Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 |
| 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 263 | 748 | 2.84 | 126 | 47.91% | 66 | 25.10% | 71 | 27.00% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 20 | 9 | 6 | 5 | 30 | 21 | +9 | 33 | XWWL | 9 | 3 | 4 | 2 | 14 | 10 | 11 | 6 | 2 | 3 | 16 | 11 | ||
| 2 | Philadelphia Union | 19 | 8 | 9 | 2 | 29 | 13 | +16 | 33 | WOLW | 10 | 5 | 5 | 0 | 18 | 5 | 9 | 3 | 4 | 2 | 11 | 8 | ||
| 3 | 1 | New York City | 18 | 9 | 5 | 4 | 37 | 21 | +16 | 32 | WXXL | 11 | 7 | 3 | 1 | 28 | 12 | 7 | 2 | 2 | 3 | 9 | 9 | |
| 4 | 1 | CF Montréal | 19 | 9 | 2 | 8 | 33 | 35 | -2 | 29 | LLWW | 9 | 5 | 0 | 4 | 17 | 14 | 10 | 4 | 2 | 4 | 16 | 21 | |
| 5 | 1 | Orlando City | 19 | 8 | 4 | 7 | 24 | 28 | -4 | 28 | WLLW | 10 | 5 | 0 | 5 | 15 | 19 | 9 | 3 | 4 | 2 | 9 | 9 | |
| 6 | 2 | Charlotte FC | 20 | 8 | 2 | 10 | 23 | 24 | -1 | 26 | WWLL | 10 | 7 | 0 | 3 | 15 | 7 | 10 | 1 | 2 | 7 | 8 | 17 | |
| 7 | 2 | FC Cincinnati | 19 | 7 | 5 | 7 | 30 | 33 | -3 | 26 | XXXW | 9 | 3 | 2 | 4 | 17 | 16 | 10 | 4 | 3 | 3 | 13 | 17 | |
| 8 | 2 | Columbus Crew | 18 | 6 | 7 | 5 | 23 | 20 | +3 | 25 | WOWO | 8 | 3 | 2 | 3 | 10 | 7 | 10 | 3 | 5 | 2 | 13 | 13 | |
| 9 | 2 | New England Revolution | 19 | 6 | 7 | 6 | 31 | 32 | -1 | 25 | LXOW | 10 | 4 | 4 | 2 | 15 | 12 | 9 | 2 | 3 | 4 | 16 | 20 | |
| 10 | 1 | Inter Miami | 18 | 6 | 4 | 8 | 18 | 27 | -9 | 22 | LXWL | 9 | 5 | 2 | 2 | 14 | 12 | 9 | 1 | 2 | 6 | 4 | 15 | |
| 11 | Atlanta United | 18 | 5 | 5 | 8 | 26 | 29 | -3 | 20 | LXLL | 9 | 4 | 3 | 2 | 17 | 13 | 9 | 1 | 2 | 6 | 9 | 16 | ||
| 12 | Toronto FC | 19 | 5 | 4 | 10 | 26 | 36 | -10 | 19 | XLLW | 11 | 5 | 1 | 5 | 16 | 19 | 8 | 0 | 3 | 5 | 10 | 17 | ||
| 13 | D.C. United | 17 | 5 | 2 | 10 | 23 | 37 | -14 | 17 | LWLL | 9 | 3 | 1 | 5 | 13 | 15 | 8 | 2 | 1 | 5 | 10 | 22 | ||
| 14 | Chicago Fire | 19 | 4 | 5 | 10 | 18 | 27 | -9 | 17 | LLWL | 9 | 3 | 3 | 3 | 9 | 8 | 10 | 1 | 2 | 7 | 9 | 19 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Los Angeles | 19 | 12 | 3 | 4 | 38 | 21 | +17 | 39 | WLWW | 11 | 8 | 2 | 1 | 26 | 12 | 8 | 4 | 1 | 3 | 12 | 9 | ||
| 2 | Austin FC | 19 | 11 | 4 | 4 | 38 | 22 | +16 | 37 | WWWX | 8 | 4 | 3 | 1 | 19 | 7 | 11 | 7 | 1 | 3 | 19 | 15 | ||
| 3 | Real Salt Lake | 19 | 8 | 6 | 5 | 24 | 24 | +0 | 30 | XLOW | 9 | 6 | 3 | 0 | 15 | 6 | 10 | 2 | 3 | 5 | 9 | 18 | ||
| 4 | 1 | FC Dallas | 19 | 7 | 7 | 5 | 30 | 23 | +7 | 28 | XXLX | 9 | 5 | 2 | 2 | 16 | 9 | 10 | 2 | 5 | 3 | 14 | 14 | |
| 5 | 1 | LA Galaxy | 18 | 8 | 3 | 7 | 26 | 22 | +4 | 27 | LWLX | 10 | 5 | 1 | 4 | 16 | 13 | 8 | 3 | 2 | 3 | 10 | 9 | |
| 6 | 2 | Minnesota United | 19 | 8 | 3 | 8 | 26 | 24 | +2 | 27 | WWWL | 9 | 4 | 2 | 3 | 13 | 9 | 10 | 4 | 1 | 5 | 13 | 15 | |
| 7 | 1 | Nashville | 19 | 7 | 6 | 6 | 25 | 25 | +0 | 27 | LXWL | 7 | 2 | 4 | 1 | 10 | 8 | 12 | 5 | 2 | 5 | 15 | 17 | |
| 8 | 1 | Seattle Sounders | 18 | 8 | 2 | 8 | 26 | 22 | +4 | 26 | LWLW | 10 | 5 | 1 | 4 | 17 | 12 | 8 | 3 | 1 | 4 | 9 | 10 | |
| 9 | 1 | Portland Timbers | 20 | 6 | 8 | 6 | 32 | 29 | +3 | 26 | WXWW | 9 | 4 | 3 | 2 | 17 | 11 | 11 | 2 | 5 | 4 | 15 | 18 | |
| 10 | 1 | Vancouver Whitecaps | 19 | 7 | 3 | 9 | 20 | 31 | -11 | 24 | LWOW | 10 | 5 | 3 | 2 | 13 | 11 | 9 | 2 | 0 | 7 | 7 | 20 | |
| 11 | Houston Dynamo | 19 | 6 | 4 | 9 | 24 | 25 | -1 | 22 | XLLW | 11 | 4 | 4 | 3 | 15 | 12 | 8 | 2 | 0 | 6 | 9 | 13 | ||
| 12 | Colorado Rapids | 18 | 5 | 5 | 8 | 21 | 26 | -5 | 20 | XLLX | 9 | 5 | 2 | 2 | 14 | 7 | 9 | 0 | 3 | 6 | 7 | 19 | ||
| 13 | 1 | Sporting Kansas City | 20 | 5 | 4 | 11 | 18 | 34 | -16 | 19 | WLLW | 9 | 3 | 2 | 4 | 8 | 9 | 11 | 2 | 2 | 7 | 10 | 25 | |
| 14 | 1 | San Jose Earthquakes | 18 | 4 | 7 | 7 | 29 | 37 | -8 | 19 | XWLO | 9 | 4 | 4 | 1 | 19 | 17 | 9 | 0 | 3 | 6 | 10 | 20 | |
| 12 | +2 | Valentín CASTELLANOS (New York City, 5p) |
| 11 | +1 | Jesús FERREIRA (FC Dallas) |
| +1 | Sebastián DRIUSSI (Austin FC, 2p) | |
| 10 | +1 | Jeremy EBOBISSE (San Jose Earthquakes, 1p) |
| +1 | Hany MUKHTAR (Nashville, 1p) | |
| 9 | +1 | Lewis MORGAN (New York Red Bulls, 4p) |
| Taxiarchis FOUNTAS (D.C. United) | ||
| +1 | Brandon VÁZQUEZ (FC Cincinnati) | |
| 8 | Paul ARRIOLA (FC Dallas) | |
| Leonardo CAMPANA (Inter Miami) | ||
| +1 | Diego RUBIO (Colorado Rapids, 2p) | |
| Jesús JIMÉNEZ (Toronto FC) | ||
| 7 | +1 | Jarosław NIEZGODA (Portland Timbers) |
| +3 | Julián CARRANZA (Philadelphia Union, 1p) | |
| +1 | Cristian ARANGO (Los Angeles, 1p) | |
| Dániel GAZDAG (Philadelphia Union, 1p) | ||
| Javier HERNÁNDEZ (LA Galaxy) | ||
| Djordje MIHAILOVIC (CF Montréal) | ||
| Ercan KARA (Orlando City) | ||
| Adam BUKSA (New England Revolution) | ||
| +1 | Rommel QUIOTO (CF Montréal, 2p) | |
| Darwin QUINTERO (Houston Dynamo, 1p) | ||
| Emanuel REYNOSO (Minnesota United, 2p) |
| Friday, 8 July 2022 | |||||
| Vancouver Whitecaps | 1-3 | Minnesota United | |||
| 66 | Cavallini | 71 | Lawrence | ||
| 84 | Amarilla | ||||
| 88 | Fragapane | ||||
| Philadelphia Union | 7-0 | D.C. United | |||
| 9 | Bedoya | ||||
| 22 | Carranza | ||||
| 25 | Carranza | ||||
| 37 | Bedoya | ||||
| 45 | Uhre | ||||
| 59 | Uhre | ||||
| 72 | Carranza | ||||
| Los Angeles | 3-2 | LA Galaxy | |||
| 17 | Cifuentes | 55 | Grandsir | ||
| 70 | Cifuentes | 81 | Raveloson | ||
| 72 | Arango | ||||
| Saturday, 9 July 2022 | |||||
| Houston Dynamo | 2-2 | FC Dallas | |||
| 69 | Úlfarsson | 27 | Hedges | ||
| 90 | Hadebe | 90 | Ferreira | ||
| Chicago Fire | 2-3 | Columbus Crew | |||
| 29 | Czichos | 63 | Etienne | ||
| 41 | Mueller | 75 | Etienne | ||
| 83 | Cucho | ||||
| CF Montréal | 1-2 | Sporting Kansas City | |||
| 13 | Quioto | 29 | Espinoza | ||
| 63 | Walter | ||||
| Seattle Sounders | 0-3 | Portland Timbers | |||
| 24 | Niezgoda | ||||
| 82(p) | Moreno | ||||
| 85 | Asprilla | ||||
| Real Salt Lake | 2-2 | Colorado Rapids | |||
| 45 | Savarino | 67(p) | Rubio | ||
| 51 | Meram | 89 | Abubakar | ||
| Toronto FC | 2-2 | San Jose Earthquakes | |||
| 71 | Kerr | 26 | Ebobisse | ||
| 75 | Osorio | 90 | Skahan | ||
| Orlando City | 1-0 | Inter Miami | |||
| 90(og) | Lowe | ||||
| New York City | 4-2 | New England Revolution | |||
| 10(p) | Talles Magno | 18 | Bou | ||
| 44(p) | Castellanos | 77 | Bou | ||
| 49 | Gabriel Pereira | ||||
| 82 | Castellanos | ||||
| Atlanta United | 0-3 | Austin FC | |||
| 9 | Felipe | ||||
| 17 | Finlay | ||||
| 57 | Driussi | ||||
| FC Cincinnati | 1-1 | New York Red Bulls | |||
| 21 | Vázquez | 29(p) | Morgan | ||
| Charlotte FC | 4-1 | Nashville | |||
| 26(p) | Fuchs | 67(p) | Mukhtar | ||
| 61 | Świderski | ||||
| 89 | Sergio Ruiz | ||||
| 90 | André Bava | ||||
