Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 238 | 584 | 2.45 | 114 | 47.90% | 58 | 24.37% | 66 | 27.73% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 30 | 15 | 6 | 9 | 38 | 29 | +9 | 51 | WLOW | 15 | 10 | 2 | 3 | 18 | 9 | 15 | 5 | 4 | 6 | 20 | 20 | ||
| 2 | Columbus Crew | 29 | 13 | 8 | 8 | 37 | 33 | +4 | 47 | XLOX | 14 | 9 | 2 | 3 | 19 | 11 | 15 | 4 | 6 | 5 | 18 | 22 | ||
| 3 | Kansas City Wizards | 30 | 11 | 6 | 13 | 36 | 35 | +1 | 39 | WLWL | 15 | 7 | 3 | 5 | 25 | 19 | 15 | 4 | 3 | 8 | 11 | 16 | ||
| 4 | Chicago Fire | 30 | 9 | 9 | 12 | 37 | 38 | -1 | 36 | WOLW | 15 | 4 | 7 | 4 | 14 | 13 | 15 | 5 | 2 | 8 | 23 | 25 | ||
| 5 | Toronto FC | 30 | 9 | 8 | 13 | 33 | 41 | -8 | 35 | WXLL | 15 | 6 | 6 | 3 | 19 | 15 | 15 | 3 | 2 | 10 | 14 | 26 | ||
| 6 | New England Revolution | 30 | 9 | 5 | 16 | 32 | 50 | -18 | 32 | LWWL | 15 | 7 | 3 | 5 | 21 | 18 | 15 | 2 | 2 | 11 | 11 | 32 | ||
| 7 | Philadelphia Union | 29 | 8 | 7 | 14 | 34 | 46 | -12 | 31 | WLXL | 15 | 6 | 6 | 3 | 22 | 16 | 14 | 2 | 1 | 11 | 12 | 30 | ||
| 8 | D.C. United | 30 | 6 | 4 | 20 | 21 | 47 | -26 | 22 | LOLW | 15 | 3 | 1 | 11 | 12 | 25 | 15 | 3 | 3 | 9 | 9 | 22 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Real Salt Lake | 30 | 15 | 11 | 4 | 45 | 20 | +25 | 56 | XWOW | 15 | 11 | 4 | 0 | 31 | 7 | 15 | 4 | 7 | 4 | 14 | 13 | |
| 2 | 1 | LA Galaxy | 29 | 17 | 5 | 7 | 42 | 25 | +17 | 56 | LWWL | 14 | 8 | 2 | 4 | 25 | 18 | 15 | 9 | 3 | 3 | 17 | 7 | |
| 3 | FC Dallas | 29 | 12 | 14 | 3 | 41 | 26 | +15 | 50 | LXWW | 15 | 8 | 6 | 1 | 25 | 13 | 14 | 4 | 8 | 2 | 16 | 13 | ||
| 4 | Seattle Sounders | 30 | 14 | 6 | 10 | 39 | 35 | +4 | 48 | LWWW | 15 | 8 | 3 | 4 | 21 | 16 | 15 | 6 | 3 | 6 | 18 | 19 | ||
| 5 | Colorado Rapids | 30 | 12 | 10 | 8 | 44 | 32 | +12 | 46 | XWXL | 15 | 8 | 5 | 2 | 26 | 11 | 15 | 4 | 5 | 6 | 18 | 21 | ||
| 6 | San Jose Earthquakes | 30 | 13 | 7 | 10 | 34 | 33 | +1 | 46 | LWLW | 15 | 7 | 3 | 5 | 17 | 14 | 15 | 6 | 4 | 5 | 17 | 19 | ||
| 7 | Houston Dynamo | 30 | 9 | 6 | 15 | 40 | 49 | -9 | 33 | WWLX | 15 | 6 | 3 | 6 | 25 | 21 | 15 | 3 | 3 | 9 | 15 | 28 | ||
| 8 | Chivas USA | 30 | 8 | 4 | 18 | 31 | 45 | -14 | 28 | LLLW | 15 | 6 | 2 | 7 | 19 | 19 | 15 | 2 | 2 | 11 | 12 | 26 | ||
| 18 | +4 | Chris WONDOLOWSKI (San Jose Earthquakes, 3p) |
| 17 | Edson BUDDLE (LA Galaxy) | |
| 15 | +2 | Dwayne DE ROSARIO (Toronto FC, 2p) |
| 14 | +1 | Omar CUMMINGS (Colorado Rapids) |
| 13 | Sébastien LE TOUX (Philadelphia Union, 2p) | |
| Juan Pablo ÁNGEL (New York Red Bulls, 3p) | ||
| +1 | Conor CASEY (Colorado Rapids, 3p) | |
| 12 | +2 | Álvaro SABORIO (Real Salt Lake, 2p) |
| 11 | Jeff CUNNINGHAM (FC Dallas, 3p) | |
| 10 | Kei KAMARA (Kansas City Wizards) | |
| Fredy MONTERO (Seattle Sounders) | ||
| Steve ZAKUANI (Seattle Sounders) | ||
| 9 | Justin BRAUN (Chivas USA) | |
| 8 | Guillermo BARROS SCHELOTTO (Columbus Crew, 4p) | |
| David FERREIRA (FC Dallas, 4p) | ||
| 7 | Landon DONOVAN (LA Galaxy, 3p) | |
| Danny MWANGA (Philadelphia Union) | ||
| Chad BARRETT (Toronto FC) | ||
| Brian CHING (Houston Dynamo) | ||
| Javier MORALES (Real Salt Lake) | ||
| Marco PAPPA (Chicago Fire) |
| Wednesday, 20 October 2010 | |||||
| San Jose Earthquakes | 3-0 | Chivas USA | |||
| 55(p) | Wondolowski | ||||
| 59 | Wondolowski | ||||
| 72 | Wondolowski | ||||
| Thursday, 21 October 2010 | |||||
| New York Red Bulls | 2-0 | New England Revolution | |||
| 17 | Richards | ||||
| 90 | Lindpere | ||||
| Saturday, 23 October 2010 | |||||
| D.C. United | 2-3 | Toronto FC | |||
| 2 | Quaranta | 23 | Maicon Carioca | ||
| 39(p) | Moreno | 48 | De Rosario | ||
| 65 | De Rosario | ||||
| Houston Dynamo | 2-1 | Seattle Sounders | |||
| 27 | Cameron | 12 | Riley | ||
| 46 | Weaver | ||||
| Colorado Rapids | 2-2 | Real Salt Lake | |||
| 16 | Cummings | 90 | Saborio | ||
| 51 | Casey | 90(p) | Saborio | ||
| Kansas City Wizards | 4-1 | San Jose Earthquakes | |||
| 36 | Diop | 70 | Wondolowski | ||
| 60 | Diop | ||||
| 76 | Diop | ||||
| 90(og) | Eduardo | ||||
| Chivas USA | 1-4 | Chicago Fire | |||
| 57 | Maldonado | 40 | McBride | ||
| 47 | Ljungberg | ||||
| 68 | Carr | ||||
| 90 | Husidić | ||||
