Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 169 | 406 | 2.40 | 85 | 50.30% | 42 | 24.85% | 42 | 24.85% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 22 | 12 | 5 | 5 | 31 | 20 | +11 | 41 | OWLW | 12 | 9 | 1 | 2 | 19 | 7 | 10 | 3 | 4 | 3 | 12 | 13 | ||
| 2 | New York Red Bulls | 22 | 11 | 4 | 7 | 27 | 23 | +4 | 37 | WWLW | 11 | 7 | 1 | 3 | 12 | 8 | 11 | 4 | 3 | 4 | 15 | 15 | ||
| 3 | Toronto FC | 21 | 7 | 6 | 8 | 22 | 25 | -3 | 27 | OLLW | 12 | 6 | 5 | 1 | 15 | 9 | 9 | 1 | 1 | 7 | 7 | 16 | ||
| 4 | 1 | Kansas City Wizards | 21 | 7 | 5 | 9 | 21 | 23 | -2 | 26 | WWLX | 11 | 5 | 3 | 3 | 15 | 10 | 10 | 2 | 2 | 6 | 6 | 13 | |
| 5 | 1 | Chicago Fire | 19 | 6 | 6 | 7 | 27 | 28 | -1 | 24 | LLWO | 9 | 3 | 4 | 2 | 11 | 9 | 10 | 3 | 2 | 5 | 16 | 19 | |
| 6 | New England Revolution | 21 | 6 | 3 | 12 | 21 | 35 | -14 | 21 | LLLW | 11 | 5 | 2 | 4 | 14 | 13 | 10 | 1 | 1 | 8 | 7 | 22 | ||
| 7 | Philadelphia Union | 21 | 5 | 5 | 11 | 25 | 37 | -12 | 20 | WLXX | 9 | 3 | 4 | 2 | 14 | 12 | 12 | 2 | 1 | 9 | 11 | 25 | ||
| 8 | D.C. United | 21 | 4 | 3 | 14 | 15 | 35 | -20 | 15 | WLLL | 11 | 3 | 1 | 7 | 9 | 16 | 10 | 1 | 2 | 7 | 6 | 19 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 22 | 13 | 4 | 5 | 32 | 16 | +16 | 43 | LLWL | 10 | 6 | 2 | 2 | 19 | 11 | 12 | 7 | 2 | 3 | 13 | 5 | ||
| 2 | Real Salt Lake | 22 | 11 | 7 | 4 | 36 | 16 | +20 | 40 | OWXX | 11 | 8 | 3 | 0 | 26 | 6 | 11 | 3 | 4 | 4 | 10 | 10 | ||
| 3 | FC Dallas | 21 | 9 | 10 | 2 | 28 | 17 | +11 | 37 | OWWW | 10 | 6 | 3 | 1 | 15 | 7 | 11 | 3 | 7 | 1 | 13 | 10 | ||
| 4 | 1 | Seattle Sounders | 22 | 9 | 5 | 8 | 25 | 26 | -1 | 32 | WOWW | 12 | 6 | 2 | 4 | 16 | 13 | 10 | 3 | 3 | 4 | 9 | 13 | |
| 5 | 1 | Colorado Rapids | 21 | 8 | 7 | 6 | 25 | 21 | +4 | 31 | WLXW | 10 | 5 | 4 | 1 | 14 | 7 | 11 | 3 | 3 | 5 | 11 | 14 | |
| 6 | 2 | San Jose Earthquakes | 20 | 8 | 5 | 7 | 22 | 22 | +0 | 29 | LWWL | 10 | 5 | 2 | 3 | 13 | 10 | 10 | 3 | 3 | 4 | 9 | 12 | |
| 7 | Houston Dynamo | 22 | 6 | 5 | 11 | 27 | 36 | -9 | 23 | LWLL | 11 | 5 | 3 | 3 | 20 | 14 | 11 | 1 | 2 | 8 | 7 | 22 | ||
| 8 | Chivas USA | 20 | 5 | 4 | 11 | 22 | 26 | -4 | 19 | LOLW | 9 | 3 | 2 | 4 | 11 | 11 | 11 | 2 | 2 | 7 | 11 | 15 | ||
| 13 | Edson BUDDLE (LA Galaxy) | |
| 12 | Juan Pablo ÁNGEL (New York Red Bulls, 2p) | |
| 10 | +2 | Fredy MONTERO (Seattle Sounders) |
| 9 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| Sébastien LE TOUX (Philadelphia Union, 2p) | ||
| 8 | Kei KAMARA (Kansas City Wizards) | |
| Álvaro SABORIO (Real Salt Lake) | ||
| Chris WONDOLOWSKI (San Jose Earthquakes, 1p) | ||
| +1 | Conor CASEY (Colorado Rapids, 3p) | |
| 7 | Danny MWANGA (Philadelphia Union) | |
| Justin BRAUN (Chivas USA) | ||
| Steve ZAKUANI (Seattle Sounders) | ||
| Marco PAPPA (Chicago Fire) | ||
| Jeff CUNNINGHAM (FC Dallas, 2p) | ||
| 6 | Guillermo BARROS SCHELOTTO (Columbus Crew, 3p) | |
| Chad BARRETT (Toronto FC) | ||
| +1 | Omar CUMMINGS (Colorado Rapids) | |
| David FERREIRA (FC Dallas, 3p) | ||
| Brian CHING (Houston Dynamo) | ||
| Javier MORALES (Real Salt Lake) | ||
| 5 | Landon DONOVAN (LA Galaxy, 3p) | |
| Brek SHEA (FC Dallas) | ||
| Marko PEROVIĆ (New England Revolution) | ||
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Steven LENHART (Columbus Crew) | ||
| Robbie FINDLEY (Real Salt Lake, 1p) | ||
| Zack SCHILAWSKI (New England Revolution) |
| Sunday, 22 August 2010 | |||||
| D.C. United | 2-0 | Philadelphia Union | |||
| 22 | Allsopp | ||||
| 63 | Allsopp | ||||
| Saturday, 28 August 2010 | |||||
| Colorado Rapids | 3-0 | Houston Dynamo | |||
| 2 | Smith | ||||
| 16 | Cummings | ||||
| 23 | Casey | ||||
| New York Red Bulls | 2-0 | San Jose Earthquakes | |||
| 45 | Richards | ||||
| 63 | Henry | ||||
| Columbus Crew | 0-0 | FC Dallas | |||
| New England Revolution | 1-2 | Philadelphia Union | |||
| 31 | Stolica | 82 | McInerney | ||
| 90 | Mapp | ||||
| LA Galaxy | 0-2 | Kansas City Wizards | |||
| 12 | Arnaud | ||||
| 70 | Conrad | ||||
| Seattle Sounders | 2-1 | Chicago Fire | |||
| 36 | Montero | 28(p) | Thorrington | ||
| 90 | Montero | ||||
| Toronto FC | 0-0 | Real Salt Lake | |||
