | ||||
| 46 | Rodríguez | ||||
| Nashville | 4-0 | FC Dallas | |||
| 5 | Mukhtar | ||||
| 26 | Shaffelburg | ||||
| 33 | Mukhtar | ||||
| 72 | Romney | ||||
| Charlotte FC | 1-2 | Orlando City | |||
| 66 | McKinze Gaines | 62 | Kara | ||
| 89 | Akindele | ||||
| Friday, 26 August 2022 | |||||
| Portland Timbers | 2-1 | Seattle Sounders | |||
| 41(p) | Asprilla | 8 | Gómez | ||
| 51 | Blanco | ||||
| Austin FC | 4-1 | Los Angeles | |||
| 32 | Fagúndez | 61 | Arango | ||
| 47 | Urruti | ||||
| 51 | Urruti | ||||
| 59 | Driussi | ||||
| Saturday, 27 August 2022 | |||||
| FC Dallas | 1-1 | Real Salt Lake | |||
| 7 | Velasco | 69 | Julio | ||
| New York Red Bulls | 3-1 | Inter Miami | |||
| 43 | Morgan | 19 | Higuaín | ||
| 53 | Edelman | ||||
| 74 | Clark | ||||
| Sporting Kansas City | 1-0 | San Jose Earthquakes | |||
| 10 | Sallói | ||||
| Chicago Fire | 0-2 | CF Montréal | |||
| 19 | Koné | ||||
| 24 | Quioto | ||||
| Vancouver Whitecaps | 0-3 | Nashville | |||
| 19 | Leal | ||||
| 23 | Maher | ||||
| 49 | Maher | ||||
| Philadelphia Union | 6-0 | Colorado Rapids | |||
| 9 | Gazdag | ||||
| 20(p) | Gazdag | ||||
| 30(p) | Carranza | ||||
| 83 | Gazdag | ||||
| 87 | Burke | ||||
| 90 | Real | ||||
| Minnesota United | 2-1 | Houston Dynamo | |||
| 79(og) | Picault | 45 | Baird | ||
| 84 | Amarilla | ||||
| FC Cincinnati | 2-2 | Columbus Crew | |||
| 36 | Vázquez | 74 | Etienne | ||
| 77 | Miazga | 90 | Moreira | ||
| Charlotte FC | 0-2 | Toronto FC | |||
| 49 | Insigne | ||||
| 66 | Bernardeschi | ||||