Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 231 | 557 | 2.41 | 110 | 47.62% | 57 | 24.68% | 64 | 27.71% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | New York Red Bulls | 29 | 14 | 6 | 9 | 36 | 29 | +7 | 48 | LOWW | 14 | 9 | 2 | 3 | 16 | 9 | 15 | 5 | 4 | 6 | 20 | 20 | ||
| 2 | Columbus Crew | 29 | 13 | 8 | 8 | 37 | 33 | +4 | 47 | XLOX | 14 | 9 | 2 | 3 | 19 | 11 | 15 | 4 | 6 | 5 | 18 | 22 | ||
| 3 | Kansas City Wizards | 29 | 10 | 6 | 13 | 32 | 34 | -2 | 36 | LWLL | 14 | 6 | 3 | 5 | 21 | 18 | 15 | 4 | 3 | 8 | 11 | 16 | ||
| 4 | Chicago Fire | 29 | 8 | 9 | 12 | 33 | 37 | -4 | 33 | OLWL | 15 | 4 | 7 | 4 | 14 | 13 | 14 | 4 | 2 | 8 | 19 | 24 | ||
| 5 | Toronto FC | 29 | 8 | 8 | 13 | 30 | 39 | -9 | 32 | XLLL | 15 | 6 | 6 | 3 | 19 | 15 | 14 | 2 | 2 | 10 | 11 | 24 | ||
| 6 | 1 | New England Revolution | 29 | 9 | 5 | 15 | 32 | 48 | -16 | 32 | WWLX | 15 | 7 | 3 | 5 | 21 | 18 | 14 | 2 | 2 | 10 | 11 | 30 | |
| 7 | 1 | Philadelphia Union | 29 | 8 | 7 | 14 | 34 | 46 | -12 | 31 | WLXL | 15 | 6 | 6 | 3 | 22 | 16 | 14 | 2 | 1 | 11 | 12 | 30 | |
| 8 | D.C. United | 29 | 6 | 4 | 19 | 19 | 44 | -25 | 22 | OLWL | 14 | 3 | 1 | 10 | 10 | 22 | 15 | 3 | 3 | 9 | 9 | 22 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 29 | 17 | 5 | 7 | 42 | 25 | +17 | 56 | LWWL | 14 | 8 | 2 | 4 | 25 | 18 | 15 | 9 | 3 | 3 | 17 | 7 | ||
| 2 | Real Salt Lake | 29 | 15 | 10 | 4 | 43 | 18 | +25 | 55 | WOWX | 15 | 11 | 4 | 0 | 31 | 7 | 14 | 4 | 6 | 4 | 12 | 11 | ||
| 3 | FC Dallas | 29 | 12 | 14 | 3 | 41 | 26 | +15 | 50 | LXWW | 15 | 8 | 6 | 1 | 25 | 13 | 14 | 4 | 8 | 2 | 16 | 13 | ||
| 4 | Seattle Sounders | 29 | 14 | 6 | 9 | 38 | 33 | +5 | 48 | WWWW | 15 | 8 | 3 | 4 | 21 | 16 | 14 | 6 | 3 | 5 | 17 | 17 | ||
| 5 | 1 | Colorado Rapids | 29 | 12 | 9 | 8 | 42 | 30 | +12 | 45 | WXLW | 14 | 8 | 4 | 2 | 24 | 9 | 15 | 4 | 5 | 6 | 18 | 21 | |
| 6 | 1 | San Jose Earthquakes | 28 | 12 | 7 | 9 | 30 | 29 | +1 | 43 | LWOL | 14 | 6 | 3 | 5 | 14 | 14 | 14 | 6 | 4 | 4 | 16 | 15 | |
| 7 | 1 | Houston Dynamo | 29 | 8 | 6 | 15 | 38 | 48 | -10 | 30 | WLXW | 14 | 5 | 3 | 6 | 23 | 20 | 15 | 3 | 3 | 9 | 15 | 28 | |
| 8 | 1 | Chivas USA | 28 | 8 | 4 | 16 | 30 | 38 | -8 | 28 | LWLL | 14 | 6 | 2 | 6 | 18 | 15 | 14 | 2 | 2 | 10 | 12 | 23 | |
| 17 | +1 | Edson BUDDLE (LA Galaxy) |
| 14 | Chris WONDOLOWSKI (San Jose Earthquakes, 2p) | |
| 13 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| +1 | Omar CUMMINGS (Colorado Rapids) | |
| Sébastien LE TOUX (Philadelphia Union, 2p) | ||
| Juan Pablo ÁNGEL (New York Red Bulls, 3p) | ||
| 12 | +1 | Conor CASEY (Colorado Rapids, 3p) |
| 11 | Jeff CUNNINGHAM (FC Dallas, 3p) | |
| 10 | Kei KAMARA (Kansas City Wizards) | |
| Álvaro SABORIO (Real Salt Lake, 1p) | ||
| Fredy MONTERO (Seattle Sounders) | ||
| +1 | Steve ZAKUANI (Seattle Sounders) | |
| 9 | Justin BRAUN (Chivas USA) | |
| 8 | Guillermo BARROS SCHELOTTO (Columbus Crew, 4p) | |
| David FERREIRA (FC Dallas, 4p) | ||
| 7 | Landon DONOVAN (LA Galaxy, 3p) | |
| Danny MWANGA (Philadelphia Union) | ||
| Chad BARRETT (Toronto FC) | ||
| Brian CHING (Houston Dynamo) | ||
| +1 | Javier MORALES (Real Salt Lake) | |
| Marco PAPPA (Chicago Fire) |
| Sunday, 10 October 2010 | |||||
| Houston Dynamo | 1-2 | New England Revolution | |||
| 59 | Oduro | 43 | Joseph | ||
| 73 | Dube | ||||
| Tuesday, 12 October 2010 | |||||
| Chicago Fire | 0-2 | Kansas City Wizards | |||
| 45 | Arnaud | ||||
| 80 | Bunbury | ||||
| Friday, 15 October 2010 | |||||
| Seattle Sounders | 2-1 | Chivas USA | |||
| 9 | Zakuani | 90 | Padilla | ||
| 25 | Alonso | ||||
| Saturday, 16 October 2010 | |||||
| New England Revolution | 1-0 | Kansas City Wizards | |||
| 31 | Joseph | ||||
| LA Galaxy | 1-3 | Colorado Rapids | |||
| 9 | Buddle | 18(og) | Buddle | ||
| 30 | Casey | ||||
| 67 | Cummings | ||||
| Chicago Fire | 0-0 | D.C. United | |||
| Real Salt Lake | 2-0 | FC Dallas | |||
| 59 | Grabavoy | ||||
| 89 | Morales | ||||
| Toronto FC | 2-2 | Columbus Crew | |||
| 29 | Maicon Carioca | 15 | Marshall | ||
| 38 | Peterson | 90 | Hesmer | ||
| San Jose Earthquakes | 0-1 | Houston Dynamo | |||
| 23 | Hainault | ||||
| Philadelphia Union | 2-1 | New York Red Bulls | |||
| 8 | Fred | 48 | Borman | ||
| 28 | Orozco | ||||
