Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 221 | 534 | 2.41 | 106 | 47.96% | 55 | 24.89% | 60 | 27.15% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 28 | 14 | 6 | 8 | 35 | 27 | +8 | 48 | OWWX | 14 | 9 | 2 | 3 | 16 | 9 | 14 | 5 | 4 | 5 | 19 | 18 | ||
| 2 | Columbus Crew | 28 | 13 | 7 | 8 | 35 | 31 | +4 | 46 | LOXL | 14 | 9 | 2 | 3 | 19 | 11 | 14 | 4 | 5 | 5 | 16 | 20 | ||
| 3 | Kansas City Wizards | 27 | 9 | 6 | 12 | 30 | 33 | -3 | 33 | LLLW | 14 | 6 | 3 | 5 | 21 | 18 | 13 | 3 | 3 | 7 | 9 | 15 | ||
| 4 | 1 | Chicago Fire | 27 | 8 | 8 | 11 | 33 | 35 | -2 | 32 | WLWL | 13 | 4 | 6 | 3 | 14 | 11 | 14 | 4 | 2 | 8 | 19 | 24 | |
| 5 | 1 | Toronto FC | 28 | 8 | 7 | 13 | 28 | 37 | -9 | 31 | LLLW | 14 | 6 | 5 | 3 | 17 | 13 | 14 | 2 | 2 | 10 | 11 | 24 | |
| 6 | Philadelphia Union | 28 | 7 | 7 | 14 | 32 | 45 | -13 | 28 | LXLW | 14 | 5 | 6 | 3 | 20 | 15 | 14 | 2 | 1 | 11 | 12 | 30 | ||
| 7 | New England Revolution | 27 | 7 | 5 | 15 | 29 | 47 | -18 | 26 | LXXL | 14 | 6 | 3 | 5 | 20 | 18 | 13 | 1 | 2 | 10 | 9 | 29 | ||
| 8 | D.C. United | 28 | 6 | 3 | 19 | 19 | 44 | -25 | 21 | LWLL | 14 | 3 | 1 | 10 | 10 | 22 | 14 | 3 | 2 | 9 | 9 | 22 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | LA Galaxy | 28 | 17 | 5 | 6 | 41 | 22 | +19 | 56 | WWLW | 13 | 8 | 2 | 3 | 24 | 15 | 15 | 9 | 3 | 3 | 17 | 7 | |
| 2 | 1 | Real Salt Lake | 28 | 14 | 10 | 4 | 41 | 18 | +23 | 52 | OWXW | 14 | 10 | 4 | 0 | 29 | 7 | 14 | 4 | 6 | 4 | 12 | 11 | |
| 3 | FC Dallas | 28 | 12 | 14 | 2 | 41 | 24 | +17 | 50 | XWWX | 15 | 8 | 6 | 1 | 25 | 13 | 13 | 4 | 8 | 1 | 16 | 11 | ||
| 4 | Seattle Sounders | 28 | 13 | 6 | 9 | 36 | 32 | +4 | 45 | WWWW | 14 | 7 | 3 | 4 | 19 | 15 | 14 | 6 | 3 | 5 | 17 | 17 | ||
| 5 | 1 | San Jose Earthquakes | 27 | 12 | 7 | 8 | 30 | 28 | +2 | 43 | WOLW | 13 | 6 | 3 | 4 | 14 | 13 | 14 | 6 | 4 | 4 | 16 | 15 | |
| 6 | 1 | Colorado Rapids | 28 | 11 | 9 | 8 | 39 | 29 | +10 | 42 | XLWX | 14 | 8 | 4 | 2 | 24 | 9 | 14 | 3 | 5 | 6 | 15 | 20 | |
| 7 | 1 | Chivas USA | 27 | 8 | 4 | 15 | 29 | 36 | -7 | 28 | WLLL | 14 | 6 | 2 | 6 | 18 | 15 | 13 | 2 | 2 | 9 | 11 | 21 | |
| 8 | 1 | Houston Dynamo | 27 | 7 | 6 | 14 | 36 | 46 | -10 | 27 | XWLL | 13 | 5 | 3 | 5 | 22 | 18 | 14 | 2 | 3 | 9 | 14 | 28 | |
| 16 | +2 | Edson BUDDLE (LA Galaxy) |
| 14 | +2 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) |
| 13 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| Sébastien LE TOUX (Philadelphia Union, 2p) | ||
| Juan Pablo ÁNGEL (New York Red Bulls, 3p) | ||
| 12 | Omar CUMMINGS (Colorado Rapids) | |
| 11 | Jeff CUNNINGHAM (FC Dallas, 3p) | |
| Conor CASEY (Colorado Rapids, 3p) | ||
| 10 | Kei KAMARA (Kansas City Wizards) | |
| Álvaro SABORIO (Real Salt Lake, 1p) | ||
| Fredy MONTERO (Seattle Sounders) | ||
| 9 | Justin BRAUN (Chivas USA) | |
| Steve ZAKUANI (Seattle Sounders) | ||
| 8 | Guillermo BARROS SCHELOTTO (Columbus Crew, 4p) | |
| +1 | David FERREIRA (FC Dallas, 4p) | |
| 7 | Landon DONOVAN (LA Galaxy, 3p) | |
| Danny MWANGA (Philadelphia Union) | ||
| Chad BARRETT (Toronto FC) | ||
| Brian CHING (Houston Dynamo) | ||
| Marco PAPPA (Chicago Fire) | ||
| 6 | Marko PEROVIĆ (New England Revolution) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Javier MORALES (Real Salt Lake) |
| Sunday, 3 October 2010 | |||||
| Chivas USA | 1-2 | LA Galaxy | |||
| 63 | Gordon | 15 | Buddle | ||
| 39 | Beckham | ||||
| Thursday, 7 October 2010 | |||||
| Philadelphia Union | 0-1 | LA Galaxy | |||
| 27 | Buddle | ||||
| Friday, 8 October 2010 | |||||
| Chicago Fire | 2-0 | Columbus Crew | |||
| 30 | Lowry | ||||
| 53 | McBride | ||||
| Saturday, 9 October 2010 | |||||
| D.C. United | 0-2 | San Jose Earthquakes | |||
| 45 | Wondolowski | ||||
| 55 | Wondolowski | ||||
| FC Dallas | 2-2 | Colorado Rapids | |||
| 27 | Rodríguez | 13 | Larentowicz | ||
| 37 | Ferreira | 51 | Larentowicz | ||
| New York Red Bulls | 0-0 | Real Salt Lake | |||
| Kansas City Wizards | 1-2 | Seattle Sounders | |||
| 84(p) | Arnaud | 66 | Nyassi | ||
| 78 | Fernández | ||||
| Chivas USA | 3-0 | Toronto FC | |||
| 51 | Villafaña | ||||
| 88 | Padilla | ||||
| 90 | Espinoza | ||||
