Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 186 | 436 | 2.34 | 94 | 50.54% | 47 | 25.27% | 45 | 24.19% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 24 | 13 | 5 | 6 | 33 | 23 | +10 | 44 | LWOW | 12 | 9 | 1 | 2 | 19 | 7 | 12 | 4 | 4 | 4 | 14 | 16 | ||
| 2 | New York Red Bulls | 24 | 12 | 4 | 8 | 30 | 25 | +5 | 40 | WLWW | 12 | 8 | 1 | 3 | 15 | 9 | 12 | 4 | 3 | 5 | 15 | 16 | ||
| 3 | 1 | Toronto FC | 24 | 7 | 7 | 10 | 22 | 27 | -5 | 28 | LOLO | 13 | 6 | 5 | 2 | 15 | 10 | 11 | 1 | 2 | 8 | 7 | 17 | |
| 4 | 1 | Kansas City Wizards | 22 | 7 | 6 | 9 | 22 | 24 | -2 | 27 | XWWL | 11 | 5 | 3 | 3 | 15 | 10 | 11 | 2 | 3 | 6 | 7 | 14 | |
| 5 | Chicago Fire | 22 | 6 | 8 | 8 | 28 | 30 | -2 | 26 | LOXL | 11 | 3 | 6 | 2 | 12 | 10 | 11 | 3 | 2 | 6 | 16 | 20 | ||
| 6 | 1 | Philadelphia Union | 23 | 6 | 6 | 11 | 27 | 38 | -11 | 24 | WXWL | 11 | 4 | 5 | 2 | 16 | 13 | 12 | 2 | 1 | 9 | 11 | 25 | |
| 7 | 1 | New England Revolution | 23 | 7 | 3 | 13 | 24 | 38 | -14 | 24 | LWLL | 12 | 6 | 2 | 4 | 17 | 14 | 11 | 1 | 1 | 9 | 7 | 24 | |
| 8 | D.C. United | 24 | 5 | 3 | 16 | 16 | 37 | -21 | 18 | WLLW | 12 | 3 | 1 | 8 | 9 | 17 | 12 | 2 | 2 | 8 | 7 | 20 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 24 | 14 | 5 | 5 | 36 | 18 | +18 | 47 | WXLL | 11 | 7 | 2 | 2 | 22 | 12 | 13 | 7 | 3 | 3 | 14 | 6 | ||
| 2 | Real Salt Lake | 24 | 12 | 8 | 4 | 37 | 16 | +21 | 44 | OWOW | 12 | 9 | 3 | 0 | 27 | 6 | 12 | 3 | 5 | 4 | 10 | 10 | ||
| 3 | FC Dallas | 23 | 10 | 11 | 2 | 29 | 17 | +12 | 41 | OWOW | 11 | 7 | 3 | 1 | 16 | 7 | 12 | 3 | 8 | 1 | 13 | 10 | ||
| 4 | Colorado Rapids | 23 | 9 | 7 | 7 | 29 | 24 | +5 | 34 | LWWL | 11 | 6 | 4 | 1 | 17 | 7 | 12 | 3 | 3 | 6 | 12 | 17 | ||
| 5 | 1 | San Jose Earthquakes | 22 | 9 | 6 | 7 | 24 | 23 | +1 | 33 | OWLW | 11 | 5 | 3 | 3 | 13 | 10 | 11 | 4 | 3 | 4 | 11 | 13 | |
| 6 | 1 | Seattle Sounders | 24 | 9 | 6 | 9 | 26 | 29 | -3 | 33 | OLWO | 13 | 6 | 3 | 4 | 16 | 13 | 11 | 3 | 3 | 5 | 10 | 16 | |
| 7 | 1 | Chivas USA | 23 | 7 | 4 | 12 | 25 | 29 | -4 | 25 | WLWL | 11 | 5 | 2 | 4 | 14 | 11 | 12 | 2 | 2 | 8 | 11 | 18 | |
| 8 | 1 | Houston Dynamo | 23 | 6 | 5 | 12 | 28 | 38 | -10 | 23 | LLWL | 12 | 5 | 3 | 4 | 21 | 16 | 11 | 1 | 2 | 8 | 7 | 22 | |
| 14 | +1 | Edson BUDDLE (LA Galaxy) |
| 12 | Juan Pablo ÁNGEL (New York Red Bulls, 2p) | |
| 11 | +1 | Sébastien LE TOUX (Philadelphia Union, 2p) |
| 10 | Fredy MONTERO (Seattle Sounders) | |
| 9 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| +1 | Omar CUMMINGS (Colorado Rapids) | |
| +1 | Justin BRAUN (Chivas USA) | |
| Conor CASEY (Colorado Rapids, 3p) | ||
| 8 | Kei KAMARA (Kansas City Wizards) | |
| Álvaro SABORIO (Real Salt Lake) | ||
| Chris WONDOLOWSKI (San Jose Earthquakes, 1p) | ||
| Steve ZAKUANI (Seattle Sounders) | ||
| Jeff CUNNINGHAM (FC Dallas, 2p) | ||
| 7 | Danny MWANGA (Philadelphia Union) | |
| Guillermo BARROS SCHELOTTO (Columbus Crew, 3p) | ||
| Marco PAPPA (Chicago Fire) | ||
| 6 | Marko PEROVIĆ (New England Revolution) | |
| Edgar ESPÍNDOLA (Real Salt Lake) | ||
| Chad BARRETT (Toronto FC) | ||
| David FERREIRA (FC Dallas, 3p) | ||
| Brian CHING (Houston Dynamo) | ||
| Javier MORALES (Real Salt Lake) |
| Sunday, 5 September 2010 | |||||
| Houston Dynamo | 1-2 | San Jose Earthquakes | |||
| 45 | Davis | 6 | Stephenson | ||
| 64 | Geovanni | ||||
| Wednesday, 8 September 2010 | |||||
| Chicago Fire | 0-0 | Toronto FC | |||
| Thursday, 9 September 2010 | |||||
| Seattle Sounders | 0-0 | Real Salt Lake | |||
| Friday, 10 September 2010 | |||||
| Chivas USA | 2-0 | New England Revolution | |||
| 6 | Braun | ||||
| 36 | Paulo Nagamura | ||||
| Saturday, 11 September 2010 | |||||
| New York Red Bulls | 3-1 | Colorado Rapids | |||
| 17 | Henry | 52 | Cummings | ||
| 32 | Ream | ||||
| 58 | Richards | ||||
| LA Galaxy | 3-1 | Columbus Crew | |||
| 13 | Buddle | 85 | Mendoza | ||
| 35 | Kovalenko | ||||
| 55 | Kirovski | ||||
| Toronto FC | 0-1 | D.C. United | |||
| 81 | James | ||||
| San Jose Earthquakes | 0-0 | FC Dallas | |||
| Philadelphia Union | 1-0 | Chicago Fire | |||
| 36 | Le Toux | ||||
