Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 72 | 189 | 2.62 | 34 | 47.22% | 18 | 25.00% | 20 | 27.78% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Philadelphia Union | 5 | 4 | 1 | 0 | 9 | 2 | +7 | 13 | WWWW | 3 | 2 | 1 | 0 | 5 | 1 | 2 | 2 | 0 | 0 | 4 | 1 | ||
| 2 | 2 | New York Red Bulls | 5 | 3 | 1 | 1 | 9 | 4 | +5 | 10 | WXLW | 2 | 0 | 1 | 1 | 1 | 2 | 3 | 3 | 0 | 0 | 8 | 2 | |
| 3 | 3 | Atlanta United | 5 | 3 | 1 | 1 | 9 | 8 | +1 | 10 | WXWL | 3 | 2 | 1 | 0 | 8 | 5 | 2 | 1 | 0 | 1 | 1 | 3 | |
| 4 | 1 | Chicago Fire | 5 | 2 | 3 | 0 | 5 | 1 | +4 | 9 | OWWO | 3 | 1 | 2 | 0 | 3 | 1 | 2 | 1 | 1 | 0 | 2 | 0 | |
| 5 | 3 | Columbus Crew | 5 | 2 | 2 | 1 | 10 | 6 | +4 | 8 | LXWX | 3 | 2 | 0 | 1 | 6 | 2 | 2 | 0 | 2 | 0 | 4 | 4 | |
| 6 | 1 | Orlando City | 6 | 2 | 2 | 2 | 7 | 7 | +0 | 8 | LXWL | 3 | 1 | 0 | 2 | 5 | 6 | 3 | 1 | 2 | 0 | 2 | 1 | |
| 7 | 4 | Toronto FC | 5 | 2 | 1 | 2 | 7 | 9 | -2 | 7 | WWLL | 3 | 2 | 0 | 1 | 5 | 6 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 8 | 1 | D.C. United | 5 | 2 | 0 | 3 | 5 | 5 | +0 | 6 | LLLW | 3 | 1 | 0 | 2 | 3 | 3 | 2 | 1 | 0 | 1 | 2 | 2 | |
| 9 | 3 | Charlotte FC | 6 | 2 | 0 | 4 | 6 | 9 | -3 | 6 | LWWL | 3 | 2 | 0 | 1 | 5 | 2 | 3 | 0 | 0 | 3 | 1 | 7 | |
| 10 | 2 | FC Cincinnati | 6 | 2 | 0 | 4 | 8 | 14 | -6 | 6 | LLWW | 3 | 1 | 0 | 2 | 6 | 6 | 3 | 1 | 0 | 2 | 2 | 8 | |
| 11 | 2 | New York City | 5 | 1 | 1 | 3 | 5 | 6 | -1 | 4 | LLWO | 2 | 1 | 0 | 1 | 4 | 3 | 3 | 0 | 1 | 2 | 1 | 3 | |
| 12 | 2 | New England Revolution | 5 | 1 | 1 | 3 | 6 | 9 | -3 | 4 | LLLW | 3 | 1 | 0 | 2 | 3 | 4 | 2 | 0 | 1 | 1 | 3 | 5 | |
| 13 | CF Montréal | 5 | 1 | 1 | 3 | 9 | 14 | -5 | 4 | WXLL | 1 | 0 | 0 | 1 | 1 | 2 | 4 | 1 | 1 | 2 | 8 | 12 | ||
| 14 | Inter Miami | 5 | 0 | 1 | 4 | 3 | 13 | -10 | 1 | LLLL | 3 | 0 | 1 | 2 | 1 | 5 | 2 | 0 | 0 | 2 | 2 | 8 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 5 | 4 | 1 | 0 | 13 | 4 | +9 | 13 | WWWX | 3 | 2 | 1 | 0 | 7 | 2 | 2 | 2 | 0 | 0 | 6 | 2 | ||
| 2 | Real Salt Lake | 6 | 3 | 2 | 1 | 7 | 5 | +2 | 11 | XLWW | 2 | 2 | 0 | 0 | 3 | 1 | 4 | 1 | 2 | 1 | 4 | 4 | ||
| 3 | 1 | Austin FC | 5 | 2 | 2 | 1 | 13 | 5 | +8 | 8 | XXLW | 3 | 2 | 1 | 0 | 11 | 2 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 4 | 1 | FC Dallas | 5 | 2 | 2 | 1 | 7 | 3 | +4 | 8 | OWWL | 3 | 2 | 1 | 0 | 7 | 2 | 2 | 0 | 1 | 1 | 0 | 1 | |
| 5 | 1 | Colorado Rapids | 5 | 2 | 2 | 1 | 7 | 5 | +2 | 8 | XXWW | 3 | 2 | 1 | 0 | 6 | 1 | 2 | 0 | 1 | 1 | 1 | 4 | |
| 6 | 2 | Houston Dynamo | 5 | 2 | 2 | 1 | 6 | 4 | +2 | 8 | WXWL | 3 | 1 | 2 | 0 | 3 | 2 | 2 | 1 | 0 | 1 | 3 | 2 | |
| 7 | 4 | Minnesota United | 5 | 2 | 2 | 1 | 5 | 4 | +1 | 8 | LWWX | 3 | 1 | 1 | 1 | 3 | 3 | 2 | 1 | 1 | 0 | 2 | 1 | |
| 8 | 2 | Seattle Sounders | 5 | 2 | 1 | 2 | 6 | 6 | +0 | 7 | WXWL | 2 | 1 | 0 | 1 | 3 | 3 | 3 | 1 | 1 | 1 | 3 | 3 | |
| 9 | 2 | Nashville | 5 | 2 | 1 | 2 | 4 | 5 | -1 | 7 | WLLX | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 2 | 4 | 5 | |
| 10 | 3 | LA Galaxy | 4 | 2 | 0 | 2 | 4 | 4 | +0 | 6 | LLWW | 2 | 1 | 0 | 1 | 1 | 1 | 2 | 1 | 0 | 1 | 3 | 3 | |
| 11 | 1 | Sporting Kansas City | 6 | 2 | 0 | 4 | 4 | 9 | -5 | 6 | LWLL | 2 | 2 | 0 | 0 | 2 | 0 | 4 | 0 | 0 | 4 | 2 | 9 | |
| 12 | 3 | Portland Timbers | 5 | 1 | 3 | 1 | 6 | 8 | -2 | 6 | XLWX | 3 | 1 | 2 | 0 | 4 | 3 | 2 | 0 | 1 | 1 | 2 | 5 | |
| 13 | 1 | Vancouver Whitecaps | 5 | 1 | 1 | 3 | 3 | 9 | -6 | 4 | WLLO | 2 | 1 | 1 | 0 | 1 | 0 | 3 | 0 | 0 | 3 | 2 | 9 | |
| 14 | 1 | San Jose Earthquakes | 5 | 0 | 2 | 3 | 6 | 11 | -5 | 2 | XLLX | 3 | 0 | 2 | 1 | 6 | 8 | 2 | 0 | 0 | 2 | 0 | 3 | |
| 5 | +1 | Brandon VÁZQUEZ (FC Cincinnati) |
| 4 | +2 | Karol ŚWIDERSKI (Charlotte FC) |
| +1 | Dániel GAZDAG (Philadelphia Union, 1p) | |
| Lucas ZELARAYÁN (Columbus Crew) | ||
| Carlos VELA (Los Angeles, 1p) | ||
| +1 | Sebastián DRIUSSI (Austin FC, 1p) | |
| 3 | Lewis MORGAN (New York Red Bulls) | |
| +2 | Djordje MIHAILOVIC (CF Montréal) | |
| Jesús FERREIRA (FC Dallas) | ||
| +1 | Darwin QUINTERO (Houston Dynamo) | |
| +1 | Jesús JIMÉNEZ (Toronto FC) |
| Saturday, 26 March 2022 | |||||
| Sporting Kansas City | 1-0 | Real Salt Lake | |||
| 81 | Russell | ||||
| Charlotte FC | 2-0 | FC Cincinnati | |||
| 6 | Świderski | ||||
| 55 | Świderski | ||||
| Sunday, 27 March 2022 | |||||
| Portland Timbers | 1-1 | Orlando City | |||
| 80(p) | Paredes | 52 | Júnior Urso | ||
| Saturday, 2 April 2022 | |||||
| D.C. United | 0-1 | Atlanta United | |||
| 90 | Moreno | ||||
| Colorado Rapids | 1-1 | Real Salt Lake | |||
| 56 | Abubakar | 45(p) | Ruíz | ||
| Columbus Crew | 0-1 | Nashville | |||
| 28 | Muyl | ||||
| New England Revolution | 0-1 | New York Red Bulls | |||
| 90(og) | Polster | ||||
| Chicago Fire | 0-0 | FC Dallas | |||
| Vancouver Whitecaps | 1-0 | Sporting Kansas City | |||
| 73 | Raposo | ||||
| Toronto FC | 2-1 | New York City | |||
| 31 | Jiménez | 90 | Héber | ||
| 43(og) | Thiago Martins | ||||
| San Jose Earthquakes | 2-2 | Austin FC | |||
| 70(p) | Ebobisse | 11 | Urruti | ||
| 72 | Cowell | 52(p) | Driussi | ||
| Orlando City | 2-4 | Los Angeles | |||
| 36 | Alexandre Pato | 24 | Rodríguez | ||
| 45 | João Moutinho | 38 | Murillo | ||
| 51 | Ilie | ||||
| 90 | Opoku | ||||
| Philadelphia Union | 2-0 | Charlotte FC | |||
| 4 | Carranza | ||||
| 46 | Gazdag | ||||
| Minnesota United | 1-2 | Seattle Sounders | |||
| 82(p) | Reynoso | 38 | João Paulo | ||
| 49(og) | Kallman | ||||
| FC Cincinnati | 3-4 | CF Montréal | |||
| 12 | Vázquez | 17 | Mihailovic | ||
| 20(og) | Johnston | 41 | Mihailovic | ||
| 61(p) | Acosta | 45 | Kamara | ||
| 67 | Torres | ||||
| Inter Miami | 1-3 | Houston Dynamo | |||
| 66(p) | Higuaín | 49 | Quintero | ||
| 57(p) | Picault | ||||
| 90 | Picault | ||||
