Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 153 | 415 | 2.71 | 78 | 50.98% | 37 | 24.18% | 38 | 24.84% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | CF Montréal | 11 | 6 | 2 | 3 | 22 | 19 | +3 | 20 | WWWX | 4 | 3 | 0 | 1 | 9 | 5 | 7 | 3 | 2 | 2 | 13 | 14 | |
| 2 | 2 | Orlando City | 12 | 6 | 2 | 4 | 14 | 15 | -1 | 20 | WLWL | 6 | 3 | 0 | 3 | 8 | 10 | 6 | 3 | 2 | 1 | 6 | 5 | |
| 3 | 2 | Philadelphia Union | 11 | 5 | 5 | 1 | 16 | 9 | +7 | 20 | XXXX | 6 | 3 | 3 | 0 | 8 | 3 | 5 | 2 | 2 | 1 | 8 | 6 | |
| 4 | 1 | FC Cincinnati | 12 | 6 | 1 | 5 | 16 | 18 | -2 | 19 | WWWW | 5 | 2 | 0 | 3 | 9 | 8 | 7 | 4 | 1 | 2 | 7 | 10 | |
| 5 | 3 | New York Red Bulls | 11 | 5 | 4 | 2 | 17 | 9 | +8 | 19 | XXWW | 5 | 0 | 3 | 2 | 3 | 5 | 6 | 5 | 1 | 0 | 14 | 4 | |
| 6 | New York City | 10 | 5 | 2 | 3 | 21 | 10 | +11 | 17 | WOWW | 7 | 5 | 1 | 1 | 20 | 7 | 3 | 0 | 1 | 2 | 1 | 3 | ||
| 7 | Atlanta United | 10 | 4 | 2 | 4 | 15 | 14 | +1 | 14 | WLLO | 5 | 3 | 2 | 0 | 12 | 6 | 5 | 1 | 0 | 4 | 3 | 8 | ||
| 8 | 2 | D.C. United | 10 | 4 | 1 | 5 | 14 | 15 | -1 | 13 | XWLW | 6 | 3 | 0 | 3 | 10 | 8 | 4 | 1 | 1 | 2 | 4 | 7 | |
| 9 | 1 | Charlotte FC | 12 | 4 | 1 | 7 | 10 | 15 | -5 | 13 | LWLO | 6 | 4 | 0 | 2 | 7 | 4 | 6 | 0 | 1 | 5 | 3 | 11 | |
| 10 | 1 | Columbus Crew | 11 | 3 | 4 | 4 | 15 | 13 | +2 | 13 | LXWO | 5 | 3 | 0 | 2 | 9 | 4 | 6 | 0 | 4 | 2 | 6 | 9 | |
| 11 | New England Revolution | 10 | 3 | 2 | 5 | 16 | 18 | -2 | 11 | XWLW | 6 | 3 | 1 | 2 | 9 | 7 | 4 | 0 | 1 | 3 | 7 | 11 | ||
| 12 | Toronto FC | 12 | 3 | 2 | 7 | 16 | 23 | -7 | 11 | LLLL | 6 | 3 | 0 | 3 | 8 | 10 | 6 | 0 | 2 | 4 | 8 | 13 | ||
| 13 | Inter Miami | 11 | 3 | 2 | 6 | 11 | 21 | -10 | 11 | XLLW | 6 | 2 | 2 | 2 | 8 | 10 | 5 | 1 | 0 | 4 | 3 | 11 | ||
| 14 | Chicago Fire | 11 | 2 | 4 | 5 | 8 | 13 | -5 | 10 | LLLL | 6 | 1 | 3 | 2 | 5 | 5 | 5 | 1 | 1 | 3 | 3 | 8 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 11 | 7 | 2 | 2 | 23 | 12 | +11 | 23 | LXWW | 6 | 4 | 2 | 0 | 14 | 5 | 5 | 3 | 0 | 2 | 9 | 7 | ||
| 2 | 1 | FC Dallas | 11 | 6 | 4 | 1 | 19 | 8 | +11 | 22 | WWXW | 6 | 5 | 1 | 0 | 14 | 4 | 5 | 1 | 3 | 1 | 5 | 4 | |
| 3 | 1 | Austin FC | 11 | 6 | 2 | 3 | 23 | 11 | +12 | 20 | LLWW | 6 | 4 | 1 | 1 | 15 | 3 | 5 | 2 | 1 | 2 | 8 | 8 | |
| 4 | LA Galaxy | 11 | 6 | 1 | 4 | 12 | 10 | +2 | 19 | LWLW | 5 | 3 | 0 | 2 | 5 | 5 | 6 | 3 | 1 | 2 | 7 | 5 | ||
| 5 | Real Salt Lake | 12 | 5 | 4 | 3 | 12 | 16 | -4 | 19 | WLWO | 5 | 4 | 1 | 0 | 8 | 4 | 7 | 1 | 3 | 3 | 4 | 12 | ||
| 6 | 1 | Houston Dynamo | 11 | 4 | 3 | 4 | 14 | 13 | +1 | 15 | WLLL | 7 | 3 | 3 | 1 | 10 | 7 | 4 | 1 | 0 | 3 | 4 | 6 | |
| 7 | 1 | Colorado Rapids | 11 | 4 | 3 | 4 | 13 | 12 | +1 | 15 | WLWO | 6 | 4 | 2 | 0 | 10 | 1 | 5 | 0 | 1 | 4 | 3 | 11 | |
| 8 | 1 | Nashville | 11 | 4 | 3 | 4 | 11 | 12 | -1 | 15 | LWXL | 2 | 1 | 1 | 0 | 3 | 1 | 9 | 3 | 2 | 4 | 8 | 11 | |
| 9 | 1 | Portland Timbers | 12 | 3 | 6 | 3 | 18 | 18 | +0 | 15 | WXLO | 6 | 2 | 3 | 1 | 12 | 8 | 6 | 1 | 3 | 2 | 6 | 10 | |
| 10 | 4 | Minnesota United | 10 | 4 | 2 | 4 | 11 | 9 | +2 | 14 | LLWW | 6 | 3 | 1 | 2 | 9 | 5 | 4 | 1 | 1 | 2 | 2 | 4 | |
| 11 | San Jose Earthquakes | 11 | 2 | 4 | 5 | 19 | 26 | -7 | 10 | XWLW | 6 | 2 | 3 | 1 | 13 | 13 | 5 | 0 | 1 | 4 | 6 | 13 | ||
| 12 | Sporting Kansas City | 12 | 2 | 3 | 7 | 10 | 23 | -13 | 9 | LOXO | 5 | 2 | 2 | 1 | 5 | 4 | 7 | 0 | 1 | 6 | 5 | 19 | ||
| 13 | 1 | Vancouver Whitecaps | 10 | 2 | 2 | 6 | 10 | 20 | -10 | 8 | XWLL | 5 | 2 | 2 | 1 | 7 | 6 | 5 | 0 | 0 | 5 | 3 | 14 | |
| 14 | 1 | Seattle Sounders | 8 | 2 | 1 | 5 | 9 | 13 | -4 | 7 | LLLW | 3 | 1 | 0 | 2 | 3 | 4 | 5 | 1 | 1 | 3 | 6 | 9 | |
| 9 | +2 | Jesús FERREIRA (FC Dallas) |
| 7 | +2 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| Sebastián DRIUSSI (Austin FC, 1p) | ||
| Jesús JIMÉNEZ (Toronto FC) | ||
| 6 | +1 | Dániel GAZDAG (Philadelphia Union, 1p) |
| +1 | Valentín CASTELLANOS (New York City, 2p) | |
| +1 | Djordje MIHAILOVIC (CF Montréal) | |
| Brandon VÁZQUEZ (FC Cincinnati) | ||
| +1 | Leonardo CAMPANA (Inter Miami) | |
| +1 | Diego RUBIO (Colorado Rapids, 1p) | |
| 5 | Javier HERNÁNDEZ (LA Galaxy) | |
| +1 | Ola KAMARA (D.C. United, 1p) | |
| +1 | Darwin QUINTERO (Houston Dynamo, 1p) | |
| +1 | Taxiarchis FOUNTAS (D.C. United) | |
| +1 | Luciano ACOSTA (FC Cincinnati, 2p) | |
| 4 | Maximiliano URRUTI (Austin FC) | |
| Julián CARRANZA (Philadelphia Union, 1p) | ||
| Karol ŚWIDERSKI (Charlotte FC) | ||
| Lewis MORGAN (New York Red Bulls, 1p) | ||
| Cristian ESPINOZA (San Jose Earthquakes, 2p) | ||
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Sebastián FERREIRA (Houston Dynamo) | ||
| Adam BUKSA (New England Revolution) | ||
| Carlos VELA (Los Angeles, 1p) | ||
| THIAGO Eduardo ANDRADE (New York City) | ||
| Ronaldo CISNEROS (Atlanta United) |
| Sunday, 8 May 2022 | |||||
| Vancouver Whitecaps | 1-0 | Toronto FC | |||
| 90 | Ricketts | ||||
| Austin FC | 0-1 | LA Galaxy | |||
| 6 | Delgado | ||||
| Nashville | 2-0 | Real Salt Lake | |||
| 63 | Romney | ||||
| 90 | Sapong | ||||
| Saturday, 14 May 2022 | |||||
| Houston Dynamo | 2-0 | Nashville | |||
| 16 | Carrasquilla | ||||
| 53(p) | Quintero | ||||
| Colorado Rapids | 2-0 | Los Angeles | |||
| 17(p) | Zardes | ||||
| 28(p) | Rubio | ||||
| LA Galaxy | 1-3 | FC Dallas | |||
| 67 | Douglas Costa | 11 | Ferreira | ||
| 20 | Arriola | ||||
| 23 | Ferreira | ||||
| Chicago Fire | 1-2 | FC Cincinnati | |||
| 83 | Durán | 33(og) | Czichos | ||
| 85 | Acosta | ||||
| Vancouver Whitecaps | 3-3 | San Jose Earthquakes | |||
| 52 | Cavallini | 62 | Monteiro | ||
| 75 | Raposo | 73 | Ebobisse | ||
| 90 | Godoy | 81 | Ebobisse | ||
| Portland Timbers | 7-2 | Sporting Kansas City | |||
| 12 | Tuiloma | 57 | Russell | ||
| 46 | Blanco | 75 | Tzionis | ||
| 52 | Blanco | ||||
| 56 | Nathan | ||||
| 69 | Nathan | ||||
| 88 | Loría | ||||
| 90 | Moreno | ||||
| Real Salt Lake | 2-1 | Austin FC | |||
| 55 | Chang | 24 | Ring | ||
| 88 | Brody | ||||
| Toronto FC | 0-1 | Orlando City | |||
| 90 | Smith | ||||
| Philadelphia Union | 1-1 | New York Red Bulls | |||
| 47 | Gazdag | 66 | Luquinhas | ||
| New York City | 2-0 | Columbus Crew | |||
| 9 | Talles Magno | ||||
| 57 | Castellanos | ||||
| Inter Miami | 2-2 | D.C. United | |||
| 31 | Campana | 45 | Fountas | ||
| 45 | Lowe | 74 | Kamara | ||
| Charlotte FC | 0-2 | CF Montréal | |||
| 45 | Mihailovic | ||||
| 67 | Johnston | ||||
