Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 42 | 106 | 2.52 | 21 | 50.00% | 10 | 23.81% | 11 | 26.19% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | Columbus Crew | 3 | 2 | 1 | 0 | 9 | 4 | +5 | 7 | WXW- | 2 | 2 | 0 | 0 | 6 | 1 | 1 | 0 | 1 | 0 | 3 | 3 | |
| 2 | 3 | Philadelphia Union | 3 | 2 | 1 | 0 | 5 | 2 | +3 | 7 | WWX- | 2 | 1 | 1 | 0 | 3 | 1 | 1 | 1 | 0 | 0 | 2 | 1 | |
| 3 | 2 | New York Red Bulls | 3 | 2 | 0 | 1 | 7 | 3 | +4 | 6 | LWW- | 1 | 0 | 0 | 1 | 0 | 1 | 2 | 2 | 0 | 0 | 7 | 2 | |
| 4 | 2 | D.C. United | 3 | 2 | 0 | 1 | 4 | 2 | +2 | 6 | LWW- | 2 | 1 | 0 | 1 | 3 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | |
| 5 | 2 | Atlanta United | 3 | 2 | 0 | 1 | 5 | 5 | +0 | 6 | WLW- | 2 | 2 | 0 | 0 | 5 | 2 | 1 | 0 | 0 | 1 | 0 | 3 | |
| 6 | 2 | Chicago Fire | 3 | 1 | 2 | 0 | 2 | 0 | +2 | 5 | WOO- | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 2 | 0 | |
| 7 | 2 | New York City | 3 | 1 | 1 | 1 | 4 | 2 | +2 | 4 | WOL- | 1 | 1 | 0 | 0 | 4 | 1 | 2 | 0 | 1 | 1 | 0 | 1 | |
| 8 | 4 | Orlando City | 3 | 1 | 1 | 1 | 3 | 2 | +1 | 4 | LOW- | 2 | 1 | 0 | 1 | 3 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | |
| 9 | 3 | New England Revolution | 3 | 1 | 1 | 1 | 5 | 5 | +0 | 4 | LWX- | 2 | 1 | 0 | 1 | 3 | 3 | 1 | 0 | 1 | 0 | 2 | 2 | |
| 10 | 4 | FC Cincinnati | 3 | 1 | 0 | 2 | 2 | 7 | -5 | 3 | WLL- | 1 | 0 | 0 | 1 | 0 | 1 | 2 | 1 | 0 | 1 | 2 | 6 | |
| 11 | 1 | Toronto FC | 3 | 0 | 1 | 2 | 3 | 7 | -4 | 1 | LLX- | 1 | 0 | 0 | 1 | 1 | 4 | 2 | 0 | 1 | 1 | 2 | 3 | |
| 12 | 1 | Inter Miami | 3 | 0 | 1 | 2 | 1 | 7 | -6 | 1 | LLO- | 2 | 0 | 1 | 1 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 5 | |
| 13 | Charlotte FC | 3 | 0 | 0 | 3 | 1 | 6 | -5 | 0 | LLL- | 1 | 0 | 0 | 1 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 5 | ||
| 14 | 2 | CF Montréal | 3 | 0 | 0 | 3 | 2 | 8 | -6 | 0 | LLL- | 1 | 0 | 0 | 1 | 1 | 2 | 2 | 0 | 0 | 2 | 1 | 6 | |
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 2 | Los Angeles | 3 | 2 | 1 | 0 | 6 | 1 | +5 | 7 | WXW- | 2 | 1 | 1 | 0 | 4 | 1 | 1 | 1 | 0 | 0 | 2 | 0 | |
| 2 | 3 | Real Salt Lake | 3 | 2 | 1 | 0 | 4 | 2 | +2 | 7 | WWO- | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 1 | 1 | 0 | 3 | 2 | |
| 3 | 2 | Austin FC | 3 | 2 | 0 | 1 | 10 | 2 | +8 | 6 | LWW- | 2 | 2 | 0 | 0 | 10 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | |
| 4 | 2 | Colorado Rapids | 3 | 2 | 0 | 1 | 5 | 3 | +2 | 6 | WWL- | 2 | 2 | 0 | 0 | 5 | 0 | 1 | 0 | 0 | 1 | 0 | 3 | |
| 5 | 3 | LA Galaxy | 3 | 2 | 0 | 1 | 4 | 3 | +1 | 6 | LWW- | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 1 | 0 | 1 | 3 | 3 | |
| 6 | 2 | Portland Timbers | 3 | 1 | 2 | 0 | 4 | 3 | +1 | 5 | WXX- | 2 | 1 | 1 | 0 | 3 | 2 | 1 | 0 | 1 | 0 | 1 | 1 | |
| 7 | 2 | Minnesota United | 3 | 1 | 2 | 0 | 3 | 2 | +1 | 5 | WXX- | 1 | 0 | 1 | 0 | 1 | 1 | 2 | 1 | 1 | 0 | 2 | 1 | |
| 8 | 2 | FC Dallas | 3 | 1 | 1 | 1 | 3 | 2 | +1 | 4 | WLX- | 2 | 1 | 1 | 0 | 3 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | |
| 9 | 2 | Houston Dynamo | 3 | 1 | 1 | 1 | 2 | 2 | +0 | 4 | WLO- | 2 | 1 | 1 | 0 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | |
| 10 | 6 | Nashville | 3 | 1 | 1 | 1 | 2 | 3 | -1 | 4 | LXW- | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 1 | 2 | 3 | |
| 11 | 3 | Seattle Sounders | 3 | 1 | 0 | 2 | 3 | 4 | -1 | 3 | WLL- | 2 | 1 | 0 | 1 | 3 | 3 | 1 | 0 | 0 | 1 | 0 | 1 | |
| 12 | 5 | Sporting Kansas City | 3 | 1 | 0 | 2 | 2 | 5 | -3 | 3 | LWL- | 1 | 1 | 0 | 0 | 1 | 0 | 2 | 0 | 0 | 2 | 1 | 5 | |
| 13 | 1 | San Jose Earthquakes | 3 | 0 | 1 | 2 | 4 | 8 | -4 | 1 | LXL- | 2 | 0 | 1 | 1 | 4 | 6 | 1 | 0 | 0 | 1 | 0 | 2 | |
| 14 | 1 | Vancouver Whitecaps | 3 | 0 | 1 | 2 | 1 | 6 | -5 | 1 | LOL- | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 6 | |
| 4 | +1 | Lucas ZELARAYÁN (Columbus Crew) |
| 3 | Lewis MORGAN (New York Red Bulls) | |
| Carlos VELA (Los Angeles, 1p) | ||
| Sebastián DRIUSSI (Austin FC) | ||
| 2 | Michael ESTRADA (D.C. United, 1p) | |
| +1 | Dániel GAZDAG (Philadelphia Union, 1p) | |
| +1 | Javier HERNÁNDEZ (LA Galaxy) | |
| +1 | Derrick ETIENNE (Columbus Crew) | |
| Ola KAMARA (D.C. United, 1p) | ||
| +2 | Darwin QUINTERO (Houston Dynamo) | |
| Francisco CALVO (San Jose Earthquakes) | ||
| +1 | Cory BURKE (Philadelphia Union) | |
| +2 | Brandon VÁZQUEZ (FC Cincinnati) | |
| +1 | Diego RUBIO (Colorado Rapids) | |
| Cecilio DOMÍNGUEZ (Austin FC) | ||
| +1 | Jesús JIMÉNEZ (Toronto FC) | |
| Ethan FINLAY (Austin FC) | ||
| Yimmi CHARÁ (Portland Timbers) |
| Saturday, 12 March 2022 | |||||
| D.C. United | 0-2 | Chicago Fire | |||
| 32 | Ivanov | ||||
| 80 | Bornstein | ||||
| FC Dallas | 2-0 | Nashville | |||
| 85(p) | Jara | ||||
| 87 | Velasco | ||||
| Houston Dynamo | 2-1 | Vancouver Whitecaps | |||
| 33 | Quintero | 14 | Cavallini | ||
| 50 | Quintero | ||||
| Colorado Rapids | 2-0 | Sporting Kansas City | |||
| 21 | Rubio | ||||
| 51 | Kaye | ||||
| Columbus Crew | 2-1 | Toronto FC | |||
| 56 | Zelarayán | 14 | Jiménez | ||
| 65 | Etienne | ||||
| New England Revolution | 2-3 | Real Salt Lake | |||
| 45 | Boateng | 78 | Córdova | ||
| 62 | Altidore | 88 | Glad | ||
| 90 | Schmitt | ||||
| Portland Timbers | 1-0 | Austin FC | |||
| 62 | Tuiloma | ||||
| Seattle Sounders | 3-2 | LA Galaxy | |||
| 17 | Morris | 6 | Hernández | ||
| 45(p) | Montero | 48 | Douglas Costa | ||
| 72 | Arreaga | ||||
| Orlando City | 1-2 | FC Cincinnati | |||
| 42 | Júnior Urso | 13 | Vázquez | ||
| 53 | Vázquez | ||||
| Philadelphia Union | 2-0 | San Jose Earthquakes | |||
| 23 | Burke | ||||
| 58(p) | Gazdag | ||||
| New York City | 4-1 | CF Montréal | |||
| 7 | Callens | 52 | Brault-Guillard | ||
| 20 | Rodríguez | ||||
| 64 | Talles Magno | ||||
| 83 | Thiago Andrade | ||||
| Inter Miami | 0-2 | Los Angeles | |||
| 45 | Opoku | ||||
| 82 | Tajouri-Shradi | ||||
| Sunday, 13 March 2022 | |||||
| New York Red Bulls | 0-1 | Minnesota United | |||
| 51 | Amarilla | ||||
| Atlanta United | 2-1 | Charlotte FC | |||
| 60(p) | Martínez | 66 | Armour | ||
| 90 | Mulraney | ||||
