| ROUND | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| Season archive |
| Games | Goals | H | D | A | ||||
| 71 | 173 | 2.43 | 37 | 52.11% | 13 | 18.31% | 21 | 29.58% |
| Eastern | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | 1 | Columbus Crew | 8 | 6 | 2 | 0 | 14 | 6 | +8 | 20 | WWWW | 4 | 4 | 0 | 0 | 7 | 2 | 4 | 2 | 2 | 0 | 7 | 4 | |
| 2 | 1 | New York Red Bulls | 9 | 5 | 0 | 4 | 9 | 12 | -3 | 15 | LLLW | 5 | 3 | 0 | 2 | 6 | 6 | 4 | 2 | 0 | 2 | 3 | 6 | |
| 3 | Toronto FC | 9 | 4 | 1 | 4 | 12 | 13 | -1 | 13 | WOWL | 4 | 4 | 0 | 0 | 9 | 2 | 5 | 0 | 1 | 4 | 3 | 11 | ||
| 4 | Chicago Fire | 8 | 2 | 3 | 3 | 11 | 12 | -1 | 9 | XLXW | 3 | 1 | 1 | 1 | 4 | 3 | 5 | 1 | 2 | 2 | 7 | 9 | ||
| 5 | Kansas City Wizards | 8 | 2 | 2 | 4 | 8 | 9 | -1 | 8 | LXLL | 5 | 2 | 2 | 1 | 7 | 3 | 3 | 0 | 0 | 3 | 1 | 6 | ||
| 6 | New England Revolution | 10 | 2 | 2 | 6 | 10 | 15 | -5 | 8 | LOLL | 5 | 1 | 2 | 2 | 6 | 8 | 5 | 1 | 0 | 4 | 4 | 7 | ||
| 7 | Philadelphia Union | 7 | 1 | 1 | 5 | 7 | 15 | -8 | 4 | XLLL | 2 | 1 | 1 | 0 | 4 | 3 | 5 | 0 | 0 | 5 | 3 | 12 | ||
| 8 | D.C. United | 9 | 1 | 0 | 8 | 4 | 18 | -14 | 3 | LLLW | 5 | 1 | 0 | 4 | 2 | 8 | 4 | 0 | 0 | 4 | 2 | 10 | ||
| Western | Overall | Home | Away | |||||||||||||||||||||
| P | W | D | L | F | A | Gdf | Pts | Form | P | W | D | L | F | A | P | W | D | L | F | A | ||||
| 1 | LA Galaxy | 10 | 8 | 2 | 0 | 16 | 2 | +14 | 26 | WOWW | 5 | 4 | 1 | 0 | 8 | 2 | 5 | 4 | 1 | 0 | 8 | 0 | ||
| 2 | Real Salt Lake | 9 | 5 | 1 | 3 | 17 | 10 | +7 | 16 | WWWW | 4 | 3 | 1 | 0 | 10 | 4 | 5 | 2 | 0 | 3 | 7 | 6 | ||
| 3 | San Jose Earthquakes | 8 | 5 | 1 | 2 | 12 | 7 | +5 | 16 | WOWW | 4 | 3 | 0 | 1 | 7 | 3 | 4 | 2 | 1 | 1 | 5 | 4 | ||
| 4 | Houston Dynamo | 10 | 5 | 1 | 4 | 14 | 10 | +4 | 16 | WLWL | 6 | 4 | 0 | 2 | 10 | 4 | 4 | 1 | 1 | 2 | 4 | 6 | ||
| 5 | Colorado Rapids | 8 | 4 | 1 | 3 | 9 | 7 | +2 | 13 | WLLW | 3 | 1 | 1 | 1 | 5 | 4 | 5 | 3 | 0 | 2 | 4 | 3 | ||
| 6 | Seattle Sounders | 10 | 3 | 3 | 4 | 9 | 13 | -4 | 12 | LWLX | 6 | 2 | 1 | 3 | 4 | 7 | 4 | 1 | 2 | 1 | 5 | 6 | ||
| 7 | FC Dallas | 9 | 2 | 5 | 2 | 10 | 10 | +0 | 11 | LXWW | 5 | 1 | 3 | 1 | 6 | 6 | 4 | 1 | 2 | 1 | 4 | 4 | ||
| 8 | Chivas USA | 10 | 3 | 1 | 6 | 11 | 14 | -3 | 10 | LLLW | 5 | 2 | 0 | 3 | 6 | 7 | 5 | 1 | 1 | 3 | 5 | 7 | ||
| 9 | Edson BUDDLE (LA Galaxy) | |
| 6 | Dwayne DE ROSARIO (Toronto FC, 2p) | |
| 5 | Kei KAMARA (Kansas City Wizards) | |
| +1 | Chris WONDOLOWSKI (San Jose Earthquakes, 1p) | |
| 4 | Guillermo BARROS SCHELOTTO (Columbus Crew, 2p) | |
| Álvaro SABORIO (Real Salt Lake) | ||
| Sébastien LE TOUX (Philadelphia Union) | ||
| Zack SCHILAWSKI (New England Revolution) | ||
| Juan Pablo ÁNGEL (New York Red Bulls, 1p) | ||
| Jeff CUNNINGHAM (FC Dallas, 2p) | ||
| 3 | Brad DAVIS (Houston Dynamo, 2p) | |
| +1 | Chad BARRETT (Toronto FC) | |
| Brian McBRIDE (Chicago Fire, 1p) | ||
| Fredy MONTERO (Seattle Sounders) | ||
| +1 | Justin BRAUN (Chivas USA) | |
| Jesus PADILLA (Chivas USA) | ||
| Steve ZAKUANI (Seattle Sounders) | ||
| Javier MORALES (Real Salt Lake) | ||
| Conor CASEY (Colorado Rapids, 3p) |
| Thursday, 20 May 2010 | |||||
| FC Dallas | 0-1 | LA Galaxy | |||
| 17 | Magee | ||||
| New York Red Bulls | 1-3 | Columbus Crew | |||
| 81 | Tchani | 35 | Gaven | ||
| 39 | Iro | ||||
| 83 | Rentería | ||||
| Saturday, 22 May 2010 | |||||
| Houston Dynamo | 2-0 | D.C. United | |||
| 10 | Cruz | ||||
| 55 | Oduro | ||||
| Seattle Sounders | 0-1 | San Jose Earthquakes | |||
| 11 | Wondolowski | ||||
| Chivas USA | 1-2 | Real Salt Lake | |||
| 80 | Braun | 45 | Wingert | ||
| 89 | Espíndola | ||||
| Toronto FC | 1-0 | New England Revolution | |||
| 53 | Barrett | ||||
| Sunday, 23 May 2010 | |||||
| Kansas City Wizards | 0-1 | Columbus Crew | |||
| 64 | Rentería | ||||