Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 123 | 335 | 2.72 | 62 | 50.41% | 29 | 23.58% | 32 | 26.02% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | New York Red Bulls | 9 | 5 | 2 | 2 | 15 | 7 | +8 | 17 | WWOL | 4 | 0 | 2 | 2 | 2 | 4 | 5 | 5 | 0 | 0 | 13 | 3 | |
| 2 | 1 | Philadelphia Union | 8 | 5 | 2 | 1 | 12 | 5 | +7 | 17 | XLWW | 5 | 3 | 2 | 0 | 7 | 2 | 3 | 2 | 0 | 1 | 5 | 3 | |
| 3 | 1 | Orlando City | 10 | 5 | 2 | 3 | 12 | 11 | +1 | 17 | WLWW | 6 | 3 | 0 | 3 | 8 | 10 | 4 | 2 | 2 | 0 | 4 | 1 | |
| 4 | 2 | CF Montréal | 9 | 4 | 2 | 3 | 16 | 18 | -2 | 14 | WXWW | 3 | 2 | 0 | 1 | 5 | 4 | 6 | 2 | 2 | 2 | 11 | 14 | |
| 5 | 5 | Columbus Crew | 9 | 3 | 3 | 3 | 13 | 9 | +4 | 12 | WOLL | 5 | 3 | 0 | 2 | 9 | 4 | 4 | 0 | 3 | 1 | 4 | 5 | |
| 6 | 2 | Atlanta United | 9 | 3 | 2 | 4 | 11 | 13 | -2 | 11 | LLOL | 4 | 2 | 2 | 0 | 8 | 5 | 5 | 1 | 0 | 4 | 3 | 8 | |
| 7 | 2 | Toronto FC | 9 | 3 | 2 | 4 | 16 | 19 | -3 | 11 | LLWX | 5 | 3 | 0 | 2 | 8 | 9 | 4 | 0 | 2 | 2 | 8 | 10 | |
| 8 | 3 | New York City | 7 | 3 | 1 | 3 | 16 | 10 | +6 | 10 | WWLL | 4 | 3 | 0 | 1 | 15 | 7 | 3 | 0 | 1 | 2 | 1 | 3 | |
| 9 | 3 | New England Revolution | 9 | 3 | 1 | 5 | 14 | 16 | -2 | 10 | WLWL | 5 | 3 | 0 | 2 | 7 | 5 | 4 | 0 | 1 | 3 | 7 | 11 | |
| 10 | 3 | Charlotte FC | 10 | 3 | 1 | 6 | 9 | 13 | -4 | 10 | LOLW | 4 | 3 | 0 | 1 | 6 | 2 | 6 | 0 | 1 | 5 | 3 | 11 | |
| 11 | 2 | FC Cincinnati | 9 | 3 | 1 | 5 | 11 | 17 | -6 | 10 | WLOL | 4 | 1 | 0 | 3 | 7 | 8 | 5 | 2 | 1 | 2 | 4 | 9 | |
| 12 | 2 | Inter Miami | 9 | 3 | 1 | 5 | 9 | 18 | -9 | 10 | LWWW | 5 | 2 | 1 | 2 | 6 | 8 | 4 | 1 | 0 | 3 | 3 | 10 | |
| 13 | 5 | Chicago Fire | 9 | 2 | 4 | 3 | 6 | 7 | -1 | 10 | LLOL | 5 | 1 | 3 | 1 | 4 | 3 | 4 | 1 | 1 | 2 | 2 | 4 | |
| 14 | 5 | D.C. United | 8 | 3 | 0 | 5 | 10 | 13 | -3 | 9 | LWLL | 5 | 2 | 0 | 3 | 8 | 8 | 3 | 1 | 0 | 2 | 2 | 5 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Austin FC | 9 | 6 | 2 | 1 | 22 | 8 | +14 | 20 | WWWW | 5 | 4 | 1 | 0 | 15 | 2 | 4 | 2 | 1 | 1 | 7 | 6 | ||
| 2 | Los Angeles | 8 | 6 | 1 | 1 | 19 | 8 | +11 | 19 | WWLW | 4 | 3 | 1 | 0 | 10 | 3 | 4 | 3 | 0 | 1 | 9 | 5 | ||
| 3 | LA Galaxy | 9 | 5 | 1 | 3 | 10 | 7 | +3 | 16 | LWOW | 4 | 3 | 0 | 1 | 4 | 2 | 5 | 2 | 1 | 2 | 6 | 5 | ||
| 4 | FC Dallas | 9 | 4 | 4 | 1 | 14 | 7 | +7 | 16 | XWOW | 5 | 4 | 1 | 0 | 12 | 4 | 4 | 0 | 3 | 1 | 2 | 3 | ||
| 5 | 1 | Real Salt Lake | 10 | 4 | 4 | 2 | 10 | 13 | -3 | 16 | WOLX | 4 | 3 | 1 | 0 | 6 | 3 | 6 | 1 | 3 | 2 | 4 | 10 | |
| 6 | 1 | Minnesota United | 8 | 4 | 2 | 2 | 11 | 6 | +5 | 14 | WWLL | 5 | 3 | 1 | 1 | 9 | 4 | 3 | 1 | 1 | 1 | 2 | 2 | |
| 7 | Houston Dynamo | 9 | 3 | 3 | 3 | 12 | 11 | +1 | 12 | LLOW | 6 | 2 | 3 | 1 | 8 | 7 | 3 | 1 | 0 | 2 | 4 | 4 | ||
| 8 | 2 | Colorado Rapids | 9 | 3 | 3 | 3 | 11 | 11 | +0 | 12 | WOLL | 5 | 3 | 2 | 0 | 8 | 1 | 4 | 0 | 1 | 3 | 3 | 10 | |
| 9 | 1 | Nashville | 8 | 3 | 2 | 3 | 8 | 9 | -1 | 11 | LXWW | 0 | 0 | 0 | 0 | 0 | 0 | 8 | 3 | 2 | 3 | 8 | 9 | |
| 10 | 1 | Portland Timbers | 10 | 2 | 5 | 3 | 10 | 15 | -5 | 11 | LOOW | 5 | 1 | 3 | 1 | 5 | 6 | 5 | 1 | 2 | 2 | 5 | 9 | |
| 11 | 1 | Sporting Kansas City | 10 | 2 | 2 | 6 | 8 | 16 | -8 | 8 | XOLL | 5 | 2 | 2 | 1 | 5 | 4 | 5 | 0 | 0 | 5 | 3 | 12 | |
| 12 | 1 | Seattle Sounders | 7 | 2 | 1 | 4 | 9 | 11 | -2 | 7 | LLWX | 3 | 1 | 0 | 2 | 3 | 4 | 4 | 1 | 1 | 2 | 6 | 7 | |
| 13 | San Jose Earthquakes | 8 | 1 | 3 | 4 | 15 | 20 | -5 | 6 | WXLX | 5 | 1 | 3 | 1 | 12 | 13 | 3 | 0 | 0 | 3 | 3 | 7 | ||
| 14 | Vancouver Whitecaps | 8 | 1 | 1 | 6 | 6 | 17 | -11 | 4 | LLLW | 3 | 1 | 1 | 1 | 3 | 3 | 5 | 0 | 0 | 5 | 3 | 14 | ||
| 7 | +1 | Sebastián DRIUSSI (Austin FC, 1p) |
| +3 | Jesús JIMÉNEZ (Toronto FC) | |
| 6 | +1 | Jesús FERREIRA (FC Dallas) |
| 5 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) | |
| +1 | Valentín CASTELLANOS (New York City, 2p) | |
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| +1 | Leonardo CAMPANA (Inter Miami) | |
| +1 | Diego RUBIO (Colorado Rapids) | |
| 4 | Maximiliano URRUTI (Austin FC) | |
| Karol ŚWIDERSKI (Charlotte FC) | ||
| +1 | Lewis MORGAN (New York Red Bulls, 1p) | |
| Dániel GAZDAG (Philadelphia Union, 1p) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| Cristian ESPINOZA (San Jose Earthquakes, 2p) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| +1 | Sebastián FERREIRA (Houston Dynamo) | |
| Ola KAMARA (D.C. United, 1p) | ||
| Carlos VELA (Los Angeles, 1p) | ||
| +1 | THIAGO Eduardo ANDRADE (New York City) | |
| Darwin QUINTERO (Houston Dynamo) |
| Sunday, 24 April 2022 | |||||
| Orlando City | 0-3 | New York Red Bulls | |||
| 26 | Luquinhas | ||||
| 48 | Cásseres | ||||
| 88(p) | Morgan | ||||
| New York City | 5-4 | Toronto FC | |||
| 38 | Castellanos | 13 | Jiménez | ||
| 49 | Thiago Andrade | 27 | Jiménez | ||
| 54 | Rodríguez | 86 | Kerr | ||
| 58 | Parks | 90 | Bradley | ||
| 75 | Gabriel Pereira | ||||
| FC Cincinnati | 1-2 | Los Angeles | |||
| 45 | Acosta | 59 | Acosta | ||
| 79 | Musovski | ||||
| Inter Miami | 2-1 | Atlanta United | |||
| 28 | Campana | 13 | Cisneros | ||
| 64 | Duke | ||||
| Saturday, 30 April 2022 | |||||
| Houston Dynamo | 1-2 | Austin FC | |||
| 5 | Ferreira | 39 | Pereira | ||
| 66 | Driussi | ||||
| Colorado Rapids | 2-0 | Portland Timbers | |||
| 30 | Rubio | ||||
| 90 | Kaye | ||||
| Columbus Crew | 3-0 | D.C. United | |||
| 28 | Pedro Santos | ||||
| 43 | Etienne | ||||
| 75 | Nagbe | ||||
| New England Revolution | 2-0 | Inter Miami | |||
| 1 | Rivera | ||||
| 64 | Buksa | ||||
| Sporting Kansas City | 2-2 | FC Dallas | |||
| 22(p) | Russell | 36 | Velasco | ||
| 77 | Sallói | 42 | Ferreira | ||
| Chicago Fire | 1-2 | New York Red Bulls | |||
| 17(p) | Shaqiri | 75 | Klimala | ||
| 90(p) | Klimala | ||||
| CF Montréal | 2-1 | Atlanta United | |||
| 4 | Miller | 51 | Moreno | ||
| 82 | Torres | ||||
| Real Salt Lake | 1-0 | LA Galaxy | |||
| 49 | Silva | ||||
| Toronto FC | 1-2 | FC Cincinnati | |||
| 65 | Jiménez | 44 | Murphy | ||
| 52 | Acosta | ||||
| Orlando City | 2-1 | Charlotte FC | |||
| 16 | Ruan | 60(p) | Fuchs | ||
| 45 | Torres | ||||
