Major League| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 177 | 421 | 2.37 | 90 | 50.85% | 44 | 24.86% | 43 | 24.29% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | Columbus Crew | 23 | 13 | 5 | 5 | 32 | 20 | +12 | 44 | WOWL | 12 | 9 | 1 | 2 | 19 | 7 | 11 | 4 | 4 | 3 | 13 | 13 | ||
| 2 | New York Red Bulls | 23 | 11 | 4 | 8 | 27 | 24 | +3 | 37 | LWWL | 11 | 7 | 1 | 3 | 12 | 8 | 12 | 4 | 3 | 5 | 15 | 16 | ||
| 3 | 1 | Kansas City Wizards | 22 | 7 | 6 | 9 | 22 | 24 | -2 | 27 | XWWL | 11 | 5 | 3 | 3 | 15 | 10 | 11 | 2 | 3 | 6 | 7 | 14 | |
| 4 | 1 | Toronto FC | 22 | 7 | 6 | 9 | 22 | 26 | -4 | 27 | LOLL | 12 | 6 | 5 | 1 | 15 | 9 | 10 | 1 | 1 | 8 | 7 | 17 | |
| 5 | Chicago Fire | 20 | 6 | 7 | 7 | 28 | 29 | -1 | 25 | XLLW | 10 | 3 | 5 | 2 | 12 | 10 | 10 | 3 | 2 | 5 | 16 | 19 | ||
| 6 | New England Revolution | 22 | 7 | 3 | 12 | 24 | 36 | -12 | 24 | WLLL | 12 | 6 | 2 | 4 | 17 | 14 | 10 | 1 | 1 | 8 | 7 | 22 | ||
| 7 | Philadelphia Union | 22 | 5 | 6 | 11 | 26 | 38 | -12 | 21 | XWLX | 10 | 3 | 5 | 2 | 15 | 13 | 12 | 2 | 1 | 9 | 11 | 25 | ||
| 8 | D.C. United | 23 | 4 | 3 | 16 | 15 | 37 | -22 | 15 | LLWL | 12 | 3 | 1 | 8 | 9 | 17 | 11 | 1 | 2 | 8 | 6 | 20 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 23 | 13 | 5 | 5 | 33 | 17 | +16 | 44 | XLLW | 10 | 6 | 2 | 2 | 19 | 11 | 13 | 7 | 3 | 3 | 14 | 6 | ||
| 2 | Real Salt Lake | 23 | 12 | 7 | 4 | 37 | 16 | +21 | 43 | WOWX | 12 | 9 | 3 | 0 | 27 | 6 | 11 | 3 | 4 | 4 | 10 | 10 | ||
| 3 | FC Dallas | 22 | 10 | 10 | 2 | 29 | 17 | +12 | 40 | WOWW | 11 | 7 | 3 | 1 | 16 | 7 | 11 | 3 | 7 | 1 | 13 | 10 | ||
| 4 | 1 | Colorado Rapids | 22 | 9 | 7 | 6 | 28 | 21 | +7 | 34 | WWLX | 11 | 6 | 4 | 1 | 17 | 7 | 11 | 3 | 3 | 5 | 11 | 14 | |
| 5 | 1 | Seattle Sounders | 23 | 9 | 5 | 9 | 26 | 29 | -3 | 32 | LWOW | 12 | 6 | 2 | 4 | 16 | 13 | 11 | 3 | 3 | 5 | 10 | 16 | |
| 6 | San Jose Earthquakes | 20 | 8 | 5 | 7 | 22 | 22 | +0 | 29 | LWWL | 10 | 5 | 2 | 3 | 13 | 10 | 10 | 3 | 3 | 4 | 9 | 12 | ||
| 7 | Houston Dynamo | 22 | 6 | 5 | 11 | 27 | 36 | -9 | 23 | LWLL | 11 | 5 | 3 | 3 | 20 | 14 | 11 | 1 | 2 | 8 | 7 | 22 | ||
| 8 | Chivas USA | 22 | 6 | 4 | 12 | 23 | 29 | -6 | 22 | LWLO | 10 | 4 | 2 | 4 | 12 | 11 | 12 | 2 | 2 | 8 | 11 | 18 | ||
| 13 | Edson BUDDLE (LA Galaxy) | |
| 12 | Juan Pablo ÁNGEL (New York Red Bulls, 2p) | |
| 10 | Fredy MONTERO (Seattle Sounders) | |
| +1 | Sébastien LE TOUX (Philadelphia Union, 2p) | |
| 9 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| +1 | Conor CASEY (Colorado Rapids, 3p) | |
| 8 | Kei KAMARA (Kansas City Wizards) | |
| Álvaro SABORIO (Real Salt Lake) | ||
| Chris WONDOLOWSKI (San Jose Earthquakes, 1p) | ||
| +2 | Omar CUMMINGS (Colorado Rapids) | |
| +1 | Justin BRAUN (Chivas USA) | |
| +1 | Steve ZAKUANI (Seattle Sounders) | |
| +1 | Jeff CUNNINGHAM (FC Dallas, 2p) | |
| 7 | Danny MWANGA (Philadelphia Union) | |
| +1 | Guillermo BARROS SCHELOTTO (Columbus Crew, 3p) | |
| Marco PAPPA (Chicago Fire) | ||
| 6 | +1 | Marko PEROVIĆ (New England Revolution) |
| +1 | Edgar ESPÍNDOLA (Real Salt Lake) | |
| Chad BARRETT (Toronto FC) | ||
| David FERREIRA (FC Dallas, 3p) | ||
| Brian CHING (Houston Dynamo) | ||
| Javier MORALES (Real Salt Lake) |
| Sunday, 29 August 2010 | |||||
| Chivas USA | 1-0 | D.C. United | |||
| 13 | Braun | ||||
| Saturday, 4 September 2010 | |||||
| D.C. United | 0-1 | Columbus Crew | |||
| 23 | Barros Schelotto | ||||
| FC Dallas | 1-0 | Toronto FC | |||
| 47 | Cunningham | ||||
| Colorado Rapids | 3-0 | Chivas USA | |||
| 52 | Casey | ||||
| 68 | Cummings | ||||
| 81 | Cummings | ||||
| New England Revolution | 3-1 | Seattle Sounders | |||
| 70 | Tierney | 59 | Zakuani | ||
| 73 | Perović | ||||
| 81 | Dube | ||||
| Chicago Fire | 1-1 | LA Galaxy | |||
| 88 | John | 90 | González | ||
| Real Salt Lake | 1-0 | New York Red Bulls | |||
| 4 | Espíndola | ||||
| Philadelphia Union | 1-1 | Kansas City Wizards | |||
| 33 | Le Toux | 69 | Arnaud | ||
