Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 161 | 391 | 2.42 | 81 | 50.31% | 40 | 24.84% | 40 | 24.84% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 21 | 12 | 4 | 5 | 31 | 20 | +11 | 40 | WLWL | 11 | 9 | 0 | 2 | 19 | 7 | 10 | 3 | 4 | 3 | 12 | 13 | ||
| 2 | New York Red Bulls | 21 | 10 | 4 | 7 | 25 | 23 | +2 | 34 | WLWO | 10 | 6 | 1 | 3 | 10 | 8 | 11 | 4 | 3 | 4 | 15 | 15 | ||
| 3 | Toronto FC | 20 | 7 | 5 | 8 | 22 | 25 | -3 | 26 | LLWL | 11 | 6 | 4 | 1 | 15 | 9 | 9 | 1 | 1 | 7 | 7 | 16 | ||
| 4 | Chicago Fire | 18 | 6 | 6 | 6 | 26 | 26 | +0 | 24 | LWOW | 9 | 3 | 4 | 2 | 11 | 9 | 9 | 3 | 2 | 4 | 15 | 17 | ||
| 5 | 1 | Kansas City Wizards | 20 | 6 | 5 | 9 | 19 | 23 | -4 | 23 | WLXW | 11 | 5 | 3 | 3 | 15 | 10 | 9 | 1 | 2 | 6 | 4 | 13 | |
| 6 | 1 | New England Revolution | 20 | 6 | 3 | 11 | 20 | 33 | -13 | 21 | LLWW | 10 | 5 | 2 | 3 | 13 | 11 | 10 | 1 | 1 | 8 | 7 | 22 | |
| 7 | Philadelphia Union | 19 | 4 | 5 | 10 | 23 | 34 | -11 | 17 | XXLL | 9 | 3 | 4 | 2 | 14 | 12 | 10 | 1 | 1 | 8 | 9 | 22 | ||
| 8 | D.C. United | 20 | 3 | 3 | 14 | 13 | 35 | -22 | 12 | LLLL | 10 | 2 | 1 | 7 | 7 | 16 | 10 | 1 | 2 | 7 | 6 | 19 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 21 | 13 | 4 | 4 | 32 | 14 | +18 | 43 | LWLX | 9 | 6 | 2 | 1 | 19 | 9 | 12 | 7 | 2 | 3 | 13 | 5 | ||
| 2 | Real Salt Lake | 21 | 11 | 6 | 4 | 36 | 16 | +20 | 39 | WXXW | 11 | 8 | 3 | 0 | 26 | 6 | 10 | 3 | 3 | 4 | 10 | 10 | ||
| 3 | FC Dallas | 20 | 9 | 9 | 2 | 28 | 17 | +11 | 36 | WWWX | 10 | 6 | 3 | 1 | 15 | 7 | 10 | 3 | 6 | 1 | 13 | 10 | ||
| 4 | 2 | San Jose Earthquakes | 19 | 8 | 5 | 6 | 22 | 20 | +2 | 29 | WWLL | 10 | 5 | 2 | 3 | 13 | 10 | 9 | 3 | 3 | 3 | 9 | 10 | |
| 5 | 1 | Seattle Sounders | 21 | 8 | 5 | 8 | 23 | 25 | -2 | 29 | OWWW | 11 | 5 | 2 | 4 | 14 | 12 | 10 | 3 | 3 | 4 | 9 | 13 | |
| 6 | 1 | Colorado Rapids | 20 | 7 | 7 | 6 | 22 | 21 | +1 | 28 | LXWX | 9 | 4 | 4 | 1 | 11 | 7 | 11 | 3 | 3 | 5 | 11 | 14 | |
| 7 | Houston Dynamo | 21 | 6 | 5 | 10 | 27 | 33 | -6 | 23 | WLLX | 11 | 5 | 3 | 3 | 20 | 14 | 10 | 1 | 2 | 7 | 7 | 19 | ||
| 8 | Chivas USA | 20 | 5 | 4 | 11 | 22 | 26 | -4 | 19 | LOLW | 9 | 3 | 2 | 4 | 11 | 11 | 11 | 2 | 2 | 7 | 11 | 15 | ||
| 13 | Edson BUDDLE (LA Galaxy) | |
| 12 | +1 | Juan Pablo ÁNGEL (New York Red Bulls, 2p) |
| 9 | +1 | Dwayne DE ROSARIO (Toronto FC, 2p) |
| Sébastien LE TOUX (Philadelphia Union, 2p) | ||
| 8 | +1 | Kei KAMARA (Kansas City Wizards) |
| Álvaro SABORIO (Real Salt Lake) | ||
| +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 1p) | |
| Fredy MONTERO (Seattle Sounders) | ||
| 7 | Danny MWANGA (Philadelphia Union) | |
| Justin BRAUN (Chivas USA) | ||
| Steve ZAKUANI (Seattle Sounders) | ||
| Marco PAPPA (Chicago Fire) | ||
| Jeff CUNNINGHAM (FC Dallas, 2p) | ||
| Conor CASEY (Colorado Rapids, 3p) | ||
| 6 | +1 | Guillermo BARROS SCHELOTTO (Columbus Crew, 3p) |
| Chad BARRETT (Toronto FC) | ||
| David FERREIRA (FC Dallas, 3p) | ||
| +3 | Brian CHING (Houston Dynamo) | |
| Javier MORALES (Real Salt Lake) | ||
| 5 | Landon DONOVAN (LA Galaxy, 3p) | |
| +1 | Brek SHEA (FC Dallas) | |
| +1 | Marko PEROVIĆ (New England Revolution) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Omar CUMMINGS (Colorado Rapids) | ||
| +1 | Steven LENHART (Columbus Crew) | |
| Robbie FINDLEY (Real Salt Lake, 1p) | ||
| Zack SCHILAWSKI (New England Revolution) |
| Wednesday, 18 August 2010 | |||||
| Chicago Fire | 2-1 | New England Revolution | |||
| 32 | Husidić | 16 | Perović | ||
| 85 | Carr | ||||
| Saturday, 21 August 2010 | |||||
| FC Dallas | 1-0 | Chivas USA | |||
| 71 | Shea | ||||
| Houston Dynamo | 4-3 | Chicago Fire | |||
| 31 | Ching | 55 | Carr | ||
| 50 | Palmer | 70(og) | Boswell | ||
| 59 | Ching | 81 | Conde | ||
| 85 | Ching | ||||
| Columbus Crew | 3-1 | Colorado Rapids | |||
| 6(p) | Barros Schelotto | 45 | Mastroeni | ||
| 53 | Garey | ||||
| 80 | Lenhart | ||||
| Kansas City Wizards | 4-1 | New England Revolution | |||
| 16 | Diop | 37 | Mansally | ||
| 27 | Diop | ||||
| 65 | Kamara | ||||
| 69 | Jewsbury | ||||
| Toronto FC | 1-4 | New York Red Bulls | |||
| 49 | De Rosario | 35 | Marquez | ||
| 41(og) | Nane | ||||
| 61(p) | Ángel | ||||
| 77 | Robinson | ||||
| San Jose Earthquakes | 1-0 | LA Galaxy | |||
| 4 | Wondolowski | ||||
